阅读说明：本技术 一种防治家禽腺肌胃炎的药物组合物及其应用 (Pharmaceutical composition for preventing and treating poultry adenofibromyositis and application thereof ) 是由 孙月川 黄松 王一凡 崔明旭 史德胜 吴燕子 刘爱玲 李守军 于 2019-10-24 设计创作，主要内容包括：本发明公开了一种防治家禽腺肌胃炎的药物组合物及其应用,该组合物主要由黄芪、蒲公英、当归3味中药材与B族维生素、碳酸氢钠、纤维素酶等组成。本发明组合物可以制成散剂、极细粉等剂型,供临床使用。该组合物组方合理、效果明显,在临床上可替代畜禽用抗菌药物的使用,用于家禽腺胃炎、肌胃炎等疾病的防治。(The invention discloses a pharmaceutical composition for preventing and treating poultry adenoid muscular gastritis and application thereof, wherein the composition mainly comprises 3 Chinese medicinal materials of astragalus, dandelion and angelica, B vitamins, sodium bicarbonate, cellulose and the like. The composition can be prepared into powder, superfine powder and other dosage forms for clinical use. The composition has reasonable formula and obvious effect, can be used for clinically replacing antibacterial drugs for livestock and poultry, and is used for preventing and treating diseases such as proventriculitis and muscular gastritis of poultry.)

1. The pharmaceutical composition for preventing and treating poultry adenomyositis is characterized by comprising the following components: astragalus root, dandelion herb, Chinese angelica root, vitamin B₂Vitamin B₆Vitamin U, bismuth aluminate, sodium bicarbonate, β -D-glucose oxidoreductase, cellulase and cod liver oil powder.

2. The pharmaceutical composition for preventing and treating poultry adenoid myogastritis according to claim 1, wherein the pharmaceutical composition comprises the following components in parts by weight: 2-7 parts of astragalus membranaceus, 1-6 parts of dandelion, 1-2 parts of angelica sinensis and vitamin B₂0.01 to 0.1 part of vitamin B₆0.01 to 0.1 portion of vitamin U, 0.01 to 0.1 portion of bismuth aluminate, 0.05 to 0.4 portion of sodium bicarbonate, 0.01 to 0.1 portion of β -D-glucose oxidoreductase, 0.01 to 0.1 portion of cellulase and 0.05 to 0.2 portion of cod liver oil powder.

3. The pharmaceutical composition for preventing and treating poultry adenoid myogastritis according to claim 1 or 2, wherein the pharmaceutical composition comprises the following components in parts by weight: 4-6 parts of astragalus membranaceus, 2-4 parts of dandelion, 1-2 parts of angelica sinensis and vitamin B₂0.01 to 0.05 part of vitamin B₆0.01 to 0.05 part of vitamin U, 0.01 to 0.05 part of bismuth aluminate, 0.1 to 0.2 part of sodium bicarbonate, 0.01 to 0.05 part of β -D-glucose oxidoreductase, 0.01 to 0.05 part of cellulase and 0.05 to 0.2 part of cod liver oil powder.

4. The pharmaceutical composition for preventing and treating poultry adenomyositis according to any one of claims 1-3, wherein the pharmaceutical composition comprises the following components in parts by weight: 5 parts of astragalus root, 3 parts of dandelion, 1 part of angelica and vitamin B₂0.01 part of vitamin B₆0.01 part, 0.02 part of vitamin U, 0.24 part of bismuth aluminate, 0.16 part of sodium bicarbonate, 0.02 part of β -D-glucose oxidoreductase, 0.02 part of cellulase and 0.05 part of cod liver oil powder.

5. A method for preparing the pharmaceutical composition for preventing and treating poultry adenomyositis as claimed in any one of claims 1-4, characterized by comprising the following steps:

(1) weighing the Chinese medicinal materials according to formula ratio, pulverizing, sieving, and mixing in high-efficiency mixer for 30-40min to obtain Chinese medicinal powder;

(2) weighing other medicinal components except the traditional Chinese medicinal materials according to the formula, mixing and crushing, adding the medicinal components in an equal amount in the step (1) for three times, and sieving to obtain medicinal material mixed powder;

(3) and (3) mixing the medicinal material mixed powder obtained in the step (2) with the rest of the Chinese medicinal material powder in a mixer for 60min to obtain the Chinese medicinal composition.

6. A pharmaceutical preparation comprising the pharmaceutical composition for preventing and treating poultry adenomyositis as claimed in any one of claims 1 to 4.

7. The pharmaceutical formulation of claim 6, wherein the pharmaceutical formulation is in the form of a powder, a superfine powder.

8. A feed additive, which comprises the pharmaceutical composition for preventing and treating poultry adenofibromyositis according to any one of claims 1 to 4.

Technical Field

The invention belongs to the technical field of veterinary medicines, and particularly relates to a pharmaceutical composition for preventing and treating poultry adenofibromyositis and application thereof.

Background

The poultry glandular myositis is an epidemic disease which is mainly characterized by the appearance symptoms of poor growth, emaciation, poor uniformity, excessive feed of excrement and the like, enlargement of glandular stomach, or flat or even disappearance of glandular stomach papilla, ulcer and shedding of glandular stomach mucous membrane, gizzard lining and musculo stomach mucous membrane, crater-like ulcer and erosions of musculo stomach.

Since 2008, the adenofibromyositis continuously develops from the northeast to the northeast and eastern China, and at present, the adenofibromyositis widely occurs in the northeast, northwestern and southward China. The disease can cause great harm to poultry groups and can not be recovered in a short time. Especially in recent years, poultry seedlings find muscular gastric ulcer bleeding, and poultry farms have proventriculitis all the year round, and once infected with the disease, the disease causes great economic loss to breeding plants.

The pathogenesis of the poultry adenoid myogastritis is complex, no consistent conclusion is made at present, and most of the poultry adenoid myogastritis is divided into infectious factors and non-infectious factors according to etiological features. Non-infectious factors are: biogenic amines, mycotoxins, copper sulfate poisoning, and the like; the etiology of infectious gonad myositis is complex: adenovirus viruses of adenogastric infectious bronchitis, and poplar. There are also some feeding problems such as stress, poultry house density, etc.

In addition, because the young poultry is weak, the immunity is low, or the female parent is born or the temperature and the humidity are high for a long time when the young poultry is born, the young poultry has the condition of glandular gastric ulcer; at the moment, the poor feed is eaten, the functional abnormality of the muscular stomach and glandular stomach can be caused, and the symptoms of feed intake reduction, large weight difference and loose feces appear in the early stage or the middle stage of the poultry group.

The inventor develops a combined medicament by combining the effects of inhibiting virus and bacteria in a digestive system of poultry adenomyositis, regulating the digestive system, improving the immunity of poultry, repairing sores and ulcers and the like of a plurality of traditional Chinese medicines through long-term clinical tests. The prescription is monarch drug of astragalus, ministerial drug of angelica, and tangible blood is generated from intangible qi, so the astragalus is used for greatly tonifying spleen and lung qi to enrich the source and make qi flourish and blood generate; when a small amount of angelica is added to nourish blood and regulate nutrient, yang grows yin and grows, and qi is vigorous and blood grows. Can be used for treating unhealed sores and ulcers after ulceration, the recipe has the effects of benefiting qi and nourishing blood, strengthening body resistance and expelling toxin, and promoting granulation and healing; the dandelion has the effects of clearing away heat and toxic materials, eliminating stagnation and relieving swelling, has the gastrointestinal protection effect, can relieve the damage of gastric ulcer or gastritis to the gastrointestinal tract, has the repairing effect on gastric mucosa damage, and can promote gastrointestinal peristalsis; the sodium bicarbonate neutralizes gastric acid and slows down the damage of the gastric acid to the myoglandular stomach; the B vitamins are water-soluble vitamins which are indispensable for maintaining the normal function and the metabolic activity of the human body, the deficiency of the vitamin B6 is positively correlated with the damage degree of poultry glandular muscles and stomachs, and the disease can be alleviated after the vitamin B6 is added; the glucose oxidase has multiple functions of inhibiting mildew, detoxifying, enhancing immunity, promoting digestion and the like, and can be widely applied to livestock and poultry feeds; the cellulase plays a biological catalysis role in decomposing cellulose; the fish liver oil powder can improve the immunity of poultry and strengthen physique. The invention has special effect on poultry adenoid myogastritis caused by poultry congenital myogastric ulcer bleeding.

The pharmaceutical composition is green and environment-friendly, and has the characteristics of small toxic and side effects, no drug resistance and the like; the poultry is reasonably used, digestive tract diseases can be effectively prevented, meanwhile, the use of antibiotics is avoided, the safety and the reliability of poultry products are ensured, and the poultry feed has wide application prospect in poultry breeding.

Disclosure of Invention

In view of the above, the invention successfully develops the pharmaceutical composition for preventing and treating the poultry adenoid myogastritis, and the pharmaceutical composition is clinically applied to prove the curative effect of the pharmaceutical composition. Specifically, the traditional Chinese medicine formula is utilized to simultaneously solve the problems of clinical adenomuscular gastritis, adenomuscular stomach erosion, loose stool discharge, decreased feed intake and the like; meanwhile, sodium bicarbonate is utilized to neutralize gastric acid, so that the disease of muscular gastric ulcer and bleeding of the young poultry can be effectively solved. The invention has no residue and no adverse effect, and has remarkable curative effect on poultry adenoid myogastritis.

The invention provides a pharmaceutical composition for treating proventriculitis of poultry, which comprises the following components of astragalus, dandelion, angelica and vitamin B₂Vitamin B₆2-7 parts of astragalus membranaceus, 1-6 parts of dandelion, 1-2 parts of angelica sinensis and vitamin B₂0.01 to 0.1 part of vitamin B₆0.01 to 0.1 portion of vitamin U, 0.01 to 0.1 portion of bismuth aluminate, 0.05 to 0.4 portion of sodium bicarbonate, 0.01 to 0.1 portion of β -D-glucose oxidoreductase, 0.01 to 0.1 portion of cellulase and 0.05 to 0.2 portion of cod liver oil powder.

Preferably, the pharmaceutical composition comprises the following components in parts by weight: 4-6 parts of astragalus membranaceus, 2-4 parts of dandelion, 1-2 parts of angelica sinensis and vitamin B₂0.01 to 0.05 part of vitamin B₆0.01 to 0.05 part of vitamin U, 0.01 to 0.05 part of bismuth aluminate, 0.1 to 0.2 part of sodium bicarbonate, 0.01 to 0.05 part of β -D-glucose oxidoreductase, 0.01 to 0.05 part of cellulase and 0.05 to 0.2 part of cod liver oil powder.

More preferably, the pharmaceutical composition comprises the following components in parts by weight: 5 parts of astragalus root, 3 parts of dandelion, 1 part of angelica and vitamin B₂0.01 part of vitamin B₆0.01 part, 0.02 part of vitamin U, 0.24 part of bismuth aluminate, 0.16 part of sodium bicarbonate, 0.02 part of β -D-glucose oxidoreductase, 0.02 part of cellulase and 0.05 part of cod liver oil powder.

The second aspect of the invention provides a preparation method of a pharmaceutical composition for preventing and treating poultry adenomyositis, which comprises the following steps:

(1) weighing the Chinese medicinal materials according to formula ratio, pulverizing, sieving, and mixing in high-efficiency mixer for 30-40min to obtain Chinese medicinal powder.

(2) Weighing other medicinal components except the traditional Chinese medicinal materials according to the formula, mixing and crushing, adding the medicinal components in an equivalent amount obtained in the step (1) for three times, and sieving to obtain medicinal material mixed powder.

(3) And (3) mixing the medicinal material mixed powder obtained in the step (2) with the rest of the Chinese medicinal material powder in a mixer for 60min to obtain the Chinese medicinal composition.

In a third aspect of the invention, a pharmaceutical preparation is provided, which comprises the pharmaceutical composition for preventing and treating proventriculitis of poultry.

The medicinal preparation can be powder, superfine powder and other preparations for clinical use.

In a fourth aspect of the invention, a feed additive is provided, which comprises the pharmaceutical composition for preventing and treating proventriculitis of poultry.

The use method of the pharmaceutical composition as a feed additive comprises the following steps: the pharmaceutical composition of the invention is added into feed and taken along with the feed. The medicine is taken for 3-7 days according to daily food intake. Is suitable for young poultry, and can be added into feed at a weight ratio of 0.05-0.3% for preventing and treating glandular muscular gastritis of poultry of 2-3 days old; when used for preventing and treating proventriculitis of poultry of 10-25 days old, the feed is added into one-ton feed according to 0.3-1% of the weight for taking.

The compound medicine of the invention comprises:

astragalus root: warm in nature and sweet in taste. It enters lung and spleen meridians. Has the effects of invigorating qi, invigorating yang, consolidating superficial resistance, arresting sweating, inducing diuresis, relieving swelling, expelling pus, and healing sore.

Chinese angelica: sweet and pungent in flavor and warm in nature. It enters liver, heart and spleen meridians. Has the functions of enriching blood, promoting blood circulation, regulating menstruation, relieving pain, moistening intestines and relaxing bowels. Can be used for treating blood deficiency, sallow complexion, giddiness, palpitation, menoxenia, amenorrhea, dysmenorrhea, asthenia cold, abdominal pain, rheumatalgia, traumatic injury, superficial infection, pyocutaneous disease, intestinal dryness, and constipation.

Dandelion: bitter, sweet and cold. It enters liver and stomach meridians. Clearing away heat and toxic material, dispersing swelling and dissipating stagnation, inducing diuresis and treating stranguria. Can be used for treating furuncle, swelling, acute mastitis, scrofula, conjunctival congestion, pharyngalgia, pulmonary abscess, intestinal abscess, jaundice due to damp-heat pathogen, and stranguria with astringency and pain due to heat.

Bismuth aluminate: can form a protective film on the gastric mucosa.

Sodium bicarbonate: and (4) weak alkalinity. Can be used for relieving gastralgia, heartburn and acid regurgitation caused by hyperchlorhydria.

Vitamin B₂: is involved in the growth and metabolism of cells and is a body tissueEssential nutrients for metabolism and repair, and can also participate in the metabolism of vitamin B6 and nicotinic acid.

Vitamin B₆: vitamin B₆The deficiency is positively correlated with the degree of glandular gastral injury of poultry, and can improve the symptoms of glandular gastris.

Vitamin U: is an antiulcer agent, and can be used for treating gastric ulcer and duodenal ulcer.

β -D-glucose oxidoreductase, also called glucose oxidase, has multiple functions of inhibiting mildew, detoxifying, enhancing immunity, protecting liver, detoxifying and promoting digestion, and is widely applied to livestock and poultry feed as a novel green non-toxic feed additive.

Cellulase: it has biocatalytic effect in decomposing cellulose, and can decompose cellulose into protein of oligosaccharide or monosaccharide.

Fish liver oil powder: can improve immunity of fowls and enhance constitution.

Has the advantages that:

1. the invention has simple preparation process, reasonable formula, prevention and treatment combination, combined application of the medicines in the formula, no medicine residue causing food potential safety hazard, no medicine resistance of poultry to the medicine residue, and treatment of both principal and secondary aspects of diseases;

2. the pharmaceutical composition can remarkably improve the congenital gastric ulcer bleeding of young poultry caused by high temperature and long time in the carrying and hatching process of the female parent, regulate the gastrointestinal tract function, relieve the glandular myogastritis, improve the immunity of the poultry and improve the feed intake. Solves the problems of the decrease of the feed intake of the poultry, uneven weight and the like concerned by farmers.

3. The invention adopts the equivalent progressive addition method of the medicines, and compared with direct mixing, the medicine is more uniform and the clinical effect is better.

Detailed Description

The advantageous properties of the invention can be observed in connection with the following examples, which are illustrative and not limitative of the invention.