阅读说明：本技术 混合器及液相色谱仪 (Mixer and liquid chromatograph ) 是由 罗阁 宋瑶 李志伟 张振方 *** 王岱杰 于 2020-08-26 设计创作，主要内容包括：本发明提供了一种混合器及液相色谱仪,涉及液相色谱仪技术领域,本发明提供的混合器,混合器具有进流孔、出流孔和多条第一导流通道,多条第一导流通道的一端分别与进流孔流体连通,多条第一导流通道的另一端分别与出流孔流体连通,至少两条第一导流通道的延伸长度不同。本发明提供的混合器,可以打破流动相的时间顺序,并经出流孔混合排出,进而增强了混合效果。(The invention provides a mixer and a liquid chromatograph, and relates to the technical field of liquid chromatographs. The mixer provided by the invention can break the time sequence of the mobile phase, and the mobile phase is mixed and discharged through the outflow hole, so that the mixing effect is enhanced.)

1. A mixer, characterized in that the mixer has an inflow hole (101), an outflow hole (102) and a plurality of first flow guiding channels (110), one end of each of the plurality of first flow guiding channels (110) is in fluid communication with the inflow hole (101), the other end of each of the plurality of first flow guiding channels (110) is in fluid communication with the outflow hole (102), and the extension lengths of at least two of the first flow guiding channels (110) are different.

2. A mixer according to claim 1, wherein the first flow guiding channel (110) has a corner portion (111), the corner portion (111) being adapted to change the flow direction of the fluid in the first flow guiding channel (110).

3. The mixer according to claim 1, wherein a plurality of the first flow guide channels (110) each extend in a direction away from the axis of the intake bore (101).

4. The mixer of claim 1, wherein the mixer has a plurality of second guide passages (120), and wherein the plurality of first guide passages (110) are in one-to-one correspondence in fluid communication with the plurality of second guide passages (120) via guide holes (130).

5. The mixer according to claim 4, wherein a plurality of second flow guide passages (120) extend from an end communicating with the first flow guide passage (110) to an end communicating with the outflow hole (102) in a direction approaching an axis of the outflow hole (102).

6. The mixer according to claim 5, wherein the second flow guide channel (120) extends along an arc;

the second guide channels (120) have the same rotation direction and are arranged at intervals around the axis of the outflow hole (102).

7. The mixer of claim 4, wherein the mixer comprises: the gasket (100), the cavity body piece (200) and the mounting seat (300), wherein the gasket (100) is installed between the cavity body piece (200) and the mounting seat (300), the cavity body piece (200) is provided with the inflow hole (101), and the mounting seat (300) is provided with the outflow hole (102);

the gasket (100) and the cavity piece (200) form the first flow guide channel (110);

the second flow guide channel (120) is formed between the gasket (100) and the mounting seat (300).

8. The mixer according to claim 7, wherein the mounting seat (300) is provided with a mounting groove (310) communicated with the outflow hole (102), and a filter sheet (400) is mounted in the mounting groove (310).

9. The mixer of claim 8, further comprising: the filter comprises a base (500) and a top cover (600) connected with the base (500), a mounting cavity is formed between the base (500) and the top cover (600), and the gasket (100), a cavity body piece (200), a mounting seat (300) and the filter disc (400) are respectively mounted in the mounting cavity;

a sealing ring (700) is arranged between the top cover (600) and the cavity piece (200).

10. A liquid chromatograph having the mixer according to any one of claims 1 to 9.

Technical Field

The invention relates to the technical field of liquid chromatographs, in particular to a mixer and a liquid chromatograph.

Background

The high performance liquid chromatography is an important branch of the chromatography, liquid is taken as a mobile phase, a high pressure transfusion system is adopted, the mobile phase such as single solvents with different polarities or mixed solvents with different proportions, buffer solution and the like and a sample to be detected are pumped into a chromatographic column filled with a stationary phase, and after components of the sample to be detected are separated in the chromatographic column, the components enter a corresponding detector for detection, so that the qualitative and quantitative analysis of the sample is realized.

For gradient mode, the mobile phases of the components are completely independent before entering the infusion pump system, and flow mixing through the pipeline is started after entering the system, so that the mixing is very uneven, and after uneven liquid enters the detector, baseline fluctuation and ghost peaks can be generated, thereby affecting the separation effect of the sample. For the working of the quaternary pump, the opening time proportion of different channels is controlled by the four-channel electromagnetic valve to obtain a mobile phase mixture with a preset proportion, the mobile phases in the pipeline are separated from one another section by section according to the electromagnetic opening time sequence of the different channels, the mobile phases are difficult to mix, and the mixing effect is poor particularly when the mobile phases are mixed in a small proportion.

Disclosure of Invention

The invention aims to provide a mixer and a liquid chromatograph, which can break the time sequence of a mobile phase and further enhance the mixing effect.

In a first aspect, the present invention provides a mixer, which has an inlet hole, an outlet hole and a plurality of first flow guiding channels, wherein one end of each of the plurality of first flow guiding channels is in fluid communication with the inlet hole, the other end of each of the plurality of first flow guiding channels is in fluid communication with the outlet hole, and at least two of the first flow guiding channels have different extending lengths.

With reference to the first aspect, the present disclosure provides a first possible implementation manner of the first aspect, wherein the first guide passage has a corner portion for changing a flow direction of the fluid in the first guide passage.

With reference to the first aspect, the present invention provides a second possible implementation manner of the first aspect, wherein the plurality of first flow guide passages respectively extend in a direction away from the axis of the inflow hole.

With reference to the first aspect, the present disclosure provides a third possible implementation manner of the first aspect, wherein the mixer has a plurality of second flow guide channels, and the plurality of first flow guide channels are in one-to-one correspondence with the plurality of second flow guide channels through flow guide holes.

With reference to the third possible implementation manner of the first aspect, the present invention provides a fourth possible implementation manner of the first aspect, wherein a plurality of second flow guide channels respectively extend in a direction approaching an axis of the outflow hole from one end communicating with the first flow guide channel to one end communicating with the outflow hole.

With reference to the fourth possible implementation manner of the first aspect, the present invention provides a fifth possible implementation manner of the first aspect, wherein the second flow guiding passage extends along an arc;

the second guide channels are same in rotation direction and are arranged around the axis of the outflow hole at intervals.

With reference to the third possible implementation manner of the first aspect, the present invention provides a sixth possible implementation manner of the first aspect, wherein the mixer includes: the gasket is installed between the cavity body part and the mounting seat, the cavity body part is provided with the inflow hole, and the mounting seat is provided with the outflow hole;

the gasket and the cavity piece form the first flow guide channel;

the second flow guide channel is formed between the gasket and the mounting seat.

In combination with the sixth possible implementation manner of the first aspect, the present invention provides a seventh possible implementation manner of the first aspect, wherein the mounting seat is provided with a mounting groove communicated with the outflow hole, and a filter disc is mounted in the mounting groove.

With reference to the seventh possible implementation manner of the first aspect, the present invention provides an eighth possible implementation manner of the first aspect, wherein the mixer further includes: the gasket, the cavity part, the mounting seat and the filter disc are respectively mounted in the mounting cavity; and a sealing ring is arranged between the top cover and the cavity part.

In a second aspect, the present invention provides a liquid chromatograph having the mixer of the first aspect.

The embodiment of the invention has the following beneficial effects: the mixer is provided with a plurality of first flow guide channels, one ends of the first flow guide channels are respectively communicated with the inflow hole, the other ends of the first flow guide channels are respectively communicated with the outflow hole, the extending lengths of at least two first flow guide channels are different, the mobile phase flows into the first flow guide channels from the inflow hole, and the mobile phase flowing through the first flow guide channels respectively breaks the time sequence due to the different extending lengths of the first flow guide channels and is discharged through the outflow hole in a mixed mode, so that the mixing effect is enhanced.

In order to make the aforementioned and other objects, features and advantages of the present invention comprehensible, preferred embodiments accompanied with figures are described in detail below.

Drawings

In order to more clearly illustrate the technical solutions of the embodiments of the present invention or related technologies, the drawings used in the description of the embodiments or related technologies will be briefly introduced below, and it is obvious that the drawings in the following description are some embodiments of the present invention, and other drawings can be obtained by those skilled in the art without creative efforts.

FIG. 1 is a cross-sectional view of a mixer provided by an embodiment of the present invention;

FIG. 2 is a first schematic diagram of a gasket of a mixer according to an embodiment of the present invention;

FIG. 3 is a second schematic diagram of a gasket of the mixer according to the embodiment of the present invention;

fig. 4 is an exploded view of a mixer provided in an embodiment of the present invention.

Icon: 100-a gasket; 101-an inflow hole; 102-an outflow hole; 110-a first flow guide channel; 111-corner section; 120-a second flow guide channel; 130-flow guide holes; 200-a cavity member; 300-a mounting seat; 310-a mounting groove; 400-a filter disc; 500-a base; 600-a top cover; 601-drainage holes; 700-sealing ring.

Detailed Description

The technical solutions of the present invention will be described clearly and completely with reference to the accompanying drawings, and it should be understood that the described embodiments are some, but not all embodiments of the present invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

In the description of the present invention, it should be noted that the terms "center", "upper", "lower", "left", "right", "vertical", "horizontal", "inner", "outer", etc., indicate orientations or positional relationships based on the orientations or positional relationships shown in the drawings, and are only for convenience of description and simplicity of description, but do not indicate or imply that the device or element being referred to must have a particular orientation, be constructed and operated in a particular orientation, and thus, should not be construed as limiting the present invention. Furthermore, the terms "first," "second," and "third" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance. The term "physical quantity" in the formula, unless otherwise noted, is understood to mean a basic quantity of a basic unit of international system of units, or a derived quantity derived from a basic quantity by a mathematical operation such as multiplication, division, differentiation, or integration.

In the description of the present invention, it should be noted that, unless otherwise explicitly specified or limited, the terms "mounted," "connected," and "connected" are to be construed broadly, e.g., as meaning either a fixed connection, a removable connection, or an integral connection; can be mechanically or electrically connected; they may be connected directly or indirectly through intervening media, or they may be interconnected between two elements. The specific meanings of the above terms in the present invention can be understood in specific cases to those skilled in the art.