抗微生物肽模拟物

文档序号:1382313 发布日期:2020-08-14 浏览:26次 >En<

阅读说明:本技术 抗微生物肽模拟物 (Antimicrobial peptidomimetics ) 是由 谢青山 于 2018-07-02 设计创作,主要内容包括:本发明涉及式(I)的包含胍部分和卤化的联苯基部分的肽,并且涉及这些肽中的每一种的盐和溶剂化物,并且涉及用于其制备的工艺、包含它们的组合物以及这样的化合物的用途。已经发现所述化合物具有高杀微生物活性,并且适合于以非常低的浓度对抗耐药细菌,诸如甲氧西林耐受性金黄色葡萄球菌(MRSA)菌株。&lt;Image he="589" wi="700" file="DDA0002435328930000011.GIF" imgContent="drawing" imgFormat="GIF" orientation="portrait" inline="no"&gt;&lt;/Image&gt;(The present invention relates to peptides of formula (I) comprising a guanidine moiety and a halogenated biphenyl moiety, and to salts and solvates of each of these peptides, and to processes for their preparation, compositions comprising them and uses of such compounds. The compounds have been found to have high microbicidal activity and are suitable for use at very low concentrations against drug-resistant bacteria, such as methicillin-resistant staphylococcus aureus (MRSA) strains.)

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