阅读说明：本技术 含吡唑基的三并环类衍生物、其制备方法和应用 (Pyrazolyl-containing tricyclic derivatives, preparation method and application thereof ) 是由 刘世强 周远锋 刘扬 吴雪松 刘磊 包如迪 于 2018-10-18 设计创作，主要内容包括：本发明涉及含吡唑基的三并环类衍生物、其制备方法和应用。特别地,本发明涉及通式(I)所示的化合物、其制备方法及含有该化合物的药物组合物,及其作为蛋白酶如ERK(MAPK)抑制剂在治疗癌症、骨病、炎性疾病、免疫疾病、神经系统疾病、代谢性疾病、呼吸性疾病和心脏病的用途,其中通式(I)中的各取代基与说明书中的定义相同。<Image he="345" wi="497" file="DDA0002143239920000011.GIF" imgContent="drawing" imgFormat="GIF" orientation="portrait" inline="no"></Image>(The invention relates to pyrazolyl-containing tricyclic derivatives, a preparation method and application thereof. In particular, the invention relates to a compound shown in a general formula (I), a preparation method thereof, a pharmaceutical composition containing the compound and application thereof as a protease inhibitor such as ERK (MAPK) in treating cancer, bone diseases, inflammatory diseases, immune diseases, nervous system diseases, metabolic diseases, respiratory diseases and heart diseases, wherein each substituent in the general formula (I) is defined as the specification.)