阅读说明：本技术 一种调节血脂的中药制剂及其制备方法 (Chinese medicinal preparation for regulating blood fat and preparation method thereof ) 是由 王永强 于 2021-07-12 设计创作，主要内容包括：本发明公开了一种调节血脂的中药制剂,其是由黄芪、丹参、红花、当归、龙眼肉、酸枣仁、陈皮、低聚果糖、纳豆激酶粉和富铬酵母粉制成,本申请中药制剂具有消痰化瘀、健脾和胃的作用,以促进血液循环,而表现出良好的降低血脂的功效。(The invention discloses a traditional Chinese medicine preparation for regulating blood fat, which is prepared from astragalus, salvia miltiorrhiza, safflower, angelica, arillus longan, spina date seed, dried orange peel, fructo-oligosaccharide, natto kinase powder and chromium-enriched yeast powder.)

1. A traditional Chinese medicine preparation for regulating blood fat is characterized by being prepared from the following raw materials: astragalus root, root of red rooted saliva, safflower, Chinese angelica root, longan aril, wild jujube seed, dried orange peel, fructo-oligosaccharide, natto kinase powder and chromium-enriched yeast powder.

2. The traditional Chinese medicine preparation for regulating blood fat according to claim 1, which is prepared from the following raw materials in parts by weight: 4.5-5.5 parts of astragalus root, 2.5-3.5 parts of salvia miltiorrhiza, 1.5-2.5 parts of safflower, 1.5-2.5 parts of angelica, 0.5-1.5 parts of longan pulp, 1.5-2.5 parts of spina date seed, 0.5-1.5 parts of dried orange peel, 4.5-5.5 parts of fructo-oligosaccharide, 0.05-0.15 part of natto kinase powder and 0.015-0.025 part of chromium-enriched yeast powder.

3. The traditional Chinese medicine preparation for regulating blood fat according to claim 1, which is prepared from the following raw materials in parts by weight: 5 parts of astragalus membranaceus, 3 parts of salvia miltiorrhiza, 2 parts of safflower, 2 parts of angelica sinensis, 1 part of arillus longan, 2 parts of spina date seeds, 1 part of pericarpium citri reticulatae, 5 parts of fructo-oligosaccharide, 0.1 part of natto kinase powder and 0.02 part of chromium-rich yeast powder.

4. The preparation method of the traditional Chinese medicine preparation for regulating blood fat according to claim 1, which is characterized by comprising the following steps:

(1) pretreatment of raw materials: cleaning and drying the astragalus, the salvia, the safflower, the angelica, the longan pulp, the spina date seed and the dried orange peel in parts by weight, and then cutting into segments;

(2) boiling and extracting: decocting the traditional Chinese medicine components treated in the step (1) with water at 80-100 deg.C for 60min, filtering to obtain filtrate and residue, adding water into the residue, decocting for 60min, filtering to obtain filtrate and residue, and mixing the two filtrates to obtain traditional Chinese medicine extractive solution;

(3) and (3) drying treatment: spray drying the extracting solution in the step (2) to obtain traditional Chinese medicine mixed powder;

(4) preparing a preparation: and uniformly mixing the traditional Chinese medicine mixed powder with fructo-oligosaccharide, natto kinase powder and chromium-rich yeast powder to obtain the traditional Chinese medicine preparation for regulating blood fat.

Technical Field

The invention belongs to the field of traditional Chinese medicines for regulating blood fat, and particularly relates to a traditional Chinese medicine preparation for regulating blood fat and a preparation method thereof.

Background

With the improvement of living standard and the change of dietary structure of people, the sick population of hyperlipemia tends to be younger day by day, hyperlipemia is divided into primary and secondary, the primary is caused by environmental factor, the secondary frequently occurs in metabolic disorder disease or is related to age factor; the hyperlipidemia is a systemic disease caused by fat metabolism or abnormal operation, generally refers to some diseases seriously harming human health caused by one or more lipids in blood plasma higher than normal level, most of the prior clinical hyperlipidemia treatment medicines are western medicines, although the medicines have certain curative effect, the medicines can cause stimulation to gastrointestinal tract, liver and kidney and the like of human body and cause certain side effect to the human body, and based on the problems, the invention provides a traditional Chinese medicine preparation for regulating blood fat by taking phlegm elimination and blood stasis removal as a treatment rule and strengthening spleen and stomach.

Disclosure of Invention

The invention aims at the defects of the prior art and provides a traditional Chinese medicine preparation for regulating blood fat, which has the functions of dissolving phlegm and removing blood stasis, and strengthening spleen and stomach so as to promote blood circulation and show good effect of reducing blood fat;

in order to achieve the purpose, the technical scheme adopted by the invention is as follows:

a traditional Chinese medicine preparation for regulating blood fat is prepared from the following raw materials: astragalus root, root of red rooted saliva, safflower, Chinese angelica root, longan aril, wild jujube seed, dried orange peel, fructo-oligosaccharide, natto kinase powder and chromium-enriched yeast powder.

Preferably, the feed is prepared from the following raw materials in parts by weight: 4.5-5.5 parts of astragalus root, 2.5-3.5 parts of salvia miltiorrhiza, 1.5-2.5 parts of safflower, 1.5-2.5 parts of angelica, 0.5-1.5 parts of longan pulp, 1.5-2.5 parts of spina date seed, 0.5-1.5 parts of dried orange peel, 4.5-5.5 parts of fructo-oligosaccharide, 0.05-0.15 part of natto kinase powder and 0.015-0.025 part of chromium-enriched yeast powder;

preferably, the feed is prepared from the following raw materials in parts by weight: 5 parts of astragalus membranaceus, 3 parts of salvia miltiorrhiza, 2 parts of safflower, 2 parts of angelica sinensis, 1 part of arillus longan, 2 parts of spina date seeds, 1 part of pericarpium citri reticulatae, 5 parts of fructo-oligosaccharide, 0.1 part of natto kinase powder and 0.02 part of chromium-rich yeast powder;

further, the preparation method of the traditional Chinese medicine preparation for regulating blood fat specifically comprises the following steps:

(1) pretreatment of raw materials: cleaning and drying the astragalus, the salvia, the safflower, the angelica, the longan pulp, the spina date seed and the dried orange peel in parts by weight, and then cutting into segments;

(2) boiling and extracting: decocting the traditional Chinese medicine components treated in the step (1) with water at 80-100 ℃ for 60min, filtering to obtain filtrate and filter residue, adding water into the filter residue, decocting for 60min, filtering to obtain filtrate and filter residue, and mixing the two filtrates to obtain traditional Chinese medicine extract;

(3) and (3) drying treatment: spray drying the extracting solution in the step (2) to obtain traditional Chinese medicine mixed powder;

(4) preparing a preparation: and uniformly mixing the traditional Chinese medicine mixed powder with fructo-oligosaccharide, natto kinase powder and chromium-rich yeast powder to obtain the traditional Chinese medicine preparation for regulating blood fat.

Radix astragali is sweet in flavor and slightly warm in nature; spleen and lung meridian entered; invigorating qi, consolidating superficial resistance, expelling toxic materials, expelling pus, promoting urination, and promoting granulation; can be used for treating deficiency of vital energy, asthenia, chronic diarrhea, proctoptosis, spontaneous perspiration, edema, uterine prolapse, albuminuria due to chronic nephritis, diabetes, and unhealed wound.

The salvia miltiorrhiza is bitter in taste and slightly cold, enters heart and liver channels, activates blood circulation to dissipate blood stasis, clears meridians to relieve pain, clears heart and eliminates vexation, cools blood and eliminates carbuncle; can be used for treating thoracic obstruction, heart pain, abdominal pain, hypochondriac pain, abdominal mass, pain due to pyretic arthralgia, vexation, insomnia, menoxenia, dysmenorrhea, amenorrhea, and pyocutaneous disease with swelling and pain.

Safflower is pungent in flavor and warm in nature; it has effects in regulating heart and liver meridians, promoting blood circulation, removing blood stasis, and relieving pain, and can be used for treating amenorrhea, dysmenorrhea, lochiorrhea, abdominal mass, thoracic obstruction, cardialgia, abdominal pain due to blood stasis, pricking pain in chest and hypochondrium, traumatic injury, and pyocutaneous disease with swelling and pain.

Chinese angelica is sweet and pungent in flavor and warm in nature, and enters liver, heart and spleen meridians; enriching blood, promoting blood circulation, regulating menstruation, relieving pain, loosening bowel to relieve constipation; can be used for treating blood deficiency, sallow complexion, giddiness, palpitation, menoxenia, amenorrhea, dysmenorrhea, asthenia cold, abdominal pain, rheumatalgia, traumatic injury, superficial infection, pyocutaneous disease, intestinal dryness, and constipation.

The longan pulp is sweet in taste and warm in nature; heart and spleen meridians entered; tonifying heart and spleen, nourishing blood and tranquillizing; can be used for treating deficiency of both qi and blood, palpitation, amnesia, insomnia, blood deficiency, and sallow complexion.

The spina date seed is sour and neutral in taste, enters four meridians of heart, spleen, liver and gallbladder, nourishes the liver, calms the heart, soothes the nerves and restrains sweat; it is indicated for restlessness and insomnia, palpitation, polydipsia, and sweating due to debility.

The dried orange peel is bitter and pungent in flavor and warm in nature; entering lung and spleen meridians; regulating qi-flowing, invigorating spleen, eliminating dampness, and eliminating phlegm; can be used for treating abdominal distention, anorexia, vomiting, diarrhea, cough, and excessive phlegm.

The fructo-oligosaccharide is a water-soluble dietary fiber, can reduce serum cholesterol and improve lipid metabolism after long-term administration, can effectively reduce the amount of serum cholesterol, triglyceride and free fatty acid, and has good improving effect on a series of cardiovascular diseases such as hypertension and arteriosclerosis caused by high blood fat.

Nattokinase has effects of improving blood vessel elasticity and reducing blood lipid.

Selenium in chromium-rich yeast can stimulate the production of immunoglobulin, and make various immune functions of human body such as: cellular immunity, humoral immunity, non-specificity, etc. are improved.

The invention has the advantages of

The traditional Chinese medicine is profound, and the principle of dialectical treatment is studied in treatment, and most of patients with hyperlipidemia belong to damp-heat constitution and phlegm-stasis constitution.

Detailed Description

Example 1

A traditional Chinese medicine preparation for regulating blood fat is prepared from the following raw materials in parts by weight: 4.5 parts of astragalus, 2.5 parts of salvia miltiorrhiza, 1.5 parts of safflower, 1.5 parts of angelica, 0.5 part of longan pulp, 1.5 parts of spina date seed, 0.5 part of dried orange peel, 4.5 parts of fructo-oligosaccharide, 0.05 part of natto kinase powder and 0.015 part of chromium-enriched yeast powder;

the preparation method specifically comprises the following steps:

(1) pretreatment of raw materials: cleaning and drying the astragalus, the salvia, the safflower, the angelica, the longan pulp, the spina date seed and the dried orange peel in parts by weight, and then cutting into segments;

(2) boiling and extracting: decocting the traditional Chinese medicine components treated in the step (1) with water at 80 ℃ for 60min, filtering to obtain filtrate and filter residue, adding water into the filter residue, decocting for 60min, filtering to obtain filtrate and filter residue, and mixing the two filtrates to obtain traditional Chinese medicine extract;

(3) and (3) drying treatment: spray drying the extracting solution in the step (2) to obtain traditional Chinese medicine mixed powder;

(4) preparing a preparation: mixing the traditional Chinese medicine mixed powder with fructo-oligosaccharide, natto kinase powder and chromium-rich yeast powder, and packaging to obtain the traditional Chinese medicine preparation for regulating blood lipid.

Example 2

A traditional Chinese medicine preparation for regulating blood fat is prepared from the following raw materials in parts by weight: 5 parts of astragalus membranaceus, 3 parts of salvia miltiorrhiza, 2 parts of safflower, 2 parts of angelica sinensis, 1 part of arillus longan, 2 parts of spina date seeds, 1 part of pericarpium citri reticulatae, 5 parts of fructo-oligosaccharide, 0.1 part of natto kinase powder and 0.02 part of chromium-rich yeast powder;

the preparation method specifically comprises the following steps:

(1) pretreatment of raw materials: cleaning and drying the astragalus, the salvia, the safflower, the angelica, the longan pulp, the spina date seed and the dried orange peel in parts by weight, and then cutting into segments;

(2) boiling and extracting: decocting the traditional Chinese medicine components treated in the step (1) with water at 90 ℃ for 60min, filtering to obtain filtrate and filter residue, adding water into the filter residue, decocting for 60min, filtering to obtain filtrate and filter residue, and mixing the two filtrates to obtain traditional Chinese medicine extract;

(3) and (3) drying treatment: spray drying the extracting solution in the step (2) to obtain traditional Chinese medicine mixed powder;

(4) preparing a preparation: mixing the traditional Chinese medicine mixed powder with fructo-oligosaccharide, natto kinase powder and chromium-rich yeast powder, and packaging to obtain the traditional Chinese medicine preparation for regulating blood lipid.

Example 3

A traditional Chinese medicine preparation for regulating blood fat is prepared from the following raw materials in parts by weight: 5.5 parts of astragalus, 3.5 parts of salvia miltiorrhiza, 2.5 parts of safflower, 2.5 parts of angelica, 1.5 parts of longan pulp, 2.5 parts of spina date seed, 1.5 parts of dried orange peel, 5.5 parts of fructo-oligosaccharide, 0.15 part of natto kinase powder and 0.025 part of chromium-enriched yeast powder;

the preparation method specifically comprises the following steps:

(1) pretreatment of raw materials: cleaning and drying the astragalus, the salvia, the safflower, the angelica, the longan pulp, the spina date seed and the dried orange peel in parts by weight, and then cutting into segments;

(2) boiling and extracting: decocting the traditional Chinese medicine components treated in the step (1) with water at 100 ℃ for 60min, filtering to obtain filtrate and filter residue, adding water into the filter residue, decocting for 60min, filtering to obtain filtrate and filter residue, and mixing the two filtrates to obtain traditional Chinese medicine extract;

(3) and (3) drying treatment: spray drying the extracting solution in the step (2) to obtain traditional Chinese medicine mixed powder;

(4) preparing a preparation: mixing the traditional Chinese medicine mixed powder with fructo-oligosaccharide, natto kinase powder and chromium-rich yeast powder, and packaging to obtain the traditional Chinese medicine preparation for regulating blood lipid.

Example 4

A traditional Chinese medicine preparation for regulating blood fat is prepared from the following raw materials in parts by weight: 4.5 parts of astragalus, 3.5 parts of salvia miltiorrhiza, 1.5 parts of safflower, 1.5-2.5 parts of longan aril, 2.5 parts of spina date seed, 1.5 parts of dried orange peel, 5.5 parts of fructo-oligosaccharide, 0.15 part of natto kinase powder and 0.025 part of chromium-enriched yeast powder;

the preparation method specifically comprises the following steps:

(1) pretreatment of raw materials: cleaning and drying the astragalus, the salvia, the safflower, the angelica, the longan pulp, the spina date seed and the dried orange peel in parts by weight, and then cutting into segments;

(2) boiling and extracting: decocting the traditional Chinese medicine components treated in the step (1) with water at 100 ℃ for 60min, filtering to obtain filtrate and filter residue, adding water into the filter residue, decocting for 60min, filtering to obtain filtrate and filter residue, and mixing the two filtrates to obtain traditional Chinese medicine extract;

(3) and (3) drying treatment: spray drying the extracting solution in the step (2) to obtain traditional Chinese medicine mixed powder;

(4) preparing a preparation: mixing the traditional Chinese medicine mixed powder with fructo-oligosaccharide, natto kinase powder and chromium-rich yeast powder, and packaging to obtain the traditional Chinese medicine preparation for regulating blood lipid.

Example 5

A traditional Chinese medicine preparation for regulating blood fat is prepared from the following raw materials in parts by weight: 5.5 parts of astragalus, 2.5 parts of salvia miltiorrhiza, 2.5 parts of safflower, 1.5 parts of angelica, 1.5 parts of longan pulp, 1.5 parts of spina date seed, 1.5 parts of dried orange peel, 4.5 parts of fructo-oligosaccharide, 0.05 part of natto kinase powder and 0.015 part of chromium-enriched yeast powder;

the preparation method specifically comprises the following steps:

(1) pretreatment of raw materials: cleaning and drying the astragalus, the salvia, the safflower, the angelica, the longan pulp, the spina date seed and the dried orange peel in parts by weight, and then cutting into segments;

(2) boiling and extracting: decocting the traditional Chinese medicine components treated in the step (1) with water at 100 ℃ for 60min, filtering to obtain filtrate and filter residue, adding water into the filter residue, decocting for 60min, filtering to obtain filtrate and filter residue, and mixing the two filtrates to obtain traditional Chinese medicine extract;

(3) and (3) drying treatment: spray drying the extracting solution in the step (2) to obtain traditional Chinese medicine mixed powder;

(4) preparing a preparation: mixing the traditional Chinese medicine mixed powder with fructo-oligosaccharide, natto kinase powder and chromium-rich yeast powder, and packaging to obtain the traditional Chinese medicine preparation for regulating blood lipid.

The composition for regulating blood fat of rats has the function of regulating the blood fat of rats

The blood fat regulating traditional Chinese medicine composition prepared in the embodiment of the invention is used for rat experiments, 64 SD rats (100 +/-20 g) are taken and randomly divided into 8 groups, wherein 1 group is taken as a blank control group and fed with normal common feed, the other 2-8 groups are taken as experiment groups and fed with high-fat feed, after the SD rats are fed for 30 days, the rats are subjected to eye socket blood sampling after fasting for 12 hours, and the results are shown in table 1; then feeding equal amount of distilled water to 2 groups, feeding fructo-oligosaccharide granules (0.3 g/kg. d) to 3 groups, and respectively feeding the traditional Chinese medicine composition granules (0.3 g/kg. d) prepared in the invention examples 1-5 to 4-8 groups, after feeding for 15 days, after fasting for 12 hours, taking blood from eye sockets of rats, and detecting, wherein the results are shown in table 2; the detection items comprise four indexes of serum Total Cholesterol (TC), Triglyceride (TG), low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C). The data analysis is processed by SPSS19.0 statistical analysis software, and the measurement results are in terms of mean +/-standard deviationRepresents;

TABLE 1 results of measurement of various indexes of rats (1 group) in blank control group and rats (2-8 groups) in experimental groupmmol/L

	TC/mmol/L	TG/mmol/L	LDL-C/mmol/L	HDL-C/mmol/L
					Control group	1.763±0.38	0.453±0.031	1.963±0.251	1.321±0.045
Experimental group	3.473±0.32△△	0.886±0.125△△	2.604±0.432△△	0.768±0.123△△

Note: comparison with blank control:^△△P＜0.01。

as can be seen from Table 1, the four indexes of total serum cholesterol (TC), Triglyceride (TG), low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C) of the rats in the experimental group are obviously higher than those of the control group, and the rats in the experimental group are successfully modeled.

TABLE 2 measurement results of various indexes of rats 15 days after feeding fructo-oligosaccharide and the Chinese medicinal composition prepared in the examples

	TC/mmol/L	TG/mmol/L	LDL-C/mmol/L	HDL-C/mmol/L
					Group 1	1.841±0.213	0.553±0.024	2.163±0.432	1.398±0.038
2 groups of	3.156±0.281△△	0.823±0.372△△	2.412±0.232△△	0.814±0.238△△
					Group 3	2.641±0.432*	0.643±0.232*	2.173±0.376*	0.957±0.052*
4 groups of	2.434±0.032**	0.568±0.143**	1.978±0.528*	1.243±0.452*
					5 groups of	1.801±0.430**	0.483±0.212**	1.732±0.342*	1.432±0.511*
6 groups of	1.923±0.231**	0.502±0.732**	1.865±0.120*	1.332±0.328*
					7 groups of	1.852±0.146**	0.546±0.312**	1.902±0.532*	1.378±0.432*
8 groups of	1.904±0.243**	0.554±0.217**	1.965±0.235*	1.403±0.254*

Note: compared with the group 1 (blank control group),^△△p is less than 0.01; compared with the group 2, the method has the advantages that,^*P＜0.05，^**P＜0.01。

as shown in the data in Table 2, the Chinese medicinal preparation for regulating blood fat prepared in the embodiments 1 to 5 of the invention has the function of regulating the blood fat of rats.

Clinical experiments

The traditional Chinese medicine preparation for regulating blood fat prepared by the embodiment of the invention is used for treating patients with hyperlipidemia, and 42 patients with hyperlipidemia are treated, wherein 22 men and 20 women have an average age of (56 +/-8) years, and the traditional Chinese medicine composition prepared by the embodiment of the invention is used for treating the patients with hyperlipidemia;

the treatment method comprises the following steps:

the traditional Chinese medicine composition of the invention is taken by 10-20g as one dose, and each person takes one dose every time, two to three times a day (one dose is taken every 3-4 hours, the medicine dose is properly adjusted according to the self condition of the patient in the dose range), and the medicine is taken by being mixed with boiled water; taking the medicine for 30 days as a medicine taking period, and continuously taking the medicine for two periods to detect the patient, wherein the detection items comprise indexes such as serum Total Cholesterol (TC), Triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C) and the like;

the statistical method comprises the following steps:

the data is processed by SPSS19.0 statistical analysis software; measure the results inIndicated, the group comparisons were performed using the t-test.

As a result:

the statistical results of the various test indices of the patients before and after treatment are recorded in table 3.

TABLE 3 Change in the blood lipid levels before and after treatmentmmol/L

Note: compared with the treatment before the treatment,^*P＜0.05。

as can be seen from table 3, the Chinese medicinal composition prepared in the examples of the present application has the effects of reducing serum Total Cholesterol (TC), Triglyceride (TG), low-density lipoprotein cholesterol (LDL-C) and increasing high-density lipoprotein cholesterol (HDL-C), and shows a good therapeutic effect of reducing blood lipid.

The above embodiments are only preferred embodiments of the present invention, and the scope of the present invention is not limited thereto, and any simple changes or equivalent substitutions of the technical solutions that can be obviously obtained by those skilled in the art within the technical scope of the present invention are within the scope of the present invention.