阅读说明：本技术 管柱烘箱及色谱仪 (Tubular column oven and chromatograph ) 是由 沼田幸治 细尾幸平 于 2019-11-04 设计创作，主要内容包括：本发明提供一种可将保持分析管柱的保持构件制成简单的构成,从而可实现成本降低的管柱烘箱及色谱仪。管柱烘箱(6)包括移动相能够流通的分析管柱(121)、保持分析管柱(121)的保持构件(2)及对保持于保持构件(2)的分析管柱(121)进行加热的加热部,保持构件(2)包括：基部(21)；以及第一夹持部(22A)及第二夹持部(22B),设于基部(21),相互夹持分析管柱(121)的中间部(125),具有在所述夹持状态下相对于分析管柱(121)向基部(21)的相反侧突出的突出部(221),基部(21)、第一夹持部(22A)及第二夹持部(22B)形成为一体。(The invention provides a column oven and a chromatograph, which can make a holding member for holding an analysis column into a simple structure, thereby realizing cost reduction. The column oven (6) is provided with an analytical column (121) through which a mobile phase can flow, a holding member (2) for holding the analytical column (121), and a heating unit for heating the analytical column (121) held by the holding member (2), and the holding member (2) is provided with: a base (21); and a first clamping section (22A) and a second clamping section (22B) which are provided on the base section (21), which mutually clamp the intermediate section (125) of the analytical column (121), and which have a protruding section (221) that protrudes toward the opposite side of the base section (21) with respect to the analytical column (121) in the clamped state, wherein the base section (21), the first clamping section (22A), and the second clamping section (22B) are integrally formed.)

1. A tube column oven comprising:

an analytical column through which a mobile phase can flow, the analytical column having a base end portion located on an upstream side in a flow direction of the mobile phase, a tip end portion located on a downstream side in the flow direction, and an intermediate portion between the tip end portion and the base end portion;

a holding member that holds the analytical column; and

a heating unit that heats the analytical column held by the holding member,

the holding member includes:

a base; and

a first clamping section and a second clamping section provided on the base section, clamping the intermediate section of the analytical column therebetween, and having a protruding section protruding from the analytical column in the clamped state on the opposite side of the base section,

the base portion, the first clamping portion, and the second clamping portion are integrally formed.

2. The column oven according to claim 1, wherein a protruding amount of each of the protruding portions is 2 times or more and 3 times or less a thickness of the intermediate portion.

3. The column oven according to claim 1 or 2, wherein the first clamping portion and the second clamping portion each have a vent hole that penetrates in a longitudinal direction of the analytical column held by the holding member and through which air passes.

4. The pipe column oven of claim 1 or 2, wherein

The base part is in the shape of a plate,

the first clamping portion and the second clamping portion each have an inclined portion inclined with respect to the base portion at a portion on the opposite side of the analytical column in a state of being held by the holding member.

5. The pipe column oven of claim 1 or 2, comprising:

a plate-shaped fixing plate for detachably fixing the holding member,

the fixing plate has a plurality of through holes penetrating in the thickness direction,

the holding member has at least one engaging portion provided on the opposite side of the first clamping portion and the second clamping portion with respect to the base portion and engaged with the through hole,

the engaging portion is formed integrally with the base portion.

6. The pipe column oven of claim 5, wherein

Two of the engaging portions are provided apart from each other in a direction in which the first clamping portion and the second clamping portion are arranged,

the first clamping portion and the second clamping portion are deformed in a direction away from each other in the clamped state, and forces are applied to the two engaging portions in a direction in which the two engaging portions approach each other in accordance with the deformation.

7. The pipe column oven of claim 6, wherein

The two clamping parts are respectively in a cylindrical shape,

the first clamping portion is disposed on an extension line of one of the two engagement portions in the central axis direction, and the second clamping portion is disposed on an extension line of the other engagement portion in the central axis direction.

8. The pipe column oven of claim 1 or 2, wherein the base, the first clamp, and the second clamp comprise an elastomer.

9. The pipe column oven of claim 8, wherein the elastomer is a rubber material.

10. A chromatograph comprising the column oven of any of claims 1-9.

Technical Field

The present invention relates to a tube column oven and a chromatograph (chromatography).

Background

A chromatograph is known that separates a mobile phase to be analyzed into analytes that are a plurality of components by a chromatography column (see, for example, patent document 1). The chromatograph described in patent document 1 includes a holding portion that holds a plurality of columns at appropriate positions. This holding portion includes, for example, a plurality of guide members in a tubular shape. The holding portion includes a plurality of guide members having a tubular shape.

Disclosure of Invention

Problems to be solved by the invention

However, the holding portion of the chromatograph described in patent document 1 includes a plurality of members, and thus has a problem that the configuration thereof becomes complicated and the cost at the time of manufacturing increases.

The invention provides a column oven and a chromatograph, which can make a holding member for holding an analysis column into a simple structure, thereby reducing the cost.

Means for solving the problems

A first embodiment of the invention relates to a tube column oven comprising: an analytical column through which a mobile phase can flow, the analytical column having a base end portion located on an upstream side in a flow direction of the mobile phase, a tip end portion located on a downstream side in the flow direction, and an intermediate portion between the tip end portion and the base end portion; a holding member that holds the analytical column; and a heating unit that heats the analytical column held by the holding member, the holding member including: a base; and a first clamping portion and a second clamping portion provided in the base portion, clamping the intermediate portion of the analytical column therebetween, and having a protruding portion protruding toward an opposite side of the base portion with respect to the analytical column in the clamped state, wherein the base portion, the first clamping portion, and the second clamping portion are integrally formed.

A second embodiment of the present invention is directed to a chromatograph that includes the column oven of the first embodiment of the present invention.

ADVANTAGEOUS EFFECTS OF INVENTION

According to the present invention, a metal mold, for example, can be used in the manufacture of the holding member. In this case, the holding member can be quickly and easily molded. The holding member obtained by the molding includes one member, and is different from, for example, a joined body obtained by joining a plurality of members. Therefore, the holding member 2 can be made into a simple configuration. Further, since the structure is simple, the manufacturing cost for manufacturing the holding member can be suppressed accordingly, and the cost can be reduced.

Drawings

Fig. 1 is a schematic diagram (block diagram) showing a first embodiment of a chromatograph system (chromatography system) according to the present invention.

Fig. 2 is a vertical partial sectional view showing an internal structure of a column oven provided in the chromatograph system shown in fig. 1.

Fig. 3 is a perspective view showing a part of the internal structure of the column oven shown in fig. 2.

Fig. 4 is a view seen from the direction of arrow a in fig. 3.

Fig. 5 is a horizontal cross-sectional view of an engagement portion of a holding member provided in a chromatograph system (second embodiment) according to the present invention.

Description of the symbols

1: chromatograph (chromatograph system)

2: holding member

21: base part

22A: a first clamping part

22B: second clamping part

221: projection part

222: outer inclined part (inclined part)

223: vent hole

224: first inner inclined part

225: second inner inclined part

226: straight line part

227: boundary portion

23A: a first engaging part

23B: second engaging part

231: cone part

232: cone part

3: fixing plate

31: through hole

32: group of through holes

32A: first through-hole group

32B: second through hole group

32C: third through hole group

32D: fourth through hole group

33: tab

331: plug-in hole

34: reinforcing part

6: tubular column oven

61: frame body

611: upper side wall part

612: lower side wall part

613: side wall part

614: partition wall part

615: the first space

616: second space

617: discharge port

618: suction opening

62: swirling flow generating part

621: fan blower

63: heating part

631: heating device

10: system management device

11: device body

12: tubular column unit

121: analytical column

122: a second storage part

123: basal end part

124: front end part

125: intermediate section

13: flow path

14: analysis condition setting unit

15: determination unit

16: a first storage part

17: input unit

20: liquid feeding device

40: automatic sampler

80: detector

AR: air (a)

EX₂₂₁: amount of protrusion

F₂₂: counterforce (restoring force)

F₂₃: counterforce (restoring force)

LY₂₂: length of

O_23A: center shaft

O_23B: center shaft

Q: moving phase

φd₁₂₅: outer diameter

φd₂₃: outer diameter

Detailed Description

Hereinafter, the column oven and the chromatograph according to the present invention will be described in detail based on preferred embodiments shown in the attached drawings.

< first embodiment >

Fig. 1 is a schematic diagram (block diagram) showing a first embodiment of a chromatograph system according to the present invention. Fig. 2 is a vertical partial sectional view showing an internal structure of a column oven provided in the chromatograph system shown in fig. 1. Fig. 3 is a perspective view showing a part of the internal structure of the column oven shown in fig. 2. Fig. 4 is a view seen from the direction of arrow a in fig. 3.

For convenience of explanation, hereinafter, a direction in the horizontal direction is referred to as an "X-axis direction", a direction perpendicular to the X-axis in the horizontal direction is referred to as a "Y-axis direction", and a direction perpendicular to the X-axis direction and the Y-axis direction, which is a vertical direction, is referred to as a "Z-axis direction". The arrow side in each axial direction is referred to as "positive side", and the opposite side to the arrow is referred to as "negative side". In fig. 2 and 3, the upper side is referred to as "upper (or upper)" and the lower side is referred to as "lower (or lower)".

In the following, as an example, a case will be described in which the chromatograph system 1 is applied to a liquid chromatograph system that analyzes a liquid sample, which is one type of the mobile phase Q, under a plurality of analysis conditions, but the chromatograph system 1 can be similarly applied to a supercritical fluid chromatograph system or a gas chromatograph system.

As shown in fig. 1, a chromatograph system 1 includes a liquid feeding device 20, an automatic sampler 40, a column oven 6, a detector 80, and a system management device 10, which constitute a device main body 11 in the chromatograph system 1; and an analytical column 121 that is detachably replaceable with respect to the apparatus main body 11.

The liquid feeding device 20, the automatic sampler 40, the column oven 6, and the detector 80 are arranged in this order from the upstream side to the downstream side in the direction in which the mobile phase Q flows. The liquid feeding device 20, the automatic sampler 40, the column oven 6, and the detector 80 are connected via pipes constituting the flow path 13. The mobile phase Q can flow through the flow path 13.

The mobile phase Q may be a sample to be analyzed, and may be a buffer solution used for analysis, a cleaning solution such as an organic solvent for cleaning a stationary phase, or the like.

The system management device 10 is electrically connected to the liquid feeding device 20, the automatic sampler 40, the column oven 6, and the detector 80. The system management device 10 includes, for example, a Central Processing Unit (CPU) that performs logical operations, a Read Only Memory (ROM) that stores an operation program necessary for controlling the liquid delivery device 20 and the like, a Random Access Memory (RAM) that temporarily stores data and the like during control, and the like, and can control the entire spectrometer 1.

The liquid feeding device 20 includes, for example, a liquid feeding pump, and the mobile phase Q can be fed to the downstream side in the flow path 13 by the liquid feeding pump. The transfer speed of the mobile phase Q can be adjusted by changing the rotational speed of the liquid-feeding pump.

The autosampler 40 injects the mobile phase Q into the flow path 13.

The column oven 6 may be filled with an analytical column 121. Thus, the analysis column 121 is disposed in the middle of the flow path 13, and the sample can be injected from the auto-sampler 40 into the mobile phase Q and can be circulated (passed) inside. In this case, the sample can be separated into a plurality of components.

This column oven 6 can heat the analytical column 121 (along with the sample). This makes it possible to adjust the temperature of the sample to a predetermined temperature. The structure of the column oven 6 will be described later.

The detector 80 is used to detect the components separated by the analytical column 121.

Further, as shown in fig. 1, the chromatograph 1 includes a system management apparatus 10. The system management device 10 includes an analysis condition setting unit 14, a determination unit 15, an input unit 17, and a first storage unit (storage unit) 16.

In the chromatograph 1, the analytical column 121 constitutes the column unit 12 together with the second storage unit 122 attached to the analytical column 121. When the analytical column 121 is replaced, the replacement is performed together with the second storage section 122.

The analysis condition setting unit 14 can set a plurality of analysis conditions. The analysis conditions include, for example, the type of sample, the type of stationary phase packed in the analysis column 121, and the like. Thus, the chromatograph 1 can analyze a sample under a plurality of analysis conditions.

For example, when there are two kinds of samples to be analyzed, the analysis condition setting unit 14 sets a first analysis condition when one of the samples is analyzed, and the analysis condition setting unit 14 sets a second analysis condition different from the first analysis condition when the other sample is analyzed. In the first analysis condition, an analysis column 121 suitable for the analysis of one of the samples is used, and in the second analysis condition, an analysis column 121 suitable for the analysis of the other sample is used.

The determination unit 15 determines whether or not the analysis condition set by the analysis condition setting unit 14 can be selected, for example.

The first storage unit 16 stores therein mobile phase information relating to the type of the mobile phase Q, for example. The first storage unit 16 can store mobile phase information, for example, by name or number of the mobile phase Q.

The second storage unit 122 stores, for example, second information that is individual information of the analysis column 121. In the present embodiment, the analytical column 121 is determined by the kind of the stationary phase filled inside. Then, from the second information, the analysis string 121 itself can be determined.

Next, the structure of the column oven 6 will be described.

As shown in fig. 2, the column oven 6 includes: the analyzer includes a housing 61, a swirling flow generating unit 62 that generates a swirling flow in the housing 61, a heating unit 63 that heats the analytical column 121 in the housing 61, a plurality of holding members 2 that hold the analytical column 121 in the housing 61, and a plate-shaped fixing plate 3 that detachably fixes the holding members 2 in the housing 61.

The frame 61 includes a case having an upper wall 611 disposed on the upper side, a lower wall 612 disposed on the lower side, and a plurality of side walls 613 disposed between the upper wall 611 and the lower wall 612. In addition, at least the wall portions of the frame 61 preferably have heat insulating properties.

The housing 61 has a partition wall 614 that partitions the interior into a first space 615 and a second space 616. In the configuration shown in fig. 2, the first space 615 is partitioned on the X-axis direction positive side and the second space 616 is partitioned on the X-axis direction negative side by the partition wall portion 614. Further, the analytical column 121, the holding member 2, and the fixing plate 3 are disposed in the first space 615. On the other hand, the swirling flow generating section 62 and the heating section 63 are disposed in the second space 616.

The heating unit 63 includes a heater 631 that generates heat by energization, and the air AR in the housing 61 (the second space 616) is heated by the heat generated by the heater 631. Then, by this air AR, the analytical column 121 (together with the sample) held by the holding member 2 can be heated. This makes it possible to adjust the temperature of the sample to a predetermined temperature.

The swirling flow generating section 62 is disposed above the heating section 63. The swirling flow generating portion 62 discharges the air AR heated by the heating portion 63 to the first space 615 as a swirling flow. The air AR discharged to the first space 615 is supplied to the analytical column 121 for heating.

The swirling flow generating unit 62 includes a fan (fan)621 rotatably supported, and generates a swirling flow by rotation of the fan. This can surely discharge the air AR into the first space 615 and make it contact the analytical column 121 without excess or deficiency, whereby the analytical column 121 can be heated to a desired temperature.

Further, the partition wall portion 614 is provided with: an outlet 617 for discharging the air AR in the second space 616 to the first space 615; and a suction port 618 located on the lower side of the discharge port 617 for sucking the air AR in the first space 615 into the second space 616. Thus, the air AR may circulate between the first space 615 and the second space 616. As described above, in the present embodiment, the analysis column 121 is configured to be heated by the circulating air AR, but the present invention is not limited to this, and for example, the analysis column 121 may be configured to be heated by radiant heat (radiant heat) generated by a heating block (heating block).

The analytical column 121 is elongated and is disposed along the Z-axis direction in the first space 615 of the housing 61. In the present embodiment, the analytical column 121 is disposed along the Z-axis direction, but is not limited thereto, and may be disposed along the X-axis direction or the Y-axis direction, for example.

The analytical column 121 has a base end 123 located on the upstream side in the flow direction of the mobile phase Q, a tip end 124 located on the downstream side in the flow direction, and an intermediate portion 125 between the tip end 124 and the base end 123. In the present embodiment, the analytical column 121 is used such that the base end 123 is disposed on the upper side and the tip end 124 is disposed on the lower side.

Of the base end portion 123, the tip end portion 124, and the intermediate portion 125 of the analytical column 121, the intermediate portion 125 is held by the holding member 2. In the present embodiment, the cross-sectional shape of the intermediate portion 125 is circular, and the outer diameter thereof is fixed along the Z-axis direction.

As shown in fig. 2, 3, the analytical column 121 is held by two holding members 2 within the first space 615. The two holding members 2 are preferably spaced apart as far as possible in the Z-axis direction. Thereby, the holding state of the analytical column 121 is stabilized. The number of the holding members 2 used for holding the analytical column 121 is two in the present embodiment, but the present invention is not limited thereto, and may be one, or three or more, for example.

Each holding member 2 is fixed to the frame 61 via the fixing plate 3. As shown in fig. 3, the fixing plate 3 has a plate shape, and is disposed entirely in parallel with the Y axis and the Z axis, that is, in parallel with the YZ plane.

The fixing plate 3 has a plurality of through holes 31 penetrating in the thickness direction. Each through hole 31 is a portion to which the holding member 2 is detachably attached. Each through hole 31 is circular when viewed from a direction facing the fixed plate 3.

The through holes 31 constitute through hole groups 32 arranged at equal intervals in the Y-axis direction, and four through hole groups 32 are arranged in the Z-axis direction. Hereinafter, the four through hole groups 32 are referred to as a "first through hole group 32A", a "second through hole group 32B", a "third through hole group 32C", and a "fourth through hole group 32D" in this order from the upper side. The first through-hole group 32A and the second through-hole group 32B are arranged in the Y-axis direction with a shift of half the distance between two adjacent through-holes 31 in the Y-axis direction. Similarly, the third through hole group 32C and the fourth through hole group 32D are arranged in the Y axis direction by being shifted by half the distance between two adjacent through holes 31 in the Y axis direction. When the holding member 2 is fixed to the fixed plate 3, the through holes 31 of the fourth through-hole group 32D are used when the through holes 31 of the first through-hole group 32A are used, and the through holes 31 of the third through-hole group 32C are used when the through holes 31 of the second through-hole group 32B are used.

The fixed plate 3 has a plurality of projecting pieces 33 projecting toward the X-axis direction positive side on the Y-axis direction positive side and the negative side, respectively. Insertion holes 331 through which screws (bolts) are inserted are formed through the projecting pieces 33. This allows the fixing plate 3 to be fixed to the frame 61 by screwing.

The fixed plate 3 has a reinforcing portion 34 that protrudes to the negative side in the X-axis direction and extends in the Y-axis direction. The reinforcing portion 34 prevents the fixing plate 3 from flexing in the X-axis direction. This allows the holding member 2 to be smoothly attached to and detached from the fixed plate 3.

The material of the fixing plate 3 is not particularly limited, and a relatively hard metal material such as stainless steel is preferably used.

Since the two holding members 2 holding the analytical column 121 have the same configuration, one holding member 2 will be representatively described.

As shown in fig. 4, the holding member 2 includes: the base 21, the first clamping portion 22A and the second clamping portion 22B protruding toward the X-axis direction positive side of the base 21, and the first engaging portion 23A and the second engaging portion 23B protruding toward the X-axis direction negative side of the base 21.

In the holding member 2, the base 21, the first clamping portion 22A, the second clamping portion 22B, the first engaging portion 23A, and the second engaging portion 23B are integrally formed, and include an elastic body. Thus, for example, a metal mold can be used for manufacturing the holding member 2. In this case, the holding member 2 can be quickly and easily molded. The holding member 2 obtained by this molding includes one member, and is different from, for example, a joint body obtained by joining a plurality of members. Therefore, the holding member 2 can be made into a simple configuration. Further, since the structure is simple, the manufacturing cost for manufacturing the holding member 2 can be suppressed accordingly, and the cost can be reduced. Furthermore, the elastomer is elastic and is a material suitable for holding (clamping) the analytical column 121. Furthermore, the elastic body is a material suitable for stably holding the analytical column 121 because it easily generates friction with the analytical column 121. Furthermore, the elastic force or the frictional force of the elastic body can be adjusted by adjusting the composition.

The elastic body constituting the holding member 2 is a rubber material, and the rubber material is not particularly limited, and examples thereof include various rubber materials such as urethane rubber, silicone rubber, and fluororubber. Among these rubber materials, silicone rubber is particularly preferably used. The silicone rubber is excellent in heat resistance and chemical resistance, and is suitable for the chromatograph 1 that heats the analytical column 121 or uses various chemicals together.

The base 21 has a plate shape, and is arranged such that the longitudinal direction is parallel to the Y-axis direction, the width direction is parallel to the Z-axis direction, and the thickness direction is parallel to the X-axis direction. The base 21 is disposed on the X-axis direction positive side with respect to the fixed plate 3.

As shown in fig. 4, a first clamping portion 22A and a second clamping portion 22B are provided on the X-axis direction positive side of the base portion 21. The first clamping section 22A and the second clamping section 22B are disposed at a distance from each other in the Y-axis direction, and can clamp any portion of the intermediate section 125 of the analytical column 121. Thereby, the analytical column 121 can be stably held. Hereinafter, a state in which the first clamping section 22A and the second clamping section 22B clamp and hold the analytical column 121 is referred to as a "clamped state".

In order to realize the clamped state, the analytical column 121 is pushed toward the X-axis direction negative side between the first clamping portion 22A and the second clamping portion 22B. Further, the analytical column 121 is pulled out to the X-axis direction positive side in order to separate the analytical column 121 from between the first grip portion 22A and the second grip portion 22B.

The first clamping section 22A and the second clamping section 22B have the same configuration and are arranged symmetrically with respect to the analytical column 121. The configuration of the first clamping portion 22A will be representatively described. In the description, the side of the first clamping portion 22A facing the second clamping portion 22B is referred to as the "inner side", and the opposite side is referred to as the "outer side".

The first clip portion 22A is formed to directly protrude from the base portion 21 while maintaining the same width as the base portion 21. In the clamped state, the first clamping portion 22A has a protruding portion 221 that protrudes toward the X-axis direction positive side, which is the opposite side of the base portion 21 with respect to the analytical column 121.

The protrusion 221 protrudes to the positive side in the X-axis direction from the analytical column 121 in the clamped state, and has an outer diameter φ d which is the thickness of the middle portion 125 of the analytical column 121₁₂₅Is irrelevant. Thus, the holding member 2 can be applied to the outer diameter phid of which the intermediate portion 125 has various sizes₁₂₅The analytical column 121.

The projecting amount EX of the projecting portion 221₂₂₁Preferably the outer diameter phid₁₂₅The thickness of the intermediate portion 125 is 2 times or more and 3 times or less, and more preferably 2.1 times or more and 2.2 times or less. This can prevent the protrusion 221 from protruding excessively, for example, and thus can smoothly perform the operation of attaching and detaching the analytical column 121 to and from the holding member 2.

The first clamping portion 22A has an outer inclined portion (inclined portion) 222 inclined with respect to the base portion 21 at an outer portion that is a portion on the opposite side of the analytical column 121 in the clamped state.

Thus, the first clamping portion 22A has a length LY along the Y-axis direction₂₂A shape that increases from the positive side toward the negative side in the X-axis direction. In other words, the first clamping portion 22A is thicker than the distal root. Thus, when the first clamping portion 22A is deformed toward the Y-axis direction negative side in the clamped state, a reaction force (restoring force) F toward the Y-axis direction positive side is easily generated₂₂. By this reaction force F₂₂The first clamping portion 22A can sufficiently clamp the analysis column 121 between the second clamping portion 22B.

The first clamping portion 22A has a vent hole 223, and the vent hole 223 includes a through hole penetrating in the Z-axis direction, which is the longitudinal direction of the analytical column 121 in the clamped state. Air AR may pass through the vent 223. Thereby preventing or suppressing the flow of the heated air AR supplied to the analytical column 121 in the first space 615 from being obstructed by the holding member 2, whereby the analytical column 121 can be uniformly heated.

When the first clamping portion 22A is viewed from the Z-axis direction, the proportion of the vent holes 223 in the first clamping portion 22A is preferably 20% or more and 30% or less, and more preferably about 25%. This ensures the clamping force of the first clamping portion 22A and also ensures sufficient passage of the air AR through the vent hole 223.

The first clamping portion 22A has, at its inner portion, a first inner inclined portion 224 inclined such that the distance from the second clamping portion 22B gradually decreases toward the base portion 21 side, a second inner inclined portion 225 inclined such that the distance increases toward the base portion 21 side, and a straight portion 226 between the first and second inner inclined portions.

In the first inner inclined portion 224, the analytical column 121 is easily inserted between the first clamping portion 22A and the second clamping portion 22B.

In the second inside inclined portion 225, the analytical column 121 is held.

Further, a boundary 227 between the second inner inclined portion 225 of the first clamping portion 22A and the second inner inclined portion 225 of the second clamping portion 22B is rounded along the outer circumference of the intermediate portion 125 of the analytical column 121. This increases the contact area with the intermediate portion 125, and stabilizes the clamped state.

As shown in fig. 4, a first engaging portion 23A and a second engaging portion 23B are provided on the opposite side of the base portion 21 from the first clamping portion 22A and the second clamping portion 22B. The first engaging portion 23A and the second engaging portion 23B each have a cylindrical shape and are inserted into and engaged with the through hole 31 of the fixed plate 3. This causes the holding member to be fixed to the fixed plate 3. Then, by pulling out the first engaging portion 23A and the second engaging portion 23B from the through-holes 31 from the above-described fixed state, the holding member can be disengaged from the fixed plate 3, and the fixed state can be released.

The first engaging portion 23A has an outer diameter phid₂₃The tapered portion 231 is rounded so as to decrease toward the negative side in the X-axis direction (the same applies to the second engagement portion 23B). This allows the first engaging portion 23A to be easily inserted into the through hole 31, thereby allowing the holding member to be smoothly attached to the fixed plate 3.

The first engaging portion 23A and the second engaging portion 23B are arranged at a distance from each other in the Y-axis direction, which is a direction in which the first clamping portion 22A and the second clamping portion 22B are arranged. Thereby, the holding member is firmly fixed to the fixed plate 3 even in the clamped state, whereby the posture of the analytical column 121 in the Z-axis direction can be maintained. This posture is a preferable posture for analysis using the analysis string 121.

As described above, the first clamping portion 22A and the second clamping portion 22B are deformed in the Y-axis direction away from each other in the clamped state. Further, the holding member includes an elastic body of an elastic material as a whole. Accordingly, the first engaging portion 23A and the second engaging portion 23B are respectively urged in the direction in which the two engaging portions approach each other by the force F in accordance with the deformation of the respective clamping portions₂₃. Accordingly, the engaging force of the first engaging portion 23A and the second engaging portion 23B with respect to the through hole 31 of the fixed plate 3 is increased, and thereby the holding member in the clamped state is prevented from being detached from the fixed plate 3 together with the analytical column 121 regardless of the weight of the analytical column 121. This makes it possible to stably perform analysis using the analytical column 121.

Of these two engaging portions, the first engaging portion 23Central axis O of A (one of the engaging parts)_23AThe first clamping portion 22A is disposed on the extension line of the direction, and the center axis O of the second engaging portion 23B (the other engaging portion)_23BThe second clamping portion 22B is arranged on an extension of the direction. With this arrangement, when the first clamping portion 22A and the second clamping portion 22B are deformed as described above, the force F to the first engaging portion 23A and the second engaging portion 23B is reliably obtained₂₃And not excessive or insufficient.

In the present embodiment, the holding member has two engaging portions in total, i.e., the first engaging portion 23A and the second engaging portion 23B, but the number of the engaging portions is not limited thereto, and may be one, three or more.

< second embodiment >

Fig. 5 is a horizontal cross-sectional view of an engagement portion of a holding member provided in a chromatograph system (second embodiment) according to the present invention.

Hereinafter, a second embodiment of the column oven and the chromatograph according to the present invention will be described with reference to the drawings, but differences from the above-described embodiments will be mainly described, and descriptions of the same matters will be omitted.

As shown in fig. 5, in the present embodiment, the first engaging portion 23A has an outer diameter Φ d on the base 21 side₂₃The tapered portion 232 is rounded so as to decrease toward the X-axis direction positive side (the same applies to the second engagement portion 23B). The taper 232 bends more steeply than the taper 231. This prevents the first engaging portion 23A from being unintentionally disengaged from the through hole 31 after the first engaging portion 23A is inserted into the through hole 31 of the fixed plate 3. Also, the fixing plate 3 may be sandwiched between the taper 232 and the base 31. This reliably maintains the fixed state of the holding member 2 on the fixed plate 3 in cooperation with the engagement of the first engaging portion 23A with respect to the through hole 31.

The column oven and the chromatograph of the present invention have been described above with respect to the illustrated embodiments, but the present invention is not limited thereto, and the respective parts constituting the column oven and the chromatograph may be replaced with any structures that can exhibit the same function. Further, any structure may be added.

Further, the column oven and the chromatograph of the present invention may be combined with two or more arbitrary configurations (features) of the above-described embodiments.