5-氟-4-(4-氟-2-甲氧基苯基)-n-{4-[(s-甲基磺亚胺酰基)甲基]吡啶-2-基}吡啶-2-胺用于治疗弥漫性大b细胞淋巴瘤中的用途
阅读说明:本技术 5-氟-4-(4-氟-2-甲氧基苯基)-n-{4-[(s-甲基磺亚胺酰基)甲基]吡啶-2-基}吡啶-2-胺用于治疗弥漫性大b细胞淋巴瘤中的用途 (Use of 5-fluoro-4- (4-fluoro-2-methoxyphenyl) -N- {4- [ (S-methylsulfonimidoyl) methyl ] pyridin-2-yl } pyridin-2-amine for the treatment of diffuse large B-cell lymphoma ) 是由 A·肖尔茨 于 2019-02-12 设计创作,主要内容包括:本发明涉及5-氟-4-(4-氟-2-甲氧基苯基)-N-{4-[(S-甲基磺亚胺酰基)甲基]吡啶-2-基}吡啶-2-胺(化合物A),更特别是(+)5-氟-4-(4-氟-2-甲氧基苯基)-N-{4-[(S-甲基磺亚胺酰基)甲基]吡啶-2-基}吡啶-2-胺(化合物A’),用于治疗弥漫性大B细胞淋巴瘤(DLBCL),尤其是生发中心B细胞型弥漫性大B细胞淋巴瘤,并且尤其是其细胞具有MYC基因和/或BCL2基因的扩增或易位和/或MYC和/或BCL2的过表达的弥散性大B细胞淋巴瘤的用途。(The present invention relates to 5-fluoro-4- (4-fluoro-2-methoxyphenyl) -N- {4- [ (S-methylsulfonimidoyl) methyl ] pyridin-2-yl } pyridin-2-amine (Compound A), more particularly (+) 5-fluoro-4- (4-fluoro-2-methoxyphenyl) -N- {4- [ (S-methylsulfonimidoyl) methyl ] pyridin-2-yl } pyridin-2-amine (Compound A'), for the treatment of diffuse large B-cell lymphoma (DLBCL), especially of germinal center B-cell type, and in particular the use of diffuse large B-cell lymphomas whose cells have an amplification or translocation of the MYC gene and/or BCL2 gene and/or overexpression of MYC and/or BCL 2.)
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