阅读说明：本技术 Ret抑制剂、其药物组合物及其在药物中的应用 (RET inhibitor, pharmaceutical composition thereof and application thereof in medicines ) 是由 谢洪明 罗明 张英俊 何锦 贾媛媛 寇玉辉 于 2021-05-07 设计创作，主要内容包括：本发明属于药物领域,涉及一种RET抑制剂、其药物组合物及其在药物中的应用。具体地,本发明涉及一种式(I)所示的化合物,或式(I)所示化合物的立体异构体、互变异构体、氮氧化物、溶剂化物、代谢产物、药学上可接受的盐或前药。本发明还涉及包含所述化合物的药物组合物、以及所述化合物及其药物组合物在制备药物中的用途,该药物尤其用于治疗和预防可用RET相关的疾病和病症,包括癌症、肠易激综合征和/或与肠易激综合征相关的疼痛。(The invention belongs to the field of medicines, and relates to a RET inhibitor, a pharmaceutical composition thereof and application thereof in medicines. Specifically, the invention relates to a compound shown in formula (I), or a stereoisomer, a tautomer, a nitrogen oxide, a solvate, a metabolite, a pharmaceutically acceptable salt or a prodrug of the compound shown in formula (I). The invention also relates to pharmaceutical compositions comprising said compounds, and the use of said compounds and their pharmaceutical compositions for the manufacture of medicaments, especially for the treatment and prevention of diseases and disorders associated with RET of interest, including cancer, irritable bowel syndrome and/or pain associated with irritable bowel syndrome.)