阅读说明：本技术 纽甜中粘性成分的去除方法 (Method for removing viscous components in neotame ) 是由 王振东 陈良 于 2019-10-12 设计创作，主要内容包括：本发明属于纽甜产品技术领域,具体的涉及一种纽甜中粘性成分的去除方法。将纽甜溶于纯净水和甲醇体系中,升温使其溶化；加入无机碱进行搅拌,控制溶液的pH为9-10；然后加入无机酸调节溶液的pH为6.0-8.0,进行中和；进行静置结晶,离心分离得到去除粘性成分的纽甜。本发明所述的纽甜中粘性成分的去除方法,工艺合理,步骤简单,易于实现,经过处理后离心得到纽甜粘性物质含量明显降低,低于传统含量所述的0.1％,明显延长了纽甜产品的保质期。(the invention belongs to the technical field of neotame products, and particularly relates to a method for removing viscous components in neotame. Dissolving neotame in a system of purified water and methanol, and heating to dissolve neotame; adding inorganic base, stirring, and controlling the pH value of the solution to be 9-10; then adding inorganic acid to adjust the pH value of the solution to 6.0-8.0 for neutralization; and standing for crystallization, and performing centrifugal separation to obtain the neotame with the viscosity components removed. The method for removing the viscous components in the neotame has the advantages of reasonable process, simple steps and easy realization, the content of the viscous substances of the neotame obtained by treatment and centrifugation is obviously reduced and is lower than the traditional content by 0.1 percent, and the quality guarantee period of the neotame product is obviously prolonged.)

1. A method for removing viscous components in neotame is characterized by comprising the following steps: the method comprises the following steps:

(1) Dissolving neotame in a system of purified water and methanol, and heating to dissolve neotame;

(2) adding inorganic base, stirring, and controlling the pH value of the solution to be 9-10;

(3) Then adding inorganic acid to adjust the pH value of the solution to 6.0-8.0 for neutralization;

(4) And standing for crystallization, and performing centrifugal separation to obtain the neotame with the viscosity components removed.

2. The method of claim 1, further comprising the step of: the mass ratio of the neotame to the purified water to the methanol in the step (1) is 1: 4: 0.5.

3. The method of claim 1, further comprising the step of: the temperature rise in the step (1) is to raise the temperature to 20-80 ℃ to melt the mixture.

4. The method of claim 1, further comprising the step of: the inorganic base in the step (2) is one of sodium carbonate, sodium bicarbonate or sodium hydroxide.

5. The method of claim 1, further comprising the step of: the stirring time in the step (2) is 0.5 to 3 hours, and the stirring temperature is 5 to 100 ℃.

6. the method of claim 1, further comprising the step of: the inorganic acid in the step (3) is one of hydrochloric acid, citric acid or phosphoric acid.

7. The method of claim 1, further comprising the step of: the crystallization temperature in the step (4) is 0-40 ℃, and the crystallization time is 12-36 hours; the rotation speed of the centrifugal machine for centrifugal separation is 1000-1200 r/min.

Technical Field

The invention belongs to the technical field of neotame products, and particularly relates to a method for removing viscous components in neotame.

Background

Neotame (N- [ N- (3, 3-dimethylbutyl) -L-alpha-aspartic acid ] -L-phenylalanine-1-methyl ester) is a high-potency sweetener developed by Neutravist, USA, and has the advantages of high sweetness, low calorie, high stability and the like, and the potential of neotame as a good sweetener is gradually discovered along with the further application.

however, in the process of storing the neotame product, the phenomenon that the neotame product is easy to generate bonding blocks is a ubiquitous phenomenon, the storage property and the usability of the product are seriously influenced, and the further industrial development of the neotame is limited.

Disclosure of Invention

The technical problem to be solved by the invention is as follows: overcomes the defects of the prior art and provides a method for removing viscous components in neotame. The method has the advantages of reasonable process, simple steps and easy realization, the content of the neotame sticky substances obtained by treatment and centrifugation is obviously reduced and is lower than the traditional content of 0.1 percent, and the shelf life of the neotame product is obviously prolonged.

The method for removing the viscous components in the neotame comprises the following steps:

(1) dissolving neotame in a system of purified water and methanol, and heating to dissolve neotame;

(2) adding inorganic base, stirring, and controlling the pH value of the solution to be 9-10;

(3) Then adding inorganic acid to adjust the pH value of the solution to 6.0-8.0 for neutralization;

(4) And standing for crystallization, and performing centrifugal separation to obtain the neotame with the viscosity components removed.

Wherein:

The sticky substance is a product of partial hydrolysis in the neotame production process, and a small amount of this product will cause the product to become sticky and lumpy, and the content of the sticky substance is about 0.1% to 1%.

The mass ratio of the neotame to the purified water to the methanol in the step (1) is 1: 4: 0.5.

The temperature rise in the step (1) is to raise the temperature to 20-80 ℃ to melt the mixture.

The inorganic base in the step (2) is one of sodium carbonate, sodium bicarbonate or sodium hydroxide.

the stirring time in the step (2) is 0.5 to 3 hours, and the stirring temperature is 5 to 100 ℃.

The inorganic acid in the step (3) is one of hydrochloric acid, citric acid or phosphoric acid.

the crystallization temperature in the step (4) is 0-40 ℃, and the crystallization time is 12-36 hours; the rotation speed of the centrifugal machine for centrifugal separation is 1000-1200 r/min.

The reaction mechanism of the method for removing the viscous components in the neotame is as follows: the neotame has an ester structure, a small amount of hydrolysis occurs in the reaction process, the product after partial hydrolysis is an amino acid structure and has certain viscosity, the product is easy to be sticky and caked, the application performance of the product is influenced, the salt structure is formed by alkali and the amino acid structure, and the salt has high solubility in the crystallization process of the neotame, so that the salt can be dissolved in the mother solution and can be well separated from the neotame product.

Compared with the prior art, the invention has the following beneficial effects:

the method for removing the viscous components in the neotame has the advantages of reasonable process, simple steps and easy realization, the content of the viscous substances in the neotame obtained by treatment and centrifugation is obviously reduced and is lower than the traditional content by 0.1 percent, and the quality guarantee period of the neotame product is obviously prolonged.

Drawings

FIG. 1 is a high performance liquid chromatogram of neotame prepared in example 1;

FIG. 2 is a high performance liquid chromatogram of neotame prepared in example 2;

FIG. 3 is a high performance liquid chromatogram of neotame prepared in example 3;

FIG. 4 is a high performance liquid chromatogram of neotame prepared in comparative example 1.

Detailed Description

the present invention is further described below with reference to examples.