阅读说明：本技术 椎间融合假体及椎间融合假体的加工方法 (Intervertebral fusion prosthesis and processing method thereof ) 是由 黄朝阳 魏崇斌 于 2021-09-03 设计创作，主要内容包括：本发明提供了一种椎间融合假体及椎间融合假体的加工方法,其中,椎间融合假体,包括：多个椎体本体,每个椎体本体的尺寸均不同,多个上终板,每个上终板的尺寸均不同,多个上终板择一地连接在一个椎体本体的顶部；多个下终板,每个下终板的尺寸均不同,多个下终板择一地连接在一个椎体本体的底部；第一紧固件,第一紧固件穿过上终板连接在椎体本体上；第二紧固件,第二紧固件穿过下终板连接在椎体本体上。本申请的技术方案有效地解决了相关技术中的一体结构的假体自身无法进行调整,使得弥补体内的椎体的差异的效果较差的问题。(The invention provides an intervertebral fusion prosthesis and a processing method thereof, wherein the intervertebral fusion prosthesis comprises: the size of each vertebral body is different, the size of each upper end plate is different, and the upper end plates are alternatively connected to the top of one vertebral body; the lower end plates are different in size and are alternatively connected to the bottom of a vertebral body; the first fastener penetrates through the upper end plate and is connected to the vertebral body; and a second fastener connected to the vertebral body through the inferior endplate. The technical scheme of the application has solved the prosthesis of integrative structure among the relevant art effectively and can't adjust for compensate the relatively poor problem of effect of the difference of internal centrum.)

1. An intervertebral fusion prosthesis, comprising:

a plurality of vertebral body (10), each of said vertebral body (10) being of a different size,

a plurality of upper endplates (20), each of the upper endplates (20) having a different size, the plurality of upper endplates (20) being alternatively attached to a top portion of one of the vertebral bodies (10);

a plurality of lower end plates (30), each lower end plate (30) having a different size, the plurality of lower end plates (30) being alternatively attached to the bottom of one of the vertebral bodies (10);

a first fastener (40), said first fastener (40) being attached to said vertebral body (10) through said superior endplate (20);

a second fastener (50), the second fastener (50) being attached to the vertebral body (10) through the inferior endplate (30).

2. The intervertebral fusion prosthesis of claim 1,

each upper end plate (20) is connected with the top of the corresponding vertebral body (10) through a first plug structure, each first plug structure comprises a first slot (41) and a first dowel (42) in plug fit with the first slot (41), one of the first slot (41) and the first dowel (42) is arranged at the top of the vertebral body (10), and the other one is arranged at the bottom of the upper end plate (20);

each lower end plate (30) is connected with the bottom of the corresponding vertebral body (10) through a second inserting structure, each second inserting structure comprises a second inserting groove (43) and a second inserting rib (44) which is inserted and matched with the second inserting groove (43), one of the second inserting grooves (43) and the second inserting ribs (44) is arranged at the bottom of the vertebral body (10), and the other one of the second inserting grooves (43) and the second inserting ribs (44) is arranged at the top of the lower end plate (30).

3. The intervertebral fusion prosthesis of claim 2,

the first slot (41) is arranged at the top of the vertebral body (10), the first dowel (42) is arranged at the bottom of the upper endplate (20), the second slot (43) is arranged at the bottom of the vertebral body (10), the second dowel (44) is arranged at the top of the lower endplate (30),

the vertebral body (10) comprises a cylindrical frame body (11) and a porous structure (12) filled in a gap of the cylindrical frame body (11), the first insertion groove (41) is formed in the top of the cylindrical frame body (11), and the second insertion groove (43) is formed in the bottom of the cylindrical frame body (11).

4. The intervertebral fusion prosthesis of claim 3,

the cylindrical frame body (11) comprises an upper annular plate (111), a middle annular plate (112) and a lower annular plate (113) which are sequentially arranged at intervals, the cylindrical frame body (11) further comprises a first vertical beam (114) arranged between the upper annular plate (111) and the middle annular plate (112) and a second vertical beam (115) arranged between the middle annular plate (112) and the lower annular plate (113), and the porous structure (12) comprises a first porous structure layer (121) connected between the upper annular plate (111) and the middle annular plate (112) and a second porous structure layer (122) connected between the lower annular plate (113) and the middle annular plate (112);

vertebral body (10) still including wearing to establish spliced pole (13) in tube-shape support body (11), the axis perpendicular to of spliced pole (13) the bottom surface of tube-shape support body (11), tube-shape support body (11) are still including connecting go up crown plate (111) with first splice bar (14) of the top lateral wall of spliced pole (13), first slot (41) set up on first splice bar (14), tube-shape support body (11) are still including connecting lower crown plate (113) with second splice bar (15) of the bottom lateral wall of spliced pole (13), second slot (43) set up on second splice bar (15).

5. The intervertebral fusion prosthesis of claim 3,

the vertebral body (10) further comprises a connecting column (13) penetrating through the cylindrical frame body (11), the axis of the connecting column (13) is perpendicular to the bottom surface of the cylindrical frame body (11), the porous structure (12) is arranged in a gap between the cylindrical frame body (11) and the connecting column (13),

the first fastening element (40) is connected to the connecting column (13) through the upper closure plate (20), and the second fastening element (50) is connected to the connecting column (13) through the lower closure plate (30).

6. The intervertebral fusion prosthesis of claim 2,

the upper endplate (20) comprises a first ring body (21) and a third porous structure layer (22) arranged in the first ring body (21), the first dowel (42) is connected to the first ring body (21) and the third porous structure layer (22), the third porous structure layer (22) comprises a plurality of first trabecular bone structures (221) which are arranged in a staggered mode, first trabecular bone structure holes are formed among the first trabecular bone structures (221) which are arranged in the staggered mode, and a plurality of first bulges (222) are arranged on the outer surface, away from the vertebral body (10), of the first trabecular bone structures (221);

the lower end plate (30) comprises a second ring body (31) and a fourth porous structure layer (32) arranged in the second ring body (31), a second dowel (44) is connected to the second ring body (31) and the fourth porous structure layer (32), wherein the fourth porous structure layer (32) comprises a plurality of second trabecular bone structures (321) which are arranged in a staggered mode, a plurality of second trabecular bone structure holes are formed between the second trabecular bone structures (321) in a staggered mode, and the second trabecular bone structures (321) are far away from a plurality of second bulges (322) arranged on the outer surface of the vertebral body (10).

7. The intervertebral fusion prosthesis of claim 6,

a plurality of first holes (2211) and a plurality of second holes (2212) are arranged on the first bone trabecular structure (221) at intervals, the diameter of each first hole (2211) is larger than that of each second hole (2212), and a third hole (2221) communicated with the second hole (2212) is arranged on the first bulge (222);

a plurality of fourth holes (3211) and a plurality of fifth holes (3212) are arranged on the second bone trabecular structure (321) at intervals, the diameter of the fourth holes (3211) is greater than that of the fifth holes (3212), and a sixth hole (3221) communicated with the fifth holes (3212) is arranged on the second protrusion (322).

8. The intervertebral fusion prosthesis of claim 6,

a first bone grafting window (223) communicated with the interior of the vertebral body (10) is arranged on the third porous structural layer (22), and a second bone grafting window (323) communicated with the interior of the vertebral body (10) is arranged on the fourth porous structural layer (32);

the cone body (10) comprises a cylindrical frame body (11) and a porous structure (12) filled in a gap of the cylindrical frame body (11), the cylindrical frame body (11) comprises an upper ring plate (111), a middle ring plate (112) and a lower ring plate (113) which are sequentially arranged at intervals, the shapes of the upper ring plate (111), the middle ring plate (112) and the lower ring plate (113) are the same, the upper ring plate (111) comprises a first outer convex arc surface (1111), a second outer convex arc surface (1112), a third outer convex arc surface (1113) and a first inner concave arc surface (1114) which are sequentially connected end to end,

wherein the first convex arc surface (1111), the second convex arc surface (1112), the third convex arc surface (1113) and the first concave arc surface (1114) are sequentially projected on a horizontal plane to form a first convex arc surface, a second convex arc surface, a third convex arc surface and a first concave arc surface, the radian of the first convex arc surface is the same as that of the third convex arc surface, the radian of the second convex arc surface is greater than that of the first convex arc surface, and the radius R1 of the second convex arc surface ranges from 5mm to 15mm,

a transverse bisection plane vertical to the axis of the cylindrical frame body (11) is set as a symmetrical plane, the upper end plate (20) and the lower end plate (30) are symmetrically arranged relative to the symmetrical plane, the upper end plate (20) is high in the middle and low in two sides,

the upper end plate (20) comprises a fifth convex arc surface (23), a sixth convex arc surface (24), a seventh convex arc surface (25) and a second concave arc surface (26) which are sequentially connected end to end, wherein the fifth convex arc surface (23), the sixth convex arc surface (24), the seventh convex arc surface (25) and the second concave arc surface (26) are sequentially projected on a horizontal plane to form a fifth convex arc surface, a sixth convex arc surface, a seventh convex arc surface and a second concave arc surface, the radian of the fifth convex arc surface is the same as that of the seventh convex arc surface, the radian of the sixth convex arc surface is greater than that of the fifth convex arc surface, and the radius R2 of the sixth convex arc surface ranges from 5mm to 15mm,

and setting a connecting line passing through the midpoint of the sixth outer convex arc line and the midpoint of the second inner concave arc line as a symmetrical line, wherein an included angle a is formed between the symmetrical line and the bottom surface of the upper end plate (20), and the included angle a ranges from 0 degree to 12 degrees.

9. A method of processing an intervertebral fusion prosthesis according to any one of claims 1 to 8, comprising the steps of:

step S10: acid-washing the upper endplate blank, the vertebral body blank and the lower endplate blank;

step S20: carrying out anodic oxidation surface treatment on the acid-washed upper endplate blank, the acid-washed vertebral body blank and the acid-washed lower endplate blank;

step S30: and connecting the upper endplate blank subjected to the anodic oxidation surface treatment with the top of the vertebral body blank through a first fastener, and connecting the lower endplate blank subjected to the anodic oxidation surface treatment with the bottom of the vertebral body blank through a second fastener to obtain the intervertebral fusion prosthesis.

10. The method for processing an intervertebral fusion prosthesis recited in claim 9, wherein in step S10, the upper endplate blank, the vertebral body blank, and the lower endplate blank are acid-washed with a mixed solution of nitric acid and hydrofluoric acid, wherein the nitric acid concentration is between 60% and 70% and the hydrofluoric acid concentration is between 45% and 60%.

Technical Field

The invention relates to the field of medical instruments, in particular to an intervertebral fusion prosthesis and a processing method thereof.

Background

Tumor, fracture, tuberculosis and the like of the vertebral body usually cause serious damage to the vertebral body, and the currently clinically applied treatment method is bone grafting reconstruction, including autologous bone grafting and allogeneic bone grafting. Prosthetic reconstruction is suitable for vertebral body replacement in a corpectomy.

Because two end faces of the prosthesis are mostly in a plane structure, the implants such as a titanium mesh used in prosthesis reconstruction cannot be well matched with vertebral endplates, stress concentration is easy to occur, the prosthesis is sunk, and the fusion effect is influenced. Most prostheses are of a one-piece structure, multiple model specifications are required to be prepared at one time during the operation, and the risk of misuse exists in the similar model specifications. Because different human bodies and internal vertebral bodies of the human bodies also have differences, the height or the angle of the human bodies needs to be adjusted when the prosthesis is implanted so as to make up the differences of the internal vertebral bodies.

Disclosure of Invention

The invention mainly aims to provide an intervertebral fusion prosthesis and a processing method thereof, which aim to solve the problem that the prosthesis with an integrated structure in the related technology cannot be adjusted so as to make up the difference of vertebral bodies in vivo and have poor effect.

In order to achieve the above object, according to one aspect of the present invention, there is provided an intervertebral fusion prosthesis comprising: the size of each vertebral body is different, the size of each upper end plate is different, and the upper end plates are alternatively connected to the top of one vertebral body; the lower end plates are different in size and are alternatively connected to the bottom of a vertebral body; the first fastener penetrates through the upper end plate and is connected to the vertebral body; and a second fastener connected to the vertebral body through the inferior endplate.

Furthermore, each upper end plate is connected with the top of the corresponding vertebral body through a first inserting structure, each first inserting structure comprises a first inserting slot and a first inserting rib matched with the first inserting slot in an inserting mode, one of the first inserting slot and the first inserting rib is arranged at the top of the vertebral body, and the other one of the first inserting slot and the first inserting rib is arranged at the bottom of the upper end plate; each lower end plate is connected with the bottom of the corresponding vertebral body through a second inserting structure, the second inserting structure comprises a second inserting groove and a second inserting rib matched with the second inserting groove in an inserting mode, one of the second inserting groove and the second inserting rib is arranged at the bottom of the vertebral body, and the other one of the second inserting groove and the second inserting rib is arranged at the top of the lower end plate.

Further, first slot sets up at the top of centrum body, and first dowel bar sets up the bottom at last end plate, and the second slot sets up in the bottom of centrum body, and the second dowel bar sets up the top at end plate down, and wherein, centrum body includes the tube-shape support body and fills the porous structure in the space of tube-shape support body, and first slot sets up at the top of tube-shape support body, and the second slot sets up the bottom at the tube-shape support body.

The cylindrical support body further comprises an upper ring plate, a middle ring plate and a lower ring plate which are sequentially arranged at intervals, the cylindrical support body further comprises a first vertical beam arranged between the upper ring plate and the middle ring plate and a second vertical beam arranged between the middle ring plate and the lower ring plate, and the porous structure comprises a first porous structure layer connected between the upper ring plate and the middle ring plate and a second porous structure layer connected between the lower ring plate and the middle ring plate; the cone body further comprises a connecting column penetrating through the cylindrical frame body, the axis of the connecting column is perpendicular to the bottom surface of the cylindrical frame body, the cylindrical frame body further comprises a first connecting rib for connecting the top side wall of the upper annular plate and the connecting column, a first slot is formed in the first connecting rib, the cylindrical frame body further comprises a second connecting rib for connecting the bottom side wall of the lower annular plate and the connecting column, and a second slot is formed in the second connecting rib.

Furthermore, the vertebral body further comprises a connecting column penetrating through the cylindrical frame body, the axis of the connecting column is perpendicular to the bottom surface of the cylindrical frame body, the porous structure is arranged in a gap between the cylindrical frame body and the connecting column, the first fastener penetrates through the upper end plate to be connected to the connecting column, and the second fastener penetrates through the lower end plate to be connected to the connecting column.

Furthermore, the upper end plate comprises a first ring body and a third porous structure layer arranged in the first ring body, and the first dowel bar is connected to the first ring body and the third porous structure layer, wherein the third porous structure layer comprises a plurality of first trabecular bone structures which are arranged in a staggered mode, first trabecular bone structure holes are formed among the plurality of first trabecular bone structures which are arranged in a staggered mode, and a plurality of first bulges are arranged on the outer surface, far away from the vertebral body, of each first trabecular bone structure; the lower end plate comprises a second ring body and a fourth porous structure layer arranged in the second ring body, the second dowel bar is connected to the second ring body and the fourth porous structure layer, the fourth porous structure layer comprises a plurality of second bone trabecula structures which are arranged in a staggered mode, second bone trabecula structure holes are formed between the plurality of second bone trabecula structures which are arranged in a staggered mode, and a plurality of second protrusions are arranged on the outer surface, far away from the vertebral body, of each second bone trabecula structure.

Furthermore, a plurality of first holes and a plurality of second holes are arranged on the first bone trabecular structure at intervals, the diameter of each first hole is larger than that of each second hole, and a third hole communicated with the second holes is arranged on each first protrusion; a plurality of fourth holes and a plurality of fifth holes are arranged on the second bone trabecula structure at intervals, the diameter of the fourth holes is larger than that of the fifth holes, and the second bulge is provided with a sixth hole communicated with the fifth holes.

Furthermore, a first bone grafting window communicated with the interior of the vertebral body is arranged on the third porous structure layer, and a second bone grafting window communicated with the interior of the vertebral body is arranged on the fourth porous structure layer; the cone body comprises a cylindrical frame body and a porous structure filled in a gap of the cylindrical frame body, the cylindrical frame body comprises an upper ring plate, a middle ring plate and a lower ring plate which are sequentially arranged at intervals, the shapes of the upper ring plate, the middle ring plate and the lower ring plate are the same, the upper ring plate comprises a first outer convex arc surface, a second outer convex arc surface, a third outer convex arc surface and a first inner concave arc surface which are sequentially connected end to end, the first outer convex arc surface, the second outer convex arc surface, the third outer convex arc surface and the first inner concave arc surface are sequentially projected on a horizontal plane to form a first outer convex arc line, a second outer convex arc line, a third outer convex arc line and a first inner concave arc line, the radian of the first outer convex arc line is the same as that of the third outer convex arc line, the radian of the second outer convex arc line is larger than that of the first outer convex arc line, the radius R1 of the second outer convex arc line ranges from 5mm to 15mm, a transverse plane perpendicular to the axis of the cylindrical frame body is set as a symmetrical plane, the upper end plate is symmetrically arranged relative to the symmetrical surface and the lower end plate, the upper end plate is high in the middle and low in two sides, the upper end plate comprises a fifth outer arc surface, a sixth outer arc surface, a seventh outer arc surface and a second inner arc surface which are sequentially connected end to end, wherein the fifth outer arc surface, the sixth outer arc surface, the seventh outer arc surface and the second inner arc surface are sequentially projected on a horizontal plane to form a fifth outer arc line, a sixth outer arc line, a seventh outer arc line and a second inner arc surface, the radian of the fifth outer arc line is the same as that of the seventh outer arc line, the radian of the sixth outer arc line is larger than that of the fifth outer arc line, the radius R2 of the sixth outer arc line ranges from 5mm to 15mm, a connecting line passing through the midpoint of the sixth outer arc line and the midpoint of the second inner arc line is set to be a symmetrical line, and an included angle a is formed between the symmetrical line and the bottom surface of the upper end plate, the angle a ranges between 0 ° and 12 °.

According to another aspect of the present invention, there is provided a method for processing an intervertebral fusion prosthesis, the method comprising the steps of: step S10: acid-washing the upper endplate blank, the vertebral body blank and the lower endplate blank; step S20: carrying out anodic oxidation surface treatment on the acid-washed upper endplate blank, the acid-washed vertebral body blank and the acid-washed lower endplate blank; step S30: and connecting the upper endplate blank subjected to the anodic oxidation surface treatment with the top of the vertebral body blank through a first fastener, and connecting the lower endplate blank subjected to the anodic oxidation surface treatment with the bottom of the vertebral body blank through a second fastener to obtain the intervertebral fusion prosthesis.

Further, in step S10, the upper endplate blank, the vertebral body blank, and the lower endplate blank are acid-washed with a mixed solution of nitric acid and hydrofluoric acid, wherein the concentration of nitric acid is between 60% and 70%, and the concentration of hydrofluoric acid is between 45% and 60%.

Applying the technical scheme of the invention, the intervertebral fusion prosthesis comprises: a plurality of vertebral body, a plurality of upper endplates, a plurality of lower endplates, a first fastener, and a second fastener. Each vertebral body is of a different size. Each of the upper endplates is of a different size, and a plurality of upper endplates are alternatively attached to the top of a vertebral body. Each lower end plate has a different size, and a plurality of lower end plates are alternatively connected to the bottom of a vertebral body. A first fastener is attached to the vertebral body through the superior endplate. A second fastener is attached to the vertebral body through the inferior endplate. Therefore, under the condition that the height or the angle of the intervertebral fusion prosthesis needs to be adjusted when the intervertebral fusion prosthesis is implanted, a plurality of upper end plates can be alternatively connected to the top of one vertebral body, the top of the intervertebral fusion prosthesis can be adjusted, and the intervertebral fusion prosthesis is fastened through the first fastening piece. Meanwhile, a plurality of lower end plates can be alternatively connected to the bottom of a vertebral body, the bottom of the implanted intervertebral fusion prosthesis can be adjusted, and the lower end plates are fastened through a second fastening piece. Like this, the top and the bottom homoenergetic of split type interbody fusion prosthesis of this application can make the adjustment, can compensate the difference of internal centrum effectively, obtain better the effect of compensateing, and then guarantee the normal process of operation. Therefore, the technical scheme of the application effectively solves the problem that the prosthesis with an integrated structure in the related technology cannot be adjusted, so that the difference of the vertebral bodies in the body is compensated, and the effect is poor.

Drawings

The accompanying drawings, which are incorporated in and constitute a part of this application, illustrate embodiments of the invention and, together with the description, serve to explain the invention and not to limit the invention. In the drawings:

FIG. 1 shows an exploded schematic view of an embodiment of an intervertebral fusion prosthesis according to the invention;

FIG. 2 illustrates a perspective view of the cylindrical cage of the intervertebral fusion prosthesis of FIG. 1;

FIG. 3 shows a schematic top view of the vertebral body of the intervertebral fusion prosthesis of FIG. 1;

FIG. 4 illustrates a schematic top view of the upper endplate of the intervertebral fusion prosthesis of FIG. 1;

FIG. 5 illustrates a side view of the upper endplate of FIG. 4;

FIG. 6 is a perspective view of a first trabecular bone structure of the intervertebral fusion prosthesis of FIG. 1;

FIG. 7 shows a schematic cross-sectional view of the first trabecular bone structure of FIG. 6;

FIG. 8 is a perspective view of a second trabecular bone structure of the intervertebral fusion prosthesis of FIG. 1;

FIG. 9 shows a schematic cross-sectional view of the second trabecular bone structure of FIG. 8;

FIG. 10 illustrates a cross-sectional view of the vertebral body of FIG. 1; and

fig. 11 shows a flow chart of an embodiment of a method of processing an intervertebral fusion prosthesis according to the invention.

Wherein the figures include the following reference numerals:

10. a vertebral body; 11. a cylindrical frame body; 111. an upper ring plate; 1111. a first convex cambered surface; 1112. a second convex arc surface; 1113. a third convex cambered surface; 1114. a first concave arc surface; 112. a middle ring plate; 113. a lower ring plate; 114. a first vertical beam; 115. a second vertical beam; 116. a third vertical beam; 12. a porous structure; 121. a first porous structure layer; 122. a second porous structure layer; 13. connecting columns; 14. a first connecting rib; 15. a second connecting rib; 20. an upper endplate; 21. a first ring body; 22. a third porous structure layer; 221. a first trabecular bone structure; 2211. a first hole; 2212. a second hole; 222. a first protrusion; 2221. a third aperture; 223. a first bone graft window; 23. a fifth convex cambered surface; 24. a sixth convex cambered surface; 25. a seventh convex cambered surface; 26. a second concave arc surface; 28. a first mounting hole; 30. a lower endplate; 31. a second ring body; 32. a fourth porous structure layer; 321. a second trabecular bone structure; 3211. a fourth aperture; 3212. a fifth aperture; 322. a second protrusion; 3221. a sixth hole; 323. a second bone graft window; 38. a second mounting hole; 40. a first fastener; 401. a first operation hole; 41. a first slot; 42. a first dowel; 43. a second slot; 44. a second dowel; 50. a second fastener.

Detailed Description

The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. The following description of at least one exemplary embodiment is merely illustrative in nature and is in no way intended to limit the invention, its application, or uses. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

It is noted that the terminology used herein is for the purpose of describing particular embodiments only and is not intended to be limiting of example embodiments according to the present application. As used herein, the singular forms "a", "an" and "the" are intended to include the plural forms as well, and it should be understood that when the terms "comprises" and/or "comprising" are used in this specification, they specify the presence of stated features, steps, operations, devices, components, and/or combinations thereof, unless the context clearly indicates otherwise.

The relative arrangement of the components and steps, the numerical expressions and numerical values set forth in these embodiments do not limit the scope of the present invention unless specifically stated otherwise. Meanwhile, it should be understood that the sizes of the respective portions shown in the drawings are not drawn in an actual proportional relationship for the convenience of description. Techniques, methods, and apparatus known to those of ordinary skill in the relevant art may not be discussed in detail but are intended to be part of the specification where appropriate. In all examples shown and discussed herein, any particular value should be construed as merely illustrative, and not limiting. Thus, other examples of the exemplary embodiments may have different values. It should be noted that: like reference numbers and letters refer to like items in the following figures, and thus, once an item is defined in one figure, further discussion thereof is not required in subsequent figures.

As shown in fig. 1 to 4, the intervertebral fusion prosthesis of the present embodiment includes: a plurality of vertebral bodies 10, a plurality of upper endplates 20, a plurality of lower endplates 30, a first fastener 40, and a second fastener 50. Each vertebral body 10 is of a different size. Each of the upper endplates 20 is of a different size, and a plurality of upper endplates 20 are alternatively attached to the top of one vertebral body 10. Each lower endplate 30 is of a different size, and a plurality of lower endplates 30 are alternatively attached to the bottom of one vertebral body 10. A first fastener 40 is attached to the vertebral body 10 through the superior endplate 20. A second fastener 50 is attached to vertebral body 10 through the lower endplate 30.

By applying the technical scheme of the embodiment, under the condition that the height or the angle of the intervertebral fusion prosthesis needs to be adjusted when the intervertebral fusion prosthesis is implanted, a plurality of upper end plates 20 can be alternatively connected to the top of one vertebral body 10, the top of the intervertebral fusion prosthesis can be adjusted, and the intervertebral fusion prosthesis is fastened through the first fastening piece 40. Also, a plurality of lower endplates 30 can be alternatively attached to the bottom of one vertebral body 10, and the bottom of the implanted intervertebral fusion prosthesis can be adjusted and fastened by the second fasteners 50. Like this, the top and the bottom of the split type intervertebral fusion prosthesis of this embodiment all can make the adjustment, can compensate the difference of internal centrum effectively, obtain better compensation effect, and then guarantee the normal process of operation. Therefore, the technical scheme of the embodiment effectively solves the problem that the prosthesis with an integrated structure in the related art cannot adjust itself, so that the difference of vertebral bodies in the body is compensated, and the effect is poor.

As shown in fig. 1-4, each upper endplate 20 is connected to the top of the corresponding vertebral body 10 via a first plug-in structure. The first inserting structure includes a first inserting groove 41 and a first inserting rib 42 inserted and matched with the first inserting groove 41. A first slot 41 is provided at the top of the vertebral body 10 and a first tendon 42 is provided at the bottom of the upper endplate 20. Thus, the first insertion groove 41 and the first dowel bar 42 are in insertion fit, so that each upper end plate 20 is rapidly connected with the top of the corresponding vertebral body 10, the first insertion groove 41 can limit the first dowel bar 42, and each upper end plate 20 is prevented from shifting relative to the top of the corresponding vertebral body 10, so that the intervertebral fusion prosthesis can be stably supported. Specifically, each first dowel bar 42 is of an equal-thickness structure, and each first slot 41 is of an equal-width structure, so that the upper end plates 20 can be alternatively connected to the top of one vertebral body 10, and the upper end plates can be conveniently inserted and matched in the up-down direction, are convenient to assemble and disassemble, and are beneficial to improving the replacement efficiency.

In an embodiment not shown in the figures, a first tendon may be disposed at the top of the vertebral body and a first slot may be disposed at the bottom of the superior endplate.

As shown in fig. 1 to 4, each lower end plate 30 is connected to the bottom of the corresponding vertebral body 10 through a second plug structure, the second plug structure includes a second slot 43 and a second rib 44 plug-fitted into the second slot 43, the second slot 43 is disposed at the bottom of the vertebral body 10, and the second rib 44 is disposed at the top of the lower end plate 30. In this way, the second insertion slot 43 and the second tendon 44 are inserted and matched, so that each lower end plate 30 is rapidly connected with the bottom of the corresponding vertebral body 10, and the second insertion slot 43 can limit the second tendon 44, thereby preventing each lower end plate 30 from shifting relative to the bottom of the corresponding vertebral body 10, and enabling the intervertebral fusion prosthesis to be stably supported. Specifically, each second dowel 44 is of an equal-thickness structure, and each second slot 43 is of an equal-width structure, so that the plurality of lower end plates 30 are alternatively connected to the bottom of one vertebral body 10, and the lower end plates are conveniently spliced and matched in the up-down direction, are convenient to assemble and disassemble, and are beneficial to improving the replacement efficiency.

In an embodiment not shown in the figures, a second tendon may be provided at the bottom of the vertebral body and a second slot may be provided at the top of the inferior endplate.

As shown in fig. 1-4, a first slot 41 is provided at the top of the vertebral body 10, a first tendon 42 is provided at the bottom of the superior endplate 20, and a second slot 43 is provided at the bottom of the vertebral body 10. A second tendon 44 is disposed on top of the lower endplate 30. The vertebral body 10 includes a cylindrical frame 11 and a porous structure 12 filled in the gap of the cylindrical frame 11, wherein a first slot 41 is disposed at the top of the cylindrical frame 11, and a second slot 43 is disposed at the bottom of the cylindrical frame 11. The cylindrical frame body 11 has a shape similar to a human vertebral body, which can provide uniform supporting force so that each of the upper end plate 20 and each of the lower end plate 30 can provide stable supporting force. The porous structure 12 is arranged to guide bone tissue to grow into the intervertebral fusion prosthesis, so that the intervertebral fusion prosthesis has better bone growth effect and better implantation stability.

As shown in fig. 1 to 4, the cylindrical frame 11 includes an upper ring plate 111, a middle ring plate 112, and a lower ring plate 113, which are sequentially disposed at intervals. The cylindrical frame 11 further includes a first vertical beam 114 disposed between the upper ring plate 111 and the middle ring plate 112, and a second vertical beam 115 disposed between the middle ring plate 112 and the lower ring plate 113. The porous structure 12 includes a first porous structure layer 121 connected between the upper ring plate 111 and the middle ring plate 112, and a second porous structure layer 122 connected between the lower ring plate 113 and the middle ring plate 112. In this way, the first porous structure layer 121 can guide bone tissue growth into the space between the upper ring plate 111 and the middle ring plate 112, resulting in better bone growth into the vertebral body 10 and thus better implant stability. Meanwhile, the second porous structure layer 122 can guide bone tissue to grow into the gap between the lower ring plate 113 and the middle ring plate 112, so that the vertebral body 10 has better bone growth effect, and better implantation stability is obtained. The arrangement of the upper ring plate 111, the middle ring plate 112, the first vertical beam 114, the lower ring plate 113 and the second vertical beam 115 provides the cylindrical frame 11 with sufficient structural strength to provide good supporting force. The vertebral body 10 further comprises a connecting column 13 penetrating through the cylindrical frame body 11, the axis of the connecting column 13 is perpendicular to the bottom surface of the cylindrical frame body 11, the cylindrical frame body 11 further comprises a first connecting rib 14 connecting the top side wall of the upper annular plate 111 and the connecting column 13, and the first slot 41 is arranged on the first connecting rib 14. The cylindrical frame 11 further includes a second connecting rib 15 connecting the lower ring plate 113 and the bottom side wall of the connecting column 13, and the second slot 43 is disposed on the second connecting rib 15. The arrangement of the connection column 13 facilitates the building of the first connection rib 14 and the second connection rib 15 inside the cylindrical frame body 11, so that the first connection rib 14 and the second connection rib 15 are stably and reliably connected inside the cylindrical frame body 11. The first insertion grooves 41 are formed in the first connection ribs 14, so that the possibility that the structural strength of the cylindrical frame body 11 is weakened due to the fact that the first insertion grooves 41 are formed at other positions (such as the first vertical beams 114) can be reduced, and the structural stability of the cylindrical frame body 11 can be ensured. The second insertion grooves 43 are formed in the second connection ribs 15, so that the possibility that the structural strength of the cylindrical frame body 11 is weakened due to the second insertion grooves 43 being formed at other positions (such as the second vertical beams 115) can be reduced, and the structural stability of the cylindrical frame body 11 can be ensured.

In this embodiment, the first connecting rib 14 and the second connecting rib 15 are three, the three first connecting ribs 14 are radially arranged in the upper ring plate 111, and the three second connecting ribs 15 are radially arranged in the lower ring plate 113, so that the cylindrical frame body 11 can provide uniform supporting force. Of course, in the embodiment not shown in the drawings, the number of the first connecting ribs and the second connecting ribs is not limited to three, but may be two, four, five, and more.

As shown in fig. 1 and 2, in the present embodiment, in order to ensure the stability of the supporting effect of the cylindrical frame body 11, there are three first vertical beams 114, three first vertical beams 114 are arranged at intervals along the circumferential direction of the upper ring plate 111, three second vertical beams 115 are arranged at intervals along the circumferential direction of the lower ring plate 113, and the three first vertical beams 114 and the three second vertical beams 115 are arranged in a one-to-one correspondence manner. In order to disperse the stress concentrated at the connecting column 13, the cylindrical frame 11 further includes a third vertical beam 116, the third vertical beam is connected between the first connecting rib 14 and the second connecting rib 15, and the third vertical beam 116 can disperse the stress at the connecting column 13, so that the cylindrical frame 11 can provide uniform supporting force, and the upper end plate 20 or the lower end plate 30 is prevented from sinking. Of course, in the embodiment not shown in the drawings, the number of the first vertical beam and the second vertical beam is not limited to three, and may be two, four, five, or more.

As shown in fig. 1 to 4, the vertebral body 10 further includes a connection column 13 inserted into the cylindrical frame 11. The axis of the connecting column 13 is perpendicular to the bottom surface of the cylindrical frame body 11. The porous structure 12 is disposed in a gap between the cylindrical frame body 11 and the connection column 13. Thus, the porous structure 12 can guide bone tissue to grow into the gap between the cylindrical frame body 11 and the connecting column 13, so that the vertebral body 10 has better bone growth effect, and better implantation stability is obtained. A first fastener 40 is attached to connecting post 13 through upper endplate 20 and a second fastener 50 is attached to connecting post 13 through lower endplate 30. Thus, the first fastener 40 connected to the connecting column 13 can improve the connection strength between the first fastener 40 and the vertebral body 10, and the second fastener 50 connected to the connecting column 13 can improve the connection strength between the second fastener 50 and the vertebral body 10, so as to increase the implantation stability of the vertebral body 10.

As shown in fig. 1 and 2, in the present embodiment, for the convenience of connection, the connection column 13 is a tubular structure, a first thread structure is disposed between the first end of the connection column 13 and the first fastening member 40, and a second thread structure is disposed between the second end of the connection column 13 and the second fastening member 50. In order to reduce the weight, a plurality of hollow holes are arranged on the side wall of the connecting column 13.

As shown in fig. 1, 4-9, the upper endplate 20 includes a first ring 21 and a third porous structure layer 22 disposed within the first ring 21, and the first tendon 42 is connected to the first ring 21 and the third porous structure layer 22. The first ring member 21 is shaped to resemble a human vertebral body to provide uniform support and to prevent subsidence of the upper endplate 20. The third porous structural layer 22 can guide bone tissue to grow into the void in the first annulus 21, resulting in better bone ingrowth of the upper endplate 20 and thus better implant stability. Specifically, the third porous structure layer 22 can fully cover the surface of the first ring body 21 away from the vertebral body 10, fully contact with the bone tissue of the human body, and simultaneously have the advantages of displacement prevention and better support stability.

As shown in fig. 1, 4 to 9, in the present embodiment, the third porous structure layer 22 is provided with a first mounting hole 28 for passing the first fastening member 40. The third porous structure layer 22 includes a plurality of first trabecular bone structures 221 arranged in an interlaced manner, first trabecular bone structure holes are formed between the plurality of first trabecular bone structures 221 arranged in an interlaced manner, and a plurality of first protrusions 222 are arranged on the outer surface of the first trabecular bone structure 221 away from the vertebral body 10. The first plurality of projections 222 increases friction, prevents relative sliding between the contacting surfaces of the upper endplate 20 and the vertebral body in the body, prevents deflection of the intervertebral fusion prosthesis, and prevents the intervertebral fusion prosthesis from being removed from the implantation site. Specifically, the first mounting hole 28 is a first countersunk hole, the first fastener 40 is preferably a first countersunk bolt, and a bolt head of the first countersunk bolt is located in the first countersunk hole, so that the bolt head of the first countersunk bolt does not protrude out of the first trabecular bone structure 221 and is far away from the outer surface of the vertebral body 10, and the first countersunk bolt is prevented from interfering with the vertebral body in the body. Meanwhile, the bolt head of the first countersunk head bolt is filled with bone so as to induce bone to grow into the first countersunk head bolt, thereby fully increasing the bone combination and the implantation stability of the intervertebral fusion prosthesis. The first countersunk head bolt has a first operation hole 401.

As shown in fig. 1, 4 to 9, the lower end plate 30 includes a second ring 31 and a fourth porous structure layer 32 disposed in the second ring 31, and the second ribs 44 are connected to the second ring 31 and the fourth porous structure layer 32. The second ring member 31 is shaped to resemble a human vertebral body to provide uniform support and to prevent subsidence of the lower endplate 30. In the present embodiment, the fourth porous structure layer 32 is provided with a second mounting hole 38 for passing a second fastener 50. The fourth porous structural layer 32 may guide bone tissue growth into the void within the second ring 31, resulting in better bone growth into the lower endplate 30 and thus better implant stability. Specifically, the fourth porous structure layer 32 can fully cover the surface of the second ring body 31 away from the vertebral body 10, and fully contact with the bone tissue of the human body, and meanwhile, the displacement is prevented, and better support stability is obtained.

As shown in fig. 1, 4 to 9, the fourth porous structural layer 32 includes a plurality of second trabecular bone structures 321 arranged in an interlaced manner, second trabecular bone structure holes are formed between the plurality of second trabecular bone structures 321 arranged in an interlaced manner, and a plurality of second protrusions 322 are arranged on an outer surface of the second trabecular bone structure 321 away from the vertebral body 10. The second plurality of protrusions 322 may increase friction, prevent relative sliding between the contacting surfaces of the lower endplate 30 and the vertebral body in the body, prevent the intervertebral fusion prosthesis from deflecting, and prevent the intervertebral fusion prosthesis from being out of position for implantation. Specifically, the second mounting hole 38 is a second countersunk hole, the second fastener 50 is preferably a second countersunk bolt, and a bolt head of the second countersunk bolt is located in the second countersunk hole, so that the bolt head of the second countersunk bolt does not protrude out of the second trabecular bone structure 321 and is far away from the outer surface of the vertebral body 10, and interference between the second countersunk bolt and the vertebral body in the body is avoided. Meanwhile, the bolt head of the second countersunk head bolt is filled with bone so as to induce bone to grow into the second countersunk head bolt, thereby fully increasing the bone combination and the implantation stability of the intervertebral fusion prosthesis. The second countersunk head bolt is provided with a second operation hole.

As shown in fig. 1 and 4 to 9, the first trabecular bone structure 221 is provided with a plurality of first holes 2211 and a plurality of second holes 2212 at intervals, and the diameter of the first holes 2211 is larger than that of the second holes 2212. The first projection 222 is provided with a third hole 2221 communicating with the second hole 2212. In this way, the first protrusion 222 is positioned at the second hole 2212, but not at the first hole 2211, such that the first protrusion 222 has sufficient support strength to allow the first protrusion 222 to provide stable friction, and the third holes 2221, the first holes 2211, and the second holes 2212 are capable of guiding bone tissue growth into the first bone trabecular structure 221, further increasing the stability of the intervertebral fusion prosthesis.

In this embodiment, the diameter of the first trabecular bone structure 221 is between 700 microns and 900 microns, the diameter of the first aperture 2211 is in the range of 200 microns to 300 microns, and the height of the first protrusion 222 is between 0.5mm and 0.8 mm. The diameter of the first bone trabecular structure 221 is preferably 700 microns or 800 microns or 900 microns. The diameter of the first aperture 2211 is preferably 200 microns or 250 microns or 300 microns. The height of the first protrusions 222 is preferably 0.5mm or 0.6mm or 0.8 mm.

As shown in fig. 1 and 4 to 9, a plurality of fourth holes 3211 and a plurality of fifth holes 3212 are alternately disposed on the second bone trabecular structure 321, a diameter of the fourth holes 3211 is greater than a diameter of the fifth holes 3212, and a sixth hole 3221 is disposed on the second protrusion 322 and is communicated with the fifth holes 3212. In this way, the second protrusion 322 is located at the fifth hole 3212, but not at the fourth hole 3211, such that the second protrusion 322 has sufficient support strength to enable the second protrusion 322 to provide stable friction, and the plurality of fourth holes 3211, the plurality of fifth holes 3212, and the plurality of sixth holes 3221 are capable of guiding bone tissue growth into the second bone trabecular structure 321, further increasing stability of the intervertebral fusion prosthesis.

In this embodiment, the diameter of the second trabecular bone structure 321 is between 700 microns and 900 microns, the diameter of the fourth hole 3211 is in the range of 200 microns to 300 microns, and the height of the second protrusion 322 is between 0.5mm and 0.8 mm. The diameter of the second bone trabecular structure 321 is preferably 700 microns or 800 microns or 900 microns. The diameter of the fourth hole 3211 is preferably 200 microns or 250 microns or 300 microns. The height of the second protrusions 322 is preferably 0.5mm or 0.6mm or 0.8 mm.

As shown in figures 1 and 4, the third porous structural layer 22 is provided with a first bone graft window 223 communicating with the interior of the vertebral body 10. The fourth porous structural layer 32 is provided with a second bone graft window 323 communicating with the interior of the vertebral body 10. Therefore, the first bone implantation window 223 can fill and plug bone substances into the vertebral body 10, and the second bone implantation window 323 can fill and plug bone substances into the vertebral body 10, so that bone growth is induced into the vertebral body 10, bone combination is fully increased, and the implantation stability of the intervertebral fusion prosthesis is increased.

As shown in fig. 1 and 4, for convenience of processing and molding, the vertebral body 10 includes a cylindrical frame 11 and a porous structure 12 filled in a gap of the cylindrical frame 11, the cylindrical frame 11 includes an upper ring plate 111, a middle ring plate 112 and a lower ring plate 113 arranged at intervals in sequence, and the upper ring plate 111, the middle ring plate 112 and the lower ring plate 113 have the same shape. The upper ring plate 111 includes a first convex arc surface 1111, a second convex arc surface 1112, a third convex arc surface 1113 and a first concave arc surface 1114 connected end to end in sequence. Thus, the cylindrical frame body 11 is designed into a shape matched with the human vertebral body, so that the stress can be effectively dispersed, and the phenomenon that the intervertebral fusion prosthesis is sunk is avoided.

As shown in fig. 1 to 3, the first convex arc surface 1111, the second convex arc surface 1112, the third convex arc surface 1113 and the first concave arc surface 1114 are sequentially projected on the horizontal plane to form a first convex arc surface, a second convex arc surface, a third convex arc surface and a first concave arc surface, the radian of the first convex arc surface is the same as that of the third convex arc surface, the radian of the second convex arc surface is greater than that of the first convex arc surface, and the radius R1 of the second convex arc surface ranges from 5mm to 15 mm. The second convex arc within the radius R1 described above enables the vertebral body 10 to select different angular specifications of the vertebral body 10 depending on the shape of the vertebral body in the body to achieve an optimal anatomical fit with the human vertebral body. The angular dimension of each vertebral body 10 is increased by a multiple of 2mm, for example, the dimension of the vertebral body 10 with the smallest radius is 5mm, the dimension of the next vertebral body 10 is 7mm by increasing the multiple of 2mm, and so on, and the dimension of the vertebral body 10 with the largest radius is 15 mm. A plurality of vertebral bodies 10 are prepared at various angles, and the vertebral bodies with different angle specifications can be directly prepared in the operation process, so that the angle of the implanted intervertebral fusion prosthesis can be adjusted, and the number of the prepared intervertebral fusion prostheses can be reduced.

As shown in fig. 1 to 3 and 10, the height H of the vertebral body 10 is in the range of 10mm to 120mm, the height dimension of each vertebral body 10 is increased by a multiple of 2mm, for example, the dimension of the lowest vertebral body 10 is 10mm, the dimension of the next vertebral body 10 is 12mm by increasing by a multiple of 2mm, and so on, and finally the dimension of the highest vertebral body 10 is 120 mm. The plurality of vertebral bodies 10 are prepared to have various heights, and the vertebral bodies having different height specifications can be directly prepared in the operation process, so that the height of the implanted intervertebral fusion prosthesis can be adjusted, and the number of the prepared intervertebral fusion prostheses can be reduced.

As shown in FIG. 1, a transverse plane of bisection perpendicular to the axis of the cylindrical frame 11 is defined as a symmetry plane, the upper end plate 20 is symmetrically disposed with respect to the lower end plate 30 with respect to the symmetry plane, and the upper end plate 20 has a shape with a middle portion high and two sides low. In this manner, the shape of the superior endplate 20 more closely matches the shape of the superior endplate of the human vertebral body to achieve an optimal anatomical fit with the human vertebral body.

As shown in FIGS. 1 to 4, the upper end plate 20 includes a fifth convex cambered surface 23, a sixth convex cambered surface 24, a seventh convex cambered surface 25 and a second concave cambered surface 26 which are connected end to end in sequence. Thus, the upper end plate 20 is designed to be matched with the upper end plate of the human vertebral body and the lower end plate 30 is designed to be matched with the lower end plate of the human vertebral body, so that the stress can be effectively dispersed, and the phenomenon that the upper end plate 20 and the lower end plate 30 sink is avoided. Wherein, fifth evagination cambered surface 23, sixth evagination cambered surface 24, seventh evagination cambered surface 25 and second indent cambered surface 26 project into fifth evagination camber line, sixth evagination camber line, seventh evagination camber line and second indent camber line on the horizontal plane in proper order, and the radian of fifth evagination camber line is the same with the radian of seventh evagination camber line, and the radian of sixth evagination camber line is greater than the radian of fifth evagination camber line, and the radius R2 scope of sixth evagination camber line is between 5mm to 15 mm. The sixth, outer convex curve within the radius R2 described above enables the superior endplate 20 to select superior endplates of different angular sizes to achieve an optimal anatomic fit with the human vertebral body based on the shape of the superior endplate. The radius R2 of the sixth convex arc ranges from 5mm to 15mm, the angular size of each upper endplate 20 increases by a factor of 2mm, for example, the size of the upper endplate 20 with the smallest radius is 5mm, the size of the next upper endplate 20 increases by a factor of 2mm to 7mm, and so on, and the size of the upper endplate 20 with the largest radius is 15 mm. A plurality of upper end plates 20 are prepared at various angles, and the upper end plates with different angle specifications can be directly equipped in the operation process, so that the angle of the implanted intervertebral fusion prosthesis can be adjusted, and the number of the prepared intervertebral fusion prostheses can be reduced.

As shown in fig. 1 to 5, a line passing through the midpoint of the sixth convex arc and the midpoint of the second concave arc is defined as a symmetry line, and an included angle a is formed between the symmetry line and the bottom surface of the upper endplate 20, and the included angle a ranges from 0 ° to 12 °. Thus, the angular dimension of each upper endplate 20 increases by a factor of 2, e.g., the dimension of the smallest angled upper endplate 20 is 0, the dimension of the next upper endplate 20 increases by a factor of 2, and so on, and finally the dimension of the largest angled upper endplate 20 is 12. A plurality of upper end plates 20 are prepared at various angles, and the upper end plates with different angle specifications can be directly equipped in the operation process, so that the angle of the implanted intervertebral fusion prosthesis can be adjusted, and the number of the prepared intervertebral fusion prostheses can be reduced.

The superior endplate 20, vertebral body 10, and inferior endplate 30 of the present embodiment are fabricated using electron beam melting and selective laser melting techniques. The first fastener 40 and the second fastener 50 are processed using 3D printing techniques. The intervertebral fusion prosthesis is made of titanium alloy or tantalum.

The inventors have found that the prosthesis needs to be treated by an anodisation technique during its manufacture, and that the prosthesis needs to be treated by sandblasting prior to the anodisation technique. During the process of blasting the prosthesis, the inside of the prosthesis cannot be blasted, so that the inside unfused powder cannot be cleaned, sand may remain inside, and after the prosthesis is replaced to the position of the vertebral body, the unfused powder and the sand on the prosthesis can cause damage to tissues and organs of the human body.

In order to solve the above problems, the present application also provides a method of processing an intervertebral fusion prosthesis, as shown in fig. 11, which processes the above intervertebral fusion prosthesis. The processing method of the intervertebral fusion prosthesis comprises the following steps: step S10: acid-washing the upper endplate blank, the vertebral body blank and the lower endplate blank; step S20: carrying out anodic oxidation surface treatment on the acid-washed upper endplate blank, the acid-washed vertebral body blank and the acid-washed lower endplate blank; step S30: and connecting the upper endplate blank subjected to the anodic oxidation surface treatment with the top of the vertebral body blank through a first fastener, and connecting the lower endplate blank subjected to the anodic oxidation surface treatment with the bottom of the vertebral body blank through a second fastener to obtain the intervertebral fusion prosthesis. The intervertebral fusion prosthesis can solve the problem that the prosthesis with an integrated structure in the related technology cannot be adjusted, so that the difference of vertebral bodies in a body is compensated, and the problem that the effect is poor can be solved.

In addition, by adopting the processing method of the intervertebral fusion prosthesis, before the anodic oxidation surface treatment is carried out on the intervertebral fusion prosthesis, in the process of carrying out acid washing treatment on the upper endplate blank, the vertebral body blank and the lower endplate blank, titanium ions of the intervertebral fusion prosthesis react with hydrogen ions in the acid washing treatment (2Ti +6HF ═ 2TiF3+3H2 ×) so that non-molten powder in the upper endplate blank, non-molten powder in the vertebral body blank and non-molten powder in the lower endplate blank can be corroded away, and further the non-molten powder in the intervertebral fusion prosthesis can be eliminated. Therefore, the intervertebral fusion prosthesis does not need to be subjected to sand blasting treatment, sand is prevented from remaining in the upper endplate blank, the vertebral body blank and the lower endplate blank, and after the intervertebral fusion prosthesis is replaced to the vertebral body position, risk of unmelted powder and sand remaining in the intervertebral fusion prosthesis on tissues and organs of a human body can be avoided. Therefore, the technical scheme of the application effectively solves the problem that after the prosthesis in the related technology is replaced to the position of the vertebral body, unfused powder and sand on the prosthesis can cause harm to tissues and organs of a human body.

As shown in fig. 11, in step S20, the acid-washed upper endplate blank, the washed vertebral body blank, and the washed lower endplate blank are anodized to make the upper endplate blank and the lower endplate blank of different specifications be processed into different colors, so as to increase the identification degree and avoid misuse of similar specifications, such as blue, red, golden yellow, or purple. Meanwhile, the biocompatibility of the intervertebral fusion prosthesis can be improved by anodizing the surface.

As shown in fig. 11, in order to ensure that the size and the sizes of the first porous structure layer, the second porous structure layer, the third porous structure layer and the fourth porous structure layer meet the standard requirements after the intervertebral fusion prosthesis is acid-washed, in step S10, a mixed solution of nitric acid and hydrofluoric acid is used to perform acid-washing treatment on the upper endplate blank, the vertebral body blank and the lower endplate blank, wherein the concentration of nitric acid is between 60% and 70%, and the concentration of hydrofluoric acid is between 45% and 60%. The mixed solution of the nitric acid and the hydrofluoric acid contains nitric acid, hydrofluoric acid and water, the ratio of the nitric acid to the water is in the range of 1:2.4-1:3, and the ratio of the hydrofluoric acid to the water is in the range of 1:60-1: 68. Specifically, the nitric acid is 350ml-500ml, the hydrofluoric acid is 15ml-20ml, and the water is 1000ml-1200 ml.

In the description of the present invention, it is to be understood that the orientation or positional relationship indicated by the orientation words such as "front, rear, upper, lower, left, right", "lateral, vertical, horizontal" and "top, bottom", etc. are usually based on the orientation or positional relationship shown in the drawings, and are only for convenience of description and simplicity of description, and in the case of not making a reverse description, these orientation words do not indicate and imply that the device or element being referred to must have a specific orientation or be constructed and operated in a specific orientation, and therefore, should not be considered as limiting the scope of the present invention; the terms "inner and outer" refer to the inner and outer relative to the profile of the respective component itself.

Spatially relative terms, such as "above … …," "above … …," "above … …," "above," and the like, may be used herein for ease of description to describe one device or feature's spatial relationship to another device or feature as illustrated in the figures. It will be understood that the spatially relative terms are intended to encompass different orientations of the device in use or operation in addition to the orientation depicted in the figures. For example, if a device in the figures is turned over, devices described as "above" or "on" other devices or configurations would then be oriented "below" or "under" the other devices or configurations. Thus, the exemplary term "above … …" can include both an orientation of "above … …" and "below … …". The device may be otherwise variously oriented (rotated 90 degrees or at other orientations) and the spatially relative descriptors used herein interpreted accordingly.

It should be noted that the terms "first", "second", and the like are used to define the components, and are only used for convenience of distinguishing the corresponding components, and the terms have no special meanings unless otherwise stated, and therefore, the scope of the present invention should not be construed as being limited.

The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention, and various modifications and changes may be made by those skilled in the art. Any modification, equivalent replacement, or improvement made within the spirit and principle of the present invention should be included in the protection scope of the present invention.