阅读说明：本技术 一种有效提升中药饮片生物利用度和吸收效率的制备工艺和应用 (Preparation process and application for effectively improving bioavailability and absorption efficiency of traditional Chinese medicine decoction pieces ) 是由 贺鹏飞 房树申 丁毅 于 2021-04-27 设计创作，主要内容包括：本发明公开的属于中药饮片制备技术领域,具体为一种有效提升中药饮片生物利用度和吸收效率的制备工艺和应用,包括以下步骤：S1:选取何首乌根部,并将何首乌根部放入蒸馏水中进行清洗；S2:将清洗后的何首乌根部捞出后风干或晾干；S3:将何首乌根部切割成薄片状或细丝状,将切割后的何首乌根部进行杀青；S4:将杀青后的何首乌根部加入蒸馏水中,搅拌成浆液状；S5:将浆液进行喷雾干燥,得到干燥后的颗粒物料含水率为10-16％,将干燥后的颗粒物料研磨成粉状,得到何首乌粉；通过本发明制备出的中药饮片便于人体吸收,从而有效的提高了中药饮片的生物利用度和吸收效率。(The invention belongs to the technical field of preparation of traditional Chinese medicine decoction pieces, and particularly relates to a preparation process and application for effectively improving bioavailability and absorption efficiency of traditional Chinese medicine decoction pieces, which comprises the following steps: s1, selecting root parts of the polygonum multiflorum, and putting the root parts of the polygonum multiflorum into distilled water for cleaning; s2, fishing out the roots of the cleaned polygonum multiflorum and then drying in the air or airing; s3, cutting the root of the polygonum multiflorum into slices or filaments, and deactivating enzymes of the cut root of the polygonum multiflorum; s4, adding the roots of the polygonum multiflorum which is subjected to enzyme deactivation into distilled water, and stirring into a slurry; s5, spray drying the slurry to obtain dried granular material with water content of 10-16%, and grinding the dried granular material into powder to obtain Polygoni Multiflori radix powder; the traditional Chinese medicine decoction pieces prepared by the method are convenient for human body to absorb, so that the bioavailability and the absorption efficiency of the traditional Chinese medicine decoction pieces are effectively improved.)

1. A preparation process for effectively improving the bioavailability and absorption efficiency of traditional Chinese medicine decoction pieces is characterized by comprising the following steps of: the method comprises the following steps:

s1, selecting root parts of the polygonum multiflorum, and putting the root parts of the polygonum multiflorum into distilled water for cleaning;

s2, fishing out the roots of the cleaned polygonum multiflorum and then drying in the air or airing;

s3, cutting the root of the polygonum multiflorum into slices or filaments, and deactivating enzymes of the cut root of the polygonum multiflorum;

s4, adding the roots of the polygonum multiflorum which is subjected to enzyme deactivation into distilled water, and stirring into a slurry;

s5, spray drying the slurry to obtain dried granular material with water content of 10-16%, and grinding the dried granular material into powder to obtain Polygoni Multiflori radix powder;

s6, carrying out comprehensive enzymolysis on the polygonum multiflorum powder obtained in the step S5 through protease to obtain an zymolyte, adding donkey-hide gelatin powder, seaweed powder, small molecule active peptide and honey to obtain a mixture, wherein the mixture contains carbohydrate and has high nutritive value, heating the mixture to 80-100 ℃, preserving heat for 20-30min, stirring for 10-20min after heat preservation is finished, and pressing the mixture into a plurality of tablets with fixed sizes;

s7, putting the flaky mixture into an oven for drying at 80-90 ℃ to obtain the traditional Chinese medicine decoction pieces, wherein: the water content of the traditional Chinese medicine decoction pieces is 5-8%.

2. The preparation process of claim 1, wherein the process comprises the following steps: in step S3, the water-removing method is: putting the cut root of the polygonum multiflorum into a traditional Chinese medicine dryer, and carrying out enzyme deactivation by using steam, wherein the steam temperature is 120-150 ℃, and the enzyme deactivation time is 30-60 s.

3. The preparation process of claim 1, wherein the process comprises the following steps: in step S4, the root of polygonum multiflorum is stirred into a slurry state by a stirrer.

4. The preparation process of claim 1, wherein the process comprises the following steps: in step S5, the slurry is filtered through a screen before being spray-dried.

5. The preparation process of claim 4, wherein the process comprises the following steps: the screen mesh is 90-110 meshes.

6. The preparation process of claim 1, wherein the process comprises the following steps: in the step S5, the spray drying temperature is 160-180 ℃, and the air inlet pressure of the nozzle is 0.05-0.1 Mpa.

7. The preparation process of claim 1, wherein the process comprises the following steps: in the step S6, the following components are calculated according to mass fraction: taking 10-12 parts of donkey-hide gelatin powder, 5-7 parts of seaweed powder, 8-12 parts of micromolecular active peptide, 10-15 parts of honey and 60-70 parts of polygonum multiflorum powder.

8. Use of the process according to any one of claims 1 to 7 for the preparation of a medicament effective in enhancing bioavailability and absorption efficiency of decoction pieces of Chinese medicinal herbs, wherein: the Chinese medicinal decoction pieces prepared by the preparation process are used for treating anemia, osteomalacia and rheumatism, pain in skin and lining, hyperlipidemia and constipation.

Technical Field

The invention relates to the technical field of preparation of traditional Chinese medicine decoction pieces, in particular to a preparation process and application for effectively improving bioavailability and absorption efficiency of traditional Chinese medicine decoction pieces.

Background

The decoction pieces are prepared from Chinese medicinal materials according to the requirement, or can be directly used in Chinese medicine clinical application. The traditional Chinese medicine decoction pieces are the essences of traditional Chinese medicines, the properties and the effects of the traditional Chinese medicine decoction pieces can be changed by different processing methods, and the traditional Chinese medicine decoction pieces are the characteristics and the advantages of traditional Chinese medicine.

The preparation process of the polygonum multiflorum traditional Chinese medicine decoction pieces is mainly to steam polygonum multiflorum for many times and then dry or dry the polygonum multiflorum in the sun, so that the effective ingredients in the prepared polygonum multiflorum traditional Chinese medicine decoction pieces are not easy to be absorbed by human bodies.

Disclosure of Invention

The invention aims to provide a preparation process and application for effectively improving the bioavailability and absorption efficiency of traditional Chinese medicine decoction pieces, so as to solve the problem that most of effective components in polygonum multiflorum traditional Chinese medicine decoction pieces prepared by the preparation process of polygonum multiflorum traditional Chinese medicine decoction pieces in the background technology are not easy to be absorbed by human bodies.

In order to achieve the purpose, the invention provides the following technical scheme: a preparation process for effectively improving bioavailability and absorption efficiency of Chinese medicinal decoction pieces comprises the following steps:

s1, selecting root parts of the polygonum multiflorum, and putting the root parts of the polygonum multiflorum into distilled water for cleaning;

s2, fishing out the roots of the cleaned polygonum multiflorum and then drying in the air or airing;

s3, cutting the root of the polygonum multiflorum into slices or filaments, and deactivating enzymes of the cut root of the polygonum multiflorum;

s4, adding the roots of the polygonum multiflorum which is subjected to enzyme deactivation into distilled water, and stirring into a slurry;

s5, spray drying the slurry to obtain dried granular material with water content of 10-16%, and grinding the dried granular material into powder to obtain Polygoni Multiflori radix powder;

s6, carrying out comprehensive enzymolysis on the polygonum multiflorum powder obtained in the step S5 through protease to obtain an zymolyte, adding donkey-hide gelatin powder, seaweed powder, small molecule active peptide and honey to obtain a mixture, wherein the mixture contains carbohydrate and has high nutritive value, heating the mixture to 80-100 ℃, preserving heat for 20-30min, stirring for 10-20min after heat preservation is finished, and pressing the mixture into a plurality of tablets with fixed sizes;

s7, putting the flaky mixture into an oven for drying at 80-90 ℃ to obtain the traditional Chinese medicine decoction pieces, wherein: the water content of the traditional Chinese medicine decoction pieces is 5-8%.

Preferably, in step S3, the water-removing method is as follows: putting the cut root of the polygonum multiflorum into a traditional Chinese medicine dryer, and carrying out enzyme deactivation by using steam, wherein the steam temperature is 120-150 ℃, and the enzyme deactivation time is 30-60 s.

Preferably, in step S4, the root of polygonum multiflorum is stirred into a slurry by a stirrer.

Preferably, in the step S5, the slurry is filtered through a screen before being spray-dried.

Preferably, the screen mesh is 90-110 mesh.

Preferably, in the step S5, the spray drying temperature is 160-.

Preferably, in step S6, the mass fraction of: taking 10-12 parts of donkey-hide gelatin powder, 5-7 parts of seaweed powder, 8-12 parts of micromolecular active peptide, 10-15 parts of honey and 60-70 parts of polygonum multiflorum powder.

The Chinese medicinal decoction pieces prepared by the preparation process are used for treating anemia, osteomalacia and rheumatism, pain in skin and lining, hyperlipidemia and constipation.

Compared with the prior art, the invention has the beneficial effects that:

1) the traditional Chinese medicine decoction pieces prepared by the method are convenient for human body to absorb, so that the bioavailability and absorption efficiency of the traditional Chinese medicine decoction pieces are effectively improved;

2) through the addition of the donkey-hide gelatin powder and the seaweed meal, a synergistic effect is achieved in the process of preparing the traditional Chinese medicine decoction pieces, and the medicine release efficiency and the absorption efficiency of the traditional Chinese medicine decoction pieces are improved;

3) the honey is added, so that the medicinal powder is conveniently mixed and stirred;

4) the addition of the micromolecular active peptide facilitates the absorption of the Chinese medicinal decoction pieces by a human body;

5) the preparation process of the invention fully retains the active ingredients of the raw materials, thereby improving the use effect of the traditional Chinese medicine decoction pieces.

Detailed Description

The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

In the description of the present invention, it should be noted that the terms "upper", "lower", "inner", "outer", "top/bottom", and the like, indicate orientations or positional relationships for convenience in describing the present invention and simplifying the description, but do not indicate or imply that the referred device or element must have a particular orientation, be constructed and operated in a particular orientation, and thus should not be construed as limiting the present invention. Furthermore, the terms "first" and "second" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance.

In the description of the present invention, it should be noted that, unless otherwise explicitly specified or limited, the terms "mounted," "disposed," "sleeved/connected," "connected," and the like are to be construed broadly, e.g., "connected," which may be fixedly connected, detachably connected, or integrally connected; can be mechanically or electrically connected; they may be connected directly or indirectly through intervening media, or they may be interconnected between two elements. The specific meanings of the above terms in the present invention can be understood in specific cases to those skilled in the art.

The invention provides a technical scheme that: a preparation process for effectively improving bioavailability and absorption efficiency of Chinese medicinal decoction pieces comprises the following steps:

s1, selecting root parts of the polygonum multiflorum, and putting the root parts of the polygonum multiflorum into distilled water for cleaning;

s2, fishing out the roots of the cleaned polygonum multiflorum and then drying in the air or airing;

s3, cutting the root of the polygonum multiflorum into slices or filaments, and deactivating enzymes of the cut root of the polygonum multiflorum;

s4, adding the roots of the polygonum multiflorum which is subjected to enzyme deactivation into distilled water, and stirring into a slurry;

s5, spray drying the slurry to obtain dried granular material with water content of 10-16%, and grinding the dried granular material into powder to obtain Polygoni Multiflori radix powder;

s6, carrying out comprehensive enzymolysis on the polygonum multiflorum powder obtained in the step S5 through protease to obtain an zymolyte, adding donkey-hide gelatin powder, seaweed powder, small molecule active peptide and honey to obtain a mixture, wherein the mixture contains carbohydrate and has high nutritive value, heating the mixture to 80-100 ℃, preserving heat for 20-30min, stirring for 10-20min after heat preservation is finished, and pressing the mixture into a plurality of tablets with fixed sizes;

s7, putting the flaky mixture into an oven for drying at 80-90 ℃ to obtain the traditional Chinese medicine decoction pieces, wherein: the water content of the traditional Chinese medicine decoction pieces is 5-8%.

In step S3, the water-removing method is: putting the cut root of the polygonum multiflorum into a traditional Chinese medicine dryer, and carrying out enzyme deactivation by using steam, wherein the steam temperature is 120-150 ℃, and the enzyme deactivation time is 30-60 s.

In step S4, the root of polygonum multiflorum is stirred into a slurry state by a stirrer.

In step S5, the slurry is filtered through a screen before being spray-dried.

The screen mesh is 90-110 meshes.

In the step S5, the spray drying temperature is 160-180 ℃, and the air inlet pressure of the nozzle is 0.05-0.1 Mpa.

In the step S6, the following components are calculated according to mass fraction: taking 10-12 parts of donkey-hide gelatin powder, 5-7 parts of seaweed powder, 8-12 parts of micromolecular active peptide, 10-15 parts of honey and 60-70 parts of polygonum multiflorum powder.

The traditional Chinese medicine decoction pieces prepared by the preparation process are used for treating anemia, osteomalacia and rheumatism (lumbago and knee pain, pruritus all over the body and difficulty in walking), pain in skin and lining (pain is unknown), hyperlipidemia and constipation, and are mainly used for treating diseases, such as spontaneous perspiration, ceaseless intestinal wind and hematochezia.

Example 1:

s1, selecting root parts of the polygonum multiflorum, and putting the root parts of the polygonum multiflorum into distilled water for cleaning;

s2, fishing out the roots of the cleaned polygonum multiflorum and then drying in the air or airing;

s3, cutting the root of the polygonum multiflorum into slices or filaments, deactivating enzymes of the cut root of the polygonum multiflorum, putting the cut root of the polygonum multiflorum into a traditional Chinese medicine dryer, and deactivating enzymes by using steam, wherein the steam temperature is 120 ℃, and the deactivating time is 30S;

s4, adding the roots of the polygonum multiflorum which is subjected to enzyme deactivation into distilled water, and stirring the mixture into a slurry by a stirrer;

s5, spray drying the serous fluid, filtering the serous fluid by a 90-110 mesh screen before spray drying, wherein the spray drying temperature is 160 ℃, the air inlet pressure of a nozzle is 0.05Mpa, the water content of the dried granular material is 10%, and grinding the dried granular material into powder to obtain polygonum multiflorum powder;

s6, according to mass fraction: taking 10 parts of donkey-hide gelatin powder, 5 parts of seaweed powder, 8 parts of small molecule active peptide, 10 parts of honey and 60 parts of polygonum multiflorum powder, carrying out comprehensive enzymolysis on the polygonum multiflorum powder through protease to obtain an zymolyte, then adding the donkey-hide gelatin powder, the seaweed powder, the small molecule active peptide and the honey, mixing to obtain a mixture, wherein the mixture contains carbohydrate and has high nutritional value, heating the mixture to 80 ℃, preserving heat for 20min, stirring for 10min after the heat preservation is finished, and then pressing the mixture into a plurality of tablets with fixed size;

s7, drying the flaky mixture in an oven at 80 ℃ to obtain the Chinese herbal pieces, wherein: the water content of the traditional Chinese medicine decoction pieces is 5%.

Example 2:

s1, selecting root parts of the polygonum multiflorum, and putting the root parts of the polygonum multiflorum into distilled water for cleaning;

s2, fishing out the roots of the cleaned polygonum multiflorum and then drying in the air or airing;

s3, cutting the root of the polygonum multiflorum into slices or filaments, deactivating enzymes of the cut root of the polygonum multiflorum, putting the cut root of the polygonum multiflorum into a traditional Chinese medicine dryer, and deactivating enzymes by using steam, wherein the steam temperature is 135 ℃, and the deactivating time is 45S;

s4, adding the roots of the polygonum multiflorum which is subjected to enzyme deactivation into distilled water, and stirring the mixture into a slurry by a stirrer;

s5, spray drying the slurry, filtering the slurry through a 90-110 mesh screen before spray drying, wherein the spray drying temperature is 170 ℃, the air inlet pressure of a nozzle is 0.075Mpa, the water content of the dried granular material is 13%, and grinding the dried granular material into powder to obtain polygonum multiflorum powder;

s6, according to mass fraction: taking 11 parts of donkey-hide gelatin powder, 6 parts of seaweed powder, 10 parts of small molecule active peptide, 12.5 parts of honey and 65 parts of polygonum multiflorum powder, carrying out comprehensive enzymolysis on the polygonum multiflorum powder through protease to obtain an zymolyte, then adding the donkey-hide gelatin powder, the seaweed powder, the small molecule active peptide and the honey, mixing to obtain a mixture, wherein the mixture contains carbohydrate and has high nutritional value, heating the mixture to 90 ℃, keeping the temperature for 25min, stirring for 15min after the heat preservation is finished, and then pressing the mixture into a plurality of tablets with fixed size;

s7, drying the flaky mixture in an oven at 85 ℃ to obtain the Chinese herbal pieces, wherein: the water content of the traditional Chinese medicine decoction pieces is 6.5%.

Example 3:

s1, selecting root parts of the polygonum multiflorum, and putting the root parts of the polygonum multiflorum into distilled water for cleaning;

s2, fishing out the roots of the cleaned polygonum multiflorum and then drying in the air or airing;

s3, cutting the root of the polygonum multiflorum into slices or filaments, deactivating enzymes of the cut root of the polygonum multiflorum, putting the cut root of the polygonum multiflorum into a traditional Chinese medicine dryer, and deactivating enzymes by using steam, wherein the steam temperature is 150 ℃, and the deactivation time is 60S;

s4, adding the roots of the polygonum multiflorum which is subjected to enzyme deactivation into distilled water, and stirring the mixture into a slurry by a stirrer;

s5, spray drying the serous fluid, filtering the serous fluid by a 90-110 mesh screen before spray drying, wherein the spray drying temperature is 180 ℃, the air inlet pressure of a nozzle is 0.1Mpa, the water content of the dried granular material is 16%, and grinding the dried granular material into powder to obtain polygonum multiflorum powder;

s6, according to mass fraction: taking 12 parts of donkey-hide gelatin powder, 7 parts of seaweed powder, 12 parts of small molecule active peptide, 15 parts of honey and 70 parts of polygonum multiflorum powder, carrying out comprehensive enzymolysis on the polygonum multiflorum powder through protease to obtain an zymolyte, then adding the donkey-hide gelatin powder, the seaweed powder, the small molecule active peptide and the honey, mixing to obtain a mixture, wherein the mixture contains carbohydrate and has high nutritional value, then heating the mixture to 100 ℃, preserving heat for 30min, stirring for 20min after the heat preservation is finished, and then pressing the mixture into a plurality of tablets with fixed size;

s7, drying the flaky mixture in an oven at 90 ℃ to obtain the Chinese medicinal decoction pieces, wherein: the water content of the traditional Chinese medicine decoction pieces is 8%.

While there have been shown and described the fundamental principles and essential features of the invention and advantages thereof, it will be apparent to those skilled in the art that the invention is not limited to the details of the foregoing exemplary embodiments, but is capable of other specific forms without departing from the spirit or essential characteristics thereof; the present embodiments are therefore to be considered in all respects as illustrative and not restrictive, the scope of the invention being indicated by the appended claims rather than by the foregoing description, and all changes which come within the meaning and range of equivalency of the claims are therefore intended to be embraced therein.

Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.