阅读说明：本技术 一种防控口腔幽门螺杆菌喷剂及其制备方法 (Spray for preventing and controlling oral helicobacter pylori and preparation method thereof ) 是由 张学记 程晓紊 吴耀辉 于 2019-09-27 设计创作，主要内容包括：本发明公开了一种防控口腔幽门螺杆菌喷剂及其制备方法,具体涉及口腔喷剂技术领域,本发明制备的喷剂包含卵转铁蛋白、溶菌酶、辣木叶提取物和莴笋提取物。本发明能够抑制或消除口腔幽门螺杆菌,保持口腔健康,去除口腔异味。(The invention discloses a spray for preventing and controlling oral helicobacter pylori and a preparation method thereof, and particularly relates to the technical field of oral sprays. The invention can inhibit or eliminate helicobacter pylori in oral cavity, keep oral health and remove oral peculiar smell.)

1. the spray for preventing and controlling oral helicobacter pylori is characterized by comprising ovotransferrin, lysozyme, a moringa oleifera leaf extract and a asparagus lettuce extract.

2. The spray for preventing and controlling oral helicobacter pylori according to claim 1, wherein the mass percentages of the raw materials are as follows:

20-25% of ethanol, 5-15% of 70% sorbitol, 2.5-7.5% of glycerol, 0.5-1% of PEG-40 hydrogenated castor oil, 0.5-1% of essence, 0.05-0.2% of stevioside, 0.2-0.5% of sodium benzoate, 0.1-1% of ovotransferrin, 0.1-1% of lysozyme, 0.5-1% of moringa leaf extract, 0.5-1% of asparagus lettuce extract and the balance of deionized water, and the pH value of the solution obtained by mixing the raw materials is adjusted to 6.6-7.0 by using a proper amount of citric acid.

3. The spray for preventing and controlling oral helicobacter pylori according to claim 2, wherein the essence is cinnamaldehyde.

4. The spray for preventing and controlling oral helicobacter pylori according to claim 3, wherein the mass percentages of the raw materials are as follows:

23% of ethanol, 10% of 70% of sorbitol, 5% of glycerol, 0.7% of PEG-40 hydrogenated castor oil, 0.8% of cinnamaldehyde, 0.1% of stevioside, 0.3% of sodium benzoate, 0.5% of ovotransferrin, 0.6% of lysozyme, 0.6% of moringa oleifera leaf extract, 0.7% of asparagus lettuce extract and the balance of deionized water, and the pH value of a mixed solution of the raw materials is adjusted to be 6.6-7.0 by using a proper amount of citric acid.

5. the spray for preventing and controlling oral helicobacter pylori according to any one of claims 1 to 4, further comprising Rosa roxburghii, wherein the mass percentage of Rosa roxburghii is 1 to 5%.

6. the spray for preventing and controlling oral helicobacter pylori according to claim 5, wherein the mass percentage of the rosa roxburghii tratt is 3%.

7. the preparation method of the oral helicobacter pylori spray for prevention and control of claim 5, which is characterized by comprising the following steps:

S1, mixing the powder prepared from the roxburgh rose with the moringa leaf extract and the asparagus lettuce extract, adding the mixture into deionized water, uniformly mixing, heating to 70 ℃ until the mixture is dissolved, cooling the solution to room temperature, and adding ethanol, 70% sorbitol, glycerol and PEG-40 hydrogenated castor oil;

S2, dissolving ovotransferrin and lysozyme at 50 ℃, adding the dissolved ovotransferrin and lysozyme into the solution obtained in the step S1, and adding citric acid to adjust the pH value of the solution to 6.6-7.0;

s3, adding stevioside, sodium benzoate and essence into the solution obtained in the step S2, uniformly mixing, and filtering the solution through a filtering device to obtain the required product.

8. The spray for prevention and control of oral helicobacter pylori according to claim 7, wherein the filtering means of step S3 requires the mist to be controlled to 5-10 μm.

Technical Field

the invention belongs to the technical field of oral cavity sprays, and particularly relates to an oral cavity helicobacter pylori prevention and control spray and a preparation method thereof.

background

Helicobacter pylori in the oral cavity is a bacterium in the oral cavity and the stomach, can cause stomach diseases, often causes chronic gastrointestinal diseases and gastric ulcer, and can cause malignant lesion and induce cancer if measures are not taken for treatment in time.

the existing common treatment method adopts antibiotic treatment, the long-term antibiotic treatment has large damage to human bodies and is easy to generate resistance, and in addition, antibiotic pills are difficult to swallow for some people. Therefore, it is important to replace the medicine with the oral spray, and the existing common oral spray generally has the functions of antibiosis and antiphlogosis, but has poor effect on preventing and controlling the helicobacter pylori in the oral cavity.

therefore, a spray for preventing and controlling helicobacter pylori in oral cavity and a preparation method thereof are urgently needed to solve the existing problems.

disclosure of Invention

The invention aims to provide a spray for preventing and controlling oral helicobacter pylori and a preparation method thereof, and the prepared spray can inhibit or eliminate the helicobacter pylori and remove oral peculiar smell so as to keep oral health.

The technical scheme adopted by the invention is as follows:

A spray for preventing and controlling helicobacter pylori in oral cavity comprises ovotransferrin, lysozyme, Moringa oleifera leaf extract and Asparagus lettuce extract. The ovotransferrin and the lysozyme can inhibit the growth of microorganisms in the oral cavity, especially helicobacter pylori, the moringa oleifera leaf extract can keep the oral cavity fresh and free from peculiar smell, and meanwhile, the liver can be strengthened, the immunity can be enhanced, and the asparagus lettuce extract has the effects of whitening and strengthening teeth.

Preferably, the mass percentages of the raw materials are as follows:

20-25% of ethanol, 5-15% of 70% sorbitol, 2.5-7.5% of glycerol, 0.5-1% of PEG-40 hydrogenated castor oil, 0.5-1% of essence, 0.05-0.2% of stevioside, 0.2-0.5% of sodium benzoate, 0.1-1% of ovotransferrin, 0.1-1% of lysozyme, 0.5-1% of moringa leaf extract, 0.5-1% of asparagus lettuce extract and the balance of deionized water, and the pH value of the solution obtained by mixing the raw materials is adjusted to 6.6-7.0 by using a proper amount of citric acid.

preferably, the essence is cinnamaldehyde.

Preferably, the mass percentages of the raw materials are as follows:

23% of ethanol, 10% of 70% of sorbitol, 5% of glycerol, 0.7% of PEG-40 hydrogenated castor oil, 0.8% of cinnamaldehyde, 0.1% of stevioside, 0.3% of sodium benzoate, 0.5% of ovotransferrin, 0.6% of lysozyme, 0.6% of moringa oleifera leaf extract, 0.7% of asparagus lettuce extract and the balance of deionized water, and the pH value of a mixed solution of the raw materials is adjusted to be 6.6-7.0 by using a proper amount of citric acid.

Preferably, the roxburgh rose fruit beverage also comprises roxburgh rose fruit, and the mass percentage of the roxburgh rose fruit is 1-5%. Fructus Rosae Normalis is rich in vitamin C, superoxide dismutase, etc., has active substances with antiaging and anticancer effects, and also has antiviral and radioprotective effects.

Preferably, the mass percent of the roxburgh rose is 3%.

A preparation method of a spray for preventing and controlling oral helicobacter pylori comprises the following steps:

s1, mixing the powder prepared from the roxburgh rose with the moringa leaf extract and the asparagus lettuce extract, adding the mixture into deionized water, uniformly mixing, heating to 70 ℃ until the mixture is dissolved, cooling the solution to room temperature, and adding ethanol, 70% sorbitol, glycerol and PEG-40 hydrogenated castor oil;

S2, dissolving ovotransferrin and lysozyme at 50 ℃, adding the dissolved ovotransferrin and lysozyme into the solution obtained in the step S1, and adding citric acid to adjust the pH value of the solution to 6.6-7.0;

s3, adding stevioside, sodium benzoate and essence into the solution obtained in the step S2, uniformly mixing, and filtering the solution through a filtering device to obtain the required product.

preferably, the filtering device of step S3 requires the mist droplets to be controlled to 5-10 μm.

Has the advantages that: can inhibit or eliminate helicobacter pylori in oral cavity, keep oral cavity healthy, and remove oral odor.

Detailed Description