阅读说明：本技术 双特异性抗原结合分子和使用方法 (Bispecific antigen binding molecules and methods of use ) 是由 D·埃勒曼 T·T·云蒂拉 T·N·隆巴纳 D·斯拉格 C·施皮斯 于 2019-02-08 设计创作，主要内容包括：本发明提供具有对第一靶抗原(例如T细胞抗原,诸如CD3)特异性的单价臂和对第二靶抗原(例如肿瘤抗原,诸如HER2)特异性的二价臂的双特异性抗原结合分子。双特异性抗原结合分子在治疗病症,诸如癌症(例如HER2阳性癌症)中是有用的。本发明还特征在于生成双特异性抗原结合分子的方法,使用双特异性抗原结合分子治疗病症的方法,和包括双特异性抗原结合分子的组合物。(The present invention provides bispecific antigen binding molecules having a monovalent arm specific for a first target antigen (e.g., a T cell antigen such as CD3) and a bivalent arm specific for a second target antigen (e.g., a tumor antigen such as HER 2). Bispecific antigen binding molecules are useful in treating disorders, such as cancer (e.g., HER2 positive cancer). The invention also features methods of making the bispecific antigen binding molecules, methods of treating disorders using the bispecific antigen binding molecules, and compositions including the bispecific antigen binding molecules.)