阅读说明：本技术 作为ros1激酶抑制剂的大环化合物 (Macrocyclic compounds as ROS1 kinase inhibitors ) 是由 S.W.安德鲁斯 J.F.布莱克 J.哈斯 G.R.科拉科夫斯基 于 2018-03-16 设计创作，主要内容包括：用式I的化合物和其药学上可接受的盐抑制ROS1激酶的方法,其中环A、环B、W、m、D、R<Sup>2</Sup>、R<Sup>2a</Sup>、R<Sup>3</Sup>、R<Sup>3a</Sup>和Z如本文定义。本文提供的化合物和方法可用于治疗癌症(例如,如本文定义的ROS1相关癌症)。<Image he="175" wi="230" file="344296DEST_PATH_IMAGE002.GIF" imgContent="drawing" imgFormat="GIF" orientation="portrait" inline="no"></Image>(A method of inhibiting ROS1 kinase with a compound of formula I, and pharmaceutically acceptable salts thereof, wherein Ring A, Ring B, W, m, D, R 2 、R 2a 、R 3 、R 3a And Z is as defined herein. The compounds and methods provided herein are useful for treating cancer (e.g., ROS 1-related cancer, as defined herein).)