阅读说明：本技术 一种防龋齿糖果及其制备方法 (Caries prevention candy and preparation method thereof ) 是由 卜庆雨 于 2021-01-06 设计创作，主要内容包括：本发明公开了一种防龋齿糖果及其制备方法,包括青柿子单宁酸、磷酸氢二钠-柠檬酸、胶原、镧、浓缩果汁、食盐、食用香精、色素、维生素、食品添加剂、纯净水。单宁酸酚羟基与胶原氨基发生反应,使得胶原三肽相互交联,形成网状结构覆盖在牙齿上,阻断菌群营养物质来源,破坏细胞壁的结构,杀死牙菌斑致病菌,从而改善牙菌斑的形成,起到预防龋齿的作用。镧改性壳聚糖抑制下丘脑,支配神经释放乙酰胆碱,改善口腔唾液粘稠度,有效减少龋齿的形成。使用碳化-磁选结合的方法对镧进行提取,碳化处理使得金属内部生成碳质纳米纤维,松动内部的结构,多次的补充碳含量提高铁基的合成,使得镧的提取产量提升,又提高了镧的稳定性,易于保存。(The invention discloses a decayed tooth preventing candy and a preparation method thereof. The phenolic hydroxyl of the tannic acid reacts with the collagen amino to enable collagen tripeptide to be mutually crosslinked to form a net structure to cover the teeth, block the source of flora nutrient substances, destroy the structure of cell walls and kill dental plaque pathogenic bacteria, thereby improving the formation of dental plaque and playing a role in preventing dental caries. The lanthanum modified chitosan inhibits the hypothalamus, innervates nerves to release acetylcholine, improves the saliva viscosity of the oral cavity and effectively reduces the formation of decayed teeth. The lanthanum is extracted by a carbonization-magnetic separation combined method, the carbonization treatment enables carbon nano fibers to be generated inside the metal, the internal structure to be loosened, the carbon content is supplemented for many times, the iron-based synthesis is improved, the extraction yield of the lanthanum is improved, the stability of the lanthanum is improved, and the lanthanum is easy to store.)

1. The decayed tooth preventing candy is characterized by comprising the following raw materials in parts by weight: 5-10 parts of green persimmon tannic acid, 5-7 parts of disodium hydrogen phosphate-citric acid, 5-10 parts of collagen, 4-8 parts of tannin modified collagen, 3-5 parts of lanthanum, 2-5 parts of lanthanum modified chitosan, 20-30 parts of concentrated fruit juice, 2-3 parts of salt, 4-6 parts of edible essence, 3-4 parts of pigment, 10-15 parts of vitamin, 10-15 parts of food additive and 30-50 parts of purified water.

2. The caries-preventing candy as claimed in claim 1, wherein: the green persimmon tannin is prepared by pulverizing dried green persimmon peel, extracting with acetone as extractant in Soxhlet extractor to obtain colorless powder, concentrating and drying with rotary evaporator.

3. The caries-preventing candy as claimed in claim 1, wherein: the tannic acid modified collagen is prepared by dissolving a certain amount of tannic acid in a disodium hydrogen phosphate-citric acid solution, adding a collagen water bath constant temperature oscillator for reaction, and performing vacuum drying to obtain a finished product.

4. The caries-preventing candy as claimed in claim 1, wherein: the lanthanum modified chitosan is prepared by adding a lanthanum simple substance into a chitosan acetic acid solution, adjusting the pH value with ammonia water, stirring for reaction to completely separate out the lanthanum modified chitosan, filtering, washing and drying in vacuum.

5. The caries-preventing candy as claimed in claim 1, wherein: the lanthanum simple substance is obtained by smelting the alloy subjected to carbonization treatment under a vacuum condition, ensuring the carbon content in the alloy during smelting, cooling, crushing, hydrolyzing, magnetically separating to remove iron-based powder, and reducing the residual lanthanum oxide under the protection of nitrogen to obtain a finished product.

6. The caries-preventing candy as claimed in claim 1, wherein: the preservative is one of benzoic acid, sorbic acid and dehydroacetic acid.

7. The preparation method of the decayed tooth preventing candy is characterized by comprising the following specific steps:

(1) drying and crushing the green persimmon peels, sieving the crushed green persimmon peels with a 60-mesh sieve, extracting the crushed green persimmon peels in a Soxhlet extractor until the green persimmon peels are colorless, and concentrating and drying the green persimmon peels by using a rotary evaporator to obtain the green persimmon tannic acid.

(2) Dissolving the green persimmon tannic acid by using a disodium hydrogen phosphate-citric acid buffer solution with the pH of 4.0 to enable the concentration of the solution to be 2g/L, putting 5ml of tannic acid solution into a conical flask, supplementing the buffer solution to enable the total volume to be 20ml, adding a certain amount of collagen into the conical flask, reacting for 6 hours in a water bath constant temperature oscillator at the temperature of 30 ℃, and drying in vacuum to obtain the tannic acid modified collagen.

(3) Removing oxides and impurities on the surface of the lanthanum-containing alloy, carrying out smelting carbonization treatment on the alloy material by using a high-frequency induction furnace under a vacuum condition, soaking an alloy smelting solution into a charcoal ash mixed solution for 20 hours after smelting, supplementing the carbon content in an alloy mother solution, crushing the alloy, putting the alloy into deionized water for hydrolysis to obtain lanthanum oxide and iron-based alloy powder, carrying out magnetic separation to obtain nonmagnetic lanthanum hydroxide, and reducing the lanthanum hydroxide under the protection of nitrogen to generate a lanthanum simple substance.

(4) Dissolving chitosan in a 5% acetic acid solution, adding a lanthanum simple substance, adjusting the pH value to 5-6 by using 5% ammonia water, stirring and reacting for 60min at 30 ℃, dropwise adding 25% ammonia water to completely separate out lanthanum-modified chitosan, filtering and washing, and drying for 2h under vacuum at the temperature of 70 ℃ to obtain the lanthanum-modified chitosan.

(5) Mixing concentrated fruit juice with purified water, adding tannin modified collagen and lanthanum modified chitosan, placing into a 30 deg.C water bath constant temperature oscillator, reacting for 6h, adding edible essence, pigment, vitamins, food additives and antiseptic, and reacting for 3h at 40 deg.C water bath constant temperature oscillator to obtain the final product.

8. The method for preparing a caries prevention candy as claimed in claim 7, wherein in the step (2): the mass ratio of the added collagen to the green persimmon tannin is 3: 2.

9. the method for preparing a caries prevention candy as claimed in claim 7, wherein in the step (3): the carbonization treatment enables the carbon nano-fiber to be generated inside the metal, the internal structure is loosened, and the subsequent hydrolysis is easy to realize; the iron in the alloy mother liquor is always in a saturated state through the repeated carbon content supplement and smelting, the reaction is promoted to be carried out in the positive direction, the generation of the iron base is increased, and the generation rate of lanthanum is improved.

10. The method for preparing a caries prevention candy as claimed in claim 7, wherein in the step (4): the mass ratio of the lanthanum simple substance to the chitosan is 10: 1.

Technical Field

The invention relates to the technical field of foods, in particular to a decayed tooth preventing candy and a preparation method thereof.

Background

The formation of dental caries is caused by many reasons, and most widely known is that excessive intake of sugar, attachment of sugar to teeth, growth of a large amount of bacteria in the oral cavity, and formation of a large amount of organic acids to corrode teeth, thereby causing symptoms of dental caries. Meanwhile, the reduction of saliva amount can also cause the generation of decayed teeth, saliva can inhibit the generation of bacteria and eliminate dirt on the surface of teeth, and the sudden reduction of saliva secretion amount can provide a good living environment for bacteria, thereby causing the generation of decayed teeth. For people who like to eat sugar, the decayed tooth becomes the biggest stumbling stone on the sugar-loving road. Therefore, it is very necessary to prepare a caries-preventing candy which can supplement nutrition to tooth enamel, inhibit the growth of dental plaque in the oral cavity, stimulate salivary secretion, inhibit the absorption of cholesterol and keep the ecological balance of the intestinal tract.

Disclosure of Invention

The object of the present invention is to provide a caries-preventing candy which solves the problems set forth in the background above.

In order to solve the problems, the invention provides the following technical scheme of the anti-caries candy, which comprises the following raw materials in parts by weight:

5-10 parts of green persimmon tannic acid, 5-7 parts of disodium hydrogen phosphate-citric acid, 5-10 parts of collagen, 4-8 parts of tannin modified collagen, 3-5 parts of lanthanum, 2-5 parts of lanthanum modified chitosan, 20-30 parts of concentrated fruit juice, 2-3 parts of salt, 4-6 parts of edible essence, 3-4 parts of pigment, 10-15 parts of vitamin, 10-15 parts of food additive and 30-50 parts of purified water.

Preferably, the green persimmon tannin is obtained by crushing dried green persimmon peels, extracting the crushed green persimmon tannins in a Soxhlet extractor by using acetone as an extracting agent until the crushed green persimmon tannins are colorless, and concentrating and drying the extracted green persimmon tannins by using a rotary evaporator to obtain a finished product.

Preferably, the tannin modified collagen is prepared by dissolving a certain amount of tannin in a disodium hydrogen phosphate-citric acid solution, adding the solution into a collagen water bath constant-temperature oscillator for reaction, and performing vacuum drying to obtain a finished product.

Preferably, the lanthanum-modified chitosan is prepared by adding a lanthanum simple substance into a chitosan acetic acid solution, adjusting the pH value with ammonia water, stirring for reaction to completely separate out the lanthanum-modified chitosan, filtering, washing and drying in vacuum.

Preferably, the lanthanum simple substance is obtained by melting the alloy subjected to carbonization treatment under a vacuum condition, ensuring the carbon content in the alloy during melting, cooling and crushing the alloy, hydrolyzing the alloy, performing magnetic separation to remove iron-based powder, and reducing the residual lanthanum oxide under the protection of nitrogen to obtain a finished product.

Preferably, the preservative is one of benzoic acid, sorbic acid and dehydroacetic acid.

The second aspect of the invention provides a method for manufacturing a decayed tooth preventing candy, which comprises the following steps:

(1) drying and crushing the green persimmon peels, sieving the crushed green persimmon peels with a 60-mesh sieve, extracting the crushed green persimmon peels in a Soxhlet extractor until the green persimmon peels are colorless, and concentrating and drying the green persimmon peels by using a rotary evaporator to obtain the green persimmon tannic acid.

(2) Dissolving the green persimmon tannic acid by using a disodium hydrogen phosphate-citric acid buffer solution with the pH of 4.0 to enable the concentration of the solution to be 2g/L, putting 5ml of tannic acid solution into a conical flask, supplementing the buffer solution to enable the total volume to be 20ml, adding a certain amount of collagen into the conical flask, reacting for 6 hours in a water bath constant temperature oscillator at the temperature of 30 ℃, and drying in vacuum to obtain the tannic acid modified collagen.

(3) Removing oxides and impurities on the surface of the lanthanum-containing alloy, carrying out smelting carbonization treatment on the alloy material by using a high-frequency induction furnace under a vacuum condition, soaking an alloy smelting solution into a charcoal ash mixed solution for 20 hours after smelting, supplementing the carbon content in an alloy mother solution, crushing the alloy, putting the alloy into deionized water for hydrolysis to obtain lanthanum oxide and iron-based alloy powder, carrying out magnetic separation to obtain nonmagnetic lanthanum hydroxide, and reducing the lanthanum hydroxide under the protection of nitrogen to generate a lanthanum simple substance.

(4) Dissolving chitosan in a 5% acetic acid solution, adding a lanthanum simple substance, adjusting the pH value to 5-6 by using 5% ammonia water, stirring and reacting for 60min at 30 ℃, dropwise adding 25% ammonia water to completely separate out lanthanum-modified chitosan, filtering and washing, and drying for 2h under vacuum at the temperature of 70 ℃ to obtain the lanthanum-modified chitosan.

(5) Mixing concentrated fruit juice with purified water, adding tannin modified collagen and lanthanum modified chitosan, placing into a 30 deg.C water bath constant temperature oscillator, reacting for 6h, adding edible essence, pigment, vitamins, food additives and antiseptic, and reacting for 3h at 40 deg.C water bath constant temperature oscillator to obtain the final product.

Preferably, in the step (2): the mass ratio of the collagen to the green persimmon tannin is 3: 2.

preferably, in the step (3): the carbonization treatment enables the carbon nano-fiber to be generated inside the metal, the internal structure is loosened, and the subsequent hydrolysis is easy to realize; the iron in the alloy mother liquor is always in a saturated state through the repeated carbon content supplement and smelting, the reaction is promoted to be carried out in the positive direction, the generation of the iron base is increased, and the generation rate of lanthanum is improved.

Preferably, in the step (4): the mass ratio of the lanthanum simple substance to the chitosan is 10: 1.

compared with the prior art, the invention has the following beneficial effects:

the invention discloses a decayed tooth preventing candy and a preparation method thereof.

Adding tannic acid to modify collagen: the tannin molecules contain a large amount of hydroxyl, the hydroxyl is introduced into the collagen molecules after modification, peptide bonds on peptide chains of the collagen molecules are subjected to multi-point hydrogen bond combination to form cross-linking under the action of the hydroxyl, and carboxyl groups on side chains of the collagen and oxygen on the hydroxyl groups of the tannin molecules are subjected to hydrogen bond combination to form hydrogen bonds, so that the tannin modified collagen exerts the effect. Phenolic hydroxyl of the tannic acid reacts with amino of the collagen under the activation of amylase in the oral cavity, tripeptide of collagen molecules are mutually crosslinked to form a net structure, the tannic acid modified collagen is uniformly distributed in a grid to cover teeth, the contact between a tooth flora and an acidic substance is isolated, the source of flora nutrient substances is blocked, the activity of the amino on the bacterial cell wall is very high, hydrogen bonds formed by collagen side chains react with the collagen side chains to destroy the structure of the cell wall, and the pathogenic bacteria of the teeth are killed, so that the formation of dental plaque is improved, and the dental caries prevention effect is achieved. The hydroxyl bonds of the tannin modified collagen are broken into alkalescence under the decomposition of oral salivary enzyme, so that the tannin modified collagen effectively neutralizes the acid-base balance of the oral cavity, inhibits the living environment of dental plaque, improves the living environment of oral microorganisms and is beneficial to oral health.

Adding lanthanum modified chitosan: the molecular chain of the chitosan contains a large number of hydroxyl functional groups, and the hydroxyl functional groups are chelated with lanthanum ions in the reaction process to generate lanthanum modified chitosan, and hydrophilic amino groups in the molecular chain can improve the water solubility of lanthanum and are beneficial to absorption of organisms. After the lanthanum modified chitosan enters an organism, partial lanthanum is hydrolyzed and broken and exists in an ion form, and along with blood, the lanthanum modified chitosan permeates into a reticuloendothelial system in the organism, promotes the metabolism of the organism and improves the internal environment of the organism. Lanthanum ions can be swallowed by epithelial cells and diffused to the other side of the cell membrane, a calcium ion channel on the intestinal cell membrane is opened, the absorption of a body to calcium ions is increased, then the calcium ions are discharged into blood from cells under the action of a calcium pump, the calcium content on enamel is supplemented, the antibacterial property of teeth is improved, and the incidence rate of dental caries is reduced. The unhydrolyzed lanthanum-modified chitosan enters the intestinal tract along with a digestive system, is combined with in vivo lactic acid under the catalysis of intestinal hydrolase to regulate the intestinal tract into a weakly acidic environment suitable for the survival of bifidobacteria, promotes the growth and the reproduction of the bifidobacteria, inhibits the absorption of cholesterol through the decomposition of protein by the phosphoprotein phosphatase of the bifidobacteria, promotes the stability of the intestinal tract of an organism, and keeps the ecological balance of the intestinal tract. And lanthanum modified chitosan controls the parasympathetic nerve endings to release acetylcholine through inhibiting the secretion of auxin in the hypothalamus, so that the blood vessels of salivary glands are dilated, the salivary secretion with large amount and small solid is caused, the salivary viscosity of the oral cavity is improved, and the formation of dental caries is effectively reduced.

Lanthanum is very active in the air and usually exists in the form of alloy, the industrial extraction mainly comprises the steps of dehydrating lanthanum chloride hydrate and reducing by calcium metal, the method takes several days to extract crystals, the working hours are long, the extracted lanthanum is easy to absorb moisture after losing electrons, and the storage property is low, so the following scheme is provided in the application: firstly, extracting lanthanum, carbonizing the alloy to generate carbon nano fibers in the metal, loosening the internal structure, facilitating the subsequent hydrolysis, removing oxides and impurities on the surface, smelting the alloy material by using a high-frequency induction furnace under a vacuum condition, soaking the alloy smelting liquid into a wood-charcoal-ash mixed liquid after smelting, supplementing the carbon content in the alloy mother liquid, and fully dissolving carbon atoms into the alloy melt to obtain saturated alloy mother liquid. The alloy is crushed after cooling and then put into deionized water for hydrolysis to obtain lanthanum oxide and iron-based alloy powder, nonmagnetic lanthanum hydroxide is obtained through repeated magnetic separation according to the difference of magnetic properties of the lanthanum oxide and iron-based powder, the lanthanum hydroxide is reduced to generate a lanthanum simple substance under the protection of nitrogen, the iron content in the alloy mother liquor is greatly improved through multiple times of carbon supplement and smelting, the generation of lanthanum oxide is increased, and the generation rate of lanthanum is improved. The method firstly carbonizes the alloy and extracts lanthanum by magnetic separation, thereby saving the working time, being more stable than the traditional method and being easy to store.

Detailed Description

The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

The decayed tooth preventing candy comprises the following raw materials in parts by weight:

5-10 parts of green persimmon tannic acid, 5-7 parts of disodium hydrogen phosphate-citric acid, 5-10 parts of collagen, 4-8 parts of tannin modified collagen, 3-5 parts of lanthanum, 2-5 parts of lanthanum modified chitosan, 20-30 parts of concentrated fruit juice, 2-3 parts of salt, 4-6 parts of edible essence, 3-4 parts of pigment, 10-15 parts of vitamin, 10-15 parts of food additive and 30-50 parts of purified water.

Preferably, the green persimmon tannin is obtained by crushing dried green persimmon peels, extracting the crushed green persimmon tannins in a Soxhlet extractor by using acetone as an extracting agent until the crushed green persimmon tannins are colorless, and concentrating and drying the extracted green persimmon tannins by using a rotary evaporator to obtain a finished product.

Preferably, the tannin modified collagen is prepared by dissolving a certain amount of tannin in a disodium hydrogen phosphate-citric acid solution, adding the solution into a collagen water bath constant-temperature oscillator for reaction, and performing vacuum drying to obtain a finished product.

Preferably, the lanthanum-modified chitosan is prepared by adding a lanthanum simple substance into a chitosan acetic acid solution, adjusting the pH value with ammonia water, stirring for reaction to completely separate out the lanthanum-modified chitosan, filtering, washing and drying in vacuum.

Preferably, the lanthanum simple substance is obtained by melting the alloy subjected to carbonization treatment under a vacuum condition, ensuring the carbon content in the alloy during melting, cooling and crushing the alloy, hydrolyzing the alloy, performing magnetic separation to remove iron-based powder, and reducing the residual lanthanum oxide under the protection of nitrogen to obtain a finished product.

Preferably, the preservative is one of benzoic acid, sorbic acid and dehydroacetic acid.

The second aspect of the invention provides a preparation method of a decayed tooth preventing candy, which comprises the following steps:

(1) drying and crushing the green persimmon peels, sieving the crushed green persimmon peels with a 60-mesh sieve, extracting the crushed green persimmon peels in a Soxhlet extractor until the green persimmon peels are colorless, and concentrating and drying the green persimmon peels by using a rotary evaporator to obtain the green persimmon tannic acid.

(2) Dissolving the green persimmon tannic acid by using a disodium hydrogen phosphate-citric acid buffer solution with the pH of 4.0 to enable the concentration of the solution to be 2g/L, putting 5ml of tannic acid solution into a conical flask, supplementing the buffer solution to enable the total volume to be 20ml, adding a certain amount of collagen into the conical flask, reacting for 6 hours in a water bath constant temperature oscillator at the temperature of 30 ℃, and drying in vacuum to obtain the tannic acid modified collagen.

(3) Removing oxides and impurities on the surface of the lanthanum-containing alloy, carrying out smelting carbonization treatment on the alloy material by using a high-frequency induction furnace under a vacuum condition, soaking an alloy smelting solution into a charcoal ash mixed solution for 20 hours after smelting, supplementing the carbon content in an alloy mother solution, crushing the alloy, putting the alloy into deionized water for hydrolysis to obtain lanthanum oxide and iron-based alloy powder, carrying out magnetic separation to obtain nonmagnetic lanthanum hydroxide, and reducing the lanthanum hydroxide under the protection of nitrogen to generate a lanthanum simple substance.

(4) Dissolving chitosan in a 5% acetic acid solution, adding a lanthanum simple substance, adjusting the pH value to 5-6 by using 5% ammonia water, stirring and reacting for 60min at 30 ℃, dropwise adding 25% ammonia water to completely separate out lanthanum-modified chitosan, filtering and washing, and drying for 2h under vacuum at the temperature of 70 ℃ to obtain the lanthanum-modified chitosan.

(5) Mixing concentrated fruit juice with purified water, adding tannin modified collagen and lanthanum modified chitosan, placing into a 30 deg.C water bath constant temperature oscillator, reacting for 6h, adding edible essence, pigment, vitamins, food additives and antiseptic, and reacting for 3h at 40 deg.C water bath constant temperature oscillator to obtain the final product.

Preferably, in the step (2): the mass ratio of the collagen to the green persimmon tannin is 3: 2.

preferably, in the step (3): the carbonization treatment enables the carbon nano-fiber to be generated inside the metal, the internal structure is loosened, and the subsequent hydrolysis is easy to realize; the iron in the alloy mother liquor is always in a saturated state through the repeated carbon content supplement and smelting, the reaction is promoted to be carried out in the positive direction, the generation of the iron base is increased, and the generation rate of lanthanum is improved.

Preferably, in the step (4): the mass ratio of the lanthanum simple substance to the chitosan is 10: 1.

example 1: the caries-preventing candy I:

the decayed tooth preventing candy comprises the following components in parts by weight:

5 parts of green persimmon tannic acid, 5 parts of disodium hydrogen phosphate-citric acid, 5 parts of collagen, 4 parts of tannic acid modified collagen, 3 parts of lanthanum, 2 parts of lanthanum modified chitosan, 20 parts of concentrated fruit juice, 2 parts of salt, 4 parts of edible essence, 3 parts of pigment, 10 parts of vitamin, 10 parts of food additive and 30 parts of purified water.

The preparation method of the beverage comprises the following steps:

(1) drying and crushing the green persimmon peels, sieving the crushed green persimmon peels with a 60-mesh sieve, extracting the crushed green persimmon peels in a Soxhlet extractor until the green persimmon peels are colorless, and concentrating and drying the green persimmon peels by using a rotary evaporator to obtain the green persimmon tannic acid.

(2) Dissolving the green persimmon tannic acid by using a disodium hydrogen phosphate-citric acid buffer solution with the pH of 4.0 to enable the concentration of the solution to be 2g/L, putting 5ml of tannic acid solution into a conical flask, supplementing the buffer solution to enable the total volume to be 20ml, adding a certain amount of collagen into the conical flask, reacting for 6 hours in a water bath constant temperature oscillator at the temperature of 30 ℃, and drying in vacuum to obtain the tannic acid modified collagen.

(3) Removing oxides and impurities on the surface of the lanthanum-containing alloy, carrying out smelting carbonization treatment on the alloy material by using a high-frequency induction furnace under a vacuum condition, soaking an alloy smelting solution into a charcoal ash mixed solution for 20 hours after smelting, supplementing the carbon content in an alloy mother solution, crushing the alloy, putting the alloy into deionized water for hydrolysis to obtain lanthanum oxide and iron-based alloy powder, carrying out magnetic separation to obtain nonmagnetic lanthanum hydroxide, and reducing the lanthanum hydroxide under the protection of nitrogen to generate a lanthanum simple substance.

(4) Dissolving chitosan in 5% acetic acid solution, adding lanthanum simple substance, adjusting pH to 5 with 5% ammonia water, stirring and reacting at 30 ℃ for 60min, dropwise adding 25% ammonia water to completely separate out lanthanum-modified chitosan, filtering and washing, and vacuum drying at 70 ℃ for 2h to obtain lanthanum-modified chitosan.

(5) Firstly, uniformly mixing 10 parts of concentrated fruit juice and 20 parts of purified water, adding 4 parts of tannin modified collagen and 2 parts of lanthanum modified chitosan, reacting for 6 hours in a water bath constant temperature oscillator at 30 ℃, adding 4 parts of edible essence, 3 parts of pigment, 10 parts of vitamin and 10 parts of food additive, and reacting for 3 hours in a water bath constant temperature oscillator at 40 ℃ to obtain a finished product.

Example 2: and (2) preventing decayed teeth:

the decayed tooth preventing candy comprises the following components in parts by weight:

8 parts of green persimmon tannic acid, 7 parts of disodium hydrogen phosphate-citric acid, 10 parts of collagen, 8 parts of tannic acid modified collagen, 5 parts of lanthanum modified chitosan, 30 parts of concentrated fruit juice, 3 parts of salt, 6 parts of edible essence, 4 parts of pigment, 15 parts of vitamin, 15 parts of food additive and 50 parts of purified water.

The preparation method of the candy comprises the following steps:

(1) drying and crushing the green persimmon peels, sieving the crushed green persimmon peels with a 60-mesh sieve, extracting the crushed green persimmon peels in a Soxhlet extractor until the green persimmon peels are colorless, and concentrating and drying the green persimmon peels by using a rotary evaporator to obtain the green persimmon tannic acid.

(2) Dissolving the green persimmon tannic acid by using a disodium hydrogen phosphate-citric acid buffer solution with the pH of 4.0 to enable the concentration of the solution to be 2g/L, putting 5ml of tannic acid solution into a conical flask, supplementing the buffer solution to enable the total volume to be 20ml, adding a certain amount of collagen into the conical flask, reacting for 6 hours in a water bath constant temperature oscillator at the temperature of 30 ℃, and drying in vacuum to obtain the tannic acid modified collagen.

(3) Removing oxides and impurities on the surface of the lanthanum-containing alloy, carrying out smelting carbonization treatment on the alloy material by using a high-frequency induction furnace under a vacuum condition, soaking an alloy smelting solution into a charcoal ash mixed solution for 20 hours after smelting, supplementing the carbon content in an alloy mother solution, crushing the alloy, putting the alloy into deionized water for hydrolysis to obtain lanthanum oxide and iron-based alloy powder, carrying out magnetic separation to obtain nonmagnetic lanthanum hydroxide, and reducing the lanthanum hydroxide under the protection of nitrogen to generate a lanthanum simple substance.

(4) Dissolving chitosan in 5% acetic acid solution, adding lanthanum simple substance, adjusting pH to 6 with 5% ammonia water, stirring and reacting for 60min at 30 ℃, dropwise adding 25% ammonia water to completely separate out lanthanum-modified chitosan, filtering and washing, and drying in vacuum for 2h at 70 ℃ to obtain the lanthanum-modified chitosan.

(5) Firstly, uniformly mixing 15 parts of concentrated fruit juice and 25 parts of purified water, adding 8 parts of tannin modified collagen and 5 parts of lanthanum modified chitosan, reacting for 6 hours in a water bath constant temperature oscillator at 30 ℃, adding 5 parts of edible essence, 4 parts of pigment, 15 parts of vitamin and 15 parts of food additive, and reacting for 3 hours in a water bath constant temperature oscillator at 40 ℃ to obtain a finished product.

Comparative example 1: ordinary candy

The common candy comprises, by weight, 15 parts of syrup, 15 parts of vitamins, 3 parts of sweetening agents, 2 parts of edible pigments and 2 parts of preservatives.

The preparation method of the candy comprises the following steps:

(1) weighing 15 parts of syrup and 10 parts of vitamins by weight, mixing and stirring at 40 ℃, at the rotating speed of 400r/min for 30 min;

(2) and (2) adding 3 parts by weight of sweetening agent, 2 parts by weight of edible pigment and 2 parts by weight of preservative into the substance obtained in the step (1), stirring until the substances are completely dissolved, wherein the stirring temperature is 60 ℃, the rotating speed is 300r/min, and the stirring time is 1h, so as to obtain a finished product.

Comparative example 2: preparation of candy for preventing dental caries without adding tannin modified collagen

The formulation of the caries-preventing candy without tannic acid-modified collagen was the same as that of example 1. The method of manufacturing the candy is different from example 1 only in that the preparation of steps (1) and (2) is not performed, and the remaining manufacturing steps are the same as example 1.

Comparative example 3: preparation of caries-preventing candy without lanthanum-modified chitosan

The formulation of the caries-preventing candy without lanthanum-modified chitosan was the same as that of example 1. The method for preparing the candy is different from that of example 1 only in that the preparation of step (3) is not performed, and the remaining preparation steps are the same as those of example 1.

Test example 1: effect of experimental example 1 and comparative examples 1, 2, 3 on intestinal environment:

1. experimental methods

Five groups of 20 female mice with the weight of 18 g-22 g are divided into 4 groups, an intestinal environment test experiment is carried out, 2g of the anti-caries candy prepared in the example 1, the common candy prepared in the comparative example 1, the anti-caries candy without tannin modified collagen in the comparative example 2 and the anti-caries candy without lanthanum modified chitosan in the comparative example 3 are respectively dissolved in 10ml of water to be irrigated to the stomach of the mice, 2ml of each mouse is irrigated to the stomach of the control group with distilled water with the same volume, after one week of continuous once a day, the humidity of the feces of the mice is measured after 24 hours of fasting, and the normal humidity is the normal humidity.

2. Results of the experiment

Example 1, effects of comparative examples 1, 2, 3 and control on the intestinal environment:

compared with the mouse excrement weights of comparative examples 1, 2 and 3 and a control group, after one week, the weight of the mouse excrement of the group in the example 1 is the largest, and the weight of the mouse in the group in the comparative example 2 is not greatly different from that of the mouse excrement, so that the lanthanum modified chitosan can regulate the intestinal tract to be a weakly acidic environment suitable for the survival of the bifidobacteria under the catalysis of intestinal hydrolase, promote the growth and the reproduction of the bifidobacteria, promote the stability of the intestinal tract of a body and keep the ecological balance of the intestinal tract.

Test example 2: effect of test example 1 and comparative example 1 on calcium ion absorption:

1. experimental methods

Carrying out calcium ion absorption test experiments on 10 female mice with the weight of 18 g-22 g in two groups of 5 female mice, measuring 2g of the caries-preventing candy prepared in example 1 and 2g of the common candy prepared in comparative example 1 respectively, dissolving in 10ml of water, intragastrically irrigating the mice, 2ml of each mouse, intragastrically irrigating distilled water with the same volume in a control group, carrying out abdominal aorta desquamation on the mice after one continuous week every day, and measuring the calcium ion concentration in blood, wherein the higher the calcium ion absorption degree is, the better the calcium ion absorption promoting effect is.

2. Results of the experiment

Effect of test example 1 and comparative example 1 on calcium ion absorption:

through the comparison of the content measurement of calcium ions in blood between the example 1 and the comparative example 1, the result that the absorption effect of calcium ions by the mice of the group in the example 1 is better than that of calcium ions by the mice of the group in the ordinary candy group in the comparative example 1 shows that lanthanum ions can open the calcium ion channel on the intestinal cell membrane and increase the absorption of calcium ions by the body, which indicates that the candy for preventing dental caries can supplement the calcium loss on the enamel by enhancing the absorption of calcium ions and reduce the occurrence of dental caries.

It is noted that, herein, relational terms such as first and second, and the like may be used solely to distinguish one entity or action from another entity or action without necessarily requiring or implying any actual such relationship or order between such entities or actions. Also, the terms "comprises," "comprising," or any other variation thereof, are intended to cover a non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements does not include only those elements but may include other elements not expressly listed or inherent to such process, method, article, or apparatus.

Finally, it should be noted that: although the present invention has been described in detail with reference to the foregoing embodiments, it will be apparent to those skilled in the art that changes may be made in the embodiments and/or equivalents thereof without departing from the spirit and scope of the invention. Any modification, equivalent replacement, or improvement made within the spirit and principle of the present invention should be included in the protection scope of the present invention.