阅读说明：本技术 用于有不良渗透性的蛋白质、肽和小分子的口服递送的制剂 (Formulations for oral delivery of proteins, peptides and small molecules with poor permeability ) 是由 V·普拉萨尔 B·伊尔博德 A·加吕斯 T·普安托瓦 J·梅索尼耶 于 2020-04-10 设计创作，主要内容包括：本公开针对意图用于有治疗活性的合成或天然的不良渗透性分子或其盐/溶剂化物的口服递送的药物制剂。该药物制剂可包括：制剂总重量的0.01-10重量%的量的合成或天然的不良渗透性分子或其盐或溶剂化物；制剂总重量的50-80重量%的量的包含脂肪酸的甘油三酯的亲油相；以及制剂总重量的约10-50重量%的量的至少一种包含多元醇和脂肪酸的偏酯的亲油表面活性剂。(The present disclosure is directed to pharmaceutical formulations intended for oral delivery of therapeutically active synthetic or natural poorly permeable molecules or salts/solvates thereof. The pharmaceutical formulation may include: synthetic or natural poorly permeable molecules or salts or solvates thereof in an amount of 0.01 to 10% by weight of the total weight of the formulation; a lipophilic phase comprising triglycerides of fatty acids in an amount of 50-80 wt.% of the total weight of the formulation; and at least one lipophilic surfactant comprising a partial ester of a polyhydric alcohol and a fatty acid in an amount of about 10 to 50 weight% of the total weight of the formulation.)