阅读说明：本技术 氧杂氮杂喹唑啉-7(8h)-酮类化合物,其制法与医药上的用途 (Oxaazaquinazolin-7 (8H) -ones, their preparation and pharmaceutical use ) 是由 周福生 蔡礼健 蒋涛 赵吉辰 刘颖涛 赵金柱 张磊涛 刘柱博 彭灵 何宛 杨华彬 于 2020-04-28 设计创作，主要内容包括：一种对KRAS基因突变具有选择抑制作用的氧杂氮杂喹唑啉-7(8H)-酮类化合物及其药学上可接受的盐、立体异构体、溶剂化合物或前药,如式I或式II所示,式中各基团的定义详见说明书。此外,本发明还公开了包含该化合物的药物组合物,及其在制备癌症药物中的应用。(An oxazaquinazoline-7 (8H) -ketone compound with selective inhibition effect on KRAS gene mutation and pharmaceutically acceptable salts, stereoisomers, solvent compounds or prodrugs thereof are shown as a formula I or a formula II, and the definitions of all groups in the formula are shown in the specification. In addition, the invention also discloses a pharmaceutical composition containing the compound and application thereof in preparing cancer drugs.)