阅读说明：本技术 一种伤口消毒液及其制备方法 (Wound disinfectant and preparation method thereof ) 是由 杨效东 初晓君 冯新光 班文溥 谢苗苗 于 2020-06-29 设计创作，主要内容包括：本发明提供一种伤口消毒液及其制备方法,其特点是：伤口消毒液的原料中包括占原料总重量1%-20%的艾考糊精,还包括：葡萄糖酸氯已定、透明质酸和水。制备方法包括以下步骤：按照伤口消毒液原料重量配比,将艾考糊精、葡萄糖酸氯已定/透明质酸溶于一定量的水后,搅拌均匀,加入剩余的水定容,将上述液体自动罐装分装后封口,检测合格后即得成品。能够对手术或意外伤口具有清创和消毒的功效,且具有促进伤口愈合及预防瘢痕的功效,原料选择及配比合理,原料易得,成本较低,且制备方法简单,适用于大规模工业化生产。(The invention provides a wound disinfectant and a preparation method thereof, and is characterized in that: the wound disinfectant comprises the raw materials of icodextrin which accounts for 1 to 20 percent of the total weight of the raw materials, and also comprises: chlorhexidine gluconate, hyaluronic acid and water. The preparation method comprises the following steps: dissolving icodextrin and chlorhexidine gluconate/hyaluronic acid in a certain amount of water according to the weight ratio of the raw materials of the wound disinfectant, uniformly stirring, adding the rest water to a constant volume, automatically canning, subpackaging and sealing the liquid, and obtaining a finished product after the detection is qualified. The wound cleaning and disinfecting liquid has the effects of cleaning and disinfecting an operation wound or an accidental wound, has the effects of promoting wound healing and preventing scars, is reasonable in raw material selection and proportion, easy to obtain raw materials, low in cost and simple in preparation method, and is suitable for large-scale industrial production.)

1. The wound disinfectant is characterized in that raw materials of the wound disinfectant comprise icodextrin accounting for 1% -20% of the total weight of the raw materials.

2. The wound disinfection solution of claim 1, wherein the raw materials of the wound disinfection solution further comprise: chlorhexidine gluconate, hyaluronic acid and water.

3. The wound disinfection solution as claimed in claim 1 or 2, wherein the wound disinfection solution comprises the following raw materials in percentage by weight: 3-8% of icodextrin, 0.01-0.1% of chlorhexidine gluconate, 0.05-2% of hyaluronic acid and the balance of water, wherein the water is one of water for injection or sterile water.

4. A method for preparing the wound disinfection solution of any of claims 1-3, wherein the method comprises the steps of:

dissolving icodextrin and chlorhexidine gluconate/hyaluronic acid in a certain amount of water according to the weight ratio of the raw materials of the wound disinfectant, uniformly stirring, adding the rest water to a constant volume, automatically canning, subpackaging and sealing the liquid, and obtaining a finished product after the detection is qualified.

Technical Field

The invention belongs to the technical field of disinfectant, and particularly relates to a wound disinfectant and a preparation method thereof.

Background

Wounds can be defined as skin defects caused by mechanical, electrical, thermal, chemical, etc. factors or due to physiological allergies, wound infection remains a fearful and expensive complication, and therefore, reasonable and timely wound debridement and disinfection are of paramount importance. However, the wound disinfection solution on the market only has basic wound cleaning or disinfection effects, and does not have other effects, such as the disinfection solution mentioned in patent CN106421180A "an anti-pus wound disinfection solution" only has cleaning and disinfection effects.

Icodextrin is a glucan formed by hydrolyzing starch, and has good water solubility, safety and biocompatibility. The pharmaceutical preparation taking the icodextrin as the raw material is approved to be on the market in more than 30 countries and regions, and has good safety, biocompatibility and stability; the colloidal solution prepared from the icodextrin has good ultrafiltration effect and hydration floating effect, and can be used as peritoneal dialysis solution and surgical anti-adhesion washing solution, (Cooker, 2002) and the like show that the icodextrin has good biocompatibility [3 ]; (chemistry, 1994) et al in a randomized multicenter clinical trial demonstrated that icodextrin solutions are safe and effective for long-term use as peritoneal dialysis solutions [4 ]; (Catena, 2012), et al in a single-center, prospective randomized trial, demonstrated that 4% icodextrin use in patients with small intestinal obstruction was safe and reduced the risk of intra-abdominal adhesions forming and re-obstruction [5 ]. The applicant finds that a colloidal solution formed by icodextrin has the effects of promoting wound healing and preventing scars in the process of studying icodextrin, because the icodextrin solution is the colloidal solution, has certain permeability and hydration floating effect, has good anti-adhesion property, can form a layer of protective film on wounds, and because the icodextrin has good biocompatibility, does not stimulate the wounds, and has good safety.

How to produce the wound disinfectant by reasonably matching the icodextrin serving as a raw material for producing the disinfectant with other raw materials can have the effects of debriding and disinfecting an operation or accidental wound and the effects of promoting wound healing and preventing scars, which is a technical problem to be solved urgently at present in the field.

Disclosure of Invention

Aiming at the problems in the prior art, the invention provides the wound disinfectant and the preparation method thereof, which have the effects of debriding and disinfecting an operation wound or an accidental wound, the effects of promoting wound healing and preventing scars, reasonable raw material selection and proportion, easily obtained raw materials, lower cost and simple preparation method, and are suitable for large-scale industrial production.

In order to solve the above problems, the object of the present invention is achieved by the following technical solutions:

the wound disinfectant is characterized in that raw materials of the wound disinfectant comprise icodextrin accounting for 1% -20% of the total weight of the raw materials.

The improvement of the technical scheme is as follows: the wound disinfectant raw materials also comprise: chlorhexidine gluconate, hyaluronic acid and water.

The technical scheme is further improved as follows: the wound disinfection solution comprises the following raw materials in percentage by weight: 3-8% of icodextrin, 0.01-0.1% of chlorhexidine gluconate, 0.05-2% of hyaluronic acid and the balance of water, wherein the water is one of water for injection or sterile water.

The invention also provides a preparation method of the wound disinfection solution, which is characterized by comprising the following steps:

dissolving icodextrin and chlorhexidine gluconate/hyaluronic acid in a certain amount of water according to the weight ratio of the raw materials of the wound disinfectant, uniformly stirring, adding the rest water to a constant volume, automatically canning, subpackaging and sealing the liquid, and obtaining a finished product after the detection is qualified.

Compared with the prior art, the invention has the following advantages and positive effects:

the wound disinfectant containing the icodextrin, provided by the invention, has the effects of debriding and disinfecting an operation wound or an accidental wound, and has the effects of promoting wound healing and preventing scars. The icodextrin has good biocompatibility and good permeability and hydration floating effect, so that the icodextrin has good anti-adhesion property, and meanwhile, the raw material of the icodextrin is starch, so that the icodextrin is convenient and easy to obtain and is more convenient to popularize and apply widely. At present, no wound disinfectant containing the icodextrin, which can promote wound healing and prevent scar, is available on the market, and the gap on the market is filled.

Detailed Description

The present invention will be described in further detail with reference to specific examples.

According to the specific implementation mode of the wound disinfection solution, the raw materials of the wound disinfection solution comprise icodextrin accounting for 1-20% of the total weight of the raw materials. Further, the raw materials of the wound disinfection solution also comprise: chlorhexidine gluconate, hyaluronic acid and water.

Preferably, the wound disinfection solution comprises the following raw materials in percentage by weight: 3-8% of icodextrin, 0.01-0.1% of chlorhexidine gluconate, 0.05-2% of hyaluronic acid and the balance of water, wherein the water is one of water for injection or sterile water. 3-8% of icodextrin, 0.01-0.1% of chlorhexidine gluconate, 0.05-2% of hyaluronic acid and the balance of water, wherein the water is one of water for injection or sterile water.

The invention also provides a specific implementation mode of the preparation method of the wound disinfection solution, and the preparation method comprises the following steps:

dissolving icodextrin and chlorhexidine gluconate/hyaluronic acid in a certain amount of water according to the weight ratio of the raw materials of the wound disinfectant, uniformly stirring, adding the rest water to a constant volume, automatically canning, subpackaging and sealing the liquid, and obtaining a finished product after the detection is qualified.

The following are specific examples of the wound disinfection solution of the invention: