阅读说明：本技术 一种可显影补片及其制备方法 (Developable patch and preparation method thereof ) 是由 马建民 于 2019-10-14 设计创作，主要内容包括：本发明公开一种可显影补片及其制备方法,所述可显影补片主要由可显影线通过编织或刺绣的方式与聚丙烯单丝或聚丙烯补片复合而成；所述可显影线为复合镍钛丝、铂依合金丝、黄金、钨丝、钛丝、银丝、医用不锈钢丝、高分子复合丝中的任意一种；所述可显影补片的制备方法为：显影线的选择及处理、聚丙烯单丝或补片的处理和可显影补片的复合。本发明具有良好的物理性能和生物安全性,满足临床需要；能够有效帮助医生对疝修补手术患者的术后检查,确认补片是否挛缩移位,降低患者术后复发率及风险。(The invention discloses a developable patch and a preparation method thereof, wherein the developable patch is mainly formed by compounding a developable thread with a polypropylene monofilament or a polypropylene patch in a weaving or embroidering way; the developable line is any one of a composite nickel-titanium wire, a platinum-alloy wire, gold, a tungsten wire, a titanium wire, a silver wire, a medical stainless steel wire and a polymer composite wire; the preparation method of the developable patch comprises the following steps: selection and treatment of development lines, treatment of polypropylene monofilaments or patches, and compounding of developable patches. The invention has good physical properties and biological safety, and meets the clinical requirements; can effectively help doctors to check the hernia repair operation patients after operation, confirm whether the patch is contracture and displaced, and reduce the recurrence rate and risk of the patients after operation.)

1. A developable patch characterized by: the developable patch is mainly formed by compounding developable threads with polypropylene monofilaments or polypropylene patches in a weaving or embroidering mode; the developable line is any one of a composite nickel-titanium wire, a platinum-alloy wire, gold, a tungsten wire, a titanium wire, a silver wire, a medical stainless steel wire and a polymer composite wire; the physical indexes of the polypropylene monofilament comprise: the monofilament diameter is 0.03-0.2mm, the breaking force is 200-1000cN, the breaking elongation is 20-80%, and the heat shrinkage is 0.5-6%; the polypropylene patch is any one of a polypropylene monofilament flat sheet, a polypropylene double-filament flat sheet, a polypropylene multifilament flat sheet, a polypropylene 3D patch, a polypropylene net plug and a polypropylene composite patch.

2. The developable patch according to claim 1, characterized in that: the high-molecular composite filament is prepared by stirring, granulating, injection molding and extruding a modified PP/PE/PU/EVA/PLA/PVC/TPE/TPR/PTFE/PET/latex/silica gel serving as a carrier and barium sulfate according to a mixing ratio, wherein the mass ratio of the mixing ratio is 0.25-10.

3. The developable patch according to claim 2, characterized in that: the mass ratio value of the mixing ratio is 1.5-5.

4. A developable patch according to claim 1 or 2, characterized in that: the physical indexes of the polymer composite yarn comprise: the monofilament diameter is 0.04-0.8mm, the breaking force is 100-800cN, the elongation at break is 5-30%, and the heat shrinkage is 1-6%.

5. The developable patch according to claim 4, wherein: the physical indexes of the polymer composite yarn comprise: the monofilament diameter is 0.1-0.5 mm, the breaking force is 300-600 cN, the breaking elongation is 20-25%, and the thermal shrinkage is 2-4%.

6. The developable patch according to claim 1, characterized in that: the physical indexes of the polypropylene monofilament comprise: the monofilament diameter is 0.05-0.15mm, the breaking force is 500-900cN, the breaking elongation is 30-40%, and the thermal shrinkage is 2-3%.

7. A method of preparing the developable patch according to claim 1, comprising the steps of:

s1, selection and processing of the development line: selecting a proper developing line, cleaning and warping the developing line;

s2, processing polypropylene monofilament or patch: cleaning and warping the polypropylene monofilament; cleaning and drying the polypropylene patch;

s3, compounding developable patches: the developing thread and the polypropylene monofilament are woven or embroidered to combine with the polypropylene patch to form the developing patch.

8. The method of preparing a developable patch according to claim 7, characterized in that: the knitting process in the step S3 specifically includes: 10-28 machine number, 6/cm-20/cm drawing density, 2000 warp feeding amount and 4000mm/rack, and the hole shape of the developable patch is designed by inputting a tissue map and is any one of a circle, a hexagon, a square and a rhombus.

9. The method of preparing a developable patch according to claim 8, characterized in that: the knitting process in the step S3 specifically includes: the machine number is 12-18, the drawing density is 8/cm-12/cm, and the let-off quantity is 2500-.

10. The method of preparing a developable patch according to claim 7, characterized in that: the embroidery process in the step S3 is any one of hand embroidery or machine embroidery, and the embroidery pattern is one or more of a circle, a trapezoid, a square, an ellipse, a concentric circle, a #, a field font and a square.

Technical Field

The invention relates to the technical field of biological tissue patches, in particular to a developable patch and a preparation method thereof.

Background

Hernia refers to the common and frequently encountered diseases in general surgery, in which some tissue or organ in the body leaves the normal anatomical position and is formed through the weakness, defect or gap formed by the congenital or acquired origin, and the abdominal hernia is the most common, especially the inguinal hernia, and accounts for about 90% -95% of the abdominal hernia. The traditional hernia repair is to suture and reinforce soft tissues, and the recurrence rate after the operation of the method is as high as 10-15%. The tension-free hernia repair is to repair a weak part by using a repair material, and the laparoscopic hernia repair for treating abdominal external hernia is well applied to clinical treatment of hernia surgery and achieves a satisfactory curative effect. Clinical statistics shows that the tension-free repair operation has the characteristics of low postoperative recurrence rate, simple and convenient operation, light injury of patients, quick recovery and little pain.

The ideal hernia repair material has the physical characteristics that are not changed after being implanted into a human body and can resist mechanical stress; the chemical property is stable, and no harmful substance is generated; good biocompatibility, no inflammation reaction and foreign body reaction, no carcinogenicity and no sensitization. In addition, the patch material should also be elastically bendable; easy sewing; allowing collagen fibers to grow in; can resist infection and is easy to disinfect; no influence of body fluid.

Three synthetic patch materials which are widely used clinically at present are polyester patches, polypropylene patches and expanded polytetrafluoroethylene patches. The polyester patch of the three patch materials is basically abandoned due to the heavy foreign matter and inflammatory reaction, and the expanded polytetrafluoroethylene is high in price and cannot resist infection and pollution. The single-filament polypropylene patch which is commonly applied in the domestic market and has the largest use amount is produced by the United states Barde company, in recent years, the domestic polypropylene patch is rapidly developed, and various large-pore light polypropylene patches become research and development hot spots of various medical instrument companies. The company carries out research, development and innovation on the postoperative exploitability of the polypropylene patch, and the patent provides a preparation method of the developable patch, and the developable patch can carry out X-ray exploration after the hernia repair operation is carried out, so that a doctor can accurately evaluate and judge the fitting property of the patch and the tissues of a patient and whether the patch contractures and displaces. Therefore, the possibility of relapse of the patient is analyzed, corresponding treatment and prevention measures are proposed, and the postoperative risk of the patient is reduced.

Disclosure of Invention

The invention aims to provide a developable patch and a preparation method thereof aiming at the defects and shortcomings of the prior art.

In order to achieve the purpose, the invention adopts the technical scheme that: the developable patch has the innovation points that: the developable patch is mainly formed by compounding developable threads with polypropylene monofilaments or polypropylene patches in a weaving or embroidering mode; the developable line is any one of a composite nickel-titanium wire, a platinum-alloy wire, gold, a tungsten wire, a titanium wire, a silver wire, a medical stainless steel wire and a polymer composite wire; the physical indexes of the polypropylene monofilament comprise: the monofilament diameter is 0.03-0.2mm, the breaking force is 200-1000cN, the breaking elongation is 20-80%, and the heat shrinkage is 0.5-6%; the polypropylene patch is any one of a polypropylene monofilament flat sheet, a polypropylene double-filament flat sheet, a polypropylene multifilament flat sheet, a polypropylene 3D patch, a polypropylene net plug and a polypropylene composite patch.

Further, the high-molecular composite filament is prepared by stirring, granulating, injection molding and extruding modified PP/PE/PU/EVA/PLA/PVC/TPE/TPU/TPR/PTFE/PET/latex/silica gel which is used as a carrier and barium sulfate according to a mixing ratio, wherein the mass ratio of the mixing ratio is 0.25-10.

Further, the mass ratio value of the mixing ratio is 1.5-5.

Further, the physical indexes of the polymer composite yarn include: the monofilament diameter is 0.04-0.8mm, the breaking force is 100-800cN, the elongation at break is 5-30%, and the heat shrinkage is 1-6%.

Further, the physical indexes of the polymer composite yarn include: the monofilament diameter is 0.1-0.5 mm, the breaking force is 300-600 cN, the breaking elongation is 20-25%, and the thermal shrinkage is 2-4%.

Further, the physical indexes of the polypropylene monofilament include: the monofilament diameter is 0.05-0.15mm, the breaking force is 500-900cN, the breaking elongation is 30-40%, and the thermal shrinkage is 2-3%.

A method of preparing a developable patch, comprising the steps of:

s1, selection and processing of the development line: selecting a proper developing line, cleaning and warping the developing line; s2, processing polypropylene monofilament or patch: cleaning and warping the polypropylene monofilament; cleaning and drying the polypropylene patch;

s3, compounding developable patches: the developing thread and the polypropylene monofilament are woven or embroidered to combine with the polypropylene patch to form the developing patch.

Further, the knitting process in step S3 specifically includes: 10-28 machine number, 6/cm-20/cm drawing density, 2000 warp feeding amount and 4000mm/rack, and the hole shape of the developable patch is designed by inputting a tissue map and is any one of a circle, a hexagon, a square and a rhombus.

Further, the knitting process in step S3 specifically includes: the machine number is 12-18, the drawing density is 8/cm-12/cm, and the let-off quantity is 2500-.

Further, the embroidery process in step S3 is any one of hand embroidery and machine embroidery, and the embroidery pattern is one or more of a circle, a trapezoid, a square, an ellipse, a concentric circle, a #, a field, and a square.

The invention has the beneficial effects that:

the invention has good physical properties and biological safety, and meets the clinical requirements; can effectively help doctors to check the hernia repair operation patients after operation, confirm whether the patch is contracture and displaced, and reduce the recurrence rate and risk of the patients after operation.

Drawings

FIG. 1 is a developed patch 2 (FIG. 1B) made by combining a macromolecular composite yarn developing thread on a polypropylene 3D patch 1 (FIG. 1A) by a manual embroidery process according to the present invention; adopting a metallic titanium wire, and combining the metallic titanium wire as a developing line on a polypropylene 3D patch (figure 1A) by a manual embroidery process to prepare a developable patch 3 (figure 1C);

FIG. 2 shows the three patches of FIG. 1 sewn on fresh pork, each placed under a Siemens digital X-ray camera at 45kV, 10mAs exposure, resulting in photographs FIG. 2a, FIG. 2b, and FIG. 2c, respectively.

Detailed Description

The invention will be further described with reference to the accompanying drawings.

In order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention will be described in detail with reference to the accompanying drawings and the detailed description. It should be understood that the detailed description and specific examples, while indicating the invention, are intended for purposes of illustration only and are not intended to limit the scope of the invention.

In order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention is described in further detail below with reference to specific embodiments. It should be understood that the detailed description and specific examples, while indicating the invention, are intended for purposes of illustration only and are not intended to limit the scope of the invention.