阅读说明：本技术 五元并六元氮杂芳环类化合物、其制备方法、药用组合物及其应用 (Five-membered and six-membered nitrogen heteroaromatic ring compound, preparation method thereof, medicinal composition and application thereof ) 是由 邓贤明 王洪睿 曾涛玲 张婷 姜婷婷 于 2018-05-17 设计创作，主要内容包括：本发明涉及药物化学领域,五元并六元氮杂芳环类化合物、其制备方法、药用组合物及其应用。具体地,涉及一类具有通过特异性地增强Ras蛋白泛素化降解的化合物,其制备方法、包含该化合物的药物组合物,以及这些化合物在制备用于预防或治疗与生物体内与Ras活性相关的疾病的药物中的用途,尤其是在制备用于预防或治疗肿瘤生长与转移的药物中的用途。<Image he="546" wi="680" file="DDA0002278202600000011.GIF" imgContent="drawing" imgFormat="GIF" orientation="portrait" inline="no"></Image>(The invention relates to the field of pharmaceutical chemistry, in particular to a five-membered and six-membered nitrogen-heterocyclic aromatic ring compound, a preparation method thereof, a medicinal composition and application thereof. In particular to a compound with the function of specifically enhancing the ubiquitination degradation of Ras protein, a preparation method thereof, a pharmaceutical composition containing the compound and the application of the compound in preparing medicaments for preventing or treating diseases related to Ras activity in organisms, in particular to the preparation of medicaments for preventing or treating the diseases in the organismsThe application of the compound in preparing medicines for preventing or treating tumor growth and metastasis.)