阅读说明：本技术 用于治疗儿童性早熟及青少年发育迟缓的骨胶原蛋白茯苓膏 (Bone collagen poria cocos paste for treating sexual precocity and juvenile developmental retardation of children ) 是由 张涌 于 2021-07-03 设计创作，主要内容包括：本发明公开了用于治疗儿童性早熟及青少年发育迟缓的骨胶原蛋白茯苓膏,由以下质量份的原料组成：骨胶原蛋白肽450-550g、核桃肽450-550g、茯苓950-1100g、山楂450-550g、麦芽950-1100g、莲子950-1100g、鸡内金450-550g、蜂蜜950-1100g,本发明组方合理,配伍科学,骨胶原蛋白肽促进骨质发育,增强骨骼成长,核桃肽提高记忆力、开发智力、提高人体免疫力,茯苓利水渗湿,健脾,宁心,山楂消食健胃,行气散瘀,化浊降脂,麦芽行气消食,健脾开胃,回乳消胀,莲子补脾止泻,止带,益肾涩精,养心安神,鸡内金健胃消食,涩精止遗,通淋化石,本发明诸药合用,可促进营养成分的吸收,促进青少年儿童的生长和智力发育,对儿童性早熟及青少年发育迟缓有治疗作用。(The invention discloses a bone collagen tuckahoe ointment for treating sexual precocity and juvenile developmental retardation of children, which is composed of the following raw materials in parts by mass: 550g of ossein peptide, 550g of walnut peptide, 550g of poria cocos, 950, 550g of hawthorn, 950, 1100g of malt, 950, 1100g of lotus seed, 950, 550g of endothelium corneum gigeriae galli and 1100g of honey, and the invention has reasonable formula and scientific compatibility, the ossein peptide promotes bone development, enhances bone growth, the walnut peptide improves memory, develops intelligence and improves human immunity, the poria cocos promotes diuresis and excretes dampness, the spleen and the heart are strengthened, the hawthorn digestion and the stomach are strengthened, the qi and the blood stasis are promoted, the malt promotes qi circulation and digestion, the spleen and the appetite are strengthened, the milk is restored and the distension is relieved, the lotus seed tonifies the spleen and the diarrhea, the leucorrhea is stopped, the kidney is astringed, the heart is nourished and the mind is calmed, the endothelium corneum gigeriae galli the stomach is strengthened, the nocturnal emission is stopped, the stranguria is relieved and the medicines are used together, can promote absorption of nutrient components, promote growth and intelligence development of teenagers and children, and treat sexual precocity and hypoevolutism of teenagers.)

1. The bone collagen poria cocos paste for treating sexual precocity and juvenile developmental retardation of children is characterized by comprising the following raw materials in parts by mass: 550g of ossein peptide 450-.

2. The bone collagen tuckahoe ointment for treating sexual precocity and juvenile developmental delay of children according to claim 1, which is characterized by comprising the following raw materials in parts by mass: 500g of ossein peptide, 500g of walnut peptide, 1000g of tuckahoe, 500g of hawthorn, 1000g of malt, 1000g of lotus seed, 500g of chicken's gizzard-membrane and 1000g of honey.

3. The ossein poria cocos paste for treating sexual precocity and juvenile developmental delay of children according to claim 1, wherein the preparation method comprises the following steps:

(1) selecting raw materials according to a formula, removing impurities and silt from the raw materials, and cleaning the raw materials for later use;

(2) putting the medicinal materials except the bone collagen peptide and the walnut peptide into a container, adding a proper amount of purified water, immersing all the medicinal materials by 15 cm higher, and soaking for about 12 hours;

(3) putting the soaked medicinal materials into a decocting pot for decocting. Boiling with strong fire, boiling with slow fire for 1 hr, filtering to obtain first decoction, adding appropriate amount of purified water, boiling with strong fire, boiling with slow fire for 40min, filtering to obtain second decoction, decocting with second decoction for three times, filtering to obtain filtrate, removing residues, mixing decoctions, and filtering with 100 mesh sieve;

(4) pouring the filtrate into a concentration pot, concentrating, and concentrating into fluid extract until the concentrated medicinal liquid is not scattered on paper;

(5) placing the fluid extract into paste collecting machine, adjusting slow fire, slowly adding Mel, stirring continuously, concentrating until the liquid medicine is "fish eye bubble", and can be pulled to make flag or "water drop bead", sequentially adding ossein peptide and walnut peptide when paste collecting is nearly completed, and mixing well to obtain the final product;

(6) putting the collected paste into a clean wide-mouth container, covering the container with clean gauze, naturally cooling, bottling, and storing in shade.

Technical Field

The invention relates to the field of traditional Chinese medicines for treating sexual precocity and juvenile developmental retardation of children, in particular to a bone collagen poria cocos paste for treating sexual precocity and juvenile developmental retardation of children.

Background

In recent years, with the improvement of living standard of people, the problems of precocious puberty are more and more caused by fast food, inferior stationery, bad work and rest, environmental influence and the like, and it is understood that most of the fundamental causes are still unclear except for a few of the precise causes of precocious puberty, and are common children endocrine diseases, and the onset of diseases is in an increasing trend at present; on the other hand, due to the influence of living habits such as food, sleep, exercise and the like, many teenagers grow and develop slowly, and further psychological burden is caused; at present, the western medicine mainly depends on hormone treatment for growth and development, has great side effect and can not meet the requirements of patients.

Disclosure of Invention

In order to solve the technical problems, the technical scheme provided by the invention is as follows: the bone collagen poria cocos paste for treating sexual precocity and juvenile developmental retardation of children is prepared from the following raw materials in parts by mass: 550g of ossein peptide 450-.

Preferably, the feed consists of the following raw materials in parts by mass: 500g of ossein peptide, 500g of walnut peptide, 1000g of tuckahoe, 500g of hawthorn, 1000g of malt, 1000g of lotus seed, 500g of chicken's gizzard-membrane and 1000g of honey.

The preparation method comprises the following steps:

(1) selecting raw materials according to a formula, removing impurities and silt from the raw materials, and cleaning the raw materials for later use;

(2) putting the medicinal materials except the bone collagen peptide and the walnut peptide into a container, adding a proper amount of purified water, immersing all the medicinal materials by 15 cm higher, and soaking for about 12 hours;

(3) putting the soaked medicinal materials into a decocting pot for decocting. Boiling with strong fire, boiling with slow fire for 1 hr, filtering to obtain first decoction, adding appropriate amount of purified water, boiling with strong fire, boiling with slow fire for 40min, filtering to obtain second decoction, decocting with second decoction for three times, filtering to obtain filtrate, removing residues, mixing decoctions, and filtering with 100 mesh sieve;

(4) pouring the filtrate into a concentration pot, concentrating, and concentrating into fluid extract until the concentrated medicinal liquid is not scattered on paper;

(5) placing the fluid extract into paste collecting machine, adjusting slow fire, slowly adding Mel, stirring continuously, concentrating until the liquid medicine is "fish eye bubble", and can be pulled to make flag or "water drop bead", sequentially adding ossein peptide and walnut peptide when paste collecting is nearly completed, and mixing well to obtain the final product;

(6) putting the collected paste into a clean wide-mouth container, covering the container with clean gauze, naturally cooling, bottling, and storing in shade.

In the invention: the ossein peptide is combined with calcium to promote the development of bone and enhance the growth of bone; the ossein peptide promotes the accumulation of bone and prevents osteoporosis by promoting the effect of osteoblasts; the ossein peptide can promote the production of osteoblast, recover the original power of skeleton and slow down the loss of bone by inhibiting the formation of osteoclast;

the walnut peptide is prepared by performing deep processing on a walnut which is in good reputation of brain gold by applying multi-link biotechnology such as biological low-temperature compound enzymolysis and the like, removing redundant grease in the walnut, effectively refining nutrient substances of the walnut, and forming the walnut small molecular peptide rich in 18 amino acids, vitamins and mineral substances; it has the following functions: 1) improving the memory: the memory is the process of active activity of cerebral cortex nerve cells, recording and storing; once a person is tired, particularly when the brain is tired, the activity of brain cells on the cerebral cortex can be inhibited, and even the brain cells are in a dormant state; at this time, any information entering the brain from the outside cannot be effectively received and responded, so that the memory can be reduced; the walnut small molecular peptide can enable cerebral cortex nerve cells to move vigorously, promote brain tissue metabolism and restore brain cell functions; for people who often use the brain, the brain health can be quickly restored, the brain health is protected, the thinking agility is enhanced, and the hypomnesis is effectively prevented;

2) developing intelligence and improving learning ability: the walnut peptide is rich in glutamic acid which is one of 18 amino acids, is the only amino acid participating in the brain metabolism of human bodies, and is also an indispensable important nutrient substance for the intelligence activities of human beings; glutamic acid can promote intelligence development, maintain and improve brain function; the medicine is widely applied to medicines in medicine, and plays an indispensable role in the healthy development of the brain of children; the walnut peptide can be eaten to effectively develop the intelligence of children and improve the learning ability of the children;

3) sleeping peacefully: with the acceleration of life rhythm and the increase of social pressure, people suffering from insomnia disorder increase year by year; the large amount of glutamic acid contained in the walnut peptide can be decarboxylated to form gamma-aminobutyric acid, which is a central nerve regulator and can relieve the tension and disorder state of brain nerves and restore the brain nerves to be normal, so that the walnut peptide is easier to fall asleep and has better sleep quality; meanwhile, the gamma-aminobutyric acid also has a remarkable relieving effect on the anxiety mood caused by insomnia;

4) anti-oxidation, prevention of senile dementia: the aging process of human body is actually the function of redundant free radicals in the body, and the redundant free radicals can cause the damage of normal cells and tissues of the human body, thereby causing various diseases; the walnut peptide has the effects of resisting oxidation and removing redundant free radicals in the body; the excellent ability of eliminating free radicals can effectively delay the aging of human bodies and prevent various diseases caused by the aging of the human bodies; the occurrence of alzheimer's disease, which is caused by aging of brain cells; GABA (gamma-aminobutyric acid) rich in walnut peptide can delay the aging of brain cells, so that the illness probability of senile dementia is effectively reduced;

5) improving digestive system, promoting nutrient absorption: the walnut peptide is rich in 18 amino acids, and the rich amino acids can promote the growth and the propagation of beneficial bacteria in vivo, enhance the gastrointestinal function of a human body and promote digestion; on the other hand, the small molecular peptide can serve as a carrier function in a human body, so that nutrient substances can be rapidly transported into cells, and the absorption of the nutrient substances is enhanced;

6) auxiliary treatment of cardiovascular and cerebrovascular diseases: the walnut peptide can effectively improve the ACE inhibition rate in vivo; thereby effectively reducing the generation of angiotensin II and achieving the effect of lowering blood pressure; in addition, the walnut peptide has remarkable antioxidant activity, can prevent the oxidation of low-density lipoprotein, and has the functions of preventing and treating cardiovascular diseases (atherosclerosis, coronary heart disease, ischemic heart disease, hyperlipidemia and the like);

7) improving the immunity of the human body: the walnut peptide has strong antibacterial action and wide antibacterial range, and can effectively prevent the colony number of harmful bacteria in a human body and prevent the human body from being damaged by the harmful bacteria; on the other hand, the walnut peptide can enhance the phagocytic capacity of phagocytic cells playing an important role in the human immune system; the immunity of the human body is improved by enhancing the capability of the human body to remove apoptotic cells, metabolic wastes and harmful viruses;

8) anticancer, inhibition of cancer cell growth: the reason cancer makes the greatest change in color is its extremely rapid progression; the walnut peptide can effectively inhibit the growth of cancer cells, thereby slowing the disease development of cancer and achieving the effect of resisting cancer;

poria cocos is sweet and light in flavor and mild in nature; the heart, lung, spleen and kidney meridians are entered; the product has effects in promoting diuresis, eliminating dampness, invigorating spleen, and calming heart; can be used for treating edema, oliguria, palpitation due to phlegm and fluid retention, spleen deficiency, anorexia, loose stool, diarrhea, uneasiness, palpitation, and insomnia;

maslinic acid, sweet and slightly warm; spleen, stomach and liver meridians entered; promoting digestion, invigorating stomach, promoting qi circulation, removing blood stasis, eliminating turbid pathogen, and reducing blood lipid; can be used for treating meat food stagnation, gastric cavity distention, dysentery abdominal pain, blood stasis amenorrhea, puerperal blood stasis, heart and abdominal pain, thoracic obstruction, cardialgia, hernia pain, and hyperlipidemia; the charred fructus crataegi has effects of resolving food stagnation.

Can be used for treating food stagnation and diarrhea;

malt is sweet and flat; spleen and stomach meridians entered; can promote qi circulation, promote digestion, invigorate spleen, stimulate appetite, promote lactation and relieve distension; can be used for treating dyspepsia, abdominal pain, spleen deficiency, anorexia, breast pain, breast weaning, hypochondriac pain due to stagnation of liver-qi, and pain of liver and stomach;

the lotus seeds are sweet and astringent in taste and mild in nature; spleen, kidney and heart meridians entered; has effects in invigorating spleen, relieving diarrhea, stopping leukorrhagia, invigorating kidney, arresting seminal emission, nourishing heart, and tranquilizing mind; can be used for treating diarrhea due to spleen deficiency, leukorrhagia, spermatorrhea, palpitation, and insomnia;

endothelium corneum Gigeriae Galli is sweet and neutral; entering spleen, stomach, small intestine and bladder meridians; invigorating stomach, resolving food stagnation, arresting seminal emission, relieving stranguria, and removing calculus; can be used for treating dyspepsia, emesis, dysentery, infantile malnutrition, enuresis, nocturnal emission, stranguria with stone, pain, gallbladder distention, and hypochondriac pain;

the honey can regulate and tonify the spleen and the stomach; pain due to deficiency of the major epigastrium and abdomen; cough due to dryness of the lung; constipation due to intestinal dryness; conjunctival congestion; aphtha; unhealing ulcer; rubella with pruritus; scald by hot water or fire; rhagades of hands and feet;

the Chinese medicinal composition has the advantages of reasonable formula and scientific compatibility, the bone collagen peptide promotes bone development and enhances bone growth, the walnut peptide improves memory, develops intelligence and improves human immunity, the poria cocos induces diuresis and excrets dampness, the spleen and the heart are calmed, the hawthorn fruits promote digestion and invigorate the stomach, the qi and blood stasis are promoted, the turbid pathogen is dissolved and reduced in fat, the malt promotes qi and digestion, the spleen and the appetite are strengthened and appetized, the lotus seeds tonify the spleen and stop diarrhea, the leucorrhea is stopped, the kidney and the seminal emission are benefited, the heart and the mind are nourished and tranquilized, the chicken gizzard-membrane promotes digestion, the seminal emission is stopped, and stranguria and fossil are removed.

Detailed Description

Example one

The bone collagen poria cocos paste for treating sexual precocity and juvenile developmental retardation of children is prepared from the following raw materials in parts by mass: 500g of ossein peptide, 500g of walnut peptide, 1000g of tuckahoe, 500g of hawthorn, 1000g of malt, 1000g of lotus seed, 500g of chicken's gizzard-membrane and 1000g of honey.

The preparation method comprises the following steps:

(1) selecting raw materials according to a formula, removing impurities and silt from the raw materials, and cleaning the raw materials for later use;

(2) putting the medicinal materials except the bone collagen peptide and the walnut peptide into a container, adding a proper amount of purified water, immersing all the medicinal materials by 15 cm higher, and soaking for about 12 hours;

(3) putting the soaked medicinal materials into a decocting pot for decocting. Boiling with strong fire, boiling with slow fire for 1 hr, filtering to obtain first decoction, adding appropriate amount of purified water, boiling with strong fire, boiling with slow fire for 40min, filtering to obtain second decoction, decocting with second decoction for three times, filtering to obtain filtrate, removing residues, mixing decoctions, and filtering with 100 mesh sieve;

(4) pouring the filtrate into a concentration pot, concentrating, and concentrating into fluid extract until the concentrated medicinal liquid is not scattered on paper;

(5) placing the fluid extract into paste collecting machine, adjusting slow fire, slowly adding Mel, stirring continuously, concentrating until the liquid medicine is "fish eye bubble", and can be pulled to make flag or "water drop bead", sequentially adding ossein peptide and walnut peptide when paste collecting is nearly completed, and mixing well to obtain the final product;

(6) putting the collected paste into a clean wide-mouth container, covering the container with clean gauze, naturally cooling, bottling, and storing in shade.

Example two

The bone collagen poria cocos paste for treating sexual precocity and juvenile developmental retardation of children is prepared from the following raw materials in parts by mass: 500g of ossein peptide, 500g of walnut peptide, 1000g of tuckahoe, 500g of hawthorn, 1000g of malt, 1000g of lotus seed, 500g of chicken's gizzard-membrane and 1000g of honey.

The preparation method comprises the following steps:

(1) selecting raw materials according to a formula, removing impurities and silt from the raw materials, and cleaning the raw materials for later use;

(2) putting the medicinal materials except the bone collagen peptide and the walnut peptide into a container, adding a proper amount of purified water, immersing all the medicinal materials by 15 cm higher, and soaking for about 12 hours;

(3) putting the soaked medicinal materials into a decocting pot for decocting. Boiling with strong fire, boiling with slow fire for 1 hr, filtering to obtain first decoction, adding appropriate amount of purified water, boiling with strong fire, boiling with slow fire for 40min, filtering to obtain second decoction, decocting with second decoction for three times, filtering to obtain filtrate, removing residues, mixing decoctions, and filtering with 100 mesh sieve;

(4) pouring the filtrate into a concentration pot, concentrating, and concentrating into fluid extract until the concentrated medicinal liquid is not scattered on paper;

(5) placing the fluid extract into paste collecting machine, adjusting slow fire, slowly adding Mel, stirring continuously, concentrating until the liquid medicine is "fish eye bubble", and can be pulled to make flag or "water drop bead", sequentially adding ossein peptide and walnut peptide when paste collecting is nearly completed, and mixing well to obtain the final product;

(6) putting the collected paste into a clean wide-mouth container, covering the container with clean gauze, naturally cooling, bottling, and storing in shade.

EXAMPLE III

The bone collagen poria cocos paste for treating sexual precocity and juvenile developmental retardation of children is prepared from the following raw materials in parts by mass: 500g of ossein peptide, 500g of walnut peptide, 1000g of tuckahoe, 500g of hawthorn, 1000g of malt, 1000g of lotus seed, 500g of chicken's gizzard-membrane and 1000g of honey.

The preparation method comprises the following steps:

(1) selecting raw materials according to a formula, removing impurities and silt from the raw materials, and cleaning the raw materials for later use;

(2) putting the medicinal materials except the bone collagen peptide and the walnut peptide into a container, adding a proper amount of purified water, immersing all the medicinal materials by 15 cm higher, and soaking for about 12 hours;

(3) putting the soaked medicinal materials into a decocting pot for decocting. Boiling with strong fire, boiling with slow fire for 1 hr, filtering to obtain first decoction, adding appropriate amount of purified water, boiling with strong fire, boiling with slow fire for 40min, filtering to obtain second decoction, decocting with second decoction for three times, filtering to obtain filtrate, removing residues, mixing decoctions, and filtering with 100 mesh sieve;

(4) pouring the filtrate into a concentration pot, concentrating, and concentrating into fluid extract until the concentrated medicinal liquid is not scattered on paper;

(5) placing the fluid extract into paste collecting machine, adjusting slow fire, slowly adding Mel, stirring continuously, concentrating until the liquid medicine is "fish eye bubble", and can be pulled to make flag or "water drop bead", sequentially adding ossein peptide and walnut peptide when paste collecting is nearly completed, and mixing well to obtain the final product;

(6) putting the collected paste into a clean wide-mouth container, covering the container with clean gauze, naturally cooling, bottling, and storing in shade.

First, the sexual precocity treatment experiment verification of children

1. Randomly selecting 100 sexual precocity patients at the outpatient department, wherein the patients are 6-12 years old, taking the medicine prepared in the embodiment 3, and taking the medicine in the morning and the evening in sequence for 3 months continuously to judge the curative effect;

2. and (3) judging the curative effect:

and (3) curing: breast retraction to B1, no hair growth, no vaginal secretions, bone age less than actual age, B ultrasound: the volume of uterus and ovary (testis) is not increased.

The method has the following advantages: breast B3 to B2 or B4 to B3, no hair growth, vaginal secretion reduction or disappearance, bone age less than actual age, B-ultrasound: the volume of uterus and ovary (testis) is not increased.

And (4) invalidation: the continued development of the sex characteristics, breast B3-B4, the growth of pubic hair, more vaginal secretion, bone age greater than the actual age, bone age over 1 year, type-B ultrasonography: uterine and ovarian (testicular) volume increase, (female ovary >1mL } male testicular >4 mL).

3. The treatment results are as follows:

the curative example 80, the effective example 16 and the ineffective example 4 have the total cure rate of 80 percent and the total effective rate of 96 percent, so the invention has better curative effect on the sexual precocity of children.

Second, experimental verification of treatment for development retardation of teenagers

1. Randomly selecting 100 teenager hypoevolutism patients at the outpatient clinic, wherein the patients are 6-16 years old, taking the medicine prepared in the embodiment 3, and sequentially taking the medicine in the morning and the evening for 5 months continuously to judge the curative effect;

2. and (3) judging the curative effect:

and (3) curing: the height rise is more than 3cm after being taken;

the method has the following advantages: the height rise after taking the medicine is 2-3 cm;

and (4) invalidation: the height is unchanged after taking the medicine.

3. Therapeutic results

The traditional Chinese medicine composition has the advantages that the curative example 78, the effective example 15 and the ineffective example 7 are adopted, the total curative rate is 78 percent, and the total effective rate is 93 percent, so that the traditional Chinese medicine composition has a better curative effect on treating juvenile hypoevolutism.

The present invention and the embodiments thereof have been described above without limitation, and it is within the scope of the present invention that those skilled in the art should be able to devise similar structural modes and embodiments without inventive changes without departing from the spirit and scope of the present invention.