阅读说明：本技术 用于治疗代谢性病症的组合物和方法 (Compositions and methods for treating metabolic disorders ) 是由 A.D.贝伦 M.S.芬曼 N.R.A.比利 于 2013-01-05 设计创作，主要内容包括：本发明提供了用于改善双胍化合物的胃肠道耐受性和用于治疗有需要的患者、特别是患有使用双胍化合物治疗的禁忌症的个体的代谢性病症和/或诱导重量减轻的方法,所述方法包括施用靶向小肠的包括二甲双胍的此类双胍化合物的延迟释放制剂。(The present invention provides methods for improving the gastrointestinal tolerance of biguanide compounds and for treating metabolic disorders and/or inducing weight loss in a patient in need thereof, in particular in an individual suffering from contraindications to treatment with a biguanide compound, said methods comprising administering a delayed-release formulation of such biguanide compounds including metformin targeted to the small intestine.)