阅读说明：本技术 纳米脂质载体透皮吸收制剂及制备方法 (Transdermal absorption preparation of nano lipid carrier and preparation method thereof ) 是由 李秋涛 于 2021-08-23 设计创作，主要内容包括：本发明公开了纳米脂质载体透皮吸收制剂及制备方法,该纳米脂质载体透皮吸收制剂由以下重量份数的原料制备而成：表皮生长因子5-50份、脂质材料20-100份、乳化剂25-100份、抗氧剂1-15份、抗菌剂0.5-5份、透皮促进剂1-10份、生物材料增稠剂0.5-100份、辅料20-50份、纯水余量,材料溶解,脂质材料在40-50℃的水浴中加热溶解,得到液态的脂质材料,材料融水：所述溶解的液态脂质材料与乳化剂混合均匀,加热到60-90℃为脂相,然后将脂相与纯水温度一致条件下。本发明所述的纳米脂质载体透皮吸收制剂及制备方法,能够细致化的进行材料混合,提高了预成品的生产质量,从而提高了整体的透皮吸收制剂的合格率,降低了成分刺激反应,从而降低了使用时的不良反应增加。(The invention discloses a nano lipid carrier transdermal absorption preparation and a preparation method thereof, wherein the nano lipid carrier transdermal absorption preparation is prepared from the following raw materials in parts by weight: 5-50 parts of epidermal growth factor, 20-100 parts of lipid material, 25-100 parts of emulsifier, 1-15 parts of antioxidant, 0.5-5 parts of antibacterial agent, 1-10 parts of transdermal enhancer, 0.5-100 parts of biomaterial thickener, 20-50 parts of auxiliary material and the balance of pure water, dissolving the materials, heating and dissolving the lipid material in water bath at 40-50 ℃ to obtain liquid lipid material, and melting the materials: mixing the dissolved liquid lipid material and emulsifier uniformly, heating to 60-90 deg.C to obtain lipid phase, and mixing the lipid phase with pure water at the same temperature. The transdermal absorption preparation of the nano lipid carrier and the preparation method can finely mix materials, and improve the production quality of the preformed product, thereby improving the qualification rate of the whole transdermal absorption preparation, reducing the component irritation reaction and further reducing the increase of adverse reactions in use.)

1. The nanometer lipid carrier transdermal absorption preparation is characterized in that: the nanometer lipid carrier transdermal absorption preparation is prepared from the following raw materials in parts by weight: 5-50 parts of epidermal growth factor, 20-100 parts of lipid material, 25-100 parts of emulsifier, 1-15 parts of antioxidant, 0.5-5 parts of antibacterial agent, 1-10 parts of transdermal enhancer, 0.5-100 parts of biomaterial thickener, 20-50 parts of auxiliary material and the balance of pure water.

2. The method for preparing the nano lipid carrier transdermal absorption preparation according to claim 1, which is characterized by comprising the following steps:

the method comprises the following steps: dissolving the lipid material in 40-50 deg.C water bath to obtain liquid lipid material;

step two: melting water of the material: uniformly mixing the dissolved liquid lipid material and an emulsifier, heating to 60-90 ℃ to form a lipid phase, and slowly adding the lipid phase into pure water under the condition that the temperature of the lipid phase is consistent with that of the pure water;

step three: mixing materials: adding emulsifier, antioxidant and antibacterial agent, stirring and mixing at 30-40 deg.C and 8000r/min with centrifuge, emulsifying at 55-85 deg.C for 10-15min, homogenizing with high pressure homogenizer at 70-85 deg.C, and cooling to room temperature to obtain nanometer lipid carrier transdermal absorption preparation;

step four: and (3) drying a finished product: and finally, adding auxiliary materials and a transdermal absorption enhancer to obtain the nano lipid carrier transdermal absorption preparation, drying, coating, punching and packaging.

3. The nano lipid carrier transdermal absorption preparation according to claim 1, which is characterized in that: the epidermal growth factor is at least one of human epidermal growth factor, mouse epidermal growth factor, rabbit epidermal growth factor or pig epidermal growth factor, and the epidermal growth factor is added with herba Andrographitis and flos Lonicerae, which are mixed according to equal weight, cleaned, dried and pulverized.

4. The nano lipid carrier transdermal absorption preparation according to claim 1, which is characterized in that: the lipid material is selected from fats or oils of animal origin, or lipid materials/oils of plants, microorganisms, or any mixture of said raw materials.

5. The nano lipid carrier transdermal absorption preparation according to claim 1, which is characterized in that: the transdermal enhancer is colorless, tasteless and nontoxic liquid polyolefin, has high permeability and no damage to skin, and can be used as a medicinal transdermal enhancer.

6. The method for preparing the nano lipid carrier transdermal absorption preparation according to claim 2, wherein the method comprises the following steps: in the third step, the stirring time of the centrifugal machine is 3-5min, and the emulsification is carried out by uniformly shearing at a high speed of 8000-11000r/min for 4-6 min.

7. The method for preparing the nano lipid carrier transdermal absorption preparation according to claim 2, wherein the method comprises the following steps: in the fourth step, the drying temperature is 30-50 ℃, and the drying time is 1 h.

Technical Field

The invention relates to the field of nano-lipid transdermal absorption preparations, in particular to a nano-lipid carrier transdermal absorption preparation and a preparation method thereof.

Background

The nano-lipid carrier transdermal absorption preparation refers to a method for leading active ingredients to be locally applied through skin or enter the systemic circulation through the skin so as to exert the efficacy. The non-destructive transdermal drug delivery can avoid the first-pass effect of the effective components in gastrointestinal enzymolysis and liver metabolism before entering blood circulation, not only improves the stability of the effective components, but also reduces potential toxic and side effects, and patients are more convenient and more easily accepted in the treatment process and can stop drug delivery at any time, so that the transdermal drug delivery system becomes a drug delivery application which is highly concerned in various countries in recent years;

however, when the existing nano lipid carrier transdermal absorption preparation is prepared and produced, in order to pursue production efficiency, materials cannot be subjected to mixed emulsification production in a detailed mode, and the production quality of a preformed product is reduced, so that the qualification rate of the whole transdermal absorption preparation is reduced, and secondly, the adverse reaction is increased when the transdermal absorption preparation is used due to excessive component stimulation reaction.

Disclosure of Invention

The invention mainly aims to provide a nano lipid carrier transdermal absorption preparation and a preparation method thereof, which can effectively solve the problems in the background technology that: the existing transdermal absorption preparation of the nano lipid carrier reduces the production quality of the preformed product during the preparation and production, and the stimulation reaction of the components is too great.

In order to achieve the purpose, the invention adopts the technical scheme that:

the nanometer lipid carrier transdermal absorption preparation is prepared from the following raw materials in parts by weight: 5-50 parts of epidermal growth factor, 20-100 parts of lipid material, 25-100 parts of emulsifier, 1-15 parts of antioxidant, 0.5-5 parts of antibacterial agent, 1-10 parts of transdermal enhancer, 0.5-100 parts of biomaterial thickener, 20-50 parts of auxiliary material and the balance of pure water.

The preparation method of the nano lipid carrier transdermal absorption preparation comprises the following steps:

the method comprises the following steps: dissolving the lipid material in 40-50 deg.C water bath to obtain liquid lipid material;

step two: melting water of the material: uniformly mixing the dissolved liquid lipid material and an emulsifier, heating to 60-90 ℃ to form a lipid phase, and slowly adding the lipid phase into pure water under the condition that the temperature of the lipid phase is consistent with that of the pure water;

step three: mixing materials: adding emulsifier, antioxidant and antibacterial agent, stirring and mixing at 30-40 deg.C and 8000r/min with centrifuge, emulsifying at 55-85 deg.C for 10-15min, homogenizing with high pressure homogenizer at 70-85 deg.C, and cooling to room temperature to obtain nanometer lipid carrier transdermal absorption preparation;

step four: and (3) drying a finished product: and finally, adding auxiliary materials and a transdermal absorption enhancer to obtain the nano lipid carrier transdermal absorption preparation, drying, coating, punching and packaging.

As a further scheme of the invention, the epidermal growth factor is at least one of human epidermal growth factor, mouse epidermal growth factor, rabbit epidermal growth factor or pig epidermal growth factor, the epidermal growth factor is added with common andrographis herb and honeysuckle flower, and the common andrographis herb and the honeysuckle flower are mixed according to equal weight, cleaned, dried and crushed.

As a further scheme of the invention, the epidermal growth factor is at least one of human epidermal growth factor, mouse epidermal growth factor, rabbit epidermal growth factor or pig epidermal growth factor, the epidermal growth factor is added with common andrographis herb and honeysuckle flower, and the common andrographis herb and the honeysuckle flower are mixed according to equal weight, cleaned, dried and crushed.

As a further embodiment of the invention, the lipid material is selected from fats or oils of animal origin, or lipid materials/oils of plants, microorganisms, or any mixture of said raw materials.

As a further scheme of the invention, the transdermal enhancer is colorless, tasteless and nontoxic liquid polyolefin, has high permeability and no damage to skin, and can be used as a medicinal transdermal enhancer.

As a further scheme of the invention, in the third step, the stirring time of the centrifugal machine is 3-5min, and the emulsification is carried out by uniformly shearing at a high speed of 8000-11000r/min for 4-6 min.

In the fourth step, the drying temperature is 30-50 ℃ and the drying time is 1 h.

Compared with the prior art, the invention has the following beneficial effects:

through the arranged material mixing, when the materials are mixed, the materials are firstly stirred and mixed by using a centrifugal machine, and the materials are preliminarily separated, so that the emulsifying effect is improved during preliminary emulsification, and then a high-pressure homogenizer is used for high-speed homogenization and material mixing is carried out in a refining manner, so that the production quality of a preformed product is improved, and the qualification rate of the whole transdermal absorption preparation is improved;

the andrographis paniculata and the honeysuckle are added into the epidermal growth factor, then the andrographis paniculata and the honeysuckle are mixed according to equal weight, washed, dried and crushed, and the andrographis paniculata and the honeysuckle are added to play roles of clearing away heat and toxic materials, diminishing inflammation, reducing swelling and relieving pain, so that the component irritation reaction is reduced, and the adverse reaction increase in use is reduced.

Drawings

Fig. 1 is a flow chart of a preparation method of the nano lipid carrier transdermal absorption preparation of the present invention.

Detailed Description

In order to make the technical means, the creation characteristics, the achievement purposes and the effects of the invention easy to understand, the invention is further described with the specific embodiments.

The nanometer lipid carrier transdermal absorption preparation is prepared from the following raw materials in parts by weight: 5-50 parts of epidermal growth factor, 20-100 parts of lipid material, 25-100 parts of emulsifier, 1-15 parts of antioxidant, 0.5-5 parts of antibacterial agent, 1-10 parts of transdermal enhancer, 0.5-100 parts of biomaterial thickener, 20-50 parts of auxiliary material and the balance of pure water.

As shown in fig. 1, the preparation method of the nano lipid carrier transdermal absorption preparation comprises the following steps:

the method comprises the following steps: dissolving the lipid material in 40-50 deg.C water bath to obtain liquid lipid material;

step two: melting water of the material: uniformly mixing the dissolved liquid lipid material and an emulsifier, heating to 60-90 ℃ to form a lipid phase, and slowly adding the lipid phase into pure water under the condition that the temperature of the lipid phase is consistent with that of the pure water;

step three: mixing materials: adding emulsifier, antioxidant and antibacterial agent, stirring and mixing at 30-40 deg.C and 8000r/min with centrifuge, emulsifying at 55-85 deg.C for 10-15min, homogenizing with high pressure homogenizer at 70-85 deg.C, and cooling to room temperature to obtain nanometer lipid carrier transdermal absorption preparation;

step four: and (3) drying a finished product: finally adding auxiliary materials and a transdermal absorption enhancer to obtain a nano lipid carrier transdermal absorption preparation, drying, coating, punching and packaging to obtain the nano lipid carrier transdermal absorption preparation;

the epidermal growth factor is at least one of human epidermal growth factor, mouse epidermal growth factor, rabbit epidermal growth factor or pig epidermal growth factor, and the epidermal growth factor is added with herba Andrographitis and flos Lonicerae, which are mixed according to equal weight, cleaned, dried and pulverized.

The lipid material is selected from fats or oils of animal origin, or lipid materials/oils of plants, microorganisms, or any mixture of said raw materials.

The transdermal enhancer is colorless, tasteless and nontoxic liquid polyolefin, has high permeability and no damage to skin, and can be used as a medicinal transdermal enhancer.

In the third step, the stirring time of the centrifugal machine is 3-5min, and the emulsification is carried out by uniformly shearing at a high speed of 8000-11000r/min for 4-6 min.

In the fourth step, the drying temperature is 30-50 ℃ and the drying time is 1 h.

The foregoing shows and describes the general principles and broad features of the present invention and advantages thereof. It will be understood by those skilled in the art that the present invention is not limited to the embodiments described above, which are described in the specification and illustrated only to illustrate the principle of the present invention, but that various changes and modifications may be made therein without departing from the spirit and scope of the present invention, which fall within the scope of the invention as claimed. The scope of the invention is defined by the appended claims and equivalents thereof.