阅读说明：本技术 作为gpr40激动剂的3-苯基-4-己炔酸衍生物 (3-phenyl-4-hexynoic acid derivatives as GPR40 agonists ) 是由 马特乌什·马赫 拉多斯劳·吉达 达米安·斯穆加 菲利普·史迪玛 米科拉伊·马特洛克 卡塔日 于 2019-01-07 设计创作，主要内容包括：式(I)的化合物及其盐,其中R表示直链或支化的、伯或仲非环烃基C3-C15基团,其可以是饱和或不饱和的,或者直链或支化的、伯或仲非环烃基C3-C15基团,其可以是饱和或不饱和的且其中一个或多个氢原子被氟原子取代；X表示氢原子或卤素原子,*表示手性中心。该化合物可用于治疗由GPR40介导的疾病,尤其是II型糖尿病。<Image he="610" wi="687" file="DDA0002653133940000011.GIF" imgContent="drawing" imgFormat="GIF" orientation="portrait" inline="no"></Image>(Compounds of formula (I) and salts thereof, wherein R represents a linear or branched, primary or secondary acyclic hydrocarbyl C3-C15 group, which may be saturated or unsaturated, or a linear or branched, primary or secondary acyclic hydrocarbyl C3-C15 group, which may be saturated or unsaturated, and salts thereofWherein one or more hydrogen atoms are replaced by fluorine atoms; x represents a hydrogen atom or a halogen atom, and X represents a chiral center. The compounds are useful for the treatment of diseases mediated by GPR40, in particular type II diabetes.)