阅读说明：本技术 重组糖蛋白及其用途 (Recombinant glycoproteins and uses thereof ) 是由 K·李 C·黄 C·德马里亚 于 2014-10-22 设计创作，主要内容包括：本发明涉及重组糖蛋白及其用途。本文提供了具有改变的(例如,改进的)糖基化概貌的重组糖蛋白(例如,重组人α-半乳糖苷酶-A蛋白),和包括一种或多种这些蛋白的药物组合物和试剂盒。还提供了生产用于糖蛋白(例如,重组人α-半乳糖苷酶-A)重组表达的哺乳动物细胞的方法、产生重组糖蛋白的方法和包括施用至少一种所述重组糖蛋白(例如,重组人α-半乳糖苷酶-A蛋白)至受试者的治疗方法。(The present invention relates to recombinant glycoproteins and uses thereof. Provided herein are recombinant glycoproteins (e.g., recombinant human α -galactosidase-a proteins) with altered (e.g., improved) glycosylation profiles, and pharmaceutical compositions and kits comprising one or more of these proteins. Also provided are methods of producing mammalian cells for recombinant expression of glycoproteins (e.g., recombinant human alpha-galactosidase-a), methods of producing recombinant glycoproteins, and therapeutic methods comprising administering at least one of the recombinant glycoproteins (e.g., recombinant human alpha-galactosidase-a protein) to a subject.)