阅读说明：本技术 用于宠物的止泻组合物及其制备方法 (Antidiarrheal composition for pets and preparation method thereof ) 是由 卢熀兴 霍丽萍 陈琳琳 韩志宏 于 2019-12-31 设计创作，主要内容包括：本发明涉及一种用于宠物的止泻组合物,包括以下组分：溶菌酶5～20重量份,酵母葡聚糖2～10重量份,杆菌肽锌5～20重量份,蒙脱石5～30重量份,碱式碳酸铋2～15重量份,鞣酸蛋白2～10重量份,大蒜素2～15重量份,益生元2～10重量份,L-谷氨酰胺2～10重量份。本发明还涉及一种用于宠物的止泻组合物的制备方法。本发明的用于宠物的止泻组合物可以治疗和缓解宠物犬猫因各种原因引起的腹泻,并能维护胃肠道健康。(The invention relates to an antidiarrheal composition for pets, which comprises the following components: 5-20 parts of lysozyme, 2-10 parts of yeast glucan, 5-20 parts of bacitracin zinc, 5-30 parts of montmorillonite, 2-15 parts of bismuth subcarbonate, 2-10 parts of tannase, 2-15 parts of allicin, 2-10 parts of prebiotics and 2-10 parts of L-glutamine. The invention also relates to a preparation method of the antidiarrheal composition for pets. The antidiarrheal composition for pets can treat and relieve diarrhea of pet dogs and cats caused by various reasons, and can maintain gastrointestinal health.)

1. An antidiarrheal composition for pets comprising the following components: 5-20 parts of lysozyme, 2-10 parts of yeast glucan, 5-20 parts of bacitracin zinc, 5-30 parts of montmorillonite, 2-15 parts of bismuth subcarbonate, 2-10 parts of tannase, 2-15 parts of allicin, 2-10 parts of prebiotics and 2-10 parts of L-glutamine.

2. The antidiarrheal composition for pets according to claim 1, wherein said lysozyme is an enteric pellet, said allicin is a microencapsulated powder, and said yeast glucan is β -1, 3-D-glucan.

3. The antidiarrheal composition for pet dogs and cats according to claim 1, wherein: the prebiotics are one or more of fructo-oligosaccharide, mannose oligomer, maltose oligomer, isomaltose oligomer, galacto-oligosaccharide, xylo-oligosaccharide, soybean oligosaccharide, lactulose oligomer, chitosan oligomer, inulin and polydextrose.

4. An anti-diarrheal composition for pets according to any of claims 1 to 3, which is characterized in that: the component also comprises 3-20 parts by weight of flavoring agent; the flavoring agent is one or more of meat powder, liver powder, meat hydrolyzed protein powder, yeast powder and yeast extract.

5. An antidiarrheal composition for pets according to claim 4, characterized in that: the meat powder is one or more of pork powder, mutton powder, beef powder, chicken powder, duck powder and fish powder; the meat-flavor protein hydrolysate is one or more of pork-flavor protein hydrolysate, mutton-flavor protein hydrolysate, beef-flavor protein hydrolysate, chicken-flavor protein hydrolysate, duck-flavor protein hydrolysate and fish-flavor protein hydrolysate.

6. An antidiarrheal composition for pets according to claim 4, characterized in that: the components also comprise 10-60 parts by weight of pharmaceutical excipients; the pharmaceutical excipients are one or more of fillers, adhesives, glidants, lubricants, disintegrants and wetting agents.

7. An antidiarrheal composition for pets according to claim 6, characterized in that: the filler is one or more of microcrystalline cellulose, low-substituted hydroxypropyl cellulose, starch, pregelatinized starch, dextrin, maltodextrin, sucrose, lactose, glucose, fructose, maltose, sorbitol, mannitol, erythritol, isomalt and calcium hydrogen phosphate; the binder is one or more of povidone, hydroxypropyl methylcellulose, hydroxypropyl cellulose, sodium carboxymethyl cellulose, starch paste, gelatin, xanthan gum, and guar gum; the glidant is silicon dioxide or fumed silica; the lubricant is one or more of magnesium stearate, stearic acid, glyceryl behenate, polyethylene glycol, hydrogenated vegetable oil, sodium fumarate stearate and talcum powder; the disintegrant is one or more of crospovidone, croscarmellose sodium and sodium carboxymethyl starch; the wetting agent is one or more of pure water, ethanol and isopropanol.

8. An antidiarrheal composition for pets according to claim 1, characterized in that: is a solid preparation; the solid preparation comprises coated tablets and granules.

9. A preparation method of an antidiarrheal tablet for pets is characterized by comprising the following specific steps:

wet granulating yeast glucan, bacitracin zinc, bismuth subcarbonate, montmorillonite, tannase protein, prebiotics, L-glutamine and a filler to obtain granules;

mixing the obtained granule with lysozyme enteric-coated pellet, garlicin microcapsule powder, disintegrant and glidant, and adding lubricant during mixing to obtain total mixed powder;

pressing the total mixed powder into plain tablets;

mixing flavoring agent, binder and wetting agent to obtain coating solution, and coating to obtain coated tablet.

10. A preparation method of antidiarrheal granules for pets is characterized by comprising the following specific steps:

adding yeast glucan, bacitracin zinc, bismuth subcarbonate, montmorillonite, albumin tannate, prebiotics, L-glutamine and a filler into a fluidized bed, and granulating by adopting a top-spraying granulation process to obtain granules;

mixing the obtained granules with lysozyme enteric-coated pellet, allicin microcapsule powder, and flavoring agent;

the obtained mixed granules are filled into an aluminum foil bag according to a certain weight to obtain the granules.

Technical Field

The invention relates to an antidiarrheal composition for pet dogs and cats and a preparation method of the antidiarrheal composition, and belongs to the field of animal health care products.

Background

With the increasing living standard of people, the family pet feeding is gradually popularized. However, many pet infectious diseases have zoonosis and cause no small harm to the development of pet industry and human health. Therefore, the immunity of the pet is improved and the healthy growth of the pet is ensured.

Gastrointestinal inflammation is a common disease of pet dogs and cats, and is mainly caused by factors such as malnutrition, overfatigue or cold, which causes the function of defense diseases to be reduced, so that the gastrointestinal barrier function is weakened, and bacteria (such as escherichia coli, clostridium perfringens, salmonella, vibrio and the like) in the gastrointestinal tract are enhanced in virulence, and finally diseases are caused. Symptoms typically include acute or chronic diarrhea, soft stools, blood in the stool, vomiting, poor nutrient digestion and absorption, weight loss, and loss of appetite.

The antibiotic can kill pathogenic bacteria and has certain curative effect on gastrointestinal tract inflammation, but can also cause intestinal bacteria group imbalance after long-term use, thereby causing superinfection.

Disclosure of Invention

The invention aims to provide a composition for treating diarrhea of dogs and cats and maintaining gastrointestinal tract health of dogs and cats and a preparation method of the composition.

The invention provides a technical scheme for solving the technical problems, which comprises the following steps: an antidiarrheal composition for pets comprising the following components: 5-20 parts of lysozyme, 2-10 parts of yeast glucan, 5-20 parts of bacitracin zinc, 5-30 parts of montmorillonite, 2-15 parts of bismuth subcarbonate, 2-10 parts of tannase, 2-15 parts of allicin, 2-10 parts of prebiotics and 2-10 parts of L-glutamine.

The lysozyme is an alkaline protein, can dissolve bacterial cell walls, causes the cell walls to break, and then the content escapes to dissolve the bacteria, is a safe and efficient broad-spectrum antibacterial agent, and has different degrees of antibacterial effects on escherichia coli, staphylococcus, streptococcus, salmonella, pasteurella multocida, salmonella dysentery, aerobacter and the like. The antibacterial activity is stable, and the antibacterial agent has good antibacterial effect on drug-resistant strains. The lysozyme is one of nonspecific immune factors of the organism, participates in various immune reactions of the organism, can enhance immunity, kill putrefying cocci in intestinal tracts, maintain the normalization of flora in the intestinal tracts, promote the proliferation of bifidobacteria, strengthen the defense factors of albumin, sterilized protein and Y-globulin and enhance the anti-infection capacity.

The yeast glucan is a polysaccharide- β -glucan which exists in yeast cell walls and has the activity of enhancing immunity, the yeast β -glucan can be specifically combined with macrophages to stimulate and activate immune factors, so that the immune function is enhanced, the immunity of the organism can be effectively improved, meanwhile, the yeast glucan can be used for effectively regulating the micro-ecology of the digestive tract in vivo and promoting the proliferation of beneficial bacteria in vivo and the excretion of harmful substances in the intestinal tract, and the stability of intestinal flora is maintained.

The bacitracin zinc is a polypeptide antibiotic, has strong antibacterial action on gram-positive bacteria, and also has antibacterial effect on a few gram-negative bacteria, spirochetes and actinomycetes and even on penicillin-resistant staphylococcus. The antibacterial mechanism is to inhibit the formation of bacterial cell walls and damage the bacterial cell serosa. Can promote the growth of beneficial microorganisms in intestinal tracts, increase the permeability of intestinal mucosa and promote the absorption of nutrient substances. Dogs are used to promote animal growth and to prevent bacterial diarrhea. The bacitracin zinc is hardly absorbed by oral administration, and is mostly excreted with feces within 2 days, so that the safety is high. The bacteria show little resistance to zinc bacitracin and no cross-resistance with other antibiotics.

The bismuth subcarbonate is a coordination compound which is not absorbed after being taken orally, but can rapidly neutralize gastric acid, and the generated bismuth salt can form a protective film on the ulcer surface of an inflammation part, resist the invasion of the gastric acid and have an astringent effect. In addition, it can kill helicobacter pylori to promote healing of inflammation. Can be combined with hydrogen sulfide generated by abnormal fermentation in intestinal cavity to inhibit intestinal peristalsis and relieve diarrhea.

Montmorillonite is a natural aluminosilicate clay ore, which is not absorbed after oral administration, but has strong covering power on digestive tract mucosa, and can protect mucosa, and adsorb various viruses, bacteria and their toxins. Can be used for treating esophagitis, gastritis and peptic ulcer, especially diarrhea due to various reasons.

The tannic acid protein is not decomposed in stomach, and is decomposed to obtain tannic acid in small intestine to solidify surface protein of intestinal mucosa to form a protective film, which can reduce liquid exudation, relieve intestinal irritation and peristalsis, and has astringent and antidiarrheal effects.

Allicin is a trithioallyl ether compound, and naturally exists in the bulb of garlic of the family Liliaceae. The allicin can inhibit the propagation of dysentery bacillus and typhoid bacillus, and has obvious inhibiting and killing effect on staphylococcus, pneumococcus and the like. The oral administration of allicin can be used for treating animal enteritis, diarrhea, anorexia, etc. Has obvious inhibiting and killing effect on harmful bacteria such as escherichia coli, salmonella, staphylococcus aureus, dysentery bacillus, typhoid bacillus, pneumococcus, streptococcus and the like, and has no inhibiting effect on beneficial bacteria such as lactobacillus casei. Are known as "natural antibiotics".

Prebiotics are a class of organic substances that are not digested and absorbed by the host but that selectively promote the metabolism and proliferation of beneficial bacteria in the body, thereby improving the health of the host. The common prebiotics are oligosaccharide substances which cannot be decomposed, absorbed and utilized by human bodies after being taken orally, but can promote the growth of beneficial intestinal flora, inhibit the growth of harmful bacteria, improve the intestinal micro-ecological environment and promote the absorption and utilization of lipid, protein and minerals.

L-glutamine participates in the biosynthesis of glucosamine, which is a constituent of mucoprotein in the digestive tract, thereby promoting the repair of mucosal epithelial tissues and being beneficial to the elimination of ulcer lesions, and therefore, the L-glutamine can be used for treating gastric and duodenal ulcers, gastritis and hyperacidity.

The lysozyme is an enteric-coated pellet, the allicin is microcapsule powder, and the yeast glucan is β -1, 3-D-glucan.

The prebiotics is one or more of fructo-oligosaccharide, mannose oligomer, maltose oligomer, isomaltose oligosaccharide, galacto-oligosaccharide, xylo-oligosaccharide, soybean oligosaccharide, lactulose oligosaccharide, chitosan oligomer, inulin and polydextrose.

The antidiarrheal composition for pets comprises 3-20 parts by weight of flavoring agent; the flavoring agent is one or more of meat powder, liver powder, meat hydrolyzed protein powder, yeast powder and yeast extract.

The meat powder is one or more of pork powder, mutton powder, beef powder, chicken powder, duck powder and fish powder; the meat-flavor protein hydrolysate is one or more of pork-flavor protein hydrolysate, mutton-flavor protein hydrolysate, beef-flavor protein hydrolysate, chicken-flavor protein hydrolysate, duck-flavor protein hydrolysate and fish-flavor protein hydrolysate.

The antidiarrheal composition for pets comprises 10-60 parts by weight of pharmaceutic adjuvant; the pharmaceutical excipients are one or more of fillers, adhesives, glidants, lubricants, disintegrants and wetting agents.

The filler is one or more of microcrystalline cellulose, low-substituted hydroxypropyl cellulose, starch, pregelatinized starch, dextrin, maltodextrin, sucrose, lactose, glucose, fructose, maltose, sorbitol, mannitol, erythritol, isomalt and calcium hydrogen phosphate; the binder is one or more of povidone, hydroxypropyl methylcellulose, hydroxypropyl cellulose, sodium carboxymethyl cellulose, starch paste, gelatin, xanthan gum, and guar gum; the glidant is silicon dioxide or fumed silica; the lubricant is one or more of magnesium stearate, stearic acid, glyceryl behenate, polyethylene glycol, hydrogenated vegetable oil, sodium fumarate stearate and talcum powder; the disintegrant is one or more of crospovidone, croscarmellose sodium and sodium carboxymethyl starch; the wetting agent is one or more of pure water, ethanol and isopropanol.

The antidiarrheal composition for pets is a solid preparation; the solid preparation comprises coated tablets and granules.

The invention provides a technical scheme for solving the technical problems, which comprises the following steps: a preparation method of an antidiarrheal tablet for pets comprises the following specific steps:

A. wet granulating yeast glucan, bacitracin zinc, bismuth subcarbonate, montmorillonite, tannase protein, prebiotics, L-glutamine and a filler to obtain granules;

B. mixing the obtained granule with lysozyme enteric-coated pellet, garlicin microcapsule powder, disintegrant and glidant, and adding lubricant during mixing to obtain total mixed powder;

C. pressing the total mixed powder into plain tablets;

D. mixing flavoring agent, binder and wetting agent to obtain coating solution, and coating to obtain coated tablet.

The invention provides a technical scheme for solving the technical problems, which comprises the following steps: a preparation method of antidiarrheal granules for pets comprises the following specific steps:

A. adding yeast glucan, bacitracin zinc, bismuth subcarbonate, montmorillonite, albumin tannate, prebiotics, L-glutamine and a filler into a fluidized bed, and granulating by adopting a top-spraying granulation process to obtain granules;

B. mixing the obtained granules with lysozyme enteric-coated pellet, allicin microcapsule powder, and flavoring agent;

C. the obtained mixed granules are filled into an aluminum foil bag according to a certain weight to obtain the granules.

The invention has the positive effects that: the raw materials of the antidiarrheal composition for pets of the invention do not contain antibiotics, the main raw materials are lysozyme, yeast glucan, bacitracin zinc, bismuth subcarbonate, montmorillonite, tannalbin, prebiotics, L-glutamine and allicin, most of the raw materials are not absorbed by organisms after being taken, the side effect is small, and no systemic adverse reaction exists. The compound preparation has the functions of relieving diarrhea, sterilizing, diminishing inflammation, repairing gastrointestinal mucosa and promoting the growth of beneficial bacteria. The composition has good mouthfeel and is easily accepted by dogs and cats. Frequent use of antibiotics by pets such as dogs, cats and the like easily causes drug resistance and imbalance of intestinal flora. The composition of the invention can promote the growth of beneficial bacteria in the intestinal tract, inhibit the reproduction of pathogenic bacteria, and keep the intestinal tract microecological balance after long-term administration. The composition for stopping diarrhea of pet dogs and cats can be directly fed to the dogs and cats by using the method, and can also be added into pet food according to dosage to be fed together.

Detailed Description