阅读说明：本技术 用于耗尽cd117+细胞的组合物和方法 (Compositions and methods for depleting CD117+ cells ) 是由 布拉德利·R·皮尔斯 安东尼·博伊坦诺 拉胡尔·帕尔乔杜里 肖恩·麦克唐纳 拉吉夫·潘瓦尔 于 2018-10-23 设计创作，主要内容包括：本发明提供了组合物和方法,该组合物和方法可用于耗尽CD117+细胞,以及用于治疗尤其是多种造血疾病、代谢紊乱、癌症和自身免疫性疾病。本文描述了抗体、其抗原结合片段、及缀合物,它们可以被应用于通过例如耗尽患者诸如人类的CD117+细胞的群体来实现对这些状况的治疗。本文描述的组合物和方法可以用于通过例如耗尽CD117+癌细胞或自身免疫性细胞的群体来直接治疗紊乱。本文描述的组合物和方法还可以用于准备患者以便于造血干细胞移植疗法,并且通过在移植程序之前选择性地耗尽内源性造血干细胞来改善造血干细胞移植物的植入。(The present invention provides compositions and methods useful for depleting CD117+ cells, and for treating, inter alia, a variety of hematopoietic diseases, metabolic disorders, cancer, and autoimmune diseases. Described herein are antibodies, antigen-binding fragments thereof, and conjugates that can be applied to achieve treatment of these conditions by, for example, depleting a population of CD117+ cells in a patient, such as a human. The compositions and methods described herein can be used to directly treat a disorder by, for example, depleting a population of CD117+ cancer cells or autoimmune cells. The compositions and methods described herein can also be used to prepare patients for hematopoietic stem cell transplantation therapy and to improve engraftment of hematopoietic stem cell grafts by selectively depleting endogenous hematopoietic stem cells prior to the transplantation procedure.)