阅读说明：本技术 盐酸舍曲林晶型i的制备方法 (Process for the preparation of sertraline hydrochloride form I ) 是由 沈杞容 王冬冬 陶颉 孙小燕 贾佩骞 李俊峰 赵志良 于 2020-12-17 设计创作，主要内容包括：本发明提供了一种盐酸舍曲林晶型I的制备方法。该制备方法包括：在70℃以上对在无水乙醇中的盐酸舍曲林乙醇合物进行加热,得到的固液混合体系,固液混合体系中的固体物为具有盐酸舍曲林晶型I的盐酸舍曲林。本申请的制备方法对制备条件的要求较宽泛,无需限定高真空条件,仅需将酸舍曲林乙醇合物在无水乙醇中在70℃以上的条件下加热即可,在该过程中盐酸舍曲林乙醇合物溶解后发生转晶,得到盐酸舍曲林晶型I的盐酸舍曲林。该制备方法得到的晶粒较大,外观透明完整,与现有技术由于晶体过小形成团块而导致外观不透明盐酸舍曲林晶型I不同。晶粒越大,更有利于控制盐酸舍曲林制剂溶出速率,显著提高盐酸舍曲林制剂溶出曲线与原研制剂的拟合度。(The invention provides a preparation method of sertraline hydrochloride crystal form I. The preparation method comprises the following steps: heating sertraline hydrochloride ethanol hydrate in absolute ethanol at the temperature of more than 70 ℃ to obtain a solid-liquid mixing system, wherein the solid in the solid-liquid mixing system is sertraline hydrochloride with a sertraline hydrochloride crystal form I. The preparation method has wide requirements on preparation conditions, high vacuum conditions are not limited, only the sertraline hydrochloride ethanol complex is heated in absolute ethanol at the temperature of more than 70 ℃, and in the process, the sertraline hydrochloride ethanol complex is dissolved and then is subjected to crystal transformation to obtain sertraline hydrochloride of the sertraline hydrochloride crystal form I. The crystal grain obtained by the preparation method is larger, the appearance is transparent and complete, and the preparation method is different from the prior art that the appearance is opaque due to the fact that the crystal is too small to form a block. The larger the crystal grain is, the better the control of the dissolution rate of the sertraline hydrochloride preparation is, and the fitting degree of the dissolution curve of the sertraline hydrochloride preparation and the original grinding agent is obviously improved.)

1. A process for preparing sertraline hydrochloride form I, said process comprising:

heating sertraline hydrochloride ethanol hydrate in absolute ethanol at the temperature of more than 70 ℃ to obtain a solid-liquid mixing system, wherein the solid in the solid-liquid mixing system is sertraline hydrochloride with sertraline hydrochloride crystal form I.

2. The method according to claim 1, wherein the heating temperature is 70 to 78 ℃.

3. The method of claim 1, wherein the heating is performed under normal pressure.

4. The method according to claim 3, wherein the ratio of sertraline hydrochloride ethanolate to the absolute ethanol is 1g: 0.5-2 mL.

5. The method according to claim 1, wherein the heating time is 2 to 4 hours.

6. The process according to claim 1, wherein the sertraline hydrochloride ethanolate is more than 95% pure.

7. The method according to claim 1, wherein stirring is performed during the heating, and the stirring speed is 30 to 300 r/min.

8. The production method according to claim 1, further comprising a solid-liquid separation process of the solid-liquid mixed system while the solid-liquid mixed system is hot.

9. The production method according to claim 8, wherein the solid-liquid separation is filtration or centrifugation.

Technical Field

The invention relates to the technical field of preparation of sertraline hydrochloride, and particularly relates to a preparation method of a sertraline hydrochloride crystal form I.

Background

Sertraline hydrochloride is a selective 5-hydroxytryptamine reuptake inhibitor antidepressant, is mainly used for treating adult major depression, and is also used for treating obsessive-compulsive disorder, panic disorder and social phobia of children or adults. Sertraline hydrochloride may exist in different crystalline forms, polymorphs, which differ in stability, physical properties, spectroscopic data, and methods of preparation, having the following chemical structure:

patent US5248699 discloses four polymorphs I, III, IV and V. Characterized by single crystal x-ray analysis, powder x-ray diffraction, infrared spectroscopy and differential scanning calorimetry. According to this patent, the preferential formation of form I, II, or V, in an acidic solution comprising isopropanol, ethane, methyl isobutyl ketone, glacial acetic acid or preferably ethyl acetate depends on the rate of crystallization. Form I is obtained by crystallizing sertraline hydrochloride in acidic solution using the organic solvents listed above. Crystallization of form I is carried out at a temperature of about 20 ℃ to about the reflux temperature of the solvent, preferably about 40-60 ℃.

Patent CN00815052 discloses a preparation method of sertraline hydrochloride polymorph I. Sertraline hydrochloride polymorph I can be formed from amorphous sertraline hydrochloride, or polymorph CSC1, or polymorph CSC2, or a non-alcoholic suspension of sertraline hydrochloride alcohol solvate, after prolonged stirring, or with rapid reaction times after seeding with some seed crystals of sertraline hydrochloride polymorph I. In the examples, the patent discloses the preparation of sertraline hydrochloride polymorph I by heating sertraline hydrochloride isopropanol solvate at 70 ℃ under high vacuum (0.1mbar) for 20 h.

Therefore, the preparation method of the sertraline hydrochloride crystal form I is complex or harsh in conditions and is not beneficial to industrial application.

Disclosure of Invention

The invention mainly aims to provide a preparation method of sertraline hydrochloride crystal form I, and aims to solve the problem that the preparation of sertraline hydrochloride crystal form I in the prior art is complex.

To achieve the above objects, according to one aspect of the present invention, there is provided a process for preparing sertraline hydrochloride form I, comprising: heating sertraline hydrochloride ethanol hydrate in absolute ethanol at the temperature of more than 70 ℃ to obtain a solid-liquid mixing system, wherein the solid in the solid-liquid mixing system is sertraline hydrochloride with a sertraline hydrochloride crystal form I.

Further, the heating temperature is 70-78 ℃.

Further, the above heating is performed under normal pressure.

Further, the ratio of the sertraline hydrochloride ethanol hydrate to the absolute ethanol is 1g: 0.5-2 mL.

Further, the heating time is 2-4 h.

Further, the purity of the sertraline hydrochloride ethanol compound is more than 95%.

Further, stirring is carried out in the heating process, and the stirring speed is 30-300 r/min.

Further, the preparation method also comprises a solid-liquid separation process of the solid-liquid mixed system when the solid-liquid mixed system is hot.

Further, the solid-liquid separation is filtration or centrifugation.

By applying the technical scheme of the invention, the preparation method has wide requirements on preparation conditions, high vacuum conditions are not required to be limited, only the sertraline hydrochloride ethanol hydrate is heated in absolute ethanol at the temperature of more than 70 ℃, and in the process, the sertraline hydrochloride ethanol hydrate is dissolved and then is subjected to crystal transformation to obtain sertraline hydrochloride of the sertraline hydrochloride crystal form I. The crystal grain obtained by the preparation method is large, the appearance is transparent and complete, and the preparation method is different from the prior art that the appearance is opaque due to the fact that the crystal is too small to form lumps. And the larger the crystal grain is, the better the control of the dissolution rate of the sertraline hydrochloride preparation is facilitated, and the fitting degree of the dissolution curve of the sertraline hydrochloride preparation and the original grinding agent is obviously improved.

Drawings

The accompanying drawings, which are incorporated in and constitute a part of this application, illustrate embodiments of the invention and, together with the description, serve to explain the invention and not to limit the invention. In the drawings:

FIG. 1 shows the XRD pattern of sertraline hydrochloride form I prepared according to example 1 of the present invention;

FIG. 2 shows a micrograph of individual transparent grains of sertraline hydrochloride prepared according to example 1 of the present invention, in which each cell has a width of 0.01 mm;

FIG. 3 shows a crystal micrograph of sertraline hydrochloride form I prepared according to example 4 of the present invention; and

figure 4 shows a crystal micrograph of commercially available sertraline hydrochloride form I.

Detailed Description

It should be noted that the embodiments and features of the embodiments in the present application may be combined with each other without conflict. The present invention will be described in detail below with reference to the embodiments with reference to the attached drawings.

The prior art processes for preparing sertraline hydrochloride form I are complicated as described in the background of the present application. In addition, under the premise that alcohol cannot be used as a solvent in the process of preparing the sertraline hydrochloride polymorphic substance I, the patent CN00815052 discloses that the sertraline hydrochloride ethanolate is subjected to crystal transformation by using ethanol, and the method is unexpectedly found to be capable of well obtaining the sertraline hydrochloride crystalline form I. And by controlling the crystal transformation temperature, the large-grain transparent sertraline hydrochloride crystal form I can be obtained, and the dissolution curve of the large-grain transparent sertraline hydrochloride crystal form I is further improved.

Based on the above findings, the present application provides a process for preparing sertraline hydrochloride form I, comprising: heating sertraline hydrochloride ethanol hydrate in absolute ethanol at the temperature of more than 65 ℃ to obtain a solid-liquid mixing system, wherein solid suspended matters in the solid-liquid mixing system are sertraline hydrochloride with sertraline hydrochloride crystal form I.

The preparation method has wide requirements on preparation conditions, high vacuum conditions are not limited, only the sertraline hydrochloride ethanol complex is heated in absolute ethanol at the temperature of more than 70 ℃, and in the process, the sertraline hydrochloride ethanol complex is dissolved and then is subjected to crystal transformation to obtain sertraline hydrochloride of the sertraline hydrochloride crystal form I. The product obtained was tested and its crystalline form showed an X-ray powder diffraction pattern (fig. 1) with characteristic peaks expressed in terms of the following 2 Θ values:

13.189，15.025，15.384，15.781，16.930，20.939，22.564，23.410，24.987，26.350，26.964，28.579，34.275，35.341

the data show that the preparation method successfully prepares the sertraline hydrochloride with the sertraline hydrochloride crystal form I, and the crystal grain obtained by using the preparation method is larger, the appearance is transparent and complete, and the preparation method is different from the prior art which has the appearance of opaque sertraline hydrochloride crystal form I due to the fact that the crystal is too small and the crystal forms are agglomerated. And the larger the crystal grain is, the better the control of the dissolution rate of the sertraline hydrochloride preparation is facilitated, and the fitting degree of the dissolution curve of the sertraline hydrochloride preparation and the original grinding agent is obviously improved.

The method has the characteristics of high reaction speed and simplicity in operation, and improves the production efficiency of the process for obtaining the sertraline hydrochloride crystal form I.

In some preferred embodiments, the heating temperature is 70-78 ℃. The acid sertraline ethanolate is heated in absolute ethyl alcohol at the temperature of 70-78 ℃ to successfully prepare a sertraline hydrochloride crystal form I, and an absolute ethyl alcohol solvent can not boil in the preparation process, so that the sertraline hydrochloride ethanolate is dissolved and crystallized under the heating condition as much as possible.

In some preferred embodiments, the heating is carried out at atmospheric pressure. Different from the prior art, the preparation method adopted by the application does not need to be limited to heating under the condition of high vacuum, the successful preparation of the sertraline hydrochloride crystal form I can be completed under normal pressure, the preparation cost is reduced, and meanwhile, the method for preparing the sertraline hydrochloride crystal form I is easy to industrially practice.

In addition to the advantages, compared with the prior art, the preparation method has the advantage that the dosage of the solvent is lower, and the ratio of the sertraline hydrochloride ethanol hydrate to the absolute ethanol is preferably 1g: 0.5-2 mL. Not only reduces the cost, but also improves the yield of sertraline crystal form I by using less ethanol solvent.

The heating time is preferably 2 to 4 hours. The good crystal transformation effect is realized within the time range, and compared with the 20h in the prior art, the preferable heating time is shorter, so that the preparation efficiency is improved, and the preparation cost is reduced.

Sertraline hydrochloride ethanolate is difficult to preserve at ambient temperature and pressure and is therefore currently being prepared in experiments, and the following illustrates the preparation of sertraline hydrochloride ethanolate: the preparation method comprises the steps of preparing sertraline hydrochloride according to a conventional method, dissolving sertraline hydrochloride in absolute ethyl alcohol at room temperature, introducing hydrogen chloride gas until the pH value is 0.5, and raising the temperature to 40 ℃. The slurry was cooled to room temperature and stirred for about 16 hours, the solid was isolated by filtration and washed with ethanol (3X 2mL) to give the product sertraline hydrochloride ethanolate in greater than 95% purity.

In order to accelerate the reaction speed and obtain the sertraline hydrochloride crystal form I with proper granularity, stirring is preferably carried out in the heating process, and the stirring speed is 30-300 r/min. Through the stirring, the growth of crystal grains on the inner wall of the equipment is avoided, the collection and the separation of crystals are facilitated, and the size of the crystal grains can be adjusted through the stirring.

After completing the transcrystallization, sertraline hydrochloride having sertraline hydrochloride form I may be isolated for storage, preferably the above preparation method further comprises: and carrying out solid-liquid separation on the hot solid-liquid mixed system. The solid-liquid separation is carried out at a heating temperature or slightly below the heating temperature as understood by those skilled in the art when the solid-liquid separation is still hot. In order to ensure as much integrity as possible of the large particles of the crystals formed, the solid-liquid separation is preferably filtration or centrifugation.

The following examples are provided to further illustrate the benefits of the present application.

Preparation of sertraline hydrochloride ethanolate Using the aforementioned Process to obtain sertraline hydrochloride ethanolate of 99% purity

Example 1

300g of sertraline hydrochloride ethanol compound and 300ml of absolute ethanol which are obtained by the preparation method are added into a 1L reaction bottle, the rotating speed is adjusted to be 100rpm, the temperature is raised to 75 ℃ in a water bath, the mixture is filtered when the mixture is hot after being kept for 2 hours, and a filter cake is dried to obtain about 244g of sertraline hydrochloride crystal form I finished product, the yield is 92%, and the crystal appearance is transparent.

Example 2

300g of sertraline hydrochloride ethanol compound and 450ml of absolute ethanol which are obtained by the preparation method are added into a 1L reaction bottle, the rotating speed is adjusted to be 100rpm, the temperature is raised to 75 ℃ in a water bath, the mixture is filtered when the mixture is hot after being kept for 2 hours, a filter cake is dried, and the finished product of the sertraline hydrochloride crystal form I, namely about 219g, the yield is 83.0 percent, and the crystal appearance is transparent.

Example 3

Adding 300g of sertraline hydrochloride ethanol compound and 300ml of absolute ethanol which are obtained by the preparation method into a 1L reaction bottle, adjusting the rotating speed to 100rpm, slowly heating to 75 ℃ in a water bath, preserving the temperature for 1h, filtering while the solution is hot, and drying a filter cake to obtain about 232g of a sertraline hydrochloride crystal form I finished product, wherein the yield is 88%, and the crystal appearance transparency is insufficient, which indicates that other crystal forms are mixed or the crystal size is smaller, so that the dissolution is influenced.

Example 4

300g of sertraline hydrochloride ethanol compound and 300ml of absolute ethanol which are obtained by the preparation method are added into a 1L reaction bottle, the rotating speed is adjusted to be 100rpm, the temperature is raised to 75 ℃ in a water bath, the mixture is filtered when the mixture is hot after the temperature is kept for 3 hours, and a filter cake is dried to obtain about 240g of sertraline hydrochloride crystal form I finished product, the yield is 91%, and the crystal appearance is transparent.

Example 5

300g of sertraline hydrochloride ethanol compound and 300ml of absolute ethanol which are obtained by the preparation method are added into a 1L reaction bottle, the rotating speed is adjusted to 300rpm, the temperature is raised to 75 ℃ in a water bath, the mixture is filtered when the mixture is hot after being kept for 2 hours, and a filter cake is dried to obtain about 231g of sertraline hydrochloride crystal form I finished product, the yield is 87.5 percent, the crystal appearance is transparent, but the abrasion or the breakage is obvious.

Example 6

300g of sertraline hydrochloride ethanol compound and 300ml of absolute ethanol which are obtained by the preparation method are added into a 1L reaction bottle, the rotating speed is adjusted to 50rpm, the temperature is raised to 75 ℃ in a water bath, the mixture is filtered when the mixture is hot after being kept for 2 hours, and a filter cake is dried to obtain about 229g of a sertraline hydrochloride crystal form I finished product, the yield is 86.7 percent, the crystal size is large, and the appearance is transparent.

Example 7

300g of sertraline hydrochloride ethanol compound and 300ml of absolute ethanol which are obtained by the preparation method are added into a 1L reaction bottle, the rotating speed is adjusted to be 100rpm, the temperature is raised to 78 ℃ in a water bath, the mixture is filtered when the mixture is hot after being kept for 2 hours, and a filter cake is dried to obtain about 248g of sertraline hydrochloride crystal form I finished product, the yield is 93.5%, and the crystal appearance is transparent.

Example 8

300g of sertraline hydrochloride ethanol compound and 600ml of absolute ethanol which are obtained by the preparation method are added into a 1L reaction bottle, the rotating speed is adjusted to be 100rpm, the temperature is raised to 75 ℃ in a water bath, the mixture is filtered when the mixture is hot after the temperature is kept for 2 hours, and a filter cake is dried to obtain about 211g of sertraline hydrochloride crystal form I finished product, the yield is 79.5%, and the crystal appearance is transparent.

Example 9

300g of sertraline hydrochloride ethanol compound and 300ml of absolute ethanol which are obtained by the preparation method are added into a 1L reaction bottle, the rotating speed is adjusted to be 100rpm, the temperature is raised to 75 ℃ in a water bath, the mixture is filtered when the mixture is hot after being kept for 2 hours, and a filter cake is dried to obtain about 244g of sertraline hydrochloride crystal form I finished product, the yield is 92%, and the crystal appearance is transparent.

Comparative example 1

300g of sertraline hydrochloride ethanol compound and 300ml of absolute ethanol which are obtained by the preparation method are added into a 1L reaction bottle, the rotating speed is adjusted to be 100rpm, the temperature is raised to 65 ℃ in a water bath, the mixture is filtered when the mixture is hot after being kept for 2 hours, and a filter cake is dried to obtain about 238g of sertraline hydrochloride crystal form I finished product, the yield is 90.2%, and the crystal appearance is opaque. This indicates that the crystal grains are small and the dissolution is not satisfactory.

The XRD pattern of sertraline hydrochloride form I of example 1 is shown in FIG. 1, and it can be seen from FIG. 1 that the present application, example 1, successfully produced sertraline hydrochloride form I. The XRD spectrums of the crystalline form I of the trolene hydrochloride of other examples have corresponding peaks at the characteristic peak positions of figure 1.

And as can be seen from a comparison of fig. 2, fig. 3 and fig. 4, the sertraline hydrochloride form I crystals prepared in example 1 of the present application are transparent, whereas the commercially available sertraline hydrochloride form I crystals are opaque.

From the above description, it can be seen that the above-described embodiments of the present invention achieve the following technical effects:

the preparation method has wide requirements on preparation conditions, high vacuum conditions are not limited, only the sertraline hydrochloride ethanol complex is heated in absolute ethanol at the temperature of more than 70 ℃, and in the process, the sertraline hydrochloride ethanol complex is dissolved and then is subjected to crystal transformation to obtain sertraline hydrochloride of the sertraline hydrochloride crystal form I. The product obtained was tested and its crystalline form showed an X-ray powder diffraction pattern (fig. 1) with characteristic peaks expressed in terms of the following 2 Θ values:

13.189，15.025，15.384，15.781，16.930，20.939，22.564，23.410，24.987，26.350，26.964，28.579，34.275，35.341

the data show that the preparation method successfully prepares the sertraline hydrochloride with the sertraline hydrochloride crystal form I, and the crystal grain obtained by using the preparation method is larger, the appearance is transparent and complete, and the preparation method is different from the prior art which has the appearance of opaque sertraline hydrochloride crystal form I due to the fact that the crystal is too small and the crystal forms are agglomerated. And the larger the crystal grain is, the better the control of the dissolution rate of the sertraline hydrochloride preparation is facilitated, and the fitting degree of the dissolution curve of the sertraline hydrochloride preparation and the original grinding agent is obviously improved.

The method has the characteristics of high reaction speed and simplicity in operation, and improves the production efficiency of the process for obtaining the sertraline hydrochloride crystal form I.

The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention, and various modifications and changes may be made by those skilled in the art. Any modification, equivalent replacement, or improvement made within the spirit and principle of the present invention should be included in the protection scope of the present invention.