阅读说明：本技术 用于治疗亨廷顿病的方法 (Methods for treating huntington's disease ) 是由 苏雷什·巴布 阿努拉哈·巴特查里亚 成宇·黄 米纳基·贾尼 文荣春 纳迪亚·瑟多伦科 于 2016-12-11 设计创作，主要内容包括：本发明涉及用于治疗亨廷顿病的方法,本发明公开了一种使用化合物治疗或改善有此需要的对象中的HD的方法,所述方法包括给所述对象施用有效量的式(I)化合物或其形式。(The present invention relates to a method for treating huntington's disease, which discloses a method of treating or ameliorating HD in a subject in need thereof using a compound, the method comprising administering to the subject an effective amount of a compound of formula (I) or a form thereof.)

1. A method of using a compound to treat or ameliorate HD in a subject in need thereof, the method comprising administering to the subject an effective amount of a compound of formula (I):

wherein the content of the first and second substances,

w is CH ═ CH or S;

x is CH₂、CH(C_1-4Alkyl group), C (C)_1-4Alkyl radical)₂、CH＝CH、O、NR₅Or a bond;

a is aryl, heteroaryl, heterocyclyl, or C_9-10A cycloalkyl group,

wherein aryl is selected from phenyl and naphthyl, each optionally substituted with 1,2,3 or 4 substituents, each selected from R₁，

Wherein heteroaryl is a saturated monocyclic, bicyclic, or tricyclic ring system having 1,2, or 3 heteroatom ring members independently selected from N, O or S, each said ring system optionally substituted with 1,2,3,4, or 5 substituents each selected from R₁，

Wherein heterocyclyl is a saturated or partially unsaturated monocyclic, bicyclic or tricyclic ring system having 1,2, or 3 heteroatom ring members independently selected from N, O or S, each said ring system being optionally substituted with 1,2,3,4, or 5 substituents each selected from R₂And are and

wherein, C_9-10Cycloalkyl is a saturated or partially unsaturated bicyclic ring system optionally substituted with 1,2,3,4, or 5 substituents each selected from R₂；

B is a heterocyclic group, and B is a heterocyclic group,

wherein heterocyclyl is a saturated or partially unsaturated monocyclic, bicyclic, or polycyclic ring system having 1,2, or 3 heteroatom ring members independently selected from N, O or S, each said ring system optionally substituted with 1,2,3,4, or 5 substituents each selected from R₄；

R₁Is halogen, hydroxy, cyano, C_1-4Alkyl, halo-C_1-4Alkyl, amino, C_1-4Alkyl-amino, (C)_1-4Alkyl radical)₂-amino, amino-C_1-4Alkyl radical, C_1-4alkyl-amino-C_1-4Alkyl, (C)_1-4Alkyl radical)₂-amino-C_1-4Alkyl, amino-carbonyl, C_1-4Alkyl-amino-carbonyl, (C)_1-4Alkyl radical)₂-amino-carbonyl, C_1-4alkyl-amino-carbonyl-C_1-4Alkyl, (C)_1-4Alkyl radical)₂-amino-carbonyl-C_1-4Alkyl radical, C_1-4Alkyl-carbonyl-amino, C_1-4alkyl-carbonyl-amino-C_1-4Alkyl, hydroxy-C_1-4Alkyl radical, C_1-4Alkyl-carbonyl, C_1-4Alkoxy, halo-C_1-4Alkoxy, amino-C_1-4Alkoxy, hydroxy-C_1-4Alkoxy radical, C_1-4alkyl-C_1-4Alkoxy radical, C_1-4alkyl-amino-C_1-4Alkoxy group, (C)_1-4Alkyl radical)₂-amino-C_1-4Alkoxy radical, C_1-4alkyl-carbonyl-amino-C_1-4Alkoxy radical, C_1-4alkoxy-C_1-4Alkoxy radical, C_1-4Alkoxy-carbonyl, C_1-4Alkoxy-carbonyl-amino, C_1-4alkoxy-carbonyl-amino-C_1-4Alkoxy radical, C_2-4Alkenyl radical, C_2-4Alkenyl-amino-carbonyl, C_3-7Cycloalkyl radical, C_3-7cycloalkyl-C_1-4Alkoxy radical, C_3-7Cycloalkenyl, heteroaryl-C_1-4Alkyl, heteroaryl-C_1-4Alkyl-amino, heteroaryl-C_1-4Alkyl-amino-carbonyl, heteroaryl-C_1-4Alkyl-carbonyl-amino, heteroaryl-C_1-4alkyl-amino-carbonyl-C_1-4Alkyl, heteroaryl-C_1-4alkyl-carbonyl-amino-C_1-4Alkyl, heterocyclyl-C_1-4Alkyl, heterocyclyl-C_1-4Alkoxy, phenyl, or phenyl-C_1-4An alkoxy group,

wherein heteroaryl is a saturated monocyclic or bicyclic ring system having 1,2, or 3 heteroatom ring members selected from N, O and S,

wherein heterocyclyl is a saturated or partially unsaturated monocyclic or bicyclic ring system having 1,2, or 3 heteroatom ring members selected from N, O and S, and

wherein each instance of phenyl, heteroaryl or heterocyclyl is optionally substituted by 1 or 2Substituted with substituents, each of said substituents being selected from R₃；

R₂Is halogen, hydroxy, cyano, oxo, hydroxy-imino, C_1-4Alkyl, halo-C_1-4Alkyl, amino, C_1-4Alkyl-amino, (C)_1-4Alkyl radical)₂-amino, amino-C_1-4Alkyl radical, C_1-4alkyl-amino-C_1-4Alkyl, (C)_1-4Alkyl radical)₂-amino-C_1-4Alkyl, amino-carbonyl, hydroxy-C_1-4Alkyl radical, C_1-4Alkoxy radical, C_1-4Alkoxy-carbonyl, C_2-4Alkenyl radical, C_3-7Cycloalkyl, or heterocyclyl-C_1-4An alkyl group, a carboxyl group,

wherein heterocyclyl is a saturated or partially unsaturated monocyclic or bicyclic ring system having 1,2, or 3 heteroatom ring members selected from N, O and S, and

wherein each instance of the heterocyclyl is optionally substituted with 1 or 2 substituents each of which is selected from R₃；

R₃Is halogen, hydroxy, nitro, oxo, hydroxy-imino, C_1-4Alkyl, amino, C_1-4Alkyl-amino, (C)_1-4Alkyl radical)₂-amino, amino-C_1-4Alkyl radical, C_1-4alkyl-amino-C_1-4Alkyl, (C)_1-4Alkyl radical)₂-amino-C_1-4Alkyl, amino-carbonyl, C_1-4Alkyl-amino-carbonyl, (C)_1-4Alkyl radical)₂-amino-carbonyl, C_1-4alkyl-amino-carbonyl-C_1-4Alkyl, (C)_1-4Alkyl radical)₂-amino-carbonyl-C_1-4Alkyl radical, C_1-4Alkyl-carbonyl-amino, C_1-4alkyl-carbonyl-amino-C_1-4Alkyl, hydroxy-C_1-4Alkyl radical, C_1-4Alkyl-carbonyl, C_1-4Alkoxy, halo-C_1-4Alkoxy, amino-C_1-4Alkoxy, hydroxy-C_1-4Alkoxy radical, C_1-4alkyl-C_1-4Alkoxy radical, C_1-4alkyl-amino-C_1-4Alkoxy group, (C)_1-4Alkyl radical)₂-amino-C_1-4Alkoxy radical,C_1-4alkyl-carbonyl-amino-C_1-4Alkoxy radical, C_1-4alkoxy-C_1-4Alkoxy radical, C_1-4Alkoxy-carbonyl, C_1-4Alkoxy-carbonyl-amino, C_1-4alkoxy-carbonyl-amino-C_1-4Alkoxy radical, C_2-4Alkenyl radical, C_2-4Alkenyl-amino-carbonyl, C_3-7Cycloalkyl radical, C_3-7cycloalkyl-C_1-4Alkoxy radical, C_3-7Cycloalkenyl, heteroaryl-C_1-4Alkyl, heteroaryl-C_1-4Alkyl-amino, heteroaryl-C_1-4Alkyl-amino-carbonyl, heteroaryl-C_1-4Alkyl-carbonyl-amino, heteroaryl-C_1-4alkyl-amino-carbonyl-C_1-4Alkyl, heteroaryl-C_1-4alkyl-carbonyl-amino-C_1-4Alkyl, heterocyclyl-C_1-4Alkyl, phenyl, or phenyl-C_1-4An alkoxy group;

R₄independently selected from halogen, C_1-4Alkyl, hydroxy-C_1-4Alkyl, amino, C_1-4Alkyl-amino, (C)_1-4Alkyl radical)₂-amino, or hydroxy-C_1-4An alkyl-amino group; and

R₅is hydrogen, C_1-4Alkyl, or hydroxy-C_1-4An alkyl group;

wherein the form of the compound is selected from the group consisting of: a prodrug form, a salt form, a hydrate form, a solvate form, a clathrate form, an isotopologue form, a racemate form, an enantiomeric form, a diastereomeric form, a stereoisomeric form, a polymorphic form, and a tautomeric form thereof.

2. The method of claim 1, wherein the compound of formula (I) is selected from compounds of formula (Ia) and formula (Ib) or forms thereof:

wherein the content of the first and second substances,

x is CH₂、CH(C_1-4Alkyl group), C (C)_1-4Alkyl radical)₂、CH＝CH、O、NR₅Or a bond;

a is aryl, heteroaryl, heterocyclyl, or C_9-10A cycloalkyl group,

wherein aryl is selected from phenyl and naphthyl, each optionally substituted with 1,2,3 or 4 substituents, each selected from R₁，

Wherein heteroaryl is a saturated monocyclic, bicyclic, or tricyclic ring system having 1,2, or 3 heteroatom ring members independently selected from N, O or S, each said ring system optionally substituted with 1,2,3,4, or 5 substituents each selected from R₁，

Wherein heterocyclyl is a saturated or partially unsaturated monocyclic, bicyclic or tricyclic ring system having 1,2, or 3 heteroatom ring members independently selected from N, O or S, each said ring system being optionally substituted with 1,2,3,4, or 5 substituents each selected from R₂And are and

wherein, C_9-10Cycloalkyl is a saturated or partially unsaturated bicyclic ring system optionally substituted with 1,2,3,4, or 5 substituents each selected from R₂；

B is a heterocyclic group, and B is a heterocyclic group,

wherein heterocyclyl is a saturated or partially unsaturated monocyclic, bicyclic, or polycyclic ring system having 1,2, or 3 heteroatom ring members independently selected from N, O or S, each said ring system optionally substituted with 1,2,3,4, or 5 substituents each selected from R₄；

R₁Is halogen, hydroxy, cyano, C_1-4Alkyl, halo-C_1-4Alkyl, amino, C_1-4Alkyl-amino, (C)_1-4Alkyl radical)₂-amino, amino-C_1-4Alkyl radical, C_1-4alkyl-amino-C_1-4Alkyl, (C)_1-4Alkyl radical)₂-amino-C_1-4Alkyl, amino-carbonyl, C_1-4Alkyl-amino-carbonyl, C_1-4alkyl-amino-carbonyl-C_1-4Alkyl radical, C_1-4Alkyl-carbonyl-amino, C_1-4alkyl-carbonyl-amino-C_1-4Alkyl, hydroxy-C_1-4Alkyl radical, C_1-4Alkyl-carbonyl, C_1-4Alkoxy, halo-C_1-4Alkoxy, amino-C_1-4Alkoxy, hydroxy-C_1-4Alkoxy radical, C_1-4alkyl-C_1-4Alkoxy radical, C_1-4alkyl-amino-C_1-4Alkoxy group, (C)_1-4Alkyl radical)₂-amino-C_1-4Alkoxy radical, C_1-4alkyl-carbonyl-amino-C_1-4Alkoxy radical, C_1-4alkoxy-C_1-4Alkoxy radical, C_1-4Alkoxy-carbonyl, C_1-4Alkoxy-carbonyl-amino, C_1-4alkoxy-carbonyl-amino-C_1-4Alkoxy radical, C_2-4Alkenyl radical, C_2-4Alkenyl-amino-carbonyl, C_3-7Cycloalkyl radical, C_3-7cycloalkyl-C_1-4Alkoxy radical, C_3-7Cycloalkenyl, heteroaryl-C_1-4Alkyl, heteroaryl-C_1-4Alkyl-amino, heteroaryl-C_1-4Alkyl-amino-carbonyl, heteroaryl-C_1-4Alkyl-carbonyl-amino, heteroaryl-C_1-4alkyl-amino-carbonyl-C_1-4Alkyl, heteroaryl-C_1-4alkyl-carbonyl-amino-C_1-4Alkyl, heterocyclyl-C_1-4Alkyl, heterocyclyl-C_1-4Alkoxy, phenyl, or phenyl-C_1-4An alkoxy group,

wherein heteroaryl is a saturated monocyclic or bicyclic ring system having 1,2, or 3 heteroatom ring members selected from N, O and S,

wherein heterocyclyl is a saturated or partially unsaturated monocyclic or bicyclic ring system having 1,2, or 3 heteroatom ring members selected from N, O and S, and

wherein each instance of phenyl, heteroaryl or heterocyclyl is optionally substituted with 1 or 2 substituents each selected from R₃；

R₂Is halogen, hydroxy, cyano, oxo, hydroxy-imino, C_1-4Alkyl, halo-C_1-4Alkyl, amino, C_1-4Alkyl-amino, (C)_1-4Alkyl radical)₂-amino, amino-C_1-4Alkyl, amino-carbonyl, hydroxy-C_1-4Alkyl radical, C_1-4Alkoxy radical, C_1-4Alkoxy-carbonyl, C_2-4Alkenyl radical, C_3-7Cycloalkyl, or heterocyclyl-C_1-4An alkyl group;

R₃is halogen, hydroxy, nitro, oxo, hydroxy-imino, C_1-4Alkyl, amino, C_1-4Alkyl-amino, (C)_1-4Alkyl radical)₂-amino, amino-C_1-4Alkyl radical, C_1-4alkyl-amino-C_1-4Alkyl, (C)_1-4Alkyl radical)₂-amino-C_1-4Alkyl, amino-carbonyl, C_1-4Alkyl-amino-carbonyl, C_1-4alkyl-amino-carbonyl-C_1-4Alkyl radical, C_1-4Alkyl-carbonyl-amino, C_1-4alkyl-carbonyl-amino-C_1-4Alkyl, hydroxy-C_1-4Alkyl radical, C_1-4Alkyl-carbonyl, C_1-4Alkoxy, halo-C_1-4Alkoxy, amino-C_1-4Alkoxy, hydroxy-C_1-4Alkoxy radical, C_1-4alkyl-C_1-4Alkoxy radical, C_1-4alkyl-amino-C_1-4Alkoxy group, (C)_1-4Alkyl radical)₂-amino-C_1-4Alkoxy radical, C_1-4alkyl-carbonyl-amino-C_1-4Alkoxy radical, C_1-4alkoxy-C_1-4Alkoxy radical, C_1-4Alkoxy-carbonyl, C_1-4Alkoxy-carbonyl-amino, C_1-4alkoxy-carbonyl-amino-C_1-4Alkoxy radical, C_2-4Alkenyl radical, C_2-4Alkenyl-amino-carbonyl, C_3-7Cycloalkyl radical, C_3-7cycloalkyl-C_1-4Alkoxy radical, C_3-7Cycloalkenyl, heteroaryl-C_1-4Alkyl, heteroaryl-C_1-4Alkyl-amino, heteroaryl-C_1-4Alkyl-amino-carbonyl, heteroaryl-C_1-4Alkyl-carbonyl-amino, heteroaryl-C_1-4alkyl-amino-carbonyl-C_1-4Alkyl, heteroaryl-C_1-4alkyl-carbonyl-amino-C_1-4Alkyl, heterocyclyl-C_1-4Alkyl, phenyl, or phenyl-C_1-4An alkoxy group;

R₄independently selected from halogen, C_1-4Alkyl, hydroxy-C_1-4Alkyl, amino, C_1-4Alkyl-amino, (C)_1-4Alkyl radical)₂-amino, or hydroxy-C_1-4An alkyl-amino group; and

R₅is hydrogen, C_1-4Alkyl, or hydroxy-C_1-4An alkyl group;

wherein the form of the compound is selected from the group consisting of: a prodrug form, a salt form, a hydrate form, a solvate form, a clathrate form, an isotopologue form, a racemate form, an enantiomeric form, a diastereomeric form, a stereoisomeric form, a polymorphic form, and a tautomeric form thereof.

3. The method of claim 1, wherein:

x is O, NH, N (CH)₃) Or a bond;

a is aryl, heteroaryl, or heterocyclyl,

wherein the aryl group is selected from the group consisting of:

wherein the heteroaryl is selected from the group consisting of:

wherein the heterocyclic group is selected from the group consisting of:

b is a heterocyclic group selected from the group consisting of:

r, where the available valency permits_1aAnd R_1bEach is one or more substituents independently selected from: halogen, hydroxy, cyano, C_1-4Alkyl, halo-C_1-4Alkyl, amino, C_1-4Alkyl-amino, (C)_1-4Alkyl radical)₂-amino, amino-C_1-4Alkyl radical, C_1-4alkyl-amino-C_1-4Alkyl, (C)_1-4Alkyl radical)₂-amino-C_1-4Alkyl, amino-carbonyl, C_1-4Alkyl-amino-carbonyl, (C)_1-4Alkyl radical)₂-amino-carbonyl, C_1-4alkyl-amino-carbonyl-C_1-4Alkyl, (C)_1-4Alkyl radical)₂-amino-carbonyl-C_1-4Alkyl radical, C_1-4Alkyl-carbonyl-amino, C_1-4alkyl-carbonyl-amino-C_1-4Alkyl, hydroxy-C_1-4Alkyl radical, C_1-4Alkyl-carbonyl, C_1-4Alkoxy, halo-C_1-4Alkoxy, amino-C_1-4Alkoxy, hydroxy-C_1-4Alkoxy radical, C_1-4alkyl-C_1-4Alkoxy radical, C_1-4alkyl-amino-C_1-4Alkoxy group, (C)_1-4Alkyl radical)₂-amino-C_1-4Alkoxy radical, C_1-4alkyl-carbonyl-amino-C_1-4Alkoxy radical, C_1-4Alkoxy radicalradical-C_1-4Alkoxy radical, C_1-4Alkoxy-carbonyl, C_1-4Alkoxy-carbonyl-amino, C_1-4alkoxy-carbonyl-amino-C_1-4Alkoxy radical, C_2-4Alkenyl radical, C_2-4Alkenyl-amino-carbonyl, C_3-7Cycloalkyl radical, C_3-7cycloalkyl-C_1-4Alkoxy radical, C_3-7Cycloalkenyl, heteroaryl-C_1-4Alkyl, heteroaryl-C_1-4Alkyl-amino, heteroaryl-C_1-4Alkyl-amino-carbonyl, heteroaryl-C_1-4Alkyl-carbonyl-amino, heteroaryl-C_1-4alkyl-amino-carbonyl-C_1-4Alkyl, heteroaryl-C_1-4alkyl-carbonyl-amino-C_1-4Alkyl, heterocyclyl-C_1-4Alkyl, heterocyclyl-C_1-4Alkoxy, phenyl, or phenyl-C_1-4An alkoxy group,

wherein heteroaryl is a saturated monocyclic or bicyclic ring system having 1,2, or 3 heteroatom ring members selected from N, O and S,

wherein heterocyclyl is a saturated or partially unsaturated monocyclic or bicyclic ring system having 1,2, or 3 heteroatom ring members selected from N, O and S, and

wherein each instance of phenyl, heteroaryl or heterocyclyl is optionally substituted with 1 or 2 substituents each selected from R₃；

R, where the available valency permits_2a、R_2bAnd R_2cEach is one or more substituents independently selected from: halogen, hydroxy, cyano, oxo, hydroxy-imino, C_1-4Alkyl, halo-C_1-4Alkyl, amino, C_1-4Alkyl-amino, (C)_1-4Alkyl radical)₂-amino, amino-C_1-4Alkyl radical, C_1-4alkyl-amino-C_1-4Alkyl, (C)_1-4Alkyl radical)₂-amino-C_1-4Alkyl, amino-carbonyl, hydroxy-C_1-4Alkyl radical, C_1-4Alkoxy radical, C_1-4Alkoxy-carbonyl, C_2-4Alkenyl radical, C_3-7Cycloalkyl, or heterocyclyl-C_1-4An alkyl group, a carboxyl group,

wherein heterocyclyl is a saturated or partially unsaturated monocyclic or bicyclic ring system having 1,2, or 3 heteroatom ring members selected from N, O and S, and

wherein each instance of the heterocyclyl is optionally substituted with 1 or 2 substituents each of which is selected from R₃；

R₃Is halogen, hydroxy, nitro, oxo, hydroxy-imino, C_1-4Alkyl, amino, C_1-4Alkyl-amino, (C)_1-4Alkyl radical)₂-amino, amino-C_1-4Alkyl radical, C_1-4alkyl-amino-C_1-4Alkyl, (C)_1-4Alkyl radical)₂-amino-C_1-4Alkyl, amino-carbonyl, C_1-4Alkyl-amino-carbonyl, (C)_1-4Alkyl radical)₂-amino-carbonyl, C_1-4alkyl-amino-carbonyl-C_1-4Alkyl, (C)_1-4Alkyl radical)₂-amino-carbonyl-C_1-4Alkyl radical, C_1-4Alkyl-carbonyl-amino, C_1-4alkyl-carbonyl-amino-C_1-4Alkyl, hydroxy-C_1-4Alkyl radical, C_1-4Alkyl-carbonyl, C_1-4Alkoxy, halo-C_1-4Alkoxy, amino-C_1-4Alkoxy, hydroxy-C_1-4Alkoxy radical, C_1-4alkyl-C_1-4Alkoxy radical, C_1-4alkyl-amino-C_1-4Alkoxy group, (C)_1-4Alkyl radical)₂-amino-C_1-4Alkoxy radical, C_1-4alkyl-carbonyl-amino-C_1-4Alkoxy radical, C_1-4alkoxy-C_1-4Alkoxy radical, C_1-4Alkoxy-carbonyl, C_1-4Alkoxy-carbonyl-amino, C_1-4alkoxy-carbonyl-amino-C_1-4Alkoxy radical, C_2-4Alkenyl radical, C_2-4Alkenyl-amino-carbonyl, C_3-7Cycloalkyl radical, C_3-7cycloalkyl-C_1-4Alkoxy radical, C_3-7Cycloalkenyl, heteroaryl-C_1-4Alkyl, heteroaryl-C_1-4Alkyl-amino, heteroaryl-C_1-4Alkyl-amino-carbonyl, heteroaryl-C_1-4Alkyl-carbonyl-amino, heteroaryl-C_1-4alkyl-amino-carbonyl-C_1-4Alkyl radicalheteroaryl-C_1-4alkyl-carbonyl-amino-C_1-4Alkyl, heterocyclyl-C_1-4Alkyl, phenyl, or phenyl-C_1-4An alkoxy group; and

R_4a、R_4b、R_4c、R_4d、R_4e、R_4fand R_4gIndependently selected from halogen, C_1-4Alkyl, hydroxy-C_1-4Alkyl, amino, C_1-4Alkyl-amino, (C)_1-4Alkyl radical)₂-amino, or hydroxy-C_1-4An alkyl-amino group;

wherein the form of the compound is selected from the group consisting of: a prodrug form, a salt form, a hydrate form, a solvate form, a clathrate form, an isotopologue form, a racemate form, an enantiomeric form, a diastereomeric form, a stereoisomeric form, a polymorphic form, and a tautomeric form thereof.

4. A method of treating or ameliorating HD in a subject in need thereof using a compound or a form thereof, the method comprising administering to the subject an effective amount of a compound selected from the group consisting of:

6- (naphthalen-2-yl) -N- (2,2,6, 6-tetramethylpiperidin-4-yl) pyridazin-3-amine

6- (benzo [ b ] thiophen-2-yl) -N-methyl-N- (2,2,6, 6-tetramethylpiperidin-4-yl) pyridazin-3-amine

2- (6- (2,2,6, 6-tetramethylpiperidin-4-yl-amino) -pyridazin-3-yl) phenol

2- (6- (methyl- (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) benzo [ b ] -thiophene-5-carbonitrile

6- (quinolin-3-yl) -N- (2,2,6, 6-tetramethylpiperidin-4-yl) pyridazin-3-amines

3- (benzo [ b ] -thiophen-2-yl) -6- (2,2,6, 6-tetramethylpiperidin-4-yl-oxy) pyridazine

2- (6- (methyl- (2,2,6, 6-tetramethylpiperidin-4-yl) amino) -pyridazin-3-yl) phenol

6- (6- (methyl- (2,2,6, 6-tetramethylpiperidin-4-yl) amino) -pyridazin-3-yl) naphthalen-2-ol

6- (benzo [ b ] -thiophen-2-yl) -N- (2,2,6, 6-tetramethylpiperidin-4-yl) pyridazin-3-amines

7- (6- ((2,2,6, 6-tetramethylpiperidin-4-yl) oxy) pyridazin-3-yl) isoquinoline

6- (6- ((2,2,6, 6-tetramethylpiperidin-4-yl) oxy) pyridazin-3-yl) isoquinoline

N-methyl-6- (quinolin-7-yl) -N- (2,2,6, 6-tetramethylpiperidin-4-yl) pyridazin-3-amine

N-methyl-6- (quinolin-6-yl) -N- (2,2,6, 6-tetramethylpiperidin-4-yl) pyridazin-3-amine

6- (isoquinolin-7-yl) -N-methyl-N- (2,2,6, 6-tetramethylpiperidin-4-yl) pyridazin-3-amine

6- (isoquinolin-6-yl) -N-methyl-N- (2,2,6, 6-tetramethylpiperidin-4-yl) pyridazin-3-amine

6- (imidazo [1,2-a ] pyridin-6-yl-pyridazin-3-yl) -methyl- (2,2,6, 6-tetramethylpiperidin-4-yl) -amine

N-methyl-6- (6-phenylpyridin-3-yl) -N- (2,2,6, 6-tetramethylpiperidin-4-yl) pyridazin-3-amine

6- (6- (1H-pyrrol-1-yl) pyridin-3-yl) -N-methyl-N- (2,2,6, 6-tetramethylpiperidin-4-yl) pyridazin-3-amine

6- (6- (1H-pyrazol-1-yl) pyridin-3-yl) -N-methyl-N- (2,2,6, 6-tetramethylpiperidin-4-yl) pyridazin-3-amine

Methyl- (6-quinoxalin-2-yl-pyridazin-3-yl) - (2,2,6, 6-tetramethylpiperidin-4-yl) -amine

Methyl- (6-quinolin-3-yl-pyridazin-3-yl) - (2,2,6, 6-tetramethylpiperidin-4-yl) -amine

N-methyl-6- (phthalazin-6-yl) -N- (2,2,6, 6-tetramethylpiperidin-4-yl) pyridazin-3-amine

6- (benzo [ c ] [1,2,5] oxa-oxadiazol-5-yl) -N- (2,2,6, 6-tetramethylpiperidin-4-yl) pyridazin-3-amine

6- (benzo [ d ] thiazol-5-yl) -N- (2,2,6, 6-tetramethylpiperidin-4-yl) pyridazin-3-amines

6- (2-methylbenzo- [ d ] oxazol-6-yl) -N- (2,2,6, 6-tetramethylpiperidin-4-yl) pyridazin-3-amine

3- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) naphthalen-2-ol

5-chloro-2- (6- (methyl (1,2,2,6, 6-pentamethylpiperidin-4-yl) amino) pyridazin-3-yl) phenol

3- (6- (2,2,6, 6-tetramethylpiperidin-4-yl-amino) pyridazin-3-yl) naphthalen-2-ol

5-chloro-2- (6- (1,2,2,6, 6-pentamethylpiperidin-4-ylamino) pyridazin-3-yl) phenol

4-hydroxy-3- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) benzonitrile

3- (6- ((2,2,6, 6-tetramethylpiperidin-4-yl) oxy) pyridazin-3-yl) naphthalen-2-ol

2- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) -4- (trifluoromethyl) phenol

2-fluoro-6- (6- (methyl- (2,2,6, 6-tetramethylpiperidin-4-yl) -amino) -pyridazin-3-yl) phenol

3, 5-dimethoxy-2- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) phenol

4, 5-dimethoxy-2- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) phenol

5-methoxy-2- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) phenol

4, 5-difluoro-2- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) phenol

5-fluoro-2- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) phenol

3-hydroxy-4- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) benzonitrile

1-allyl-6- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) naphthalen-2-ol

6- (benzo [ b ] thiophen-2-yl) -N- (1,2,2,6, 6-pentamethylpiperidin-4-yl) pyridazin-3-amine

N-allyl-3-hydroxy-4- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) benzamide

2- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) -5- (1H-pyrazol-1-yl) phenol

5- (5-methyl-oxazol-2-yl) -2- (6- (methyl- (2,2,6, 6-tetramethylpiperidin-4-yl) -amino) -pyridazin-3-yl) phenol

5- (4-hydroxymethyl) -1H-pyrazol-1-yl) -2- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) phenol

5- (1H-imidazol-1-yl) -2- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) phenol

5- (4-amino-1H-pyrazol-1-yl) -2- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) phenol

2- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) -5- (1H-pyrazol-4-yl) phenol

5- (3-amino-1H-pyrazol-1-yl) -2- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) phenol

2- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) -5- (1- (2-morpholino-ethyl) -1H-pyrazol-4-yl) phenol

2- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) -5- (1-methyl-1H-pyrazol-4-yl) phenol

5- (5-amino-1H-pyrazol-1-yl) -2- (6- (methyl- (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) phenol

2- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) -4- (1H-pyrazol-1-yl) phenol

2- ((6- ((2-hydroxy-ethyl) - (2,2,6, 6-tetramethylpiperidin-4-yl) -amino) -pyridazin-3-yl) -5-pyrazol-1-yl) phenol

2- (6- (piperidin-4-yloxy) pyridazin-3-yl) -5- (1H-pyrazol-1-yl) phenol

2- (6- (((2S,4R,6R) -2, 6-dimethylpiperidin-4-yl) oxy) pyridazin-3-yl) -5- (1H-pyrazol-1-yl) phenol

2- (6- ((-2, 6-dimethylpiperidin-4-yl) oxy) pyridazin-3-yl) -5- (1H-pyrazol-1-yl) phenol

5- (1H-pyrazol-1-yl) -2- (6- (pyrrolidin-3-yl-oxy) pyridazin-3-yl) phenol

2- (6- (((2S,4S) -2-methylpiperidin-4-yl) oxy) pyridazin-3-yl) -5- (1H-pyrazol-1-yl) phenol

(5- (1H-pyrazol-1-yl) -2- (6- (pyrrolidin-3-ylmethoxy) pyridazin-3-yl) phenol

2- (6- ((3-fluoropiperidin-4-yl) oxy) pyridazin-3-yl) -5- (1H-pyrazol-1-yl) phenol

2- (6- (1,2,2,6, 6-pentamethyl-piperidin-4-yl-oxy) -pyridazin-3-yl) -5- (1H-pyrazol-1-yl) phenol

5-1H-pyrazol-1-yl-2- (6- (2,2,6, 6-tetramethylpiperidin-4-yl-oxy) -pyridazin-3-yl) phenol

5- (1H-pyrazol-4-yl) -2- (6- ((2,2,6, 6-tetramethylpiperidin-4-yl) oxy) pyridazin-3-yl) phenol

2- (6-piperazin-1-yl-pyridazin-3-yl) -5- (1H-pyrazol-1-yl) phenol

3- (6- (azetidin-3-ylamino) -pyridazin-3-yl) naphthalen-2-ols

2- (6- (azetidin-3-ylamino) pyridazin-3-yl) -5- (1H-pyrazol-1-yl) phenol

2- (6- (3, 5-dimethylpiperazin-1-yl) pyridazin-3-yl) -5- (1H-pyrazol-1-yl) phenol

2- (6- (7-methyl-2, 7-diazaspiro [4.4] non-2-yl) pyridazin-3-yl) -5- (1H-pyrazol-1-yl) phenol

2- (6- (1, 4-diazepin-1-yl) pyridazin-3-yl) -5- (1H-pyrazol-1-yl) phenol

2- (6- (4- (2-hydroxyethyl) piperazin-1-yl) pyridazin-3-yl) -5- (1H-pyrazol-1-yl) phenol

2- (6- (3, 6-diazabicyclo [3.2.1] oct-3-yl) pyridazin-3-yl) -5- (1H-pyrazol-1-yl) phenol

2- (6- (2, 7-diazaspiro [3.5] non-7-yl) pyridazin-3-yl) -5- (1H-pyrazol-1-yl) phenol

2- (6- (3- (hydroxymethyl) piperazin-1-yl) pyridazin-3-yl) -5- (1H-pyrazol-1-yl) phenol

2- (6- (1, 7-diazaspiro [4.4] non-7-yl) pyridazin-3-yl) -5- (1H-pyrazol-1-yl) phenol

2- (6- (4-amino-4-methylpiperidin-1-yl) pyridazin-3-yl) -5- (1H-pyrazol-1-yl) phenol

2- (6- (3- (dimethylamino) piperidin-1-yl) pyridazin-3-yl) -5- (1H-pyrazol-1-yl) phenol

2- (6- (1,2,2,6, 6-pentamethylpiperidin-4-ylamino) -pyridazin-3-yl) -5-1H-pyrazol-1-yl-phenol

2- (6- (3, 3-dimethylpiperazin-1-yl) pyridazin-3-yl) -5- (1H-pyrazol-1-yl) phenol

2- (6- (7- (2-hydroxyethyl) -2, 7-diazaspiro [4.4] -non-2-yl) pyridazin-3-yl) -5- (1H-pyrazol-1-yl) phenol

2- (6- ((3aR,6aS) -hexahydropyrrolo [3,4-c ] pyrrol-2 (1H) -yl) pyridazin-3-yl) -5- (1H-pyrazol-1-yl) phenol

3- (6- (piperazin-1-yl) pyridazin-3-yl) naphthalene-2, 7-diol

5- (1H-pyrazol-1-yl) -2- (6- (1,2,3, 6-tetrahydropyridin-4-yl) pyridazin-3-yl) phenol

2- (6-piperidin-4-yl-pyridazin-3-yl) -5-1H-pyrazol-1-yl-phenol

3- (6- (1,2,3, 6-tetrahydropyridin-4-yl) pyridazin-3-yl) naphthalen-2-ol

3- (6- (1,2,3, 6-tetrahydropyridin-4-yl) pyridazin-3-yl) naphthalene-2, 7-diol

3- (6- (2,2,6, 6-tetramethyl-1, 2,3, 6-tetrahydropyridin-4-yl) pyridazin-3-yl) naphthalene-2, 7-diol

3- (6- (1-methyl-1, 2,3, 6-tetrahydropyridin-4-yl) pyridazin-3-yl) naphthalene-2, 7-diol

3- (6- (piperidin-4-yl) pyridazin-3-yl) naphthalene-2, 7-diol

3- (6- ((2,2,6, 6-tetramethylpiperidin-4-yl) oxy) pyridazin-3-yl) naphthalene-2, 7-diol

3- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) naphthalene-2, 7-diol

3- (6- ((2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) naphthalene-2, 7-diol

(3- ((7-hydroxy-6- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) naphthalen-2-yl) oxy) propyl) carbamic acid tert-butyl ester

7- (3-amino-propoxy) -3- (6- (methyl- (2,2,6, 6-tetramethylpiperidin-4-yl) -amino) -pyridazin-3-yl) naphthalen-2-ol

N- (3- ((7-hydroxy-6- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) naphthalen-2-yl) oxy) propyl) acetamide

7- (3-Hydroxypropoxy) -3- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) naphthalen-2-ol

7- (3-Methoxypropoxy) -3- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) naphthalen-2-ol

7- (2-Morpholinoethoxy) -3- (6- ((2,2,6, 6-tetramethylpiperidin-4-yl) oxy) pyridazin-3-yl) naphthalen-2-ol

3- (6- (piperidin-4-ylmethyl) pyridazin-3-yl) naphthalen-2-ol

5- (1H-pyrazol-1-yl) -2- (6- ((2,2,6, 6-tetramethylpiperidin-4-yl) methyl) pyridazin-3-yl) phenol

3-methoxy-2- (6- (methyl (2,2, 6-trimethylpiperidin-4-yl) amino) pyridazin-3-yl) -5- (5-methyloxazol-2-yl) phenol

2- (6- ((6S) -6- ((S) -1-hydroxyethyl) -2, 2-dimethylpiperidin-4-yloxy) pyridazin-3-yl) -5- (1H-pyrazol-1-yl) phenol

7-hydroxy-6- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) -2-naphthacenitrile

3- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) -7- (piperidinylmethyl) naphthalen-2-ol

3- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) -7- (pyrrolidinylmethyl) naphthalen-2-ol

1-bromo-6- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) naphthalene-2, 7-diol

1-chloro-6- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) naphthalene-2, 7-diol

7-methoxy-3- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) naphthalen-2-ol

7-methoxy-3- (6- (methyl (1,2,2,6, 6-pentamethylpiperidin-4-yl) amino) pyridazin-3-yl) naphthalen-2-ol

7- (3, 6-dihydro-2H-pyran-4-yl) -3- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) naphthalen-2-ol

3- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) -7- (tetrahydro-2H-pyran-4-yl) naphthalen-2-ol

7- (difluoromethyl) -3- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) naphthalen-2-ol

7- ((4-hydroxy-2-methylbut-2-yl) oxy) -3- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) naphthalen-2-ol

7- (3-hydroxy-3-methylbutyloxy) -3- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) naphthalen-2-ol

2- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) -5- (1H-pyrazol-4-yl) benzene-1, 3-diol

3-methoxy-2- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) -5- (1H-pyrazol-4-yl) phenol

5- (1H-pyrazol-4-yl) -2- (6- ((2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) -3- (trifluoromethyloxy) phenol

2- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) -5- (1-methyl-1H-pyrazol-4-yl) -3- (trifluoromethyloxy) phenol

2- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) -5- (1H-pyrazol-4-yl) -3- (trifluoromethyloxy) phenol

4- (3-hydroxy-4- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) -5- (trifluoromethyloxy) phenyl) -1-methylpyridin-2 (1H) -one

3-methoxy-2- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) -5- (1-methyl-1H-pyrazol-4-yl) phenol

3-methoxy-2- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) -5- (5,6,7, 8-tetrahydroimidazo [1,2-a ] pyridin-3-yl) phenol

3-methoxy-2- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) -5- (pyridin-3-yl) phenol

5- (1-cyclopentyl-1H-pyrazol-4-yl) -3-methoxy-2- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) phenol

3 ', 5-dimethoxy-4- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) - (1, 1' -diphenyl) -3-ol

3- (benzyloxy) -2- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) -5- (5-methyloxazol-2-yl) phenol

3-ethoxy-2- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) -5- (5-methyloxazol-2-yl) phenol

3- (cyclopropylmethoxy) -2- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) -pyridazin-3-yl) -5- (5-methyloxazol-2-yl) phenol

2-methyl-5- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) -1H-benzo [ d ] imidazol-6-ol

5-chloro-2- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) phenol

5- (1H-pyrazol-1-yl) -2- (6- ((2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) phenol

3-hydroxy-4- (6- ((2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) benzonitrile

2- (6- ((2, 2-dimethylpiperidin-4-yl) oxy) pyridazin-3-yl) -5- (1H-pyrazol-1-yl) phenol

2- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) -4- (1H-pyrazol-4-yl) phenol

2- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridin-3-yl) -4- (4,5,6, 7-tetrahydropyrazolo [1,5-a ] pyridin-3-yl) phenol

2- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) -4- (4,5,6, 7-tetrahydropyrazolo [1,5-a ] pyrazin-3-yl) phenol

4- (1H-indol-2-yl) -2- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) phenol

4- (Cyclopent-1-en-1-yl) -2- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) phenol

2- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) -4- (1H-pyrazol-3-yl) phenol

4- (4-hydroxy-3- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) phenyl) pyridin-2-ol

4- (4-hydroxy-3- (6- ((2,2,6, 6-tetramethylpiperidin-4-yl) oxy) pyridazin-3-yl) phenyl) -1-methylpyridin-2 (1H) -one

4- (4-hydroxy-3- (6- ((2,2,6, 6-tetramethylpiperidin-4-yl) oxy) pyridazin-3-yl) phenyl) pyridin-2-ol

5- (1H-indazol-7-yl) -2- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) phenol

4-chloro-2- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) -5- (1H-pyrazol-4-yl) phenol

4-fluoro-2- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) -5- (1H-pyrazol-4-yl) phenol

5-fluoro-4- (1H-imidazol-4-yl) -2- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) phenol

5-fluoro-2- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) -4- (1H-pyrazol-4-yl) phenol

5-fluoro-2- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) -4- (1H-pyrazol-5-yl) phenol

6-hydroxy-5- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) -2, 3-dihydro-1H-inden-1-one

6- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) -1, 4-dihydroindeno [1,2-c ] -1H-pyrazol-7-ol

6-hydroxy-5- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) -2, 3-dihydro-1H-inden-1-one oxime

5- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) -2, 3-dihydro-1H-indene-1, 6-diol

2-amino-6- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) -8H-indeno [1,2-d ] thiazol-5-ol

9- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) -5, 6-dihydroimidazo [5,1-a ] isoquinolin-8-ol

4-hydroxy-3- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) -N- ((1-methyl-1H-pyrazol-4-yl) methyl) benzamide

4- (4- (hydroxymethyl) -1H-pyrazol-1-yl) -2- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) phenol

5- (1H-pyrazol-4-yl) -2- (6- ((2,2,6, 6-tetramethylpiperidin-4-yl) methyl) pyridazin-3-yl) phenol

6- (3- (benzyloxy) isoquinolin-6-yl) -N-methyl-N- (2,2,6, 6-tetramethylpiperidin-4-yl) pyridazin-3-amine

6- (1- (benzyloxy) isoquinolin-7-yl) -N-methyl-N- (2,2,6, 6-tetramethylpiperidin-4-yl) pyridazin-3-amine

3-fluoro-5- (2-methoxypyridin-4-yl) -2- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) phenol

4- (3-fluoro-5-hydroxy-4- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) phenyl) pyridin-2 (1H) -one

4- (3-fluoro-5-hydroxy-4- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) phenyl) -1-methylpyridin-2 (1H) -one

5- (3-fluoro-5-hydroxy-4- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) phenyl) -1-methylpyridin-2 (1H) -one

3-fluoro-5- (1H-pyrazol-4-yl) -2- (6- ((2,2,6, 6-tetramethylpiperidin-4-yl) oxy) pyridazin-3-yl) phenol

5-chloro-3-fluoro-2- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) phenol

3-fluoro-2- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) -5- (1H-pyrazol-4-yl) phenol

3-fluoro-2- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) -5- (1-methyl-1H-pyrazol-4-yl) phenol

5- (5-methoxypyridin-3-yl) -2- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) phenol

5- (3-hydroxy-4- (6-methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) phenyl) pyridin-2-ol

4- (3-hydroxy-4- (6-methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) phenyl) pyridin-2-ol

5- (6-methoxypyridin-3-yl) -2- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) phenol

5- (3-hydroxy-4- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) phenyl) -3- (trifluoromethyl) pyridin-2-ol

5- (3-hydroxy-4- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) phenyl) -1-methylpyridin-2 (1H) -one

4- (3-hydroxy-4- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) phenyl) -1-methylpyridin-2 (1H) -one

5- (2-methoxypyridin-4-yl) -2- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) phenol

4- (3-hydroxy-4- (6- ((2,2,6, 6-tetramethylpiperidin-4-yl) oxy) pyridazin-3-yl) phenyl) pyridin-2-ol

5- (6- (dimethylamino) pyridin-3-yl) -2- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) phenol

4- (3-hydroxy-4- (6- ((2,2,6, 6-tetramethylpiperidin-4-yl) oxy) pyridazin-3-yl) phenyl) -1-methylpyridin-2 (1H) -one

2- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) -5- (pyrimidin-5-yl) phenol

5- (3-hydroxy-4- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) phenyl) pyridin-3-ol

1-cyclopropyl-4- (3-hydroxy-4- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) phenyl) pyridin-2 (1H) -one

2- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) -5- (1,2,3, 6-tetrahydropyridin-4-yl) phenol

5- (Cyclopent-1-en-1-yl) -2- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) phenol 5- (3, 6-dihydro-2H-pyran-4-yl) -2- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) phenol

5- (imidazo [1,5-a ] pyridin-7-yl) -2- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) phenol

5- (imidazo [1,2-a ] pyridin-7-yl) -2- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) phenol

2- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) -5- (2-methylpyridin-4-yl) phenol

5- (1H-imidazol-2-yl) -2- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) phenol

5- (1H-imidazol-4-yl) -2- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) phenol

5- (imidazo [1,2-a ] pyrazin-3-yl) -2- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) phenol

2- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) -5- (5,6,7, 8-tetrahydroimidazo [1,2-a ] pyrazin-3-yl) phenol

2- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) -5- (4-methyl-1H-imidazol-2-yl) phenol

2- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) -5- (1-methyl-1H-imidazol-4-yl) phenol

2- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) -5- (1-methyl-1H-imidazol-5-yl) phenol

2- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) -5- (4-nitro-1H-imidazol-2-yl) phenol

2- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) -5- (2-methyl-1H-imidazol-4-yl) phenol

5- (1, 2-dimethyl-1H-imidazol-4-yl) -2- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) phenol

1- (3-hydroxy-4- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) phenyl) -1H-pyrazole-4-carboxamide

2- (6- ((3aR,6aS) -5- (2-hydroxyethyl) hexahydropyrrolo [3,4-c ] pyrrol-2 (1H) -yl) pyridazin-3-yl) -5- (1H-pyrazol-4-yl) phenol

2- (6- ((3aR,6aS) -hexahydropyrrolo [3,4-c ] pyrrol-2 (1H) -yl) pyridazin-3-yl) -5- (1H-pyrazol-4-yl) phenol

2- (6- ((3aR,6aS) -5-Methylhexahydropyrrolo [3,4-c ] pyrrol-2 (1H) -yl) pyridazin-3-yl) -5- (1H-pyrazol-4-yl) phenol

4- (3-hydroxy-4- (6- (5-methylhexahydropyrrolo [3,4-c ] pyrrol-2 (1H) -yl) pyridazin-3-yl) phenyl) -1-methylpyridin-2 (1H) -one

4- (3-hydroxy-4- (6- ((3aR,6aR) -1-methylhexahydropyrrolo [3,4-b ] pyrrol-5 (1H) -yl) pyridazin-3-yl) phenyl) -1-methylpyridin-2 (1H) -one

2- (6- (2, 7-diazaspiro [4.5] decan-2-yl) pyridazin-3-yl) -5- (1H-pyrazol-4-yl) phenol

4- (4- (6- (2, 7-diazaspiro [4.5] decan-2-yl) pyridazin-3-yl) -3-hydroxyphenyl) -1-methylpyridin-2 (1H) -one

2- (6- (methyl- (2,2,6, 6-tetramethylpiperidin-4-yl) -amino) -pyridazin-3-yl) phenol

6- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) quinolin-7-ol

6- (6- (methyl (1,2,2,6, 6-pentamethylpiperidin-4-yl) amino) pyridazin-3-yl) quinolin-7-ol

6- (6- ((3aR,6aS) -5-Methylhexahydropyrrolo [3,4-c ] pyrrol-2 (1H) -yl) pyridazin-3-yl) quinolin-7-ol

2-methyl-6- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) quinolin-7-ol

7- (6- (methyl (1,2,2,6, 6-pentamethylpiperidin-4-yl) amino) pyridazin-3-yl) isoquinolin-6-ol

7- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) isoquinolin-6-ol

7- (6- ((2,2,6, 6-tetramethylpiperidin-4-yl) oxy) pyridazin-3-yl) isoquinolin-6-ol

7- (6- ((3aR,6aS) -5-Methylhexahydropyrrolo [3,4-c ] pyrrol-2 (1H) -yl) pyridazin-3-yl) isoquinolin-6-ol

1-cyclopropyl-7- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) isoquinolin-6-ol

7- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) isoquinoline-1, 6-diol

6-hydroxy-7- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) isoquinoline-1-carbonitrile

6- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) isoquinolin-7-ol

8- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) quinolin-7-ol

6- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) quinolin-6-ol

2-methyl-7- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) quinolin-6-ol

3-chloro-6- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) quinolin-7-ol

3-bromo-6- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) quinolin-7-ol

7-hydroxy-6- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) quinoline-3-carbonitrile

6- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) -3- (1-methyl-1H-imidazol-4-yl) quinolin-7-ol

3- (1H-imidazol-1-yl) -6- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) quinolin-7-ol

6- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) quinoline-3, 7-diol

3-Ethyl-6- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) quinolin-7-ol

3-isopropyl-6- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) quinolin-7-ol

7-hydroxy-6- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) quinolin-2 (1H) -one

7-hydroxy-1-methyl-6- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) quinolin-2 (1H) -one

4-methoxy-2-methyl-6- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) quinolin-7-ol

2-methyl-6- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) -4- (pyrrolidin-1-yl) quinolin-7-ol

2-methyl-6- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) -4-morpholinoquinolin-7-ol

4- (dimethylamino) -2-methyl-6- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) quinolin-7-ol

4-ethoxy-2-methyl-6- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) quinolin-7-ol

2-methyl-6- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) -4- (1-methyl-1H-pyrazol-4-yl) quinolin-7-ol

4-methoxy-7- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) quinolin-6-ol

7- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) quinoxalin-6-ol

6- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) -3- (tetrahydro-2H-pyran-4-yl) quinolin-7-ol

3-chloro-7- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) quinolin-6-ol

3-bromo-7- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) quinolin-6-ol

3-methyl-7- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) quinolin-6-ol

5-bromo-3-methyl-7- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) quinolin-6-ol

6-hydroxy-1-methyl-7- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) quinolin-4 (1H) -one

2, 3-dimethyl-7- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) quinolin-6-ol

2-methyl-7- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) quinoxalin-6-ol

3-methyl-7- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) quinoxalin-6-ol

4-methoxy-6- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) quinolin-7-ol

4- (azetidin-1-yl) -2-methyl-6- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) quinolin-7-ol

7-hydroxy-2-methyl-6- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) quinolone-4-carbonitrile

4-cyclopropyl-2-methyl-6- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) -quinolin-7-ol

4- (3, 6-dihydro-2H-pyran-4-yl) -2-methyl-6- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) quinolin-7-ol

2-methyl-6- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) -4- (tetrahydro-2H-pyran-4-yl) quinolin-7-ol

2-methyl-6- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) -4- (oxetan-3-yl) quinolin-7-ol

4- (dimethylamino) -6- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) -quinolin-7-ol

7-hydroxy-6- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) quinazolin-4 (1H) -one

6- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) quinazolin-7-ol

7-hydroxy-1-methyl-6- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) -3, 4-dihydroquinolin-2 (1H) -one

2-methyl-6- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) quinazolin-7-ol

7-hydroxy-6- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) isoquinoline-1-carbonitrile

7-hydroxy-6- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) quinoline-2-carbonitrile

6-hydroxy-7- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) quinoline-2-carbonitrile

6-hydroxy-7- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) isoquinoline-1-carboxamide

7-hydroxy-6- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) quinoline-2-carboxamide

6-hydroxy-7- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) quinoline-2-carboxamide

6-hydroxy-7- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) quinoline-2-carboxylic acid methyl ester

6-hydroxy-7- (6- (piperazin-1-yl) pyridazin-3-yl) quinoline-2-carbonitrile

7-hydroxy-6- (6- (piperazin-1-yl) pyridazin-3-yl) quinoline-2-carbonitrile

7- (6- (piperazin-1-yl) pyridazin-3-yl) isoquinolin-6-ol

7- (6- (1,2,3, 6-tetrahydropyridin-4-yl) pyridazin-3-yl) quinolin-6-ol

1-methyl-6- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) isoquinolin-7-ol

1-methyl-7- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) isoquinolin-6-ol

1, 3-dimethyl-7- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) isoquinolin-6-ol

7-hydroxy-3-methyl-6- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) isoquinoline-1-carbonitrile

1-amino-7- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) isoquinolin-6-ol

7-hydroxy-1, 3-dimethyl-6- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) quinazoline-2, 4(1H,3H) -dione

6-hydroxy-5- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) benzo [ d ] oxazol-2 (3H) -one

2-methyl-5- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) -2H-indazol-6-ol

1-methyl-5- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) -1H-indazol-6-ol

6-hydroxy-2-methyl-7- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) isoquinolin-1 (2H) -one

2-Ethyl-6-hydroxy-7- (6- ((2,2,6, 6-tetramethylpiperidin-4-yl) oxy) pyridazin-3-yl) isoquinolin-1 (2H) -one

1-ethoxy-7- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) isoquinolin-6-ol

7- (6- ((2,2,6, 6-tetramethylpiperidin-4-yl) oxy) pyridazin-3-yl) isoquinoline-1, 6-diol

7- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) -pyridazin-3-yl) -3-phenylisoquinolin-6-ol

3-methyl-7- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) isoquinolin-6-ol

3-cyclopropyl-7- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) isoquinolin-6-ol

3-isopropyl-7- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) isoquinolin-6-ol

3-propyl-7- (6- ((2,2,6, 6-tetramethylpiperidin-4-yl) oxy) -pyridazin-3-yl) isoquinolin-6-ol

3-isopropyl-7- (6- ((2,2,6, 6-tetramethylpiperidin-4-yl) oxy) -pyridazin-3-yl) isoquinolin-6-ol

3-methyl-7- (6- (piperazin-1-yl) pyridazin-3-yl) isoquinolin-6-ol

6- (3- (benzyloxy) isoquinolin-6-yl) -N-methyl-N- (2,2,6, 6-tetramethylpiperidin-4-yl) pyridazin-3-amine

3-chloro-6- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) quinolin-7-ol

3-isopropyl-6- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) quinolin-7-ol

3-methyl-7- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) quinoxalin-6-ol

4-chloro-2-methyl-6- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) quinolin-7-ol

4-chloro-7- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) quinolin-6-ol

7- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) quinolin-6-ol

5- (2-methoxy-4- (1H-pyrazol-1-yl) phenyl) -N-methyl-N- (2,2,6, 6-tetramethylpiperidin-4-yl) -1,3, 4-thiadiazol-2-amine

6- (5- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) -1,3, 4-thiadiazol-2-yl) naphthalen-2-ol

5- (2-Methoxyquinolin-3-yl) -N-methyl-N- (2,2,6, 6-tetramethylpiperidin-4-yl) -1,3, 4-thiadiazol-2-amine

5- (3-methoxy-naphthalen-2-yl) -N-methyl-N- (2,2,6, 6-tetramethylpiperidin-4-yl) -1,3, 4-thiadiazol-2-amine

5- (2-methoxy-4- (1H-pyrazol-1-yl) phenyl) -N- (1,2,2,6, 6-pentamethylpiperidin-4-yl) -1,3, 4-thiadiazol-2-amine

5- (2-methoxy-4- (1-methyl-1H-pyrazol-4-yl) phenyl) -N-methyl-N- (2,2,6, 6-tetramethylpiperidin-4-yl) -1,3, 4-thiadiazol-2-amine

5- (2-methoxy-4- (1H-pyrazol-4-yl) phenyl) -N-methyl-N- (2,2,6, 6-tetramethylpiperidin-4-yl) -1,3, 4-thiadiazol-2-amine

4- (3-methoxy-4- (5- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) -1,3, 4-thiadiazol-2-yl) phenyl) -1-methylpyridin-2 (1H) -one

5- (3-methoxy-4- (5- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) -1,3, 4-thiadiazol-2-yl) phenyl) pyridin-2-ol

5- (3-methoxy-4- (5- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) -1,3, 4-thiadiazol-2-yl) phenyl) -1-methylpyridin-2 (1H) -one

N-methyl-5- (2-methyl-4- (1-methyl-1H-pyrazol-4-yl) phenyl) -N- (2,2,6, 6-tetramethylpiperidin-4-yl) -1,3, 4-thiadiazol-2-amine

1-methyl-4- (4- (5- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) -1,3, 4-thiadiazol-2-yl) -3- (trifluoromethyloxy) phenyl) pyridin-2 (1H) -one

5- (4- (3, 5-dimethyl-1H-pyrazol-4-yl) -2-methoxyphenyl) -N-methyl-N- (2,2,6, 6-tetramethylpiperidin-4-yl) -1,3, 4-thiadiazol-2-amine

5- (2-methoxy-4- (1-methyl-1H-pyrazol-4-yl) phenyl) -N-methyl-N- (2,2,6, 6-tetramethylpiperidin-4-yl) -1,3, 4-thiadiazol-2-amine

2- (5- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) -1,3,4, -thiadiazol-2-yl-5- (1-methyl-1H-pyrazol-4-yl) phenol

2- (5- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) -1,3,4, -thiadiazol-2-yl-5- (1H-pyrazol-1-yl) phenol

5- (3-hydroxy-4- (5- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) -1,3, 4-thiadiazol-2-yl) phenyl) -1-methylpyridin-2 (1H) -one

4- (3-hydroxy-4- (5- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) -1,3, 4-thiadiazol-2-yl) phenyl) -1-methylpyridin-2 (1H) -one

5- (3-hydroxy-4- (5- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) -1,3, 4-thiadiazol-2-yl) phenyl) pyridin-2-ol

3- (5- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) -1,3, 4-thiadiazol-2-yl) naphthalene-2, 7-diol

3- (5- ((3aR,6aS) -hexahydropyrrolo [3,4-c ] pyrrol-2 (1H) -yl) -1,3, 4-thiadiazol-2-yl) naphthalene-2, 7-diol

3- (5- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) -1,3, 4-thiadiazol-2-yl) naphthalen-2-ol

3- (5- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) -1,3, 4-thiadiazol-2-yl) quinolin-2-ol

2- (5- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) -1,3, 4-thiadiazol-2-yl) -4- (1H-pyrazol-1-yl) phenol

5- (2-chloro-4- (1-methyl-1H-pyrazol-4-yl) phenyl) -N-methyl-N- (2,2,6, 6-tetramethylpiperidin-4-yl) -1,3, 4-thiadiazol-2-amine

3-chloro-2- (5- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) -1,3, 4-thiadiazol-2-yl) -5- (1-methyl-1H-pyrazol-4-yl) phenol

5- (2-chloro-4- (1-methyl-1H-pyrazol-4-yl) phenyl) -N- (2,2,6, 6-tetramethylpiperidin-4-yl) -1,3, 4-thiadiazol-2-amine

3-methoxy-2- (5- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) -1,3, 4-thiadiazol-2-yl) -5-methyloxazol-2-yl) phenol

2- (2-methoxy-4- (1H-pyrazol-1-yl) phenyl) -5- (1,2,3, 6-tetrahydropyridin-4-yl) -1,3, 4-thiadiazole

2- (5- (piperazin-1-yl) -1,3, 4-thiadiazol-2-yl) -5- (1H-pyrazol-1-yl) phenol

5- (7-Methoxyquinolin-6-yl) -N-methyl-N- (2,2,6, 6-tetramethylpiperidin-4-yl) -1,3, 4-thiadiazol-2-amine

6- (5- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) -1,3, 4-thiadiazol-2-yl) quinolin-7-ol

3-methoxy-4- (5- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) -1,3, 4-thiadiazol-2-yl) benzonitrile

3-fluoro-4- (5- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) -1,3, 4-thiadiazol-2-yl) benzonitrile methyl-3-fluoro-4- (5- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) -1,3, 4-thiadiazol-2-yl) benzoate

5- (2-methoxy-4- (3- (methylamino) -1H-pyrazol-1-yl) phenyl) -N-methyl-N- (2,2,6, 6-tetramethylpiperidin-4-yl) -1,3, 4-thiadiazol-2-amine

7-methoxy-6- (5- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) -1,3, 4-thiadiazol-2-yl) quinoline-2-carbonitrile

4- (3-methoxy-4- (5- ((2,2,6, 6-tetramethylpiperidin-4-yl) oxy) -1,3, 4-thiadiazol-2-yl) phenyl) -1-methylpyridin-2 (1H) -one

4- (3-chloro-4- (5- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) -1,3, 4-thiadiazol-2-yl) phenyl) -1-methylpyridin-2 (1H) -one

5- (2-chloro-4- (1H-pyrazol-4-yl) phenyl) -N-methyl-N- (2,2,6, 6-tetramethylpiperidin-4-yl) -1,3, 4-thiadiazol-2-amine

5- (2-chloro-4- (4,5,6, 7-tetrahydropyrazolo [1,5-a ] pyridin-3-yl) phenyl) -N-methyl-N- (2,2,6, 6-tetramethylpiperidin-4-yl) -1,3, 4-thiadiazol-2-amine

N-methyl-5- (5- (1-methyl-1H-pyrazol-4-yl) pyridin-2-yl) -N- (2,2,6, 6-tetramethylpiperidin-4-yl) -1,3, 4-thiadiazol-2-amine

2- (2-chloro-4- (1-methyl-1H-pyrazol-4-yl) phenyl) -5- ((2,2,6, 6-tetramethylpiperidin-4-yl) oxy-1, 3, 4-thiadiazole

5- (2-chloro-4- (6-methoxypyridin-3-yl) phenyl) -N-methyl-N- (2,2,6, 6-tetramethylpiperidin-4-yl) -1,3, 4-thiadiazol-2-amine

5- (4- (6-Aminopyridin-3-yl) -2-fluorophenyl) -N-methyl-N- (2,2,6, 6-tetramethylpiperidin-4-yl) -1,3, 4-thiadiazol-2-amine

5- (2-fluoro-4- (3-methyl-1H-pyrazol-5-yl) phenyl) -N-methyl-N- (2,2,6, 6-tetramethylpiperidin-4-yl) -1,3, 4-thiadiazol-2-amine

5- (2-fluoro-4- (1H-pyrazol-5-yl) phenyl) -N-methyl-N- (2,2,6, 6-tetramethylpiperidin-4-yl) -1,3, 4-thiadiazol-2-amine

5- (2, 3-difluoro-4- (1H-pyrazol-4-yl) phenyl) -N-methyl-N- (2,2,6, 6-tetramethylpiperidin-4-yl) -1,3, 4-thiadiazol-2-amine

5- (2, 3-difluoro-4- (1H-pyrazol-5-yl) phenyl) -N-methyl-N- (2,2,6, 6-tetramethylpiperidin-4-yl) -1,3, 4-thiadiazol-2-amine

5- (2, 5-difluoro-4- (1H-pyrazol-4-yl) phenyl) -N-methyl-N- (2,2,6, 6-tetramethylpiperidin-4-yl) -1,3, 4-thiadiazol-2-amine

5- (2, 5-difluoro-4- (1H-pyrazol-5-yl) phenyl) -N-methyl-N- (2,2,6, 6-tetramethylpiperidin-4-yl) -1,3, 4-thiadiazol-2-amine

5- (2, 6-difluoro-4- (1H-pyrazol-4-yl) phenyl) -N-methyl-N- (2,2,6, 6-tetramethylpiperidin-4-yl) -1,3, 4-thiadiazol-2-amine

2- (2, 5-difluoro-4- (1H-pyrazol-4-yl) phenyl) -5- ((3aR,6aS) -hexahydropyrrolo [3,4-c ] pyrrol-2 (1H) -yl) -1,3, 4-thiadiazole

5- (2-chloro-5-fluoro-4- (1H-pyrazol-4-yl) phenyl) -N-methyl-N- (2,2,6, 6-tetramethylpiperidin-4-yl) -1,3, 4-thiadiazol-2-amine

5- (3-fluoro-5- (1H-pyrazol-4-yl) pyridin-2-yl) -N-methyl-N- (2,2,6, 6-tetramethylpiperidin-4-yl) -1,3, 4-thiadiazol-2-amine

5- (4- (2-aminopyrimidin-4-yl) -2-chlorophenyl) -N-methyl-N- (2,2,6, 6-tetramethylpiperidin-4-yl) -1,3, 4-thiadiazol-2-amine

5- (5- (2-aminopyrimidin-4-yl) -2-chlorophenyl) -N-methyl-N- (2,2,6, 6-tetramethylpiperidin-4-yl) -1,3, 4-thiadiazol-2-amine

5- (4- (2, 4-Dimethylthiazol-5-yl) -2, 5-difluorophenyl) -N-methyl-N- (2,2,6, 6-tetramethylpiperidin-4-yl) -1,3, 4-thiadiazol-2-amine

5- (4- (2, 4-Dimethylthiazol-5-yl) -2, 3-difluorophenyl) -N-methyl-N- (2,2,6, 6-tetramethylpiperidin-4-yl) -1,3, 4-thiadiazol-2-amine

4- (3-hydroxy-4- (5- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) -1,3, 4-thiadiazol-2-yl) -5- (trifluoromethyloxy) phenyl) -1-methylpyridin-2 (1H) -one

5- (2-fluoro-6-methoxy-4- (1H-pyrazol-4-yl) phenyl) -N-methyl-N- (2,2,6, 6-tetramethylpiperidin-4-yl) -1,3, 4-thiadiazol-2-amine

2- (2-fluoro-6-methoxy-4- (1H-pyrazol-4-yl) phenyl) -5- ((3aR,6aS) -5-methylhexahydropyrrolo [3,4-c ] pyrrol-2 (1H) -yl) -1,3, 4-thiadiazole

5- (2, 3-difluoro-6-methoxy-4- (1H-pyrazol-4-yl) phenyl) -N-methyl-N- (2,2,6, 6-tetramethylpiperidin-4-yl) -1,3, 4-thiadiazol-2-amine

6-methoxy-2- (5- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) -1,3, 4-thiadiazol-2-yl) -3, 4-dihydroisoquinolin-1- (2H) -one

5- (2-chloro-4- (1H-pyrazol-1-yl) phenyl) -N-methyl-N- (2,2,6, 6-tetramethylpiperidin-4-yl) -1,3, 4-thiadiazol-2-amine

5- (2-chloro-4- (1H-1,2, 3-triazol-1-yl) phenyl) -N-methyl-N- (2,2,6, 6-tetramethylpiperidin-4-yl) -1,3, 4-thiadiazol-2-amine

5- (2-chloro-4- (2H-1,2, 3-triazol-2-yl) phenyl) -N-methyl-N- (2,2,6, 6-tetramethylpiperidin-4-yl) -1,3, 4-thiadiazol-2-amine

5- (2-chloro-4- (1H-1,2, 4-triazol-1-yl) phenyl) -N-methyl-N- (2,2,6, 6-tetramethylpiperidin-4-yl) -1,3, 4-thiadiazol-2-amine

5- (4- (3-amino-1H-pyrazol-1-yl) -2-chlorophenyl) -N-methyl-N- (2,2,6, 6-tetramethylpiperidin-4-yl) -1,3, 4-thiadiazol-2-amine

2- (2-chloro-4- (1H-imidazol-1-yl) phenyl) -5- ((3aR,6aS) -5-methylhexahydropyrrolo [3,4c ] pyrrol-2 (1H) -yl) -1,3, 4-thiadiazole

5- (2-chloro-4- (1H-imidazol-1-yl) phenyl) -N-methyl-N- (2,2,6, 6-tetramethylpiperidin-4-yl) -1,3, 4-thiadiazol-2-amine

5- (2-fluoro-4- (1H-imidazol-1-yl) phenyl) -N-methyl-N- (2,2,6, 6-tetramethylpiperidin-4-yl) -1,3, 4-thiadiazol-2-amine

5- (2-methoxy-4- (1H-pyrazol-5-yl) phenyl) -N-methyl-N- (2,2,6, 6-tetramethylpiperidin-4-yl) -1,3, 4-thiadiazol-2-amine

5- (4- (2, 4-Dimethylthiazol-5-yl) -2-methoxyphenyl) -N-methyl-N- (2,2,6, 6-tetramethylpiperidin-4-yl) -1,3, 4-thiadiazol-2-amine

5- (2-methoxy-4- (pyridin-3-yl) phenyl) -N-methyl-N- (2,2,6, 6-tetramethylpiperidin-4-yl) -1,3, 4-thiadiazol-2-amine

5- (2-fluoro-4- (1H-pyrazol-4-yl) phenyl) -N-methyl-N- (2,2,6, 6-tetramethylpiperidin-4-yl) -1,3, 4-thiadiazol-2-amine

5- (2-methoxy-4- (2-methoxypyridin-4-yl) phenyl) -N-methyl-N- (2,2,6, 6-tetramethylpiperidin-4-yl) -1,3, 4-thiadiazol-2-amine

5- (2-methoxy-4- (6-methoxypyridin-3-yl) phenyl) -N-methyl-N- (2,2,6, 6-tetramethylpiperidin-4-yl) -1,3, 4-thiadiazol-2-amine

2- (2-chloro-4- (1-methyl-1H-pyrazol-4-yl) phenyl) -5- ((3aR,6aS) -5-methylhexahydropyrrolo [3,4-c ] pyrrol-2 (1H) -yl) -1,3, 4-thiadiazole

2- (2-chloro-4- (1H-pyrazol-4-yl) phenyl) -5- ((3aR,6aS) -5-methylhexahydropyrrolo [3,4-c ] pyrrol-2 (1H) -yl) -1,3, 4-thiadiazole

2- (2-chloro-4- (1H-pyrazol-4-yl) phenyl) -5- ((3aR,6aR) -1-methylhexahydropyrrolo [3,4-b ] pyrrol-5 (1H) -yl) -1,3, 4-thiadiazole

1- (4- (5- (2-chloro-4- (1H-pyrazol-4-yl) phenyl) -1,3, 4-thiadiazol-2-yl) morpholin-2-yl) -N, N-dimethylmethylamine

2- (2-chloro-4- (1H-pyrazol-4-yl) phenyl) -5- (2-methyl-2, 7-diazaspiro [4.5] decan-7-yl) -1,3, 4-thiadiazole

2- (2-fluoro-4- (1H-pyrazol-4-yl) phenyl) -5- ((3aR,6aS) -5-methylhexahydropyrrolo [3,4-c ] pyrrol-2 (1H) -yl) -1,3, 4-thiadiazole

2- (2-methoxy-4- (1-methyl-1H-pyrazol-4-yl) phenyl) -5- (2, 6-diazaspiro [3.5] non-2-yl) -1,3, 4-thiadiazole

2- (2-methoxy-4- (1-methyl-1H-pyrazol-4-yl) phenyl) -5- (2, 7-diazaspiro [3.5] non-2-yl) -1,3, 4-thiadiazole

2- (5- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) -1,3, 4-thiadiazol-2-yl) -5- (1H-pyrazol-1-yl) phenol

5- (3-chloro-4- (5- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) -1,3, 4-thiadiazol-2-yl) phenyl) pyridin-2 (1H) -one

2- (5- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) -1,3, 4-thiadiazol-2-yl) -5- (3- (methylamino) -1H-pyrazol-1-yl) phenol

3-fluoro-2- (5- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) -1,3, 4-thiadiazol-2-yl) -5- (1H-pyrazol-4-yl) phenol

3, 4-difluoro-2- (5- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) -1,3, 4-thiadiazol-2-yl) -5- (1H-pyrazol-4-yl) phenol

6-hydroxy-5- (5- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) -1,3, 4-thiadiazol-2-yl) -2, 3-dihydro-1H-inden-1-one

2- (5- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) -1,3, 4-thiadiazol-2-yl) -5- (1H-pyrazol-4-yl) phenol

2- (5- (2, 6-diazaspiro [3.5] non-2-yl) -1,3, 4-thiadiazol-2-yl) -5- (1-methyl-1H-pyrazol-4-yl) phenol

2- (5- (2, 7-diazaspiro [3.5] non-2-yl) -1,3, 4-thiadiazol-2-yl) -5- (1-methyl-1H-pyrazol-4-yl) phenol

3-fluoro-2- (5- ((3aR,6aS) -hexahydropyrrolo [3,4-c ] pyrrol-2 (1H) -yl) -1,3, 4-thiadiazol-2-yl) -5- (1H-pyrazol-4-yl) phenol

3-chloro-2- (5- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) -1,3, 4-thiadiazol-2-yl) -5- (1H-pyrazol-4-yl) phenol

2- (2-methoxy-4- (1H-pyrazol-1-yl) phenyl) -5- ((2,2,6, 6-tetramethylpiperidin-4-yl) methyl) -1,3, 4-thiadiazole

2- (2, 3-difluoro-4- (1H-pyrazol-4-yl) phenyl) -5- (2, 7-diazaspiro [3.5] non-2-yl) -1,3, 4-thiadiazole

2- (5- (2, 7-diazaspiro [3.5] non-2-yl) -1,3, 4-thiadiazol-2-yl) -3-fluoro-5- (1H-pyrazol-4-yl) phenol

4-methoxy-1-methyl-3- (5- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) -1,3, 4-thiadiazol-2-yl) quinolin-2 (1H) -one

4-hydroxy-1-methyl-3- (5- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) -1,3, 4-thiadiazol-2-yl) quinolin-2 (1H) -one

3- (5- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) -1,3, 4-thiadiazol-2-yl) quinolin-2 (1H) -one

1-methyl-3- (5- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) -1,3, 4-thiadiazol-2-yl) quinolin-2 (1H) -one

2- (2-chloro-4- (1H-pyrazol-4-yl) phenyl) -5- ((3aR,6aS) -hexahydropyrrolo [3,4-c ] pyrrol-2 (1H) -yl) -1,3, 4-thiadiazole

2- (2-chloro-4- (1H-pyrazol-4-yl) phenyl) -5- (2, 7-diazaspiro [4.5] decan-2-yl) -1,3, 4-thiadiazole (R) - (4- (5- (2-chloro-4- (1H-pyrazol-4-yl) phenyl) -1,3, 4-thiadiazol-2-yl) piperazin-2-yl) methanol

2- (5- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) -1,3, 4-thiadiazol-2-yl) benzo [ b ] thiophene-5-carbonitrile

5- (3-chlorobenzo [ b ] thiophen-2-yl) -N-methyl-N- (2,2,6, 6-tetramethylpiperidin-4-yl) -1,3, 4-thiadiazol-2-amine

5- (2-methoxy-4- (1H-pyrazol-4-yl) phenyl) -N-methyl-N- (2,2,6, 6-tetramethylpiperidin-4-yl) -1,3, 4-thiadiazol-2-amine

2- {6- [ 8-azabicyclo [3.2.1] oct-3-yl (methyl) amino ] pyridazin-3-yl } -5- (1H-pyrazol-4-yl) phenol 2- [6- (8-azabicyclo [3.2.1] oct-3-ylamino) pyridazin-3-yl ] -5- (1H-pyrazol-4-yl) phenol

5- (1H-pyrazol-4-yl) -2- {6- [ (2,2,6, 6-tetramethylpiperidin-4-yl) amino ] pyridazin-3-yl } phenol

5- (1-methyl-1H-pyrazol-4-yl) -2- {6- [ (2,2,6, 6-tetramethylpiperidin-4-yl) oxy ] pyridazin-3-yl } phenol

2- [6- (8-azabicyclo [3.2.1] oct-3-yloxy) pyridazin-3-yl ] -5- (1H-pyrazol-4-yl) phenol

5- (5-methyl-1H-pyrazol-4-yl) -2- {6- [ methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino ] pyridazin-3-yl } phenol

5- (1H-imidazol-1-yl) -2- {6- [ (2,2,6, 6-tetramethylpiperidin-4-yl) oxy ] pyridazin-3-yl } phenol

5- (5-methyl-1H-pyrazol-4-yl) -2- {6- [ (2,2,6, 6-tetramethylpiperidin-4-yl) oxy ] pyridazin-3-yl } phenol

2- {6- [ methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino ] pyridazin-3-yl } -5- (4-nitro-1H-pyrazol-1-yl) phenol

6- [ 2-methoxy-4- (4-nitro-1H-pyrazol-1-yl) phenyl ] -N-methyl-N- (2,2,6, 6-tetramethylpiperidin-4-yl) pyridazin-3-amine

5- (4-amino-1H-pyrazol-1-yl) -2- {6- [ (2,2,6, 6-tetramethylpiperidin-4-yl) oxy ] pyridazin-3-yl } phenol

2- [6- (1-methyl-1, 2,3, 6-tetrahydropyridin-4-yl) pyridazin-3-yl ] -5- (1H-pyrazol-4-yl) phenol

5- (4-Nitro-1H-pyrazol-1-yl) -2- {6- [ (2,2,6, 6-tetramethylpiperidin-4-yl) oxy ] pyridazin-3-yl } phenol

5- (1H-pyrazol-4-yl) -2- [6- (1,2,3, 6-tetrahydropyridin-4-yl) pyridazin-3-yl ] phenol

2- [6- (1-ethyl-1, 2,3, 6-tetrahydropyridin-4-yl) pyridazin-3-yl ] -5- (1H-pyrazol-4-yl) phenol

2- {6- [ methyl (piperidin-4-yl) amino ] pyridazin-3-yl } -5- (1H-pyrazol-4-yl) phenol

2- [6- (piperidin-4-ylamino) pyridazin-3-yl ] -5- (1H-pyrazol-4-yl) phenol

6- [2, 5-difluoro-4- (1H-pyrazol-4-yl) phenyl ] -N-methyl-N- (2,2,6, 6-tetramethylpiperidin-4-yl) pyridazin-3-amine

2- [6- (8-azabicyclo [3.2.1] oct-2-en-3-yl) pyridazin-3-yl ] -5- (1H-pyrazol-4-yl) phenol

6- [2, 3-difluoro-4- (1H-pyrazol-4-yl) phenyl ] -N-methyl-N- (2,2,6, 6-tetramethylpiperidin-4-yl) pyridazin-3-amine

3- [2, 5-difluoro-4- (1H-pyrazol-4-yl) phenyl ] -6- [ (2,2,6, 6-tetramethylpiperidin-4-yl) oxy ] pyridazine 2- [6- (piperidin-4-yloxy) pyridazin-3-yl ] -5- (1H-pyrazol-4-yl) phenol

2- {6- [ (1R,5S) -8-azabicyclo [3.2.1] oct-3-ylamino ] pyridazin-3-yl } -5- (1H-pyrazol-4-yl) phenol

6- [ 2-methoxy-6- (1H-pyrazol-4-yl) pyridin-3-yl ] -N-methyl-N- (2,2,6, 6-tetramethylpiperidin-4-yl) pyridazin-3-amine

3- [4- (1H-pyrazol-4-yl) phenyl ] -6- [ (2,2,6, 6-tetramethylpiperidin-4-yl) oxy ] pyridazine

2- {6- [ (2, 6-dimethylpiperidin-4-yl) oxy ] pyridazin-3-yl } -5- (1H-pyrazol-4-yl) phenol

3- [ 2-fluoro-4- (1H-pyrazol-4-yl) phenyl ] -6- [ (2,2,6, 6-tetramethylpiperidin-4-yl) oxy ] pyridazine

3- [4- (1-methyl-1H-pyrazol-4-yl) thiophen-2-yl ] -6- [ (2,2,6, 6-tetramethylpiperidin-4-yl) oxy ] pyridazine

2- [6- (2, 7-diazaspiro [3.5] non-2-yl) pyridazin-3-yl ] -5- (1H-pyrazol-4-yl) phenol

3-fluoro-4- {6- [ methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino ] pyridazin-3-yl } phenol

2- {6- [ (2, 6-dimethylpiperidin-4-yl) oxy ] pyridazin-3-yl } -5- (1H-pyrazol-1-yl) phenol

N-methyl-6- (2-methyl-2H-indazol-5-yl) -N- (2,2,6, 6-tetramethylpiperidin-4-yl) pyridazin-3-amine

2-methyl-5- {6- [ (2,2,6, 6-tetramethylpiperidin-4-yl) oxy ] pyridazin-3-yl } -2H-indazole

3- (4-chloro-2-methoxyphenyl) -6- [ (2,2,6, 6-tetramethylpiperidin-4-yl) oxy ] pyridazine

N-methyl-6- (2-methylpyrazolo [1,5-a ] pyridin-3-yl) -N- (2,2,6, 6-tetramethylpiperidin-4-yl) pyridazin-3-amine

6- {6- [ (2,2,6, 6-tetramethylpiperidin-4-yl) oxy ] pyridazin-3-yl } imidazo [1,2-a ] pyridine

3- [ 2-methoxy-4- (1H-pyrazol-1-yl) phenyl ] -6- [ (2,2,6, 6-tetramethylpiperidin-4-yl) oxy ] pyridazine

3- [5- (1H-pyrazol-4-yl) thiophen-2-yl ] -6- [ (2,2,6, 6-tetramethylpiperidin-4-yl) oxy ] pyridazine

3- [5- (1-methyl-1H-pyrazol-4-yl) thiophen-2-yl ] -6- [ (2,2,6, 6-tetramethylpiperidin-4-yl) oxy ] pyridazine

3- [4- (1H-pyrazol-4-yl) thiophen-2-yl ] -6- [ (2,2,6, 6-tetramethylpiperidin-4-yl) oxy ] pyridazine

5- (3, 5-dimethyl-1H-pyrazol-4-yl) -2- {6- [ (2,2,6, 6-tetramethylpiperidin-4-yl) oxy ] pyridazin-3-yl } phenol

6- [ 2-fluoro-4- (1H-pyrazol-4-yl) phenyl ] -N-methyl-N- (2,2,6, 6-tetramethylpiperidin-4-yl) pyridazin-3-amine

3-methoxy-4- {6- [ (2,2,6, 6-tetramethylpiperidin-4-yl) oxy ] pyridazin-3-yl } phenol

3- [ 2-methoxy-4- (4-nitro-1H-pyrazol-1-yl) phenyl ] -6- [ (2,2,6, 6-tetramethylpiperidin-4-yl) oxy ] pyridazine

4- {6- [ (2,2,6, 6-tetramethylpiperidin-4-yl) oxy ] pyridazin-3-yl } benzene-1, 3-diol

6- [ 2-chloro-4- (1H-pyrazol-4-yl) phenyl ] -N-methyl-N- (2,2,6, 6-tetramethylpiperidin-4-yl) pyridazin-3-amine

2- (1H-pyrazol-4-yl) -4- {6- [ (2,2,6, 6-tetramethylpiperidin-4-yl) oxy ] pyridazin-3-yl } pyrimidin-5-amine

3- [2, 6-difluoro-4- (1H-pyrazol-4-yl) phenyl ] -6- [ (2,2,6, 6-tetramethylpiperidin-4-yl) oxy ] pyridazine

2- [6- (2, 6-diazaspiro [3.4] oct-2-yl) pyridazin-3-yl ] -5- (1H-pyrazol-4-yl) phenol

3- {6- [ methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino ] pyridazin-3-yl } -6- (1H-pyrazol-4-yl) pyridin-2-ol

6- (1H-pyrazol-4-yl) -3- {6- [ (2,2,6, 6-tetramethylpiperidin-4-yl) oxy ] pyridazin-3-yl } pyridin-2-ol

N,2,2,6, 6-pentamethyl-N- {5- [3- (1H-pyrazol-4-yl) phenoxy ] -1,3, 4-thiadiazol-2-yl } piperidin-4-amine

N,2,2,6, 6-pentamethyl-N- {5- [4- (1H-pyrazol-4-yl) phenoxy ] -1,3, 4-thiadiazol-2-yl } piperidin-4-amine

3- [2- (difluoromethyl) -4- (1H-pyrazol-4-yl) phenyl ] -6- [ (2,2,6, 6-tetramethylpiperidin-4-yl) oxy ] pyridazine and

6- [2- (difluoromethyl) -4- (1H-pyrazol-4-yl) phenyl ] -N-methyl-N- (2,2,6, 6-tetramethylpiperidin-4-yl) pyridazin-3-amine;

wherein the form of the compound is selected from the group consisting of: a prodrug form, a salt form, a hydrate form, a solvate form, a clathrate form, an isotopologue form, a racemate form, an enantiomeric form, a diastereomeric form, a stereoisomeric form, a polymorphic form, and a tautomeric form thereof.

5. A method of treating or ameliorating HD in a subject in need thereof using a compound salt or a form thereof, the method comprising administering to the subject an effective amount of a compound salt selected from the group consisting of:

2- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) -4- (trifluoromethyl) phenol hydrochloride

2- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) -4- (1H-pyrazol-1-yl) phenate hydrochloride

2- (6-piperazin-1-yl-pyridazin-3-yl) -5-1H-pyrazol-1-yl-phenol hydrochloride

3- (6- (piperazin-1-yl) pyridazin-3-yl) naphthalene-2, 7-diol trifluoroacetate salt

3- (6- (1,2,3, 6-tetrahydropyridin-4-yl) pyridazin-3-yl) naphthalene-2, 7-diol trifluoroacetate salt

3- (6- (1-methyl-1, 2,3, 6-tetrahydropyridin-4-yl) pyridazin-3-yl) naphthalene-2, 7-diol trifluoroacetate salt

3- (6- (piperidin-4-yl) pyridazin-3-yl) naphthalene-2, 7-diol trifluoroacetate salt

6-hydroxy-5- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) -2, 3-dihydro-1H-inden-1-one oxime hydrochloride

2-amino-6- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) -8H-indeno [1,2-d ] thiazol-5-ol hydrochloride

9- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) -5, 6-dihydroimidazo [5,1-a ] isoquinolin-8-ol hydrochloride

3-fluoro-5- (2-methoxypyridin-4-yl) -2- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) phenate hydrochloride

4- (3-fluoro-5-hydroxy-4- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) phenyl) pyridin-2 (1H) -one hydrochloride

4- (3-fluoro-5-hydroxy-4- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) phenyl) -1-methylpyridin-2 (1H) -one hydrochloride

5- (3-fluoro-5-hydroxy-4- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) phenyl) -1-methylpyridin-2 (1H) -one hydrochloride

3-fluoro-5- (1H-pyrazol-4-yl) -2- (6- ((2,2,6, 6-tetramethylpiperidin-4-yl) oxy) pyridazin-3-yl) phenate hydrochloride

5-chloro-3-fluoro-2- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) phenate hydrochloride

3-fluoro-2- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) -5- (1H-pyrazol-4-yl) phenol hydrochloride

3-fluoro-2- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) -5- (1-methyl-1H-pyrazol-4-yl) phenol hydrochloride

3- (1H-imidazol-1-yl) -6- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) quinolin-7-ol hydrochloride

6- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) quinoline-3, 7-diol formate salt

7-hydroxy-1-methyl-6- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) quinolin-2 (1H) -one hydrochloride

4-methoxy-7- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) quinolin-6-ol formate salt

7- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) quinoxalin-6-ol hydrochloride

2-methyl-6- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) -4- (tetrahydro-2H-pyran-4-yl) quinolin-7-ol formate salt

4- (dimethylamino) -6- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) -quinolin-7-ol formate salt

6-hydroxy-2-methyl-7- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) isoquinolin-1 (2H) -one hydrochloride

3- (5- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) -1,3, 4-thiadiazol-2-yl) naphthalen-2-ol hydrobromide

N-methyl-5- (5- (1-methyl-1H-pyrazol-4-yl) pyridin-2-yl) -N- (2,2,6, 6-tetramethylpiperidin-4-yl) -1,3, 4-thiadiazole-2-amine hydrochloride

3-fluoro-2- (5- ((3aR,6aS) -hexahydropyrrolo [3,4-c ] pyrrol-2 (1H) -yl) -1,3, 4-thiadiazol-2-yl) -5- (1H-pyrazol-4-yl) phenol dihydrochloride

2- (2-chloro-4- (1H-pyrazol-4-yl) phenyl) -5- ((3aR,6aS) -hexahydropyrrolo [3,4-c ] pyrrol-2 (1H) -yl) -1,3, 4-thiadiazole hydrochloride

2- (2-chloro-4- (1H-pyrazol-4-yl) phenyl) -5- (2, 7-diazaspiro [4.5] decan-2-yl) -1,3, 4-thiadiazole hydrochloride

(R) - (4- (5- (2-chloro-4- (1H-pyrazol-4-yl) phenyl) -1,3, 4-thiadiazol-2-yl) piperazin-2-yl) methanolic hydrochloride

2- {6- [ 8-azabicyclo [3.2.1] oct-3-yl (methyl) amino ] pyridazin-3-yl } -5- (1H-pyrazol-4-yl) phenol hydrochloride

2- [6- (8-azabicyclo [3.2.1] oct-3-ylamino) pyridazin-3-yl ] -5- (1H-pyrazol-4-yl) phenate 5- (1H-pyrazol-4-yl) -2- {6- [ (2,2,6, 6-tetramethylpiperidin-4-yl) amino ] pyridazin-3-yl } phenate

2- [6- (8-azabicyclo [3.2.1] oct-3-yloxy) pyridazin-3-yl ] -5- (1H-pyrazol-4-yl) phenol hydrochloride 2- {6- [ methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino ] pyridazin-3-yl } -5- (4-nitro-1H-pyrazol-1-yl) phenol dihydrochloride

2- [6- (1-methyl-1, 2,3, 6-tetrahydropyridin-4-yl) pyridazin-3-yl ] -5- (1H-pyrazol-4-yl) phenol trihydrochloride

5- (1H-pyrazol-4-yl) -2- [6- (1,2,3, 6-tetrahydropyridin-4-yl) pyridazin-3-yl ] phenol trihydrochloride

2- [6- (1-Ethyl-1, 2,3, 6-tetrahydropyridin-4-yl) pyridazin-3-yl ] -5- (1H-pyrazol-4-yl) phenol trihydrochloride

2- {6- [ methyl (piperidin-4-yl) amino ] pyridazin-3-yl } -5- (1H-pyrazol-4-yl) phenol tetrahydrate

2- [6- (piperidin-4-ylamino) pyridazin-3-yl ] -5- (1H-pyrazol-4-yl) phenol tetrahydrochloride salt

6- [2, 5-difluoro-4- (1H-pyrazol-4-yl) phenyl ] -N-methyl-N- (2,2,6, 6-tetramethylpiperidin-4-yl) pyridazin-3-amine tetrahy-drochloride

2- [6- (8-azabicyclo [3.2.1] oct-2-en-3-yl) pyridazin-3-yl ] -5- (1H-pyrazol-4-yl) phenol hydrochloride

6- [2, 3-difluoro-4- (1H-pyrazol-4-yl) phenyl ] -N-methyl-N- (2,2,6, 6-tetramethylpiperidin-4-yl) pyridazin-3-amine hydrochloride

3- [2, 5-difluoro-4- (1H-pyrazol-4-yl) phenyl ] -6- [ (2,2,6, 6-tetramethylpiperidin-4-yl) oxy ] pyridazine trihydrochloride

2- {6- [ (1R,5S) -8-azabicyclo [3.2.1] oct-3-ylamino ] pyridazin-3-yl } -5- (1H-pyrazol-4-yl) phenol hydrochloride

6- [ 2-methoxy-6- (1H-pyrazol-4-yl) pyridin-3-yl ] -N-methyl-N- (2,2,6, 6-tetramethylpiperidin-4-yl) pyridazin-3-amine hydrochloride

2- {6- [ (2, 6-dimethylpiperidin-4-yl) oxy ] pyridazin-3-yl } -5- (1H-pyrazol-4-yl) phenol trihydrochloride

3- [ 2-fluoro-4- (1H-pyrazol-4-yl) phenyl ] -6- [ (2,2,6, 6-tetramethylpiperidin-4-yl) oxy ] pyridazine hydrochloride

2- [6- (2, 7-diazaspiro [3.5] non-2-yl) pyridazin-3-yl ] -5- (1H-pyrazol-4-yl) phenol tetrahydrate

3- [5- (1H-pyrazol-4-yl) thiophen-2-yl ] -6- [ (2,2,6, 6-tetramethylpiperidin-4-yl) oxy ] pyridazine hydrochloride

3- [4- (1H-pyrazol-4-yl) thiophen-2-yl ] -6- [ (2,2,6, 6-tetramethylpiperidin-4-yl) oxy ] pyridazine hydrochloride

6- [ 2-chloro-4- (1H-pyrazol-4-yl) phenyl ] -N-methyl-N- (2,2,6, 6-tetramethylpiperidin-4-yl) pyridazin-3-amine trihydrochloride

3- [2, 6-difluoro-4- (1H-pyrazol-4-yl) phenyl ] -6- [ (2,2,6, 6-tetramethylpiperidin-4-yl) oxy ] pyridazine trihydrochloride

3- {6- [ methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino ] pyridazin-3-yl } -6- (1H-pyrazol-4-yl) pyridin-2-ol hydrochloride

N,2,2,6, 6-pentamethyl-N- {5- [3- (1H-pyrazol-4-yl) phenoxy ] -1,3, 4-thiadiazol-2-yl } piperidin-4-amine hydrochloride

N,2,2,6, 6-pentamethyl-N- {5- [4- (1H-pyrazol-4-yl) phenoxy ] -1,3, 4-thiadiazol-2-yl } piperidin-4-amine hydrochloride

3- [2- (difluoromethyl) -4- (1H-pyrazol-4-yl) phenyl ] -6- [ (2,2,6, 6-tetramethylpiperidin-4-yl) oxy ] pyridazine hydrochloride and

6- [2- (difluoromethyl) -4- (1H-pyrazol-4-yl) phenyl ] -N-methyl-N- (2,2,6, 6-tetramethylpiperidin-4-yl) pyridazin-3-amine hydrochloride;

wherein the compound salt form is selected from the group consisting of: prodrug forms, hydrate forms, solvate forms, clathrate forms, isotopologue forms, racemate forms, enantiomer forms, diastereomer forms, stereoisomer forms, polymorph forms and tautomer forms thereof.

6. The method of any one of claims 1,4 or 5, wherein the effective amount of the compound is in the range of about 0.001 mg/kg/day to about 500 mg/kg/day.

7. Use of a compound of any one of claims 1,4 or 5 for treating or ameliorating HD in a subject in need thereof, the use comprising administering to the subject an effective amount of the compound.

8. The use of claim 7, wherein the effective amount of the compound is in the range of about 0.001 mg/kg/day to about 500 mg/kg/day.

9. Use of a compound of any one of claims 1,4 or 5 in the manufacture of a medicament for treating or ameliorating HD in a subject in need thereof, the use comprising administering to the subject an effective amount of the medicament.

10. The use of claim 9, wherein the effective amount of the compound in the medicament is in the range of about 0.001 mg/kg/day to about 500 mg/kg/day.

11. Use of a compound of any one of claims 1,4 or 5 in a pharmaceutical composition in admixture with one or more pharmaceutically acceptable excipients for treating or ameliorating HD in a subject in need thereof, said use comprising administering to said subject an effective amount of said pharmaceutical composition.

12. The use of claim 11, wherein the effective amount of the compound in the pharmaceutical composition ranges from about 0.001 mg/kg/day to about 500 mg/kg/day.

13. An assay for detecting HTT (huntingtin) using a capture/detection antibody pair selected from MAB2166/MAB2174 and MAB2166/#5656S, wherein HTT is total HTT; and wherein the HTT is a mutated HTT and the capture/detection antibody pair is selected from the group consisting of MAB1574/#5656S, P1874/#5656S and MW1/# 5656S.

14. The assay of claim 13, wherein HTT is total HTT and the capture/detection antibody pair is MAB2166/# 5656S; and wherein the HTT is a mutant HTT and the capture/detection antibody pair is MW1/# 5656S.

Technical Field

The present invention relates to compounds, forms thereof and pharmaceutical compositions thereof, as well as methods of using these compounds, forms thereof or compositions thereof for treating or ameliorating huntington's disease. In particular, the present invention relates to substituted monocyclic heteroaryl compounds, forms thereof, and pharmaceutical compositions thereof, as well as methods of using these compounds, forms thereof, or compositions thereof for treating or ameliorating huntington's disease.

Background

Huntington's Disease (HD) is a progressive, autosomal dominant neurodegenerative disease of the brain with symptoms characterized by involuntary movements, cognitive impairment and mental decline. Death (usually caused by pneumonia or coronary artery disease) usually occurs 13 to 15 years after the onset of symptoms. In the population of western european descent, the prevalence of HD ranges from 3 to 7 per 100000 people. In north america, 30000 people are expected to have HD, while the other 200000 people are at risk of inheriting the disease from the parent of the disease. The disease is caused by the amplification of uninterrupted trinucleotide CAG repeats in the "mutated" huntington (Htt) gene, resulting in the production of HTTs (Htt proteins) with amplified polyglutamine (polyQ) sequences (stretch) (also known as "CAG repeat" sequences). There is currently no small molecule therapy directed at the root cause of the disease, leaving a highly unmet need for drugs that can be used to treat or ameliorate HD. Thus, there remains a need to identify and provide small molecule compounds for treating or ameliorating HD.

All other documents cited herein are incorporated by reference into this application as if fully set forth herein.

Disclosure of Invention

The present invention relates to a method for treating or ameliorating HD in a subject in need thereof, the method comprising administering to the subject an effective amount of a compound of formula (I), or a form and composition thereof:

wherein W, X, A and B are as defined herein.

In particular, the present invention relates to the use of a compound of formula (I) or a form or composition thereof in a method for treating or ameliorating HD in a subject in need thereof, said use comprising administering to the subject an effective amount of the compound or a form or composition thereof.

The invention also relates to the use of a compound of formula (I) or a form thereof in combination with an agent having additional or synergistic activity, thereby providing a combination product for the treatment of HD.

Detailed Description

The present invention relates to a method or use of a compound for treating or ameliorating HD in a subject in need thereof, the method or use comprising administering to the subject an effective amount of a compound of formula (I), or a form thereof:

wherein

W is CH ═ CH or S;

x is CH₂、CH(C_1-4Alkyl group), C (C)_1-4Alkyl radical)₂、CH＝CH、O、NR₅Or a bond;

a is aryl, heteroaryl, heterocyclyl, or C_9-10A cycloalkyl group,

wherein aryl is selected from phenyl and naphthyl, each optionally substituted with 1,2,3, or 4 substituents, each substituent selected from R₁，

Wherein heteroaryl is a saturated monocyclic, bicyclic, or tricyclic ring system having 1,2, or 3 heteroatom ring members independently selected from N, O or S, each ring system optionally substituted with 1,2,3,4, or 5 substituents each selected from R₁，

Wherein heterocyclyl is a saturated or partially unsaturated monocyclic, bicyclic, or tricyclic ring system having 1,2, or 3 heteroatom ring members independently selected from N, O or S, each ring system optionally substituted with 1,2,3,4, or 5 substituents each selected from R₂And are and

wherein C is_9-10Cycloalkyl is a saturated or partially unsaturated bicyclic ring system, each ring system optionally substituted with 1,2,3,4, or 5 substituents, each substituent selected from R₂；

B is a heterocyclic group, and B is a heterocyclic group,

wherein heterocyclyl is a saturated or partially unsaturated monocyclic, bicyclic, or polycyclic ring system having 1,2, or 3 heteroatom ring members independently selected from N, O or S, each ring system optionally substituted with 1,2,3,4, or 5 substituents each selected from R₄；

R₁Is halogen, hydroxy, cyano, C_1-4Alkyl, halo C_1-4Alkyl, amino, C_1-4Alkyl-amino, (C)_1-4Alkyl radical)₂-amino, amino-C_1-4Alkyl radical, C_1-4alkyl-amino-C_1-4Alkyl, (C)_1-4Alkyl radical)₂-amino-C_1-4Alkyl, amino-carbonyl, C_1-4Alkyl-amino-carbonyl, (C)_1-4Alkyl radical)₂-amino-carbonyl, C_1-4alkyl-amino-carbonyl-C_1-4Alkyl, (C)_1-4Alkyl radical)₂-amino-carbonyl-C_1-4Alkyl radical, C_1-4Alkyl-carbonyl-amino, C_1-4alkyl-carbonyl-amino-C_1-4Alkyl, hydroxy-C_1-4Alkyl radical, C_1-4Alkyl-carbonyl, C_1-4Alkoxy, halo-C_1-4Alkoxy, amino-C_1-4Alkoxy, hydroxy-C_1-4Alkoxy radical, C_1-4alkyl-C_1-4Alkoxy radical, C_1-4alkyl-amino-C_1-4Alkoxy group, (C)_1-4Alkyl radical)₂-amino-C_1-4Alkoxy radical, C_1-4alkyl-carbonyl-amino-C_1-4Alkoxy radical, C_1-4alkoxy-C_1-4Alkoxy radical, C_1-4Alkoxy-carbonyl, C_1-4Alkoxy-carbonyl-amino, C_1-4alkoxy-carbonyl-amino-C_1-4Alkoxy radical, C_2-4Alkenyl radical, C_2-4Alkenyl-amino-carbonyl, C_3-7Cycloalkyl radical, C_3-7cycloalkyl-C_1-4Alkoxy radical, C_3-7Cycloalkenyl, heteroaryl-C_1-4Alkyl, heteroaryl-C_1-4Alkyl-amino, heteroaryl-C_1-4Alkyl-amino-carbonyl, heteroaryl-C_1-4Alkyl-carbonyl-amino, heteroaryl-C_1-4alkyl-amino-carbonyl-C_1-4Alkyl, heteroaryl-C_1-4alkyl-carbonyl-amino-C_1-4Alkyl, heterocyclyl-C_1-4Alkyl, heterocyclyl-C_1-4Alkoxy, phenyl, or phenyl-C_1-4An alkoxy group,

wherein heteroaryl is a saturated monocyclic or bicyclic ring system having 1,2, or 3 heteroatom ring members selected from N, O and S,

wherein heterocyclyl is a saturated or partially unsaturated monocyclic or bicyclic ring system having 1,2, or 3 heteroatom ring members selected from N, O and S, and

wherein each instance of phenyl, heteroaryl or heterocyclyl is optionally substituted with 1 or 2 substituents, each substituent selected from R₃；

R₂Is halogen, hydroxy, cyano, oxo, hydroxy-imino, C_1-4Alkyl, halo-C_1-4Alkyl, amino, C_1-4Alkyl-amino, (C)_1-4Alkyl radical)₂-amino, amino-C_1-4Alkyl radical, C_1-4alkyl-amino-C_1-4Alkyl, (C)_1-4Alkyl radical)₂-amino-C_1-4Alkyl, amino-carbonyl, hydroxy-C_1-4Alkyl radical, C_1-4Alkoxy radical, C_1-4Alkoxy-carbonyl, C_2-4Alkenyl radical, C_3-7Cycloalkyl, or heterocyclyl-C_1-4An alkyl group, a carboxyl group,

wherein heterocyclyl is a saturated or partially unsaturated monocyclic or bicyclic ring system having 1,2 or 3 heteroatom ring members selected from N, O and S, and

wherein each instance of the heterocyclyl is optionally substituted with 1 or 2 substituents each selected from R₃；

R₃Is halogen, hydroxy, nitro, oxo, hydroxy-imino, C_1-4Alkyl, halo-C_1-4Alkyl, amino, C_1-4Alkyl-amino, (C)_1-4Alkyl radical)₂-amino, amino-C_1-4Alkyl radical, C_1-4alkyl-amino-C1-4 alkyl, (C)_1-4Alkyl radical)₂-amino-C_1-4Alkyl, amino-carbonyl, C_1-4Alkyl-amino-carbonyl, (C)_1-4Alkyl radical)₂-amino-carbonyl, C_1-4alkyl-amino-carbonyl-C_1-4Alkyl, (C)_1-4Alkyl radical)₂-amino-carbonyl-C_1-4Alkyl radical, C_1-4Alkyl-carbonyl-amino, C_1-4alkyl-carbonyl-amino-C_1-4Alkyl, hydroxy-C_1-4Alkyl radical, C_1-4Alkyl-carbonyl, C_1-4Alkoxy, halo-C_1-4Alkoxy, amino-C_1-4Alkoxy, hydroxy-C_1-4Alkoxy radical, C_1-4alkyl-C_1-4Alkoxy radical, C_1-4alkyl-amino-C_1-4Alkoxy group, (C)_1-4Alkyl radical)₂-amino-_1-4Alkoxy radical, C_1-4alkyl-carbonyl-amino-C_1-4Alkoxy radical, C_1-4alkoxy-C_1-4Alkoxy radical, C_1-4Alkoxy-carbonyl, C_1-4Alkoxy-carbonyl-amino, C_1-4alkoxy-carbonyl-amino-C_1-4Alkoxy radical, C_2-4Alkenyl radical, C_2-4Alkenyl-amino-carbonyl, C_3-7Cycloalkyl radical, C_3-7cycloalkyl-C_1-4Alkoxy radical, C_3-7Cycloalkenyl, heteroaryl-C_1-4Alkyl, heteroaryl-C_1-4Alkyl-amino, heteroaryl-C_1-4Alkyl-amino-carbonyl, heteroaryl-C_1-4Alkyl-carbonyl-amino, heteroaryl-C_1-4alkyl-amino-carbonyl-C_1-4Alkyl, heteroaryl-C_1-4alkyl-carbonyl-amino-C_1-4Alkyl, heterocyclyl-C_1-4Alkyl, phenyl, or phenyl-C_1-4An alkoxy group;

R₄independently selected from halogen, C_1-4Alkyl, hydroxy-C_1-4Alkyl, amino, C_1-4Alkyl-amino, (C)_1-4Alkyl radical)₂-amino, or hydroxy-C_1-4An alkyl-amino group; and

R₅is hydrogen, C_1-4Alkyl, or hydroxy-C_1-4An alkyl group;

wherein the form of the compound is selected from the group consisting of: a prodrug form, a salt form, a hydrate form, a solvate form, a clathrate form, an isotopologue form, a racemate form, an enantiomeric form, a diastereomeric form, a stereoisomeric form, a polymorphic form, and a tautomeric form thereof.

Embodiments of the present invention also relate to a method or use of a compound for treating or ameliorating HD in a subject in need thereof, the method or use comprising administering to the subject an effective amount of a compound of formula (I) or a form thereof, the compound of formula (I) being selected from compounds of formula (Ia) and formula (Ib):

wherein

X is CH₂、CH(C_1-4Alkyl group), C (C)_1-4Alkyl radical)₂、CH＝CH、O、NR₅Or a bond;

a is aryl, heteroaryl, heterocyclyl, or C_9-10A cycloalkyl group,

wherein aryl is selected from phenyl and naphthyl, each optionally substituted with 1,2,3, or 4 substituents, each substituent selected from R₁，

Wherein heteroaryl is a saturated monocyclic, bicyclic, or tricyclic ring system having 1,2, or 3 heteroatom ring members independently selected from N, O or S, each ring system optionally substituted with 1,2,3,4, or 5 substituents each selected from R₁，

Wherein heterocyclyl is a saturated or partially unsaturated monocyclic, bicyclic, or tricyclic ring system having 1,2, or 3 heteroatom ring members independently selected from N, O or S, each ring system optionally substituted with 1,2,3,4, or 5 substituents each selected from R₂And are and

wherein C is_9-10Cycloalkyl is a saturated or partially unsaturated bicyclic ring system, each bicyclic ring system optionally substituted with 1,2,3,4, or 5 substituents, each substituent selected from R₂；

B is a heterocyclic group, and B is a heterocyclic group,

wherein heterocyclyl is a saturated or partially unsaturated monocyclic, bicyclic, or polycyclic ring system having 1,2, or 3 heteroatom ring members independently selected from N, O or S, each ring system optionally substituted with 1,2,3,4, or 5 substituents each selected from R₄；

R₁Is halogen, hydroxyRadical, cyano radical, C_1-4Alkyl, halo C_1-4Alkyl, amino, C_1-4Alkyl-amino, (C)_1-4Alkyl radical)₂-amino, amino-C_1-4Alkyl radical, C_1-4alkyl-amino-C_1-4Alkyl, (C)_1-4Alkyl radical)₂-amino-C_1-4Alkyl, amino-carbonyl, C_1-4Alkyl-amino-carbonyl, C_1-4alkyl-amino-carbonyl-C_1-4Alkyl radical, C_1-4Alkyl-carbonyl-amino, C_1-4alkyl-carbonyl-amino-C_1-4Alkyl, hydroxy-C_1-4Alkyl radical, C_1-4Alkyl-carbonyl, C_1-4Alkoxy, halo-C_1-4Alkoxy, amino-C_1-4Alkoxy, hydroxy-C_1-4Alkoxy radical, C_1-4alkyl-C_1-4Alkoxy radical, C_1-4alkyl-amino-C_1-4Alkoxy group, (C)_1-4Alkyl radical)₂-amino-C_1-4Alkoxy radical, C_1-4alkyl-carbonyl-amino-C_1-4Alkoxy radical, C_1-4alkoxy-C_1-4Alkoxy radical, C_1-4Alkoxy-carbonyl, C_1-4Alkoxy-carbonyl-amino, C_1-4alkoxy-carbonyl-amino-C_1-4Alkoxy radical, C_2-4Alkenyl radical, C_2-4Alkenyl-amino-carbonyl, C_3-7Cycloalkyl radical, C_3-7cycloalkyl-C_1-4Alkoxy radical, C_3-7Cycloalkenyl, heteroaryl-C_1-4Alkyl, heteroaryl-C_1-4Alkyl-amino, heteroaryl-C_1-4Alkyl-amino-carbonyl, heteroaryl-C_1-4Alkyl-carbonyl-amino, heteroaryl-C_1-4alkyl-amino-carbonyl-C_1-4Alkyl, heteroaryl-C_1-4alkyl-carbonyl-amino-C_1-4Alkyl, heterocyclyl-C_1-4Alkyl, heterocyclyl-C_1-4Alkoxy, phenyl, or phenyl-C_1-4An alkoxy group,

wherein heteroaryl is a saturated monocyclic or bicyclic ring system having 1,2, or 3 heteroatom ring members selected from N, O and S,

wherein heterocyclyl is a saturated or partially unsaturated monocyclic or bicyclic ring system having 1,2, or 3 heteroatom ring members selected from N, O and S, and

wherein each instance of phenyl, heteroaryl or heterocyclyl is optionally substituted with 1 or 2 substituents, each substituent selected from R₃；

R₂Is halogen, hydroxy, cyano, oxo, hydroxy-imino, C_1-4Alkyl, halo-C_1-4Alkyl, amino, C_1-4Alkyl-amino, (C)_1-4Alkyl radical)₂-amino, amino-C_1-4Alkyl, amino-carbonyl, hydroxy-C_1-4Alkyl radical, C_1-4Alkoxy radical, C_1-4Alkoxy-carbonyl, C_2-4Alkenyl radical, C_3-7Cycloalkyl or heterocyclyl-C_1-4An alkyl group;

R₃is halogen, hydroxy, nitro, oxo, hydroxy-imino, C_1-4Alkyl, halo-C_1-4Alkyl, amino, C_1-4Alkyl-amino, (C)_1-4Alkyl radical)₂-amino, amino-C_1-4Alkyl radical, C_1-4alkyl-amino-C_1-4Alkyl, (C)_1-4Alkyl radical)₂amino-C_1-4Alkyl, amino-carbonyl, C_1-4Alkyl-amino-carbonyl, C_1-4alkyl-amino-carbonyl-C_1-4Alkyl radical, C_1-4Alkyl-carbonyl-amino, C_1-4alkyl-carbonyl-amino-C_1-4Alkyl, hydroxy-C_1-4Alkyl radical, C_1-4Alkyl-carbonyl, C_1-4Alkoxy, halo-C_1-4Alkoxy, amino-C_1-4Alkoxy, hydroxy-C_1-4Alkoxy radical, C_1-4alkyl-C_1-4Alkoxy radical, C_1-4alkyl-amino-C_1-4Alkoxy group, (C)_1-4Alkyl radical)₂-amino-C_1-4Alkoxy radical, C_1-4alkyl-carbonyl-amino-C_1-4Alkoxy radical, C_1-4alkoxy-C_1-4Alkoxy radical, C_1-4Alkoxy-carbonyl, C_1-4Alkoxy-carbonyl-amino, C_1-4alkoxy-carbonyl-amino-C_1-4Alkoxy radical, C_2-4Alkenyl radical, C_2-4Alkenyl-amino-carbonyl, C_3-7Cycloalkyl radical, C_3-7cycloalkyl-C_1-4Alkoxy radical, C_3-7Cycloalkenyl, heteroaryl-C_1-4Alkyl, heteroaryl-C_1-4Alkyl-amino, heteroaryl-C_1-4Alkyl-amino-carbonyl, heteroaryl-C_1-4Alkyl-carbonyl-amino, heteroaryl-C_1-4alkyl-amino-carbonyl-C_1-4Alkyl, heteroaryl-C_1-4alkyl-carbonyl-amino-C_1-4Alkyl, heterocyclyl-C_1-4Alkyl, phenyl, or phenyl-C_1-4An alkoxy group;

R₄independently selected from halogen, C_1-4Alkyl, hydroxy-C_1-4Alkyl, amino, C_1-4Alkyl-amino, (C)_1-4Alkyl radical)₂-amino, or hydroxy-C_1-4An alkyl-amino group; and

R₅is hydrogen, C_1-4Alkyl, or hydroxy-C_1-4An alkyl group;

wherein the form of the compound is selected from the group consisting of: a prodrug form, a salt form, a hydrate form, a solvate form, a clathrate form, an isotopologue form, a racemate form, an enantiomeric form, a diastereomeric form, a stereoisomeric form, a polymorphic form, and a tautomeric form thereof.

Another embodiment of the present invention also relates to a method for treating or ameliorating HD in a subject in need thereof, said method comprising administering to the subject an effective amount of a compound of formula (I) or a form thereof, selected from compounds of formula (Ia) and formula (Ib):

wherein

X is O, NH, N (CH)₃) Or a bond;

a is aryl, heteroaryl or heterocyclyl,

wherein aryl is selected from the group consisting of:

wherein heteroaryl is selected from the group consisting of:

wherein the heterocyclic group is selected from the group consisting of:

b is a heterocyclic group selected from the group consisting of:

r, where the available valency permits_1a、R_1bAnd R_1cEach is one or more substituents independently selected from: halogen, hydroxy, cyano, C_1-4Alkyl, halo C_1-4Alkyl, amino, C_1-4Alkyl-amino, (C)_1-4Alkyl radical)₂-amino, amino-C_1-4Alkyl radical, C_1-4alkyl-amino-C_1-4Alkyl, (C)_1-4Alkyl radical)₂-amino-C_1-4Alkyl, amino-carbonyl, C_1-4Alkyl-amino-carbonyl, (C)_1-4Alkyl radical)₂-amino-carbonyl, C_1-4alkyl-amino-carbonyl-C_1-4Alkyl, (C)_1-4Alkyl radical)₂-amino-carbonyl-C_1-4Alkyl radical, C_1-4Alkyl-carbonyl-amino, C_1-4alkyl-carbonyl-amino-C_1-4Alkyl, hydroxy-C_1-4Alkyl radical, C_1-4Alkyl-carbonyl, C_1-4Alkoxy, halo-C_1-4Alkoxy, amino-C_1-4Alkoxy, hydroxy-C_1-4Alkoxy radical, C_1-4alkyl-C_1-4Alkoxy radical, C_1-4alkyl-amino-C_1-4Alkoxy group, (C)_1-4Alkyl radical)₂amino-C_1-4Alkoxy radical, C_1-4alkyl-carbonyl-amino-C_1-4Alkoxy radical, C_1-4alkoxy-C_1-4Alkoxy radical, C_1-4Alkoxy-carbonyl, C_1-4Alkoxy-carbonyl-amino, C_1-4alkoxy-carbonyl-amino-C_1-4Alkoxy radical, C_2-4Alkenyl radical, C_2-4Alkenyl-amino-carbonyl, C_3-7Cycloalkyl radical, C_3-7cycloalkyl-C_1-4Alkoxy radical, C_3-7Cycloalkenyl, heteroaryl-C_1-4Alkyl, heteroaryl-C_1-4Alkyl-amino, heteroaryl-C_1-4Alkyl-amino-carbonyl, heteroaryl-C_1-4Alkyl-carbonyl-amino, heteroaryl-C_1-4alkyl-amino-carbonyl-C_1-4Alkyl, heteroaryl-C_1-4alkyl-carbonyl-amino-C_1-4Alkyl, heterocyclyl-C_1-4Alkyl, heterocyclyl-C_1-4Alkoxy, phenyl, or phenyl-C_1-4An alkoxy group,

wherein heteroaryl is a saturated monocyclic or bicyclic ring system having 1,2, or 3 heteroatom ring members selected from N, O and S,

wherein heterocyclyl is a saturated or partially unsaturated monocyclic or bicyclic ring system having 1,2, or 3 heteroatom ring members selected from N, O and S, and

wherein each instance of phenyl, heteroaryl or heterocyclyl is optionally substituted with 1 or 2 substituents, each substituent selected from R₃；

R, where the available valency permits_2a、R_2bAnd R_2cEach is one or more substituents independently selected from: halogen, hydroxy, cyano, oxo, hydroxy-imino, C_1-4Alkyl, halo-C_1-4Alkyl, amino, C_1-4Alkyl-amino, (C)_1-4Alkyl radical)₂-amino, amino-C_1-4Alkyl radical, C_1-4alkyl-amino-C_1-4Alkyl, (C)_1-4Alkyl radical)₂amino-C_1-4Alkyl, amino-carbonyl, hydroxy-C_1-4Alkyl radical, C_1-4Alkoxy radical, C_1-4Alkoxy-carbonyl, C_2-4Alkenyl radical, C_3-7Cycloalkyl, or heterocyclyl-C_1-4An alkyl group, a carboxyl group,

wherein heterocyclyl is a saturated or partially unsaturated monocyclic or bicyclic ring system having 1,2 or 3 heteroatom ring members selected from N, O and S, and

wherein each instance of the heterocyclyl is optionally substituted with 1 or 2 substituents each selected from R₃；

R₃Is halogen, hydroxy, nitro, oxo, hydroxy-imino, C_1-4Alkyl, amino, C_1-4Alkyl-amino, (C)_1-4Alkyl radical)₂-amino, amino-C_1-4Alkyl radical, C_1-4alkyl-amino-C_1-4Alkyl, (C)_1-4Alkyl radical)₂-amino-C_1-4Alkyl, amino-carbonyl, C_1-4Alkyl-amino-carbonyl, (C)_1-4Alkyl radical)₂-amino-carbonyl, C_1-4alkyl-amino-carbonyl-C_1-4Alkyl, (C)_1-4Alkyl radical)₂-amino-carbonyl-C_1-4Alkyl radical, C_1-4Alkyl-carbonyl-amino, C_1-4alkyl-carbonyl-amino-C_1-4Alkyl, hydroxy-C_1-4Alkyl radical, C_1-4Alkyl-carbonyl, C_1-4Alkoxy, halo-C_1-4Alkoxy, amino-C_1-4Alkoxy, hydroxy-C_1-4Alkoxy radical, C_1-4alkyl-C_1-4Alkoxy radical, C_1-4alkyl-amino-C_1-4Alkoxy group, (C)_1-4Alkyl radical)₂-amino-C_1-4Alkoxy radical, C_1-4alkyl-carbonyl-amino-C_1-4Alkoxy radical, C_1-4alkoxy-C_1-4Alkoxy radical, C_1-4Alkoxy-carbonyl, C_1-4Alkoxy-carbonyl-amino, C_1-4alkoxy-carbonyl-amino-C_1-4Alkoxy radical, C_2-4Alkenyl radical, C_2-4Alkenyl-amino-carbonyl, C_3-7Cycloalkyl radical, C_3-7cycloalkyl-C_1-4Alkoxy radical, C_3-7Cycloalkenyl, heteroaryl-C_1-4Alkyl, heteroaryl-C_1-4Alkyl-amino, heteroaryl-C_1-4Alkyl-amino-carbonyl, heteroaryl-C_1-4Alkyl-carbonyl-amino, heteroaryl-C_1-4alkyl-amino-carbonyl-C_1-4Alkyl, heteroaryl-C_1-4alkyl-carbonyl-amino-C_1-4Alkyl, heterocyclyl-C_1-4Alkyl, phenyl, or phenyl-C_1-4An alkoxy group; and

R_4a、R_4b、R_4c、R_4d、R_4e、R_4fand R_4gIndependently selected from halogen, C_1-4Alkyl, hydroxy-C_1-4Alkyl, amino, C_1-4Alkyl-amino, (C)_1-4Alkyl radical)₂-amino, or hydroxy-C_1-4An alkyl-amino group;

wherein the form of the compound is selected from the group consisting of: a prodrug form, a salt form, a hydrate form, a solvate form, a clathrate form, an isotopologue form, a racemate form, an enantiomeric form, a diastereomeric form, a stereoisomeric form, a polymorphic form, and a tautomeric form thereof.

Another aspect of the invention relates to a compound of formula (I) or a form thereof, selected from a compound of formula (Ia11), a compound of formula (Ia15), a compound of formula (Ia18) or a compound of formula (Ib 1):

wherein (when present) the first and second (e.g.,

x is selected from O, NR₅Or a bond;

a is selected from phenyl, thienyl, indazolyl, pyridyl, pyrimidinyl or phenoxy, wherein phenyl and phenoxy are each optionally substituted with 1,2 or 3 substituents, each substituent selected from R_1a，

Wherein thienyl, indazolyl, pyridyl, pyrimidinyl are each optionally substituted with 1 or 2 substituents, each substituent selected from R_1a，

B is selected from 1H-pyridineAzolyl, piperidinyl, 1,2,3, 6-tetrahydropyridinyl, (IR, 5S) -8-azabicyclo [3.2.1]Octyl, 8-azabicyclo [3.2.1]Oct-2-enyl, 2, 6-diazaspiro [3.4]]Octyl, or 2, 7-diazaspiro [3.5]]Nonyl, each optionally substituted with 1 or 2 substituents, each substituent selected from R_4a；

R_1aSelected from halogen, hydroxy, C_1-4Alkyl, halo-C_1-4Alkyl, amino, C_1-4An alkoxy group or a heteroaryl group, in which,

wherein heteroaryl is a saturated monocyclic or bicyclic ring system having 1,2 or 3 heteroatom ring members selected from N, O and S, each ring system being optionally substituted with 1 or 2 substituents each selected from R_3a；

R_3aSelected from nitro or C_1-4An alkyl group; and the combination of (a) and (b),

R_4ais C_1-4An alkyl group;

R_5ais hydrogen, C_1-4Alkyl, or hydroxy-C_1-4An alkyl group;

wherein the form of the compound is selected from the group consisting of: a prodrug form, a salt form, a hydrate form, a solvate form, a clathrate form, an isotopologue form, a racemate form, an enantiomeric form, a diastereomeric form, a stereoisomeric form, a polymorphic form, and a tautomeric form thereof.

Another aspect of the invention relates to a compound of formula (I) or a form thereof, selected from a compound of formula (Ia11), a compound of formula (Ia15), a compound of formula (Ia18) or a compound of formula (Ib 1):

wherein (when present) the first and second (e.g.,

R_1aselected from fluorine, chlorine, hydroxyl, methyl, difluoromethyl, amino, methoxy or 1H-pyrazolyl or 1H-imidazol-1-yl,

wherein 1H-pyrazolyl is optionally substituted with 1 or 2 substituents each selected from R_3a；

R_3aSelected from nitro or methyl or amino; and the combination of (a) and (b),

R_4ais methyl or ethyl;

R_5ais hydrogen or methyl;

wherein the form of the compound is selected from the group consisting of: a prodrug form, a salt form, a hydrate form, a solvate form, a clathrate form, an isotopologue form, a racemate form, an enantiomeric form, a diastereomeric form, a stereoisomeric form, a polymorphic form, and a tautomeric form thereof.

Another embodiment of the method of the invention comprises the use of a compound of formula (Ia) or a form thereof selected from compounds of formula (Ia1) or a form thereof, wherein the substituent R_1a、R_1bAnd X (when present) has a plurality of substituents separated by commas as shown in the table below; and, "- - -" indicates that one or more R's are not present_1a、R_1bAnd X substituents:

another embodiment of the method of the invention comprises the use of a compound of formula (Ia) or a form thereof selected from compounds of formula (Ia2) or a form thereof, wherein the substituent R_1a、R_1bAnd R_4a(when present) has a plurality of substituents separated by commas as shown in the following table; and, "- - -" indicates that one or more R's are not present_1a、R_1bAnd R_4aSubstituent(s):

another embodiment of the method of the invention comprises the use of a compound of formula (Ia) or a form thereof selected from compounds of formula (Ia3) or a form thereof, wherein the substituent R_1a、R_1bAnd X (when present) has a plurality of substituents separated by commas as shown in the table below; and, "- - -" indicates that one or more R's are not present_1a、R_1bAnd X substituents:

another embodiment of the methods of the present invention includes the use of a compound of formula (Ia) or a form thereof selected from compounds of formula (Ia4) or a form thereof, wherein substituent X, R_1a、R_1bAnd R_4a(when present) has a plurality of substituents separated by commas as shown in the following table; and "- -" indicates that there are no one or more X, R_1a、R_1bAnd R_4aSubstituent(s):

another implementation of the method of the inventionThe mode comprises the use of a compound of formula (Ia) or a form thereof (selected from compounds of formula (Ia5) or a form thereof), wherein the substituent R_1aAnd R_1b(when present) has a plurality of substituents separated by commas as shown in the following table; and, "- - -" indicates that one or more R's are not present_1aAnd R_1bSubstituent(s):

another embodiment of the method of the invention comprises the use of a compound of formula (Ia) or a form thereof selected from compounds of formula (Ia6) or a form thereof, wherein the substituent R_1a(when present) as shown in the following table; and, "- - -" indicates that one or more R's are not present_1aSubstituent(s):

compound (I)	R1a
		239	--
246	2,3-(CH3)2
		247	2-CH3
248	3-CH3

Another embodiment of the method of the invention comprises the use of a compound of formula (Ia) or a form thereof selected from compounds of formula (Ia7) or a form thereof, wherein the substituent R_1a(when present) as shown in the following table; and, "- - -" indicates that one or more R's are not present_1aSubstituent(s):

compound (I)	R1a
		258	--
260	2-CH3

Another embodiment of the method of the invention comprises the use of a compound of formula (Ia) or a form thereof selected from compounds of formula (Ia8) or a form thereof, wherein the substituent R_1aAnd B (when present) are as shown in the following table; and, "- - -" indicates that one or more R's are not present_1aAnd B substituents:

compound (I)	R1a	B
			209	--	6-((3aR,6aS)-5-CH3-hexahydropyrrolo [3,4-c]Pyrrole-2 (1H) -yl
269	2-CN	Piperazin-1-yl

Another embodiment of the method of the invention comprises the use of a compound of formula (Ia) or a form thereof selected from compounds of formula (Ia9) or a form thereof, wherein the substituent R_1aAnd B (when present) are as shown in the following table; and, "- - -" indicates that one or more R's are not present_1aAnd B substituents:

compound (I)	R1a	B
			214	--	6-((3aR,6aS)-5-CH3-hexahydropyrrolo [3,4-c]Pyrrole-2 (1H) -yl
270	--	Piperazin-1-yl
			291	3-CH3	Piperazin-1-yl

Another embodiment of the method of the invention comprises the use of a compound of formula (Ia) or a form thereof selected from compounds of formula (Ia10) or a form thereof, wherein the substituent R_1aAnd B (when present) are as shown in the following table; and, "- - -" indicates that one or more R's are not present_1aAnd B substituents:

compound (I)	R1a	B
			268	2-CN	Piperazin-1-yl
271	--	1,2,3, 6-tetrahydropyridin-4-yl

Another embodiment of the method of the invention includes the use of a compound of formula (Ia) or a form thereof selected from compounds of formula (Ia11) or a form thereof, wherein substituents A, X and R_4a(when present) as shown in the following table; and, "- - -" indicates that one or more of A, X and R are not present_4aSubstituent(s):

another embodiment of the invention includes a compound of formula (Ia) or a form thereof (selected from compounds of formula (Ia11) or a form thereof), wherein substituents A, X and R_4a(when present) as shown in the following table; and, "- - -" indicates that one or more of A, X and R are not present_4aSubstituent(s):

compound (I)	A	X
			420	2-OCH3-4-(4-NO2-1H-pyrazol-1-yl) phenyl	N(CH3)
428	2,5-F2-4- (1H-pyrazol-4-yl) phenyl	N(CH3)
			430	2,3-F2-4- (1H-pyrazol-4-yl) phenyl	N(CH3)
431	2,5-F2-4- (1H-pyrazol-4-yl) phenyl	O
			434	2-OCH3-4- (1H-pyrazol-4-yl) phenyl	N(CH3)
435	4- (1H-pyrazol-4-yl) phenyl	O
			437	2-F-4- (1H-pyrazol-4-yl) phenyl	O
438	4-(1-CH3-1H-pyrazol-4-yl) thiophen-2-yl	O
			440	2-F-4-OH-phenyl	N(CH3)
442	2-CH3-2H-indazol-5-yl	N(CH3)
			443	2-CH3-2H-indazol-5-yl	O
444	4-Cl-2-OCH3-phenyl radical	O
			445	2-CH3Pyrazolo [1,5-a ]]Pyridin-3-yl	N(CH3)
446	Imidazo [1,2-a ]]Pyridin-6-yl	O
			447	2-OCH3-4- (1H-pyrazol-1-yl) phenyl	O
448	5- (1H-pyrazol-4-yl) thiophen-2-yl	O
			449	5-(1-CH3-1H-pyrazol-4-yl) thiophen-2-yl	O
450	4- (1H-pyrazol-4-yl) thiophen-2-yl	O
			451	2-OH-4-[3,5-(CH3)2-1H-pyrazol-4-yl]Phenyl radical	O
452	2-F-4- (1H-pyrazol-4-yl) phenyl	N(CH3)
			453	2-OCH3-4-OH-phenyl	O
454	2-OCH3-4-(4-NO2-1H-pyrazol-1-yl) phenyl	O
			455	2,4-(OH)2-phenyl radical	O
456	2-Cl-4- (1H-pyrazol-4-yl) phenyl	N(CH3)
			457	5-amino-2- (1H-pyrazol-4-yl) pyrimidin-4-yl	O
458	2,6-F2-4- (1H-pyrazol-4-yl) phenyl	O
			464	2-(CHF2) -4- (1H-pyrazol-4-yl) phenyl	O
465	2-(CHF2) -4- (1H-pyrazol-4-yl) phenyl	N(CH3)

Another embodiment of the method of the invention includes the use of a compound of formula (Ia) or a form thereof selected from compounds of formula (Ia11) or a form thereof, wherein substituents A, X and R_4a(when present) as shown in the following table; and, "- - -" indicates that one or more of A, X and R are not present_4aSubstituent(s):

compound (I)	A	X
			420	2-OCH3-4-(4-NO2-1H-pyrazol-1-yl) phenyl	N(CH3)
428	2,5-F2-4- (1H-pyrazol-4-yl) phenyl	N(CH3)
			430	2,3-F2-4- (1H-pyrazol-4-yl) phenyl	N(CH3)
431	2,5-F2-4- (1H-pyrazol-4-yl) phenyl	O
			434	2-OCH3-4- (1H-pyrazol-4-yl) phenyl	N(CH3)
435	4- (1H-pyrazol-4-yl) phenyl	O
			437	2-F-4- (1H-pyrazol-4-yl) phenyl	O
438	4-(1-CH3-1H-pyrazol-4-yl) thiophen-2-yl	O
			440	2-F-4-OH-phenyl	N(CH3)
442	2-CH3-2H-indazol-5-yl	N(CH3)
			443	2-CH3-2H-indazol-5-yl	O
444	4-Cl-2-OCH3-phenyl radical	O
			445	2-CH3Pyrazolo [1,5-a ]]Pyridin-3-yl	N(CH3)
446	Imidazo [1,2-a ]]Pyridin-6-yl	O
			447	2-OCH3-4- (1H-pyrazol-1-yl) phenyl	O
448	5- (1H-pyrazol-4-yl) thiophen-2-yl	O
			449	5-(1-CH3-1H-pyrazol-4-yl) thiophen-2-yl	O
450	4- (1H-pyrazol-4-yl) thiophen-2-yl	O
			451	2-OH-4-[3,5-(CH3)2-1H-pyrazol-4-yl]Phenyl radical	O
452	2-F-4- (1H-pyrazol-4-yl) phenyl	N(CH3)
			453	2-OCH3-4-OH-phenyl	O
454	2-OCH3-4-(4-NO2-1H-pyrazol-1-yl) phenyl	O
			455	2,4-(OH)2-phenyl radical	O
456	2-Cl-4- (1H-pyrazol-4-yl)) Phenyl radical	N(CH3)
			457	5-amino-2- (1H-pyrazol-4-yl) pyrimidin-4-yl	O
458	2,6-F2-4- (1H-pyrazol-4-yl) phenyl	O
			464	2-(CHF2) -4- (1H-pyrazol-4-yl) phenyl	O
465	2-(CHF2) -4- (1H-pyrazol-4-yl) phenyl	N(CH3)

Another embodiment of the methods of the present invention includes the use of a compound of formula (Ia) or a form thereof selected from compounds of formula (Ia12) or a form thereof, wherein substituent X, R_1aAnd B (when present) are as shown in the following table; and "- -" indicates that there are no one or more X, R_1aAnd B substituents:

compound (I)	R1a	X	B
				66	H	NH	Azetidin-3-yl
82	OH	--	Piperazin-1-yl
				85	H	--	1,2,3, 6-tetrahydropyridin-4-yl
86	OH	--	1,2,3, 6-tetrahydropyridin-4-yl
				87	OH	--	2,2,6, 6-tetramethyl- (1,2,3, 6-tetrahydropyridin-4-yl)
88	OH	--	1-CH3- (1,2,3, 6-tetrahydropyridin-4-yl)
				89	OH	--	Piperidin-4-yl radical
99	H	CH2	Piperidin-4-yl radical

Another embodiment of the methods of the present invention includes the use of a compound of formula (Ia) or a form thereof selected from compounds of formula (Ia13) or a form thereof, wherein substituent X, R_1aAnd R_4a(when present) as shown in the following table; and "- -" indicates that there are no one or more X, R_1aAnd R_4aSubstituent(s):

another embodiment of the method of the invention comprises the use of a compound of formula (Ia) or a form thereof selected from compounds of formula (Ia14) or a form thereof, wherein substituents X and B (when present) are as shown in the following table; and, "- -" indicates that one or more X and B substituents are absent:

compound (I)	X	B
			55	O	Piperidin-4-yl radical
56	O	(2S,4R,6R)-2,6-(CH3)2-piperidin-4-yl
			57	O	2,6-(CH3)2-piperidin-4-yl
58	O	Pyrrolidin-3-yl radical
			59	O	2-CH3-piperidin-4-yl
60	OCH2	1H-pyrrolidin-3-yl
			61	O	3-F-piperidin-4-yl
65	--	Piperazin-1-yl
			67	NH	Azetidin-3-yl
68	--	3,5-(CH3)2-piperazin-1-yl
			69	--	7-CH3-2, 7-diazaspiro [4.4]Non-2-yl
70	--	[1,4]Diazepin-1-yl
			71	--	4-CH2CH2OH-piperazin-1-yl
72	--	2, 7-diazaspiro [3.5]]Non-7-yl
			73	--	2, 7-diazaspiro [3.5]]Non-7-yl
74	--	3-CH2OH-piperazin-1-yl
			75	--	1, 7-diazaspiro [4.4]]Non-7-yl
76	--	4-NH2-4-CH3-piperidin-1-yl
			77	--	3-N(CH3)2-piperidin-1-yl
79	--	3,3-(CH3)2-piperazin-1-yl
			80	--	7-CH2CH2OH-2, 7-diazaspiro [4.4]]Non-2-yl
83	--	1,2,3, 6-tetrahydropyridin-4-yl
			84	--	Piperidin-4-yl radical
102	O	(6S)-6-[(S)-CH(OH)CH3]-2,2-(CH3)2-piperidin-4-yl
			133	O	2,2-(CH3)2-piperidin-4-yl

Another embodiment of the methods of the present invention includes the use of a compound of formula (Ia) or a form thereof selected from compounds of formula (Ia15) or a form thereof, wherein substituent X, R_1aAnd R_4a(when present) as shown in the following table; and "- -" indicates that there are no one or more X, R_1aAnd R_4aSubstituent(s):

another embodiment of the invention includes compounds of formula (Ia) or a form thereof (selected from compounds of formula (Ia15) or a form thereof), wherein substituent X, R is_1aAnd R_4a(when present) as shown in the following table; and "- -" indicates that there are no one or more X, R_1aAnd R_4aSubstituent(s):

compound (I)	X	R1a	R4a
				413	NH	1H-pyrazol-4-yl	--
414	O	1-CH3-1H-pyrazol-4-yl	--
				416	N(CH3)	5-CH3-1H-pyrazol-4-yl	--
417	O	1H-imidazol-1-yl	--
				418	O	5-CH3-1H-pyrazol-4-yl	--
419	N(CH3)	4-NO2-1H-pyrazol-1-yl	--
				421	O	5-NH2-1H-pyrazol-1-yl	--
423	O	4-NO2-1H-pyrazol-1-yl	--
				460	N(CH3)	1H-pyrazol-4-yl	--
461	O	1H-pyrazol-4-yl	--

Another embodiment of the methods of the present invention includes the use of a compound of formula (Ia) or a form thereof selected from compounds of formula (Ia15) or a form thereof, wherein substituent X, R_1aAnd R_4a(when present) as shown in the following table; and "- -" indicates that there are no one or more X, R_1aAnd R_4aSubstituent(s):

compound (I)	X	R1a
			413	NH	1H-pyrazol-4-yl
414	O	1-CH3-1H-pyrazol-4-yl
			416	N(CH3)	5-CH3-1H-pyrazol-4-yl
417	O	1H-imidazol-1-yl
			418	O	5-CH3-1H-pyrazol-4-yl
419	N(CH3)	4-NO2-1H-pyrazol-1-yl
			421	O	5-NH2-1H-pyrazol-1-yl
423	O	4-NO2-1H-pyrazol-1-yl
			460	N(CH3)	1H-pyrazol-4-yl
461	O	1H-pyrazol-4-yl

Another embodiment of the method of the invention comprises the use of a compound of formula (Ia) or a form thereof selected from compounds of formula (Ia16) or a form thereof, wherein the substituent R_1aAnd R_4a(when present) as shown in the following table; and, "- - -" indicates that one or more R's are not present_1aAnd R_4aSubstituent(s):

compound (I)	R1a	R4a
			81	1H-pyrazol-1-yl	--
199	1H-pyrazol-4-yl	(CH2)2OH
			200	1H-pyrazol-4-yl	--
201	1H-pyrazol-4-yl	CH3
			202	4-(1-CH3-pyridin-2 (1H) -one)	CH3
203	4-(1-CH3-pyridin-2 (1H) -one)	CH3

Another embodiment of the method of the invention comprises the use of a compound of formula (Ia) or a form thereof selected from compounds of formula (Ia17) or a form thereof, wherein the substituent R_1a(when present) as shown in the following table; and, "- - -" indicates that one or more R's are not present_1aSubstituent(s):

compound (I)	R1a
		204	1H-pyrazol-4-yl
205	4-(1-CH3-pyridin-2 (1H) -one)

Another embodiment of the invention includes a compound of formula (Ia) or a form thereof (selected from compounds of formula (Ia18) or a form thereof), wherein substituents X and B (when present) are as shown in the table below; and, "- -" indicates that one or more X and B substituents are absent:

compound (I)	X	B
			411	N(CH3)	(1R,5S) -8-azabicyclo [3.2.1]Oct-3-yl
412	NH	(1R,5S) -8-azabicyclo [3.2.1]Oct-3-yl
			415	O	(1R,5S) -8-azabicyclo [3.2.1]Oct-3-yl
422	--	1-CH3- (1,2,3, 6-tetrahydropyridin-4-yl)
			424	--	1,2,3, 6-tetrahydropyridin-4-yl
425	--	1-CH3CH2- (1,2,3, 6-tetrahydropyridin-4-yl)
			425	N(CH3)	Piperidin-4-yl radical
427	NH	Piperidin-4-yl radical
			429	--	8-azabicyclo [3.2.1]Oct-2-en-3-yl
432	O	Piperidin-4-yl radical
			433	NH	(1R,5S) -8-azabicyclo [3.2.1]Oct-3-yl
436	O	2,6-(CH3)2-piperidin-4-yl
			439	--	2, 7-diazaspiro [3.5]]Non-2-yl
441	O	2,6-(CH3)2-piperidin-4-yl
			459	--	2, 6-diazaspiro [3.5]]Oct-2-yl

Another embodiment of the methods of the present invention includes the use of a compound of formula (Ia) or a form thereof selected from compounds of formula (Ia18) or a form thereof, wherein substituent X, R_1aAnd B (when present) are as shown in the following table; and "- -" indicates that there are no one or more X, R_1aAnd B substituents:

another embodiment of the method of the invention comprises the use of a compound of formula (Ib) or a form thereof selected from compounds of formula (Ib1) or a form thereof, wherein substituent a is as shown in the following table:

compound (I)	A
		302	6- (naphthalene-2-ol)
320	6- (naphthalene-2, 7-diol)
		331	7-OCH3-quinolin-6-yl
332	7-OH-quinolin-6-yl
		337	2-CN-7-OCH3-quinolin-6-yl
355	3-F-5- (1H-pyrazol-4-yl) -pyridin-2-yl
		364	2-(6-OCH3-3, 4-dihydroisoquinoline-1 (2H) -one)
392	6-OH-1-oxo-2, 3-dihydro-1H-inden-5-yl
		401	3-(4-OCH3-1-CH3-quinoline-1 (2H) -one)
402	3-(4-OH-1-CH3-quinoline-1 (2H) -one)
		403	3- (quinoline-2 (1H) -one)
404	3-(1-OCH3-quinoline-2 (1H) -one)
		408	5-CN-benzo [ b]Thien-2-yl
409	5-Cl-benzo [ b]Thien-2-yl

Another embodiment of the invention includes compounds of formula (Ib) or a form thereof (selected from compounds of formula (Ib1) or a form thereof), wherein substituent a is as shown in the following table:

compound (I)	A
		462	3- (1H-pyrazol-4-yl) phenoxy
463	4- (1H-pyrazol-4-yl) phenoxy

Another embodiment of the method of the invention comprises the use of a compound of formula (Ib) or a form thereof selected from compounds of formula (Ib1) or a form thereof, wherein substituent a is as shown in the following table:

compound (I)	A
		462	3- (1H-pyrazol-4-yl) phenoxy
463	4- (1H-pyrazol-4-yl) phenoxy

Another embodiment of the method of the invention comprises the use of a compound of formula (Ib) or a form thereof selected from compounds of formula (Ib2) or a form thereof, wherein substituent a is as shown in the following table:

compound (I)	A
		321	6-naphthalene-2, 7-diol

Another embodiment of the process of the invention comprises the use of a compound of formula (Ib) or a form thereof selected from compounds of formula (Ib3) or a form thereof, wherein the substituent R_1a、R_1bAnd B (when present) are as shown in the following table; and, "- - -" indicates that one or more R's are not present_1a、R_1bAnd B substituents:

another embodiment of the invention encompasses the use of a compound of formula (Ib) or a form thereof selected from compounds of formula (Ib4) or a form thereof, wherein the substituent R_1a、R_1b、R_1c、R_1d(each represents R)₁Ranges of (b) and X (when present) are as shown in the table below; and, "- - -" indicates that one or more R's are not present_1a、R_1b、R_1c、R_1dAnd X substituents:

another embodiment of the process of the invention comprises the use of a compound of formula (Ib) or a form thereof selected from compounds of formula (Ib5) or a form thereof, wherein the substituent R_1a、R_1b、R_1c、R_1d(each represents R)₁Range of) and R_4a(when present) as shown in the following table; and, "- - -" indicates that one or more R's are not present_1a、R_1b、R_1c、R_1dAnd R_4aSubstituent(s):

compound (I)	R1a	R1b	R1c	R1d	R4a
						353	1H-pyrazol-4-yl	F	F	H	--
362	1H-pyrazol-4-yl	OCH3	H	F	CH3
						370	1H-imidazol-1-yl	Cl	H	H	CH3
379	1-CH3-1H-pyrazol-4-yl	Cl	H	H	CH3
						380	1H-pyrazol-4-yl	Cl	H	H	CH3
384	1H-pyrazol-4-yl	F	H	H	CH3
						396	1H-pyrazol-4-yl	F	H	OH	--
405	1H-pyrazol-4-yl	Cl	H	H	--

Another embodiment of the process of the invention comprises the use of a compound of formula (Ib) or a form thereof selected from compounds of formula (Ib6) or a form thereof, wherein the substituent R_1a、R_1b、R_1cAnd R_1d(each represents R)₁Ranges of (d) (when present) are shown in the following table; and, "- - -" indicates that one or more R's are not present_1a、R_1b、R_1cAnd R_1dSubstituent(s):

compound (I)	R1a	R1b	R1c	R1d
					386	1-CH3-1H-pyrazol-4-yl	OCH3	H	H
395	1-CH3-1H-pyrazol-4-yl	OH	H	H
					399	1H-pyrazol-4-yl	H	F	F
400	1H-pyrazol-4-yl	OH	H	F

Another embodiment of the method of the invention comprisesUse of a compound comprising formula (Ib) or a form thereof selected from compounds of formula (Ib7) or a form thereof, wherein the substituent R_1b(when present) as shown in the following table:

compound (I)	R1b
		304	OCH3
322	OH

Another embodiment of the process of the invention comprises the use of a compound of formula (Ib) or a form thereof selected from compounds of formula (Ib8) or a form thereof, wherein the substituent R_1b(when present) as shown in the following table:

compound (I)	R1b
		303	OCH3
323	OH

Embodiments of the use of a compound of formula (I) or a form thereof include a method of using a compound of formula (I) or a form thereof for treating or ameliorating HD in a subject in need thereof, the method comprising administering to the subject an effective amount of a compound of formula (I) or a form thereof selected from the group consisting of:

wherein the form of the compound is selected from the group consisting of: a prodrug form, a salt form, a hydrate form, a solvate form, a clathrate form, an isotopologue form, a racemate form, an enantiomeric form, a diastereomeric form, a stereoisomeric form, a polymorphic form, and a tautomeric form thereof.

In another aspect, the compounds of formula (I) or forms thereof include compounds selected from the group consisting of:

wherein the form of the compound is selected from the group consisting of: a prodrug form, a salt form, a hydrate form, a solvate form, a clathrate form, an isotopologue form, a racemate form, an enantiomeric form, a diastereomeric form, a stereoisomeric form, a polymorphic form, and a tautomeric form thereof.

Another embodiment of the use of a compound of formula (I) or a form thereof comprises a method of using a compound of formula (I) or a form thereof for treating or ameliorating HD in a subject in need thereof, the method comprising administering to the subject an effective amount of a compound of formula (I) or a form thereof selected from the group consisting of (wherein, compound number (#) is a compound number¹) Indicating isolation of the salt form):

wherein the form of the compound is selected from the group consisting of: a prodrug form, a salt form, a hydrate form, a solvate form, a clathrate form, an isotopologue form, a racemate form, an enantiomeric form, a diastereomeric form, a stereoisomeric form, a polymorphic form, and a tautomeric form thereof.

In one aspect, the compounds of formula (I) or forms thereof include compounds selected from the group consisting of:

411¹2- {6- [ (1R,5S) -8-azabicyclo [3.2.1]Oct-3-yl (methyl) amino]Pyridazin-3-yl } -5- (1H-pyrazol-4-yl) phenol

412¹2- [6- ((1R,5S) -8-azabicyclo [3.2.1]Oct-3-ylamino) pyridazin-3-yl]-5- (1H-pyrazol-4-yl) phenol

413¹5- (1H-pyrazol-4-yl) -2- {6- [ (2,2,6, 6-tetramethylpiperidin-4-yl) amino]Pyridazin-3-yl } phenols

4145- (1-methyl-1H-pyrazol-4-yl) -2- {6- [ (2,2,6, 6-tetramethylpiperidin-4-yl) oxy ] pyridazin-3-yl } phenol

415¹2- [6- ((1R,5S) -8-azabicyclo [3.2.1]Oct-3-yloxy) pyridazin-3-yl]-5- (1H-pyrazol-4-yl) phenol

4165- (5-methyl-1H-pyrazol-4-yl) -2- {6- [ methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino ] pyridazin-3-yl } phenol

4175- (1H-imidazol-1-yl) -2- {6- [ (2,2,6, 6-tetramethylpiperidin-4-yl) oxy ] pyridazin-3-yl } phenol

4185- (5-methyl-1H-pyrazol-4-yl) -2- {6- [ (2,2,6, 6-tetramethylpiperidin-4-yl) oxy ] pyridazin-3-yl } phenol

419¹2- {6- [ methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino]Pyridazin-3-yl } -5- (4-nitro-1H-pyrazol-1-yl) phenol

4206- [ 2-methoxy-4- (4-nitro-1H-pyrazol-1-yl) phenyl ] -N-methyl-N- (2,2,6, 6-tetramethylpiperidin-4-yl) pyridazin-3-amine

4215- (4-amino-1H-pyrazol-1-yl) -2- {6- [ (2,2,6, 6-tetramethylpiperidin-4-yl) oxy ] pyridazin-3-yl } phenol

422¹2- [6- (1-methyl-1, 2,3, 6-tetrahydropyridin-4-yl) pyridazin-3-yl]-5- (1H-pyrazol-4-yl) phenol

4235- (4-Nitro-1H-pyrazol-1-yl) -2- {6- [ (2,2,6, 6-tetramethylpiperidin-4-yl) oxy ] pyridazin-3-yl } phenol

424¹5- (1H-pyrazol-4-yl) -2- [6- (1,2,3, 6-tetrahydropyridin-4-yl) pyridazin-3-yl]Phenol and its preparation

425¹2- [6- (1-Ethyl-1, 2,3, 6-tetrahydropyridin-4-yl) pyridazin-3-yl]-5- (1H-pyrazol-4-yl) phenol

426¹2- {6- [ methyl (piperidin-4-yl) amino]Pyridazin-3-yl } -5- (1H-pyrazol-4-yl) phenol

427¹2- [6- (piperidin-4-ylamino) pyridazin-3-yl]-5- (1H-pyrazol-4-yl) phenol

428¹6- [2, 5-difluoro-4- (1H-pyrazol-4-yl) phenyl]-N-methyl-N- (2,2,6, 6-tetramethylpiperidin-4-yl) pyridazin-3-amine

429¹2- [6- (8-azabicyclo [3.2.1]]Oct-2-en-3-yl) pyridazin-3-yl]-5- (1H-pyrazol-4-yl) phenol

430¹6- [2, 3-difluoro-4- (1H-pyrazol-4-yl) phenyl]-N-methyl-N- (2,2,6, 6-tetramethylpiperidin-4-yl) pyridazin-3-amine

431¹3- [2, 5-difluoro-4- (1H-pyrazol-4-yl) phenyl]-6- [ (2,2,6, 6-tetramethylpiperidin-4-yl) oxy ] oxy]Pyridazine

4322- [6- (piperidin-4-yloxy) pyridazin-3-yl ] -5- (1H-pyrazol-4-yl) phenol

433¹2- {6- [ (1R,5S) -8-azabicyclo [3.2.1]Oct-3-ylamino]Pyridazin-3-yl } -5- (1H-pyrazol-4-yl) phenol

434¹6- [ 2-methoxy-6- (1H-pyrazol-4-yl) pyridin-3-yl]-N-methyl-N- (2,2,6, 6-tetramethylpiperidin-4-yl) pyridazin-3-amine

4353- [4- (1H-pyrazol-4-yl) phenyl ] -6- [ (2,2,6, 6-tetramethylpiperidin-4-yl) oxy ] pyridazine

436¹2- {6- [ (2, 6-dimethylpiperidin-4-yl) oxy]Pyridazin-3-yl } -5- (1H-pyrazol-4-yl) phenol

437¹3- [ 2-fluoro-4- (1H-pyrazol-4-yl) phenyl]-6- [ (2,2,6, 6-tetramethylpiperidin-4-yl) oxy ] oxy]Pyridazine

4383- [4- (1-methyl-1H-pyrazol-4-yl) thiophen-2-yl ] -6- [ (2,2,6, 6-tetramethylpiperidin-4-yl) oxy ] pyridazine

439¹2- [6- (2, 7-diazaspiro [3.5]]Non-2-yl) pyridazin-3-yl]-5- (1H-pyrazol-4-yl) phenol

4403-fluoro-4- {6- [ methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino ] pyridazin-3-yl } phenol

4412- {6- [ (2, 6-dimethylpiperidin-4-yl) oxy ] pyridazin-3-yl } -5- (1H-pyrazol-1-yl) phenol

442N-methyl-6- (2-methyl-2H-indazol-5-yl) -N- (2,2,6, 6-tetramethylpiperidin-4-yl) pyridazin-3-amine

4432-methyl-5- {6- [ (2,2,6, 6-tetramethylpiperidin-4-yl) oxy ] pyridazin-3-yl } -2H-indazole

4443- (4-chloro-2-methoxyphenyl) -6- [ (2,2,6, 6-tetramethylpiperidin-4-yl) oxy ] pyridazine

445N-methyl-6- (2-methylpyrazolo [1,5-a ] pyridin-3-yl) -N- (2,2,6, 6-tetramethylpiperidin-4-yl) pyridazin-3-amine

4466- {6- [ (2,2,6, 6-tetramethylpiperidin-4-yl) oxy ] pyridazin-3-yl } imidazo [1,2-a ] pyridine

4473- [ 2-methoxy-4- (1H-pyrazol-1-yl) phenyl ] -6- [ (2,2,6, 6-tetramethylpiperidin-4-yl) oxy ] pyridazine

448¹3- [5- (1H-pyrazol-4-yl) thiophen-2-yl]-6- [ (2,2,6, 6-tetramethylpiperidin-4-yl) oxy ] oxy]Pyridazine

4493- [5- (1-methyl-1H-pyrazol-4-yl) thiophen-2-yl ] -6- [ (2,2,6, 6-tetramethylpiperidin-4-yl) oxy ] pyridazine

450¹3- [4- (1H-pyrazol-4-yl) thiophen-2-yl]-6- [ (2,2,6, 6-tetramethylpiperidin-4-yl) oxy ] oxy]Pyridazine

4515- (3, 5-dimethyl-1H-pyrazol-4-yl) -2- {6- [ (2,2,6, 6-tetramethylpiperidin-4-yl) oxy ] pyridazin-3-yl } phenol

4526- [ 2-fluoro-4- (1H-pyrazol-4-yl) phenyl ] -N-methyl-N- (2,2,6, 6-tetramethylpiperidin-4-yl) pyridazin-3-amine

4533-methoxy-4- {6- [ (2,2,6, 6-tetramethylpiperidin-4-yl) oxy ] pyridazin-3-yl } phenol

4543- [ 2-methoxy-4- (4-nitro-1H-pyrazol-1-yl) phenyl ] -6- [ (2,2,6, 6-tetramethylpiperidin-4-yl) oxy ] pyridazine

4554- {6- [ (2,2,6, 6-tetramethylpiperidin-4-yl) oxy ] pyridazin-3-yl } benzene-1, 3-diol

456¹6- [ 2-chloro-4- (1H-pyrazol-4-yl) phenyl]-N-methyl-N- (2,2,6, 6-tetramethyl)Arylpiperidin-4-yl) pyridazin-3-amines

4572- (1H-pyrazol-4-yl) -4- {6- [ (2,2,6, 6-tetramethylpiperidin-4-yl) oxy ] pyridazin-3-yl } pyrimidin-5-amine

458¹3- [2, 6-difluoro-4- (1H-pyrazol-4-yl) phenyl]-6- [ (2,2,6, 6-tetramethylpiperidin-4-yl) oxy ] oxy]Pyridazine

4592- [6- (2, 6-diazaspiro [3.4] oct-2-yl) pyridazin-3-yl ] -5- (1H-pyrazol-4-yl) phenol

460¹3- {6- [ methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino]Pyridazin-3-yl } -6- (1H-pyrazol-4-yl) pyridin-2-ol

4616- (1H-pyrazol-4-yl) -3- {6- [ (2,2,6, 6-tetramethylpiperidin-4-yl) oxy ] pyridazin-3-yl } pyridin-2-ol

462¹N,2,2,6, 6-pentamethyl-N- {5- [3- (1H-pyrazol-4-yl) phenoxy]-1,3, 4-thiadiazol-2-yl } piperidin-4-amine

463¹N,2,2,6, 6-pentamethyl-N- {5- [4- (1H-pyrazol-4-yl) phenoxy]-1,3, 4-thiadiazol-2-yl } piperidin-4-amine

464¹3- [2- (difluoromethyl) -4- (1H-pyrazol-4-yl) phenyl]-6- [ (2,2,6, 6-tetramethylpiperidin-4-yl) oxy ] oxy]Pyridazine, and

465¹6- [2- (difluoromethyl) -4- (1H-pyrazol-4-yl) phenyl]-N-methyl-N- (2,2,6, 6-tetramethylpiperidin-4-yl) pyridazin-3-amine

Wherein the form of the compound is selected from the group consisting of: a prodrug form, a salt form, a hydrate form, a solvate form, a clathrate form, an isotopologue form, a racemate form, an enantiomeric form, a diastereomeric form, a stereoisomeric form, a polymorphic form, and a tautomeric form thereof.

Another embodiment of the use of a compound salt of formula (I) or a form thereof comprises a method of using a compound salt of formula (I) or a form thereof for treating or ameliorating HD in a subject in need thereof, the method comprising administering to the subject an effective amount of a compound salt of formula (I) or a form thereof selected from the group consisting of:

wherein the compound salt form is selected from the group consisting of: prodrug forms, hydrate forms, solvate forms, clathrate forms, isotopologue forms, racemate forms, enantiomer forms, diastereomer forms, stereoisomer forms, polymorph forms and tautomer forms thereof.

In one aspect, the compound salt of formula (I) or a form thereof includes a compound selected from the group consisting of:

4112- {6- [ 8-azabicyclo [3.2.1] oct-3-yl (methyl) amino ] pyridazin-3-yl } -5- (1H-pyrazol-4-yl) phenol hydrochloride

4122- [6- (8-azabicyclo [3.2.1] oct-3-ylamino) pyridazin-3-yl ] -5- (1H-pyrazol-4-yl) phenol hydrochloride

4135- (1H-pyrazol-4-yl) -2- {6- [ (2,2,6, 6-tetramethylpiperidin-4-yl) amino ] pyridazin-3-yl } phenate hydrochloride

4152- [6- (8-azabicyclo [3.2.1] oct-3-yloxy) pyridazin-3-yl ] -5- (1H-pyrazol-4-yl) phenol hydrochloride

4192- {6- [ methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino ] pyridazin-3-yl } -5- (4-nitro-1H-pyrazol-1-yl) phenol dihydrochloride

4222- [6- (1-methyl-1, 2,3, 6-tetrahydropyridin-4-yl) pyridazin-3-yl ] -5- (1H-pyrazol-4-yl) phenol trihydrochloride

4245- (1H-pyrazol-4-yl) -2- [6- (1,2,3, 6-tetrahydropyridin-4-yl) pyridazin-3-yl ] phenol trihydrochloride

4252- [6- (1-ethyl-1, 2,3, 6-tetrahydropyridin-4-yl) pyridazin-3-yl ] -5- (1H-pyrazol-4-yl) phenol trihydrochloride

4262- {6- [ methyl (piperidin-4-yl) amino ] pyridazin-3-yl } -5- (1H-pyrazol-4-yl) phenol tetrahydrate

4272- [6- (piperidin-4-ylamino) pyridazin-3-yl ] -5- (1H-pyrazol-4-yl) phenol tetrahydrochloride salt

4286- [2, 5-difluoro-4- (1H-pyrazol-4-yl) phenyl ] -N-methyl-N- (2,2,6, 6-tetramethylpiperidin-4-yl) pyridazin-3-amine tetrahydrate hydrochloride

4292- [6- (8-azabicyclo [3.2.1] oct-2-en-3-yl) pyridazin-3-yl ] -5- (1H-pyrazol-4-yl) phenol hydrochloride

4306- [2, 3-difluoro-4- (1H-pyrazol-4-yl) phenyl ] -N-methyl-N- (2,2,6, 6-tetramethylpiperidin-4-yl) pyridazin-3-amine hydrochloride

4313- [2, 5-difluoro-4- (1H-pyrazol-4-yl) phenyl ] -6- [ (2,2,6, 6-tetramethylpiperidin-4-yl) oxy ] pyridazine trihydrochloride

4332- {6- [ (1R,5S) -8-azabicyclo [3.2.1] oct-3-ylamino ] pyridazin-3-yl } -5- (1H-pyrazol-4-yl) phenol hydrochloride

4346- [ 2-methoxy-6- (1H-pyrazol-4-yl) pyridin-3-yl ] -N-methyl-N- (2,2,6, 6-tetramethylpiperidin-4-yl) pyridazin-3-amine hydrochloride

4362- {6- [ (2, 6-dimethylpiperidin-4-yl) oxy ] pyridazin-3-yl } -5- (1H-pyrazol-4-yl) phenol trihydrochloride

4373- [ 2-fluoro-4- (1H-pyrazol-4-yl) phenyl ] -6- [ (2,2,6, 6-tetramethylpiperidin-4-yl) oxy ] pyridazine hydrochloride

4392- [6- (2, 7-diazaspiro [3.5] non-2-yl) pyridazin-3-yl ] -5- (1H-pyrazol-4-yl) phenol tetrahydrate

4483- [5- (1H-pyrazol-4-yl) thiophen-2-yl ] -6- [ (2,2,6, 6-tetramethylpiperidin-4-yl) oxy ] pyridazine hydrochloride

4503- [4- (1H-pyrazol-4-yl) thiophen-2-yl ] -6- [ (2,2,6, 6-tetramethylpiperidin-4-yl) oxy ] pyridazine hydrochloride

4566- [ 2-chloro-4- (1H-pyrazol-4-yl) phenyl ] -N-methyl-N- (2,2,6, 6-tetramethylpiperidin-4-yl) pyridazin-3-amine trihydrochloride

4583- [2, 6-difluoro-4- (1H-pyrazol-4-yl) phenyl ] -6- [ (2,2,6, 6-tetramethylpiperidin-4-yl) oxy ] pyridazine trihydrochloride

4603- {6- [ methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino ] pyridazin-3-yl } -6- (1H-pyrazol-4-yl) pyridin-2-ol hydrochloride

462N, 2,2,6, 6-pentamethyl-N- {5- [3- (1H-pyrazol-4-yl) phenoxy ] -1,3, 4-thiadiazol-2-yl } piperidin-4-amine hydrochloride

463N, 2,2,6, 6-pentamethyl-N- {5- [4- (1H-pyrazol-4-yl) phenoxy ] -1,3, 4-thiadiazol-2-yl } piperidin-4-amine hydrochloride

4643- [2- (difluoromethyl) -4- (1H-pyrazol-4-yl) phenyl ] -6- [ (2,2,6, 6-tetramethylpiperidin-4-yl) oxy ] pyridazine hydrochloride, and

4656- [2- (difluoromethyl) -4- (1H-pyrazol-4-yl) phenyl ] -N-methyl-N- (2,2,6, 6-tetramethylpiperidin-4-yl) pyridazin-3-amine hydrochloride

Wherein the compound salt form is selected from the group consisting of: prodrug forms, hydrate forms, solvate forms, clathrate forms, isotopologue forms, racemate forms, enantiomer forms, diastereomer forms, stereoisomer forms, polymorph forms and tautomer forms thereof.

Another embodiment of the present invention encompasses methods of using a compound of formula (I) or a form thereof for treating or ameliorating HD in a subject in need thereof, comprising administering to the subject an effective amount of a compound of formula (I) or a form thereof.

Another embodiment of the present invention encompasses methods of using a compound of formula (I) or a form thereof for treating or ameliorating HD in a subject in need thereof, comprising administering to the subject an effective amount of a salt of the compound of formula (I) or a form thereof.

Another embodiment of the invention encompasses the use of a compound of formula (I) or a form thereof for treating or ameliorating HD in a subject in need thereof, the use comprising administering to the subject an effective amount of a compound of formula (I) or a form thereof.

Another embodiment of the invention encompasses the use of a compound salt of formula (I) or a form thereof for treating or ameliorating HD in a subject in need thereof, the use comprising administering to the subject an effective amount of a compound salt of formula (I) or a form thereof.

Chemical definition

As used herein, surgeryThe word "C_1-4Alkyl "generally refers to a saturated hydrocarbon group of one to four carbon atoms having a straight or branched chain configuration, including, but not limited to, methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, sec-butyl, tert-butyl, and the like. In some embodiments, C_1-4The alkyl group comprising C_1-3Alkyl radical, C_1-2Alkyl groups, and the like. Where the available valency permits, C_1-4Alkyl groups may be optionally substituted.

As used herein, the term "C_2-6Alkenyl "generally refers to partially unsaturated hydrocarbon radicals having two to five carbon atoms in a straight or branched chain configuration and having one or more carbon-carbon double bonds therein, including but not limited to vinyl, allyl, propenyl, and the like. In some embodiments, C_2-6Alkenyl radicals comprising C_2-4Alkenyl radical, C_2-3Alkenyl groups, and the like. Where the available valency permits, C_2-6The alkenyl group may be optionally substituted.

As used herein, the term "C_1-4Alkoxy "is generally meant to have the formula-O-C_1-4Saturated hydrocarbon radicals of one to four carbon atoms in a straight or branched chain configuration of alkyl radicals include, but are not limited to, methoxy, ethoxy, n-propoxy, isopropoxy, n-butoxy, isobutoxy, sec-butoxy, tert-butoxy, and the like. In some embodiments, C_1-4Alkoxy radicals comprising C_1-3Alkoxy radical, C_1-2Alkoxy, and the like. Where the available valency permits, C_1-4Alkoxy groups may be optionally substituted.

As used herein, the term "C_3-14Cycloalkyl "generally refers to a saturated monocyclic, bicyclic, or polycyclic hydrocarbon group, including, but not limited to, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, cyclooctyl, 1H-indanyl, indenyl, tetrahydronaphthyl, and the like. In some embodiments, C_3-14Cycloalkyl radicals including C_3-10Cycloalkyl radical, C_3-8Cycloalkyl radical, C_3-7Cycloalkyl radical, C_5-8Cycloalkyl radical, C_9-10Cycloalkyl groups, and the like. Where the available valency permits, C_3-14Cycloalkyl groups may be optionally substituted.

As used herein, the term "C_3-14Cycloalkenyl "generally refers to partially unsaturated monocyclic, bicyclic, or polycyclic hydrocarbon groups having one or more chemically stable carbon-carbon double bonds therein, including, but not limited to, cyclopropenyl, cyclobutenyl, cyclopentenyl, cyclohexenyl, cycloheptenyl, cyclooctenyl, and the like. In some embodiments, C_3-14Cycloalkenyl radicals including C_3-7Cycloalkenyl radical, C_3-8Cycloalkenyl radical, C_5-8Cycloalkenyl radical, C_3-10Cycloalkenyl groups, and the like. Where the available valency permits, C_3-14Cycloalkenyl groups may be optionally substituted.

As used herein, the term "aryl" generally refers to a monocyclic, bicyclic, or polycyclic aromatic carbon atom ring structure group, including, but not limited to, phenyl, naphthyl, anthracenyl, fluorenyl, azulenyl, phenanthrenyl, and the like. Aryl groups may be optionally substituted where the available valency permits.

As used herein, the term "heteroaryl" generally refers to a monocyclic, bicyclic, or polycyclic aromatic carbon atom ring structural group in which one or more carbon atom ring members are replaced with one or more heteroatoms (e.g., O, S or N atoms) where structural stability permits, including, but not limited to, furyl, thienyl (also known as thiophenyl), pyrrolyl, pyrazolyl, imidazolyl, isoxazolyl, isothiazolyl, oxazolyl, thiazolyl, triazolyl, oxadiazolyl, thiadiazolyl, tetrazolyl, pyranyl, thiapyranyl, pyridyl, pyrimidinyl, pyrazinyl, pyridazinyl, triazinyl, indolyl, indazolyl, indolizinyl, benzofuryl, benzothienyl, benzimidazolyl, benzothiazolyl, benzoxazolyl, 9H-purinyl, quinoxalinyl, isoindolyl, quinolinyl, isoquinolinyl, quinazolinyl, indolyl, pyrrolyl, pyrazolyl, imidazolyl, isoxazolyl, thiazolyl, and the like, Acridinyl, phthalazinyl, imidazo [1,2-a ] pyridyl, imidazo [1,5-a ] pyridyl, imidazo [5, l-a ] isoquinolyl, 1, 4-dihydroindeno [1,2-c ] -1H-pyrazolyl, 2, 3-dihydro-1H-inden-1-one, 2, 3-dihydro-1H-indenyl, 3, 4-dihydroquinolin-2 (1H) -one, 5, 6-dihydroimidazo [5,1-a ] isoquinolyl, 8H-indeno [1,2-d ] thiazolyl, benzo [ c ] [1,2,5] oxadiazolyl, benzo [ d ] oxazol-2 (3H) -one, quinolin-2 (1H) -one, quinazolin-4 (1H) -one, Quinazoline-2, 4(1H,3H) -dione, benzo- [ d ] oxazolyl, pyrazolo [1,5-a ] pyridyl, and the like. Heteroaryl groups may be optionally substituted on a carbon atom ring member or a nitrogen atom ring member, as the available valency permits.

As used herein, the term "heterocyclyl" generally refers to a saturated or partially unsaturated monocyclic, bicyclic, or polycyclic carbon atom ring structure radical in which one or more carbon atom ring members are replaced with a heteroatom (e.g., O, S or N atom) as structural stability permits, including, but not limited to, oxiranyl, oxetanyl, azetidinyl, dihydrofuranyl, tetrahydrofuranyl, dihydrothienyl, tetrahydrothienyl, pyrrolinyl, pyrrolidinyl, dihydropyrazolyl, pyrazolinyl, pyrazolidinyl, dihydroimidazolyl, imidazolinyl, imidazolidinyl, isoxazolinyl, isothiazolinyl, oxazolinyl, oxazolidinyl, thiazolinyl, thiazolidinyl, triazolinyl, oxadiazolyl, thiadiazolinyl, tetrazolinyl, and the like, Tetrazolylalkyl group, dihydro-2H-pyranyl group, dihydropyridinyl group, tetrahydropyridinyl group, 1,2,3, 6-tetrahydropyridinyl group, hexahydropyridinyl group, dihydropyrimidyl group, tetrahydropyrimidinyl group, 1,4,5, 6-tetrahydropyrimidinyl group, dihydropyrazinyl group, tetrahydropyridazinyl group, piperazinyl group, piperidinyl group, morpholinyl group, thiomorpholinyl group, dihydrotriazinyl group, tetrahydrotriazinyl group, hexahydrotriazinyl group, 1, 4-diazepanyl group, indolinyl group, tetrahydroindolyl group, indolizinyl group, tetrahydroindazolyl group, dihydroisoindolyl group, dihydrobenzofuranyl group, tetrahydrobenzofuranyl group, dihydrobenzothienyl group, dihydrobenzimidazolyl group, dihydrobenzoxazolyl group, 2, 3-dihydrobenzo [ d ] oxazolyl group, Tetrahydrobenzoxazolyl, dihydrobenzoxazinyl, 3, 4-dihydro-2H-benzo [ b ] [1,4] oxazinyl, tetrahydrobenzoxazinyl, benzo [1,3] dioxolyl, benzo [1,4] dioxanyl, dihydropurinyl, tetrahydropurinyl, dihydroquinolinyl, tetrahydroquinolinyl, 1,2,3, 4-tetrahydroquinolinyl, dihydroisoquinolinyl, 3, 4-dihydroisoquinolinyl- (1H) -yl, tetrahydroisoquinolinyl, 1,2,3, 4-tetrahydroisoquinolinyl, dihydroquinazolinyl, tetrahydroquinazolinyl, dihydroquinoxalinyl, tetrahydroquinoxalinyl, 1,2,3, 4-tetrahydroquinoxalinyl, 1, 3-dioxolanyl, 2, 5-dihydro-1H-pyrrolyl, 4, 5-dihydro-1H-imidazolyl, dihydroquinoxalinyl, 1,2,3, 4-dihydroquinoxalinyl, 1, 3-dioxolanyl, 2, 5-dihydro-1H-pyrrolyl, 4, 5-dihydro-1H-imidazolyl, tetrahydro-2H-pyranyl, hexahydropyrrolo [3,4-b ] [1,4] oxazin- (2H) -yl, (4aR,7aS) -hexahydropyrrolo [3,4-b ] [1,4] oxazin- (4aH) -yl, 3, 4-dihydro-2H-pyrido [3,2-b ] [1,4] oxazinyl, (cis) -octahydrocyclopenta [ c ] pyrrolyl, hexahydropyrrolo [3,4-b ] pyrrol- (1H) -yl, (3aR,6aR) -hexahydropyrrolo [3,4-b ] pyrrol- (1H) -yl, (3aR,6aS) -hexahydropyrrolo [3,4-c ] pyrrol- (1H) -yl, 5H-pyrrolo [3,4] -b ] pyridine- (7H) -yl, 5, 7-dihydro-6H-pyrrolo [3,4-b ] pyridyl, tetrahydro-1H-pyrrolo [3,4-b ] pyridine- (2H,7H,7aH) -yl, hexahydro-1H-pyrrolo [3,4-b ] pyridine- (2H) -yl, (4aR,7aR) -hexahydro-1H-pyrrolo [3,4-b ] pyridine- (2H) -yl, octahydro-6H-pyrrolo [3,4-b ] pyridyl, 2,3,4, 9-tetrahydro-1H-carbazolyl, 1,2,3, 4-tetrahydropyrazino [1,2-a ] indolyl, 2, 3-dihydro-1H-pyrrolo [1,2-a ] indolyl, (3aR,6aR) -hexahydrocyclopenta [ c ] pyrrol- (1H) -yl, (3aR,4R,6aS) -hexahydrocyclopenta [ c ] pyrrol- (1H) -yl, (3aR,4S,6aS) -hexahydrocyclopenta [ c ] pyrrol- (1H) -yl, (3aR,5R,6aS) -hexahydrocyclopenta [ c ] pyrrol- (1H) -yl, 1, 3-dihydro-2H-isoindolyl, octahydro-2H-isoindolyl, (3aS) -1,3,3a,4,5, 6-hexahydro-2H-isoindolyl, (3aS, 4R, 7aR) -1H-isoindolyl- (3H,3aH,4H,5H,6H,7H,7aH) -yl, (3aR,7aS) -octahydro-2H-isoindolyl, (3aR,4R,7aS) -octahydro-2H-isoindolyl, (3aR,4S,7aS) -octahydro-2H-isoindolyl, 2, 5-diazabicyclo [2.2.1] heptyl, 2-azabicyclo [2.2.1] heptenyl, 3-azabicyclo [3.1.0] hexyl, 3, 6-diazabicyclo [3.1.0] hexyl, (1R,5S) -3-azabicyclo [3.1.0] hexyl, (1S,5R) -3-azabicyclo [3.2.0] heptyl, 5-azaspiro [2.4] heptyl, 2, 6-diazaspiro [3.3] heptyl, 2, 5-diazaspiro [3.4] octyl, 2, 6-diazaspiro [3.4] octyl, 2, 7-diazaspiro [3.5] nonyl, 2, 7-diazaspiro [4.4] nonyl, 2-azaspiro [4.5] decyl, 2, 8-diazaspiro [4.5] decyl, 3, 6-diazabicyclo [3.2.1] octyl, 1, 4-dihydroindeno [1,2-c ] pyrazolyl, dihydropyranyl, dihydropyridinyl, dihydroquinolinyl, 8H-indeno [1,2-d ] thiazolyl, tetrahydroimidazo [1,2-a ] pyridyl, pyridin-2 (1H) -one, (1R,5S) -8-azabicyclo [3.2.1] octyl, 8-azabicyclo [3.2.1] oct-2-enyl, and the like. Heterocyclyl groups may be optionally substituted on a carbon atom ring member or a nitrogen atom ring member, as the available valency permits.

As used herein, the term "C_2-4Alkenyl-amino-carbonyl "refers to a group of the formula: -C (═ O) -NH-C_2-4An alkenyl group.

As used herein, the term "C_1-4alkoxy-C_1-4Alkoxy "refers to a group of the formula: -O-C_1-4alkyl-O-C_1-4An alkyl group.

As used herein, the term "C_1-4Alkoxy-carbonyl "refers to a group of the formula: -C (═ O) -O-C_1-4An alkyl group.

As used herein, the term "C_1-4Alkoxy-carbonyl-amino "refers to a group of the formula: -NH-C (═ O) -O-C_1-4An alkyl group.

As used herein, the term "C_1-4alkoxy-carbonyl-amino-C_1-4Alkoxy "refers to a group of the formula: -O-C_1-4alkyl-NH-C (═ O) -O-C_1-4An alkyl group.

As used herein, the term "C_1-4alkyl-C_1-4Alkoxy "refers to a group of the formula: -O-C_1-4alkyl-C_1-4An alkyl group.

As used herein, the term "C_1-4Alkyl-amino "refers to a group of the formula: -NH-C_1-4An alkyl group.

As used herein, the term "(C)_1-4Alkyl radical)₂-amino "refers to a group of formula: -N (C)_1-4Alkyl radical)₂。

As used herein, the term "C_1-4alkyl-amino-C_1-4Alkoxy "refers to a group of the formula: -O-C_1-4alkyl-NH-C_1-4An alkyl group.

As used herein, the term "(C)_1-4Alkyl radical)₂-amino-C_1-4Alkoxy "refers to a group of the formula: -O-C_1-4alkyl-N (C)_1-4Alkyl radical)₂。

As used herein, the term "C_1-4alkyl-amino-C_1-4Alkyl "refers to a group of the formula: -C_1-4alkyl-NH-C_1-4An alkyl group.

As used herein, the term "(C)_1-4Alkyl radical)₂-amino-C_1-4Alkyl "refers to a group of the formula: -C_1-4alkyl-N (C)_1-4Alkyl radical)₂。

As used herein, the term "C_1-4Alkyl-amino-carbonyl "refers to a group of the formula: -C (═ O) -NH-C_1-4An alkyl group.

As used herein, the term "(C)_1-4Alkyl radical)₂-amino-carbonyl "refers to a group of formula: -C (═ O) -N (C)_1-4Alkyl radical)₂。

As used herein, the term "C_1-4alkyl-amino-carbonyl-C_1-4Alkyl "refers to a group of the formula: -C_1-4alkyl-C (═ O) -NH-C_1-4An alkyl group.

As used herein, the term "(C)_1-4Alkyl radical)₂-amino-carbonyl-C_1-4Alkyl "refers to a group of the formula: -C_1-4alkyl-C (═ O) -N (C)_1-4Alkyl radical)₂。

As used herein, the term "C_1-4Alkyl-carbonyl "refers to a group of the formula: -C (═ O) -C_1-4An alkyl group.

As used herein, the term "C_1-4Alkyl-carbonyl-amino "refers to a group of the formula: -NH-C (═ O) -C_1-4An alkyl group.

As used herein, the term "C_1-4alkyl-carbonyl-amino-C_1-4Alkoxy "refers to a group of the formula: -O-C_1-4alkyl-NH-C (═ O) -C_1-4An alkyl group.

As used herein, the term "C_1-4alkyl-carbonyl-amino-C_1-4Alkyl "refers to a group of the formula: -C_1-4alkyl-NH-C (═ O) -C_1-4An alkyl group.

As used herein, the term "amino" refers to a group of the formula: -NH₂。

As used herein, the term "amino-C_1-4Alkoxy "refers to a group of the formula: -O-C_1-4alkyl-NH₂。

As used herein, the term "amino-C_1-4Alkyl "refers to a group of the formula: -C_1-4alkyl-NH₂。

As used herein, the term "amino-carbonyl" refers to a group of the formula: -C (═ O) -NH₂。

As used herein, the term "cyano" refers to a group of the formula: -CN.

As used herein, the term "C_3-7cycloalkyl-C_1-4Alkoxy "refers to a group of the formula: -O-C_1-4alkyl-C_3-7A cycloalkyl group.

As used herein, the term "halo-C_1-4Alkoxy "refers to a group of the formula: -O-C_1-4Alkyl-halo, wherein, where the available valences allow, C_1-4The alkyl group may be partially or fully substituted with one or more halogen atoms. In some embodiments, halo-C_1-4Alkoxy radicals including halo-C_1-6Alkoxy, halo-C_1-4Alkoxy, and the like.

As used herein, the term "halo-C_1-4Alkyl "refers to a group of the formula: -C_1-4Alkyl-halo, wherein, where the available valences allow, C_1-4The alkyl group may be partially or fully substituted with one or more halogen atoms. In some embodiments, halo-C_1-4Alkyl radicals including halo-C_1-6Alkyl, halo-C_1-4Alkyl groups, and the like.

As used herein, the term "heteroaryl-C_1-4Alkyl "refers to a group of the formula: -C_1-4Alkyl-heteroaryl.

As used herein, the term "heteroaryl-C_1-4Alkyl-amino "refers to a group of the formula: -NH-C_1-4Alkyl-heteroaryl.

As used herein, the term "heteroaryl-C_1-4Alkyl-amino-carbonyl "refers to a group of the formula: -C (═ O) -NH-C_1-4Alkyl-A heteroaryl group.

As used herein, the term "heteroaryl-C_1-4alkyl-amino-carbonyl-C_1-4Alkyl "refers to a group of the formula: -C_1-4alkyl-C (═ O) -NH-C_1-4Alkyl-heteroaryl.

As used herein, the term "heteroaryl-C_1-4Alkyl-carbonyl-amino "refers to a group of the formula: -NH-C (═ O) -C_1-4Alkyl-heteroaryl.

As used herein, the term "heteroaryl-C_1-4alkyl-carbonyl-amino-C_1-4Alkyl "refers to a group of the formula: -C_1-4alkyl-NH-C (═ O) -C_1-4Alkyl-heteroaryl.

As used herein, the term "heterocyclyl-C_1-4Alkoxy "refers to a group of the formula: -C_1-4Alkoxy-heterocyclyl.

As used herein, the term "heterocyclyl-C_1-4Alkyl "refers to a group of the formula: -C_1-4Alkyl-heterocyclyl.

As used herein, the term "hydroxy" refers to a group of the formula: -OH.

As used herein, the term "hydroxy-C_1-4Alkoxy "refers to a group of the formula: -O-C_1-4alkyl-OH, wherein, where the available valences allow, C_1-4The alkyl group may be partially or fully substituted with one or more hydroxyl groups.

As used herein, the term "hydroxy-C_1-4Alkyl "refers to a group of the formula: -C_1-4alkyl-OH, wherein, where the available valences allow, C_1-4The alkyl group may be partially or fully substituted with one or more hydroxyl groups.

As used herein, the term "hydroxy-C_1-4Alkyl-amino "refers to a group of the formula: -NH-C_1-4alkyl-OH, wherein, where the available valences allow, C_1-4The alkyl group may be partially or fully substituted with one or more hydroxyl groups.

As used herein, the term "hydroxy-imino" refers to an ═ NOH group of the formula C (═ NOH).

As used herein, the term "oxo" refers to a group of the formula: and C is O.

As used herein, the term "phenyl-C_1-4Alkoxy "refers to a group of the formula: -C_1-4Alkoxy-phenyl.

As used herein, the term "substituent" refers to a positional variation on an atom of a core molecule substituted at the indicated atomic position which replaces one or more hydrogens on the indicated atom, provided that the indicated atom's normal valence is not exceeded, and that the substitution results in a stable compound. Combinations of substituents and/or variants are permissible only if such combinations result in stable compounds. It should be noted by those skilled in the art that any carbon and heteroatoms as described or shown herein having valences that do not appear to be satisfied are assumed to have a sufficient number of hydrogen atoms to satisfy the valences described or illustrated. In certain instances, among the substituent groups, one or more substituents having a double bond (e.g., "oxo" or "═ O") may be described, shown, or listed herein as a point of attachment, where the structure may show only a single bond as a point of attachment to the core structure of formula (I). Those skilled in the art will appreciate that while only single bonds are shown, double bonds are also meant for those substituents.

As used herein, with reference to the definitions of chemical terms provided herein, the term "etc" means variations of chemical structures that one of skill in the art can expect, including but not limited to isomers (including chain, branched, or positional isomers), hydration of ring systems (including saturated or partially unsaturated monocyclic, bicyclic, or polycyclic ring structures), and all other variations that result in stable compounds, where the available valences allow.

For the purposes of this specification, when a compound of formula (I) or one or more substituent variants of a form thereof includes a functional group incorporated in a compound of formula (I), each functional group occurring at any position within the disclosed compounds may be independently selected and independently and/or optionally substituted (as appropriate).

As used herein, the terms "independently selected" or "individually selected" refer to functional variants in a list of substituents that may occur more than once on the structure of formula (I), with the substitution pattern in each occurrence being independent of any other occurrence. Furthermore, the use of general substituent variants on any formula or structure of the compounds described herein should be understood to include the substitution of general substituents with species substituents included in a particular genus, e.g., aryl groups may be substituted with phenyl or naphthyl groups, etc., and the resulting compounds are included within the scope of the compounds described herein.

As used herein, when used in a phrase (e.g., ". C")_3-14Cycloalkyl radical, C_3-14cycloalkyl-C_1-4Alkyl, aryl-C_1-4Alkyl, heteroaryl-C_1-4Alkyl, heterocyclyl and heterocyclyl-C_1-4Alkyl) the term "… in each instance" or "in each instance (when present)" means C when used before_3-14Cycloalkyl, aryl, heteroaryl and heterocyclyl ring systems (when each is present alone or as a substituent).

As used herein, the term "optionally substituted" refers to optional substitution with the specified substituent variant, group, radical or moiety.

Compound forms

As used herein, the term "form" refers to a compound of formula (I) having a form selected from the group consisting of: in the form of a free acid, in the form of a free base, in the form of a prodrug, in the form of a salt, in the form of a hydrate, in the form of a solvate, in the form of a clathrate, in the form of an isotopologue, in the form of a racemate, in the form of an enantiomer, in the form of a diastereomer, in the form of a stereoisomer, in the form of a polymorph and in the form of a tautomer thereof.

In certain embodiments described herein, the compound of formula (I) is in the form of its free acid, free base or salt.

In certain embodiments described herein, the form of the compound of formula (I) is a salt thereof.

In certain embodiments described herein, the compound of formula (I) is in the form of its isotopologue.

In certain embodiments described herein, the compound of formula (I) is in the form of a stereoisomer, racemate, enantiomer, or diastereomer thereof.

In certain embodiments described herein, the form of the compound of formula (I) is a tautomer thereof.

In certain embodiments described herein, the form of the compound of formula (I) is a pharmaceutically acceptable form.

In certain embodiments described herein, the compound of formula (I) or a form thereof is isolated for use.

As used herein, the term "isolated" refers to the physical state of a compound of formula (I) or a form thereof, isolated and/or purified from a synthetic process (e.g., from a reaction mixture) or natural source, or a combination thereof, according to the methods of isolation or purification described herein or well known to those of skill in the art (e.g., chromatography, recrystallization, etc.), in a purity sufficient to be characterized by standard analytical techniques described herein or well known to those of skill in the art.

As used herein, the term "protected" means that the functional group in the compound of formula (I) or a form thereof is in a modified form to prevent unwanted side reactions at the protection site as the compound is reacted. Suitable protecting Groups are recognized by those skilled in the art and with reference to standard textbooks (e.g., T.W. Greene et al, Protective Groups in organic Synthesis (1991), Wiley, New York). These functional groups include hydroxyl, phenolic, amino, and carboxylic acids. Suitable protecting groups for the hydroxyl or phenolic groups include trialkylsilyl or diarylalkylsilyl groups (e.g., t-butyldimethylsilyl, t-butyldiphenylsilyl, or trimethylsilyl), tetrahydropyranyl, benzyl, substituted benzyl, methyl, methoxymethanol, and the like. Suitable protecting groups for amino, amidino and guanidino include tert-butoxycarbonyl, benzyloxycarbonyl and the like. Suitable protecting groups for carboxylic acids include alkyl, aryl or aralkyl esters. In some cases, the protecting group may also be a polymer resin, such as Wang resin or 2-chlorotrityl chloride resin. Protecting groups may be added or removed according to standard techniques well known to those skilled in the art and as described herein. One skilled in the art will also appreciate that while such protected derivatives of the compounds described herein may not themselves be pharmacologically active, they may be administered to a subject and then metabolized in vivo to form the compounds described herein which are pharmacologically active. Thus, these derivatives may be described as "prodrugs". All prodrugs of the compounds described herein are included within the scope of the use described herein.

As used herein, the term "prodrug" refers to a form (e.g., prodrug) of a compound of the invention (instant) that is converted in vivo to yield the active compound of formula (I) or a form thereof. Transformation can occur by various mechanisms (e.g., by metabolic and/or non-metabolic chemical processes), such as by hydrolysis and/or metabolism in the blood, liver, and/or other organs and tissues. The following provides a discussion of the use of prodrugs: higuchi and W.stella, "Pro-drugs as Novel Delivery Systems", proceedings of the American chemical Association, Vol.14, and Bioreversible Cariers in Drug Design, eds Edward B.Roche, the American society of pharmacy and Pegman Press, 1987.

In one example, when a compound of formula (I) or form thereof contains a carboxylic acid functional group, the prodrug may comprise an ester formed by replacing a hydrogen atom of the acid group with a functional group (e.g., alkyl, etc.). In another example, when a compound of formula (I) or a form thereof contains a hydroxyl functional group, a prodrug form may be prepared by replacing the hydrogen atom of the hydroxyl group with another functional group (e.g., an alkyl, alkylcarbonyl, phosphonate, or the like). In another example, when a compound of formula (I) or form thereof contains an amine functional group, a prodrug form may be prepared by replacing one or more amine hydrogen atoms with a functional group (e.g., an alkyl or substituted carbonyl). Pharmaceutically acceptable prodrugs of compounds of formula (I) or forms thereof include those substituted with one or more of the following groups: carboxylic acid esters, sulfonic acid esters, amino acid esters, phosphonic acid esters and monophosphoric, diphosphoric or triphosphoric acid esters or alkyl substituents (as appropriate). As described herein, it will be appreciated by those skilled in the art that one or more of these substituents may be used to provide a compound of formula (I) or a form thereof which is a prodrug.

One or more of the compounds described herein can exist in unsolvated forms as well as solvated forms with pharmaceutically acceptable solvents (e.g., water, ethanol, and the like), and the description herein is intended to include solvated forms as well as unsolvated forms.

As used herein, the term "solvate" refers to a physical association of a compound described herein with one or more solvent molecules. The physical association involves varying degrees of ionic and covalent bonding, including hydrogen bonding. In some cases, the solvate can be isolated, for example, when one or more solvent molecules are incorporated into the crystal lattice of a crystalline solid. As used herein, "solvate" includes solution phase and isolatable solvates. Non-limiting examples of suitable solvates include ethanolates, methanolates, and the like.

As used herein, the term "hydrate" refers to a solvate in which the solvent molecule is water.

The compounds of formula (I) may form salts, which are intended to be included within the scope of this specification. Unless otherwise indicated, reference herein to a compound of formula (I) or a form thereof is to be understood as including reference to a salt form thereof. The term "salt" as used herein means an acid salt with an inorganic and/or organic acid, and a basic salt with an inorganic and/or organic base. In addition, when a compound of formula (I) or a form thereof contains a basic moiety (such as, but not limited to, an amine moiety) and an acidic moiety (such as, but not limited to, a carboxylic acid), zwitterions ("inner salts") may be formed and are included within the term "salt(s)" as used herein.

As used herein, the term "pharmaceutically acceptable salts" refers to those salts of the compounds described herein that are safe and effective (i.e., non-toxic, physiologically acceptable) for use in mammals and that possess biological activity, although other salts are also useful. Salts of the compounds of formula (I) may be formed, for example, by reacting a compound of formula (I) or a form thereof with an amount of acid or base (e.g., an equivalent amount) in a medium (e.g., a medium in which the salt precipitates), or in an aqueous medium, followed by lyophilization.

Pharmaceutically acceptable salts include salts of one or more acidic or basic groups present in the compounds described herein. Embodiments of acid addition salts include, but are not limited to, acetate, ascorbate, benzoate, benzenesulfonate, bisulfate, bitartrate, borate, bromide, butyrate, chloride, citrate, camphorate, camphorsulfonate, ethanesulfonate, formate, fumarate, gentisate, gluconate, glucuronate (glucaronate), glutamate, iodide, isonicotinate, lactate, maleate, methanesulfonate, naphthalenesulfonate, nitrate, oxalate, pamoate, pantothenate, phosphate, propionate, gluconate, salicylate, succinate, sulfate, tartrate, thiocyanate, tosylate (also known as tosylate), trifluoroacetate, and the like. Certain embodiments of acid addition salts include chloride, dichloride, trichloride, bromide, acetate, formate, or trifluoroacetate.

In addition, acids generally recognized as suitable for forming pharmaceutically useful salts from basic drug compounds are discussed below: for example, P.Stahl et al, Camile G. (editor) Handbook of Pharmaceutical salts, Properties, Selection and Use, (2002) zurich: Wiley-VCH; berge et al, Journal of Pharmaceutical Sciences (1977)66(1) 1-19; gould, International J.of pharmaceuticals (1986)33, 201-217; anderson et al, The Practice of Medicinal Chemistry (1996), academic Press, New York; and The Orange Book (U.S. food and drug administration website, washington, d.c.). These disclosures are incorporated herein by reference.

Suitable basic salts include, but are not limited to, aluminum, ammonium, calcium, lithium, magnesium, potassium, sodium, and zinc salts.

All such acid and base salts are intended to be included within the scope of pharmaceutically acceptable salts as described herein. Furthermore, for the purposes of this specification, all such acid and base salts are considered equivalent to the free forms of the corresponding compounds.

The compounds of formula (I) and forms thereof may also exist in tautomeric forms. All such tautomeric forms are contemplated and are intended to be included within the scope of the compounds of formula (I) or forms thereof as described herein.

The compounds of formula (I) or forms thereof may contain asymmetric or chiral centers and thus exist in different stereoisomeric forms. The present specification is intended to include all stereoisomeric forms of the compounds of formula (I) and mixtures thereof, including racemic mixtures.

The compounds described herein may include one or more chiral centers and thus may exist as racemic mixtures (R/S) or as substantially pure enantiomers and diastereomers. The compounds may also exist as substantially pure (R) or (S) enantiomers (when a chiral center is present). In one embodiment, the compounds described herein are (S) isomers and may exist as enantiomerically pure compositions (comprising substantially only the (S) isomer). In another embodiment, the compounds described herein are (R) isomers and may exist as enantiomerically pure compositions (comprising substantially only the (R) isomer). As will be appreciated by those skilled in the art, when more than one chiral center is present, the compounds described herein may also exist as the (R, R) isomer, (R, S) isomer, (S, R) isomer, or (S, S) isomer as defined by IUPAC nomenclature.

As used herein, the term "substantially pure" refers to a compound consisting essentially of an amount of a single isomer greater than or equal to 90%, an amount of a single isomer greater than or equal to 92%, an amount of a single isomer greater than or equal to 95%, an amount of a single isomer greater than or equal to 98%, an amount of a single isomer greater than or equal to 99%, or an amount of a single isomer equal to 100%.

In one aspect of the specification, a compound of formula (I) or a form thereof is a substantially pure (S) enantiomeric form, which is present in an amount greater than or equal to 90%, an amount greater than or equal to 92%, an amount greater than or equal to 95%, an amount greater than or equal to 98%, an amount greater than or equal to 99%, or an amount equal to 100%.

In one aspect of the specification, a compound of formula (I) or a form thereof is a substantially pure (R) enantiomeric form, which is present in an amount greater than or equal to 90%, an amount greater than or equal to 92%, an amount greater than or equal to 95%, an amount greater than or equal to 98%, an amount greater than or equal to 99%, or an amount equal to 100%.

As used herein, a "racemate" is any mixture of "enantiomerically pure" isomeric forms, including, for example and without limitation, mixtures in ratios of about 50/50, about 60/40, about 70/30, or about 80/20.

In addition, the present specification includes all geometric and positional isomers. For example, if a compound of formula (I) or a form thereof contains a double bond or fused rings, both cis and trans forms and mixtures are included within the scope of the present specification. Diastereomeric mixtures can be separated into their respective diastereomers by methods well known to those skilled in the art (e.g., by chromatography and/or fractional crystallization) based on their physicochemical differences. The enantiomers may be separated by using a chiral HPLC column or other chromatographic methods known to those skilled in the art. Enantiomers may also be separated by converting the enantiomeric mixture into a diastereomeric mixture by reaction with an appropriate optically active compound (e.g., a chiral auxiliary, such as a chiral alcohol or Mosher acid chloride), separating the diastereomers and converting (e.g., hydrolyzing) each diastereomer to the corresponding pure enantiomer. Furthermore, some of the compounds of formula (I) may be atropisomers (e.g., substituted biaryls) and are considered part of the present invention.

All stereoisomers (e.g., geometric isomers, optical isomers, etc.) of the compounds of the present invention (including those of salts, solvates, esters, and prodrugs of the compounds, and salts, solvates, and esters of the prodrugs), such as those that exist due to asymmetric carbon atoms on various substituents, including enantiomeric forms (which may exist even in the absence of asymmetric carbons), rotameric forms, atropisomeric forms, and diastereomeric forms, are also included within the scope of the invention, as are positional isomers (e.g., 4-pyridyl and 3-pyridyl). Each stereoisomer of the compounds described herein may, for example, be substantially free of other isomers, or may be present in a racemic mixture as described above.

The use of the terms "salt", "solvate", "ester", "prodrug" and the like is intended to apply equally to salts, solvates, esters and prodrugs of enantiomers, stereoisomers, rotamers, tautomers, positional isomers, racemates or isotopologues of the compounds of the present invention.

The term "isotopologue" refers to isotopically enriched compounds described herein, which are identical to those described herein, but for the fact that one or more atoms are replaced by an atom having an atomic mass or mass number different from the atomic mass or mass number usually found in nature. Examples of isotopes that can be incorporated into the compounds described herein include isotopes of hydrogen, carbon, nitrogen, oxygen, phosphorus, fluorine and chlorine, each such as²H、³H、¹³C、¹⁴C、¹⁵N、¹⁸O、¹⁷O、³¹P、³²P、³⁵S、¹⁸F、³⁵C and³⁶cl, each of which is also within the scope of the present invention.

Certain isotopically enriched compounds described herein (e.g., with³H and¹⁴c-labeled ones) can be used in compound and/or substrate tissue distribution assays. Because of the tritiation (i.e.,³H) isotopes and carbon-14 (i.e.,¹⁴C) isotopes are particularly preferred for their ease of preparation and detectability. In addition, heavier isotopes are used (e.g. deuterium (i.e. deuterium)²H) Substitution) may provide certain therapeutic advantages due to higher metabolic stability (e.g., increased in vivo half-life or reduced dosage requirements) and may therefore be preferred in certain circumstances.

Polymorphic and amorphous forms of the compounds of formula (I) and salts, solvates, hydrates, esters and prodrugs of the compounds of formula (I) are further intended to be included in the present invention.

Use of compounds

The present invention relates to methods of using a compound of formula (I) or a form thereof in treating or ameliorating HD in a subject in need thereof, the method comprising administering to the subject an effective amount of the compound or a form thereof.

The invention also relates to the use of a compound of formula (I) or a form thereof for treating or ameliorating HD in a subject in need thereof.

The invention also relates to the use of compounds of formula (I) or forms thereof, which are active against HD.

The invention also relates to the use of a compound of formula (I) or a form thereof in a combination therapy to provide additional or synergistic activity, thereby enabling the development of a combination product for the treatment or amelioration of HD.

In addition to monotherapy uses, the compounds of the invention may be used in combination therapy with existing standard agents, with additional or synergistic activity with one or more known agents.

Combination therapies comprising a combination of a compound described herein and one or more known drugs can be used to treat HD, whether or not HD is responsive to the known drugs.

Embodiments of the invention include the use of a compound of formula (I) or a form thereof in a combination therapy for treating or ameliorating HD in a subject in need thereof, the use comprising administering an effective amount of a compound of formula (I) or a form thereof and an effective amount of one or more agents.

Embodiments of the invention include the use of a compound of formula (I) or a form thereof in a combination therapy for treating or ameliorating HD in a subject in need thereof, the use comprising administering an effective amount of a compound of formula (I) or a form thereof and an effective amount of one or more agents.

In embodiments of the uses or methods provided herein, a compound of formula (I) or a form thereof used in combination with one or more additional agents may be administered to a subject or contacted with a cell of a subject or patient prior to, simultaneously with, or subsequent to administration to the subject or patient, or the cell is contacted with an additional agent. The compound of formula (I) or a form thereof and the additional agent may be administered to a subject or contacted with a cell in a single composition or in different compositions. In particular embodiments, the compound of formula (I) or a form thereof is used in combination with gene therapy to inhibit HTT expression (using, for example, a viral delivery vector) or to administer another small molecule HTT inhibitor. In another embodiment, the compound of formula (I) or a form thereof is used in combination with cell replacement using differentiated non-mutated HTT stem cells. In another embodiment, the compound of formula (I) or a form thereof is used in combination with cell replacement using differentiated HTT stem cells.

In one embodiment, provided herein is the use of a compound of formula (I) or a form thereof in combination with supportive standard of care therapy, including palliative care.

Embodiments of the invention include the use of a compound of formula (I) or a form thereof in the manufacture of a kit comprising a compound of formula (I) or a form thereof, and instructions for administering an effective amount of a compound of formula (I) or a form thereof and an effective amount of one or more pharmaceutical agents in a combination therapy for treating or ameliorating HD in a subject in need thereof.

Accordingly, the present invention relates to the use of a compound of formula (I) or a form thereof for treating or ameliorating HD. According to the use of the present invention, compounds useful for selectively treating or ameliorating HD are identified and the use of these compounds for treating or ameliorating HD is provided.

One embodiment of the use of the present invention relates to the use of a compound of formula (I) or a form thereof to treat or ameliorate HD in a subject in need thereof, the use comprising administering to the subject an effective amount of a compound of formula (I) or a form thereof.

One embodiment of the use of the present invention relates to a method of treating or ameliorating HD in a subject in need thereof using a compound of formula (I) or a form thereof, the method comprising administering to the subject an effective amount of the compound. .

Embodiments of the use of the invention relate to methods of treating or ameliorating HD in a subject in need thereof using a compound of formula (I) or a form thereof, the method comprising administering to the subject an effective amount of the compound.

An embodiment of the use of the invention relates to the use of a compound of formula (I) or a form thereof in the manufacture of a medicament for treating or ameliorating HD in a subject in need thereof, the use comprising administering to the subject an effective amount of the medicament.

An embodiment of the use of the invention relates to the use of a compound of formula (I) or a form thereof in the preparation of a kit comprising a compound of formula (I) or a form thereof, and instructions for administering the compound for treating or ameliorating HD in a subject in need thereof.

In one aspect, for each of these embodiments, the subject is untreated. In another aspect, for each of these embodiments, the subject is treated.

As used herein, the term "treating" refers to: (i) preventing the disease, disorder, or symptom from occurring in a subject that may be predisposed to the disease, disorder, and/or symptom but has not yet been diagnosed as having the disease, disorder, and/or symptom; (ii) inhibiting the disease, disorder and/or symptom, i.e., arresting its development; and/or (iii) relieving the disease, disorder, and/or symptom, i.e., causing regression of the disease, disorder, and/or symptom.

As used herein, the term "subject" refers to an animal or any living organism that has sensory and autokinetic abilities and requires oxygen and organic food. Non-limiting examples include members of human, primate, equine, porcine, bovine, murine, hamster, canine, and feline species. In some embodiments, the subject is a mammal or a warm-blooded vertebrate. In other embodiments, the subject is a human. As used herein, the term "patient" is used interchangeably with "subject" and "human".

As used herein, the term "effective amount" or "therapeutically effective amount" refers to an amount of a compound of formula (I) or a form, composition or medicament thereof effective to inhibit the above-mentioned diseases and thereby produce the desired therapeutic, ameliorating, inhibitory or prophylactic effect in a subject in need thereof.

The dose administered to achieve an effective target plasma concentration may also be administered based on the weight of the subject or patient. The dosage administered on a weight basis may be in the following ranges: from about 0.001 mg/kg/day to about 3500 mg/kg/day, or from about 0.001 mg/kg/day to about 3000 mg/kg/day, or from about 0.001 mg/day to about 2500 mg/kg/day, or from about 0.001 mg/kg/day to about 2000 mg/kg/day, or from about 0.001 mg/kg/day to about 1500 mg/kg/day, or from about 0.001 mg/kg/day to about 1000 mg/kg/day, or from about 0.001 mg/kg/day to about 500 mg/kg/day, or from about 0.001 mg/kg/day to about 250 mg/kg/day, or from about 0.001 mg/kg/day to about 100 mg/kg/day, or from about 0.001 mg/kg/day to about 75 mg/kg/day, or from about 0.001 mg/kg/day to about 50 mg/kg/day, Or from about 0.001 mg/kg/day to about 40 mg/kg/day, or from about 0.001 mg/kg/day to about 30 mg/kg/day, or from about 0.001 mg/kg/day to about 20 mg/kg/day, or from about 0.001 mg/kg/day to about 10 mg/kg/day, or from about 0.01 mg/kg/day to about 2000 mg/kg/day, or from about 0.01 mg/kg/day to about 1500 mg/kg/day, or from about 0.01 mg/kg/day to about 1000 mg/kg/day, or from about 0.01 mg/kg/day to about 600 mg/kg/day, or from about 0.01 mg/kg/day to about 500 mg/kg/day, or from about 0.01 mg/kg/day to about 300 mg/kg/day, or from about 0.015 mg/kg/day to about 200 mg/kg/day, Or from about 0.02 mg/kg/day to about 100 mg/kg/day, or from about 0.025 mg/kg/day to about 100 mg/kg/day, or from about 0.03 mg/kg/day to about 100 mg/kg/day, wherein the amount is administered orally once per day (about once every 24 hours), twice per day (about once every 12 hours), or three times per day (about once every 8 hours), depending on the weight of the subject.

In certain embodiments, in a single, divided or continuous dose for patients or subjects weighing in the range of about 40kg to about 200kg (for patients or subjects above or below this range, especially children below 40kg, the dose can be adjusted), the effective amount will be in the following range: from about 0.001 mg/kg/day to about 500 mg/kg/day, or from about 0.01 mg/kg/day to about 500 mg/kg/day, or from about 0.1 mg/kg/day to about 500 mg/kg/day, or from about 1.0 mg/kg/day to about 500 mg/kg/day. Typical adult subjects are expected to have a median weight in the range of about 70 kg.

In another embodiment, where the daily dose is adjusted based on the weight of the subject or patient, the compounds described herein can be formulated at about 0.02 mg/kg/day, about 0.025 mg/kg/day, about 0.03 mg/kg/day, about 0.05 mg/kg/day, about 0.06 mg/kg/day, about 0.075 mg/kg/day, about 0.08 mg/kg/day, about 0.09 mg/kg/day, about 0.10 mg/kg/day, about 0.20 mg/kg/day, about 0.25 mg/kg/day, about 0.30 mg/kg/day, about 0.50 mg/kg/day, about 0.60 mg/kg/day, about 0.75 mg/kg/day, about 0.80 mg/kg/day, about 0.90 mg/kg/day, about 1.0 mg/kg/day, about 1.10 mg/kg/day, About 1.20 mg/kg/day, about 1.25 mg/kg/day, about 1.50 mg/kg/day, about 1.75 mg/kg/day, about 2.0 mg/kg/day, about 3.0 mg/kg/day, about 5.0 mg/kg/day, about 10 mg/kg/day, about 20 mg/kg/day, about 30 mg/kg/day, about 40 mg/kg/day, about 50 mg/kg/day, about 100 mg/kg/day, about 150 mg/kg/day, about 200 mg/kg/day, about 250 mg/kg/day, about 300 mg/kg/day, about 400 mg/kg/day, or about 500 mg/kg/day. The daily dose adjusted based on the weight of the subject or patient may be administered as a single, divided or continuous dose. In embodiments where the compound dose is administered more than once per day, the dose may be administered two, three or more times per day.

Within the scope of the present invention, an "effective amount" of a compound of formula (I) or a form thereof for use in the manufacture of a medicament, for the preparation of a pharmaceutical kit or for use in a method of treating or improving HD in a subject in need thereof is intended to include amounts within the following ranges: from about 0.001 mg/kg/day to about 3500 mg/kg/day, or from about 0.001 mg/kg/day to about 3000 mg/day, or from about 0.001 mg/kg/day to about 2500 mg/kg/day, or from about 0.001 mg/kg/day to about 2000 mg/kg/day, or from about 0.001 mg/kg/day to about 1500 mg/kg/day, or from about 0.001 mg/kg/day to about 1000 mg/kg/day, or from about 0.001 mg/kg/day to about 500 mg/kg/day, or from about 0.001 mg/kg/day to about 250 mg/kg/day, or from about 0.001 mg/kg/day to about 100 mg/kg/day, or from about 0.001 mg/kg/day to about 75 mg/kg/day, or from about 0.001 mg/kg/day to about 50 mg/kg/day, Or from about 0.001 mg/kg/day to about 40 mg/kg/day, or from about 0.001 mg/kg/day to about 30 mg/kg/day, or from about 0.001 mg/kg/day to about 20 mg/kg/day, or from about 0.001 mg/kg/day to about 10 mg/kg/day, or from about 0.01 mg/kg/day to about 2000 mg/kg/day, or from about 0.01 mg/kg/day to about 1500 mg/kg/day, or from about 0.01 mg/kg/day to about 1000 mg/kg/day, or from about 0.01 mg/kg/day to about 600 mg/kg/day, or from about 0.01 mg/kg/day to about 500 mg/kg/day, or from about 0.01 mg/kg/day to about 300 mg/kg/day, or from about 0.015 mg/kg/day to about 200 mg/kg/day, Or from about 0.02 mg/kg/day to about 100 mg/kg/day, or from about 0.025 mg/kg/day to about 100 mg/kg/day, or from about 0.03 mg/kg/day to about 100 mg/kg/day, wherein the amount is administered once per day (about 24 hours; i.e., "q.d."), twice (about 12 hours; i.e., "b.i.d." or "q.l2h"), three times (about 8 hours; i.e., "t.i.d." or "q.8h"), or four times (about 6 hours; i.e., "q.d.s.", "q.i.d." or "q.6h"), depending on the weight of the subject.

The amount may further include amounts within the following ranges: administering an amount of about 0.001mg to about 3500mg per day; administering from 0.001mg to about 3000mg per day; administering from 0.001mg to about 2500mg per day; administering from 0.001mg to about 2000mg per day; administering from 0.001mg to about 1500mg per day; administering from 0.001mg to about 1000mg per day; administering from 0.001mg to about 500mg per day; administering from 0.001mg to about 250mg per day; administering from 1.0mg to about 3500mg per day; administering from 1.0mg to about 1500mg per day; administering from 1.0mg to about 1000mg per day; administering from 10.0mg to about 600mg daily; administering 0.5mg to about 2000mg per day; or in an amount in the range of about 5.0mg to about 300mg administered per day.

For example, an effective amount can be that amount required to treat HD in a subject (more specifically, a human). The effective amount for a subject will depend on various factors including the weight, size and health of the subject. An effective amount for a given patient may be determined by routine experimentation within the skill and judgment of the clinician.

For any compound, an effective amount can be estimated initially in a cell culture assay or in a relevant animal model (e.g., a mouse, chimpanzee, marmoset, or tamarind animal model). Relevant animal models can also be used to determine appropriate concentration ranges and routes of administration. This information can then be used to determine useful doses and routes of administration for humans. Therapeutic efficacy and toxicity can be determined by standard pharmaceutical procedures in cell cultures or experimental animals, e.g. ED₅₀(therapeutically effective dose in 50% of the population) and LD₅₀(dose lethal to 50% of the population). The dose ratio between therapeutic and toxic effects is the therapeutic index and can be expressed as the ratio LD₅₀/ED₅₀. In some embodiments, the effective amount is such that a large therapeutic index is achieved. In a further embodiment, the dosage is at ED including little or no toxicity₅₀In the circulating concentration range of (c). The dosage may vary within this range depending upon the dosage form employed, the sensitivity of the patient, and the route of administration.

More specifically, the concentration-biological effect relationship observed for a compound of formula (I) or a form thereof indicates that the target plasma concentration ranges from about 0.001 μ g/mL to about 50 μ g/mL, from about 0.01 μ g/mL to about 20 μ g/mL, from about 0.05 μ g/mL to about 10 μ g/mL, or from about 0.1 μ g/mL to about 5 μ g/mL. For patients weighing from about 10kg to about 100kg (for patients within this weight range (particularly for children below 40 kg), the dose may be adjusted), and to achieve such plasma concentrations, the compounds described herein may be administered at varying doses (e.g., without limitation, 0.1ng to 10000mg), depending on the route of administration of the single, divided or continuous dose.

The exact dosage will be determined by the practitioner, depending on factors associated with the subject. The dosage and administration can be adjusted to provide a sufficient level of the active agent or to maintain the desired effect. Factors that may be considered include the severity of the disease state, the general health of the subject, race, age, body weight, sex, diet, time of day and frequency of administration, drug combination, response sensitivity, undergoing other therapies, and tolerance/response to treatment. Depending on the half-life and clearance of a particular formulation, long acting pharmaceutical compositions may be administered every 2 days, every 3 days, or every 4 days, once a week, or once every two weeks.

The compounds and compositions described herein can be administered to a subject by any drug delivery route known in the art. Non-limiting examples include oral, ocular, rectal, buccal, topical, nasal, sublingual, transdermal, subcutaneous, intramuscular, intravenous (bolus and infusion), intracerebral and pulmonary routes of administration.

In one aspect, provided herein is a method for modulating the amount of HTT (huntingtin), the method comprising contacting a human cell with a compound of formula (I) or a form thereof. In a specific embodiment, provided herein is a method of modulating the amount of HTT, comprising contacting a human cell with a compound of formula (I) or a form thereof that modulates HTT expression. The human cell may be contacted with a compound of formula (I) or a form thereof in vitro or in vivo (e.g., in a non-human animal or in a human). In particular embodiments, the human cell is from or in a human. In another specific embodiment, the human cell is from or in a human with HD. In another specific embodiment, the human cell is from or in a human with HD, which is caused by CAG repeats in the Htt gene, resulting in loss of Htt expression and/or function. In another embodiment, the human cell is from a human having HD. In another embodiment, the human cell is in a human with HD. In one embodiment, the compound is in the form of a compound of formula (I).

In particular embodiments, provided herein are methods for enhancing the inhibition of a mutant Htt transcribed from the Htt gene comprising contacting a human cell with a compound of formula (I) or a form thereof. The human cell may be contacted with a compound of formula (I) or a form thereof in vitro or in vivo (e.g., in a non-human animal or in a human). In particular embodiments, the human cell is from or in a human. In another specific embodiment, the human cell is from or in a human with HD. In another specific embodiment, the human cell is from or in a human with HD, which is caused by CAG repeats in the Htt gene, resulting in the loss of wild-type "normal" Htt expression and/or function. In another embodiment, the human cell is from a human having HD. In another embodiment, the human cell is in a human with HD. In one embodiment, the compound is in the form of a compound of formula (I).

In another aspect, provided herein is a method for modulating the inhibition of a mutant Htt transcribed from the Htt gene, comprising administering to a non-human animal model of HD a compound of formula (I) or a form thereof. In a specific embodiment, provided herein is a method for modulating the inhibition of a mutant Htt transcribed from the Htt gene, the method comprising administering to a non-human animal model of HD a compound of formula (I) or a form thereof. In a particular embodiment, the compound is in the form of a compound of formula (I).

In another aspect, provided herein is a method for reducing the amount of a mutant HTT, the method comprising contacting a human cell with a compound of formula (I) or a form thereof. In a specific embodiment, provided herein is a method for reducing the amount of a mutant HTT, comprising contacting a human cell with a compound of formula (I) that inhibits transcription of mutant HTT (huntingtin mRNA) from the HTT gene. In another embodiment, provided herein is a method for reducing the amount of HTT, the method comprising contacting a human cell with a compound of formula (I) that inhibits expression of a mutant HTT transcribed from the HTT gene. The human cell may be contacted with a compound of formula (I) or a form thereof in vitro or in vivo (e.g., in a non-human animal or in a human). In particular embodiments, the human cell is from or in a human. In another specific embodiment, the human cell is from or in a human with HD. In another specific embodiment, the human cell is from or in a human with HD, which is caused by CAG repeats in the Htt gene, resulting in loss of Htt expression and/or function. In another embodiment, the human cell is from a human having HD. In another embodiment, the human cell is in a human with HD. In one embodiment, the compound is in the form of a compound of formula (I).

In certain embodiments, treating or ameliorating HD with a compound of formula (I) or a form thereof (alone or in combination with additional agents) has a therapeutic and/or beneficial effect. In particular embodiments, treatment of HD with a compound of formula (I) or a form thereof (alone or in combination with an additional agent) results in one, two or more of the following effects: (i) reducing or improving the severity of HD; (ii) delay the onset of HD; (iii) inhibiting the progression of HD; (iv) reducing hospitalization of the subject; (v) reducing hospitalization time of the subject; (vi) increasing survival of the subject; (vii) improving the quality of life of the subject; (viii) reducing the number of symptoms associated with HD; (ix) reducing or ameliorating the severity of symptoms associated with HD; (x) Reducing the duration of symptoms associated with HD; (xi) Preventing recurrence of symptoms associated with HD; (xii) Inhibiting the development or onset of HD symptoms; and/or (xiii) inhibiting the progression of symptoms associated with HD.

Metabolites of compounds

Also included within the scope of the invention is the use of in vivo metabolites of the compounds described herein. These products may result, for example, from oxidation, reduction, hydrolysis, amidation, esterification, etc. of the administered compound, primarily due to enzymatic processes. Thus, the specification includes the use of a compound produced by a method comprising contacting a compound described herein with a mammalian tissue or a mammal for a period of time sufficient to produce a metabolite thereof.

These products are generally identified by: preparation of radiolabelled isotopologues of the compounds described hereinThe amount of the matrix (e.g.,¹⁴c or³H) A detectable dose (e.g., greater than about 0.5mg/kg) of a radiolabeled compound is administered to a mammal (e.g., rat, mouse, guinea pig, dog, monkey or human), allowing sufficient time for metabolism (typically about 30 seconds to about 30 hours), and determination of metabolic conversion products from urine, bile, blood or other biological samples. The conversion products are easy to isolate because they are "radiolabeled" due to isotopic enrichment (others are isolated by the use of antibodies that are capable of binding to epitopes that survive in the metabolite). The metabolite structure is determined in a conventional manner, for example by MS or NMR analysis. In general, analysis of metabolites can be performed in the same manner as conventional drug metabolism studies well known to those skilled in the art. The conversion products (so long as they are not found in vivo) can be used in diagnostic assays for therapeutic dosages of the compounds described herein, even if they do not possess their own biological activity.

Pharmaceutical composition

Embodiments of the invention include the use of a compound of formula (I) or a form thereof in a pharmaceutical composition for treating or ameliorating HD in a subject in need thereof, the use comprising administering an effective amount of a compound of formula (I) or a form thereof in admixture with one or more pharmaceutically acceptable excipients.

Embodiments of the invention include the use of a compound of formula (I) or a pharmaceutical composition in the form thereof in the preparation of a kit comprising a compound of formula (I) or a pharmaceutical composition in the form thereof and instructions for administering the compound for treating or ameliorating HD in a subject in need thereof.

As used herein, the term "composition" refers to a product comprising the specified ingredients in the specified amounts, as well as any product which results, directly or indirectly, from combination of the specified ingredients in the specified amounts.

The pharmaceutical composition can be formulated to achieve a physiologically compatible pH, ranging from about pH 3 to about pH 11. In some embodiments, the pharmaceutical composition is formulated to achieve a pH of about pH 3 to about pH 7. In other embodiments, the pharmaceutical composition is formulated to achieve a pH of about pH 5 to about pH 8.

The term "pharmaceutically acceptable excipient" refers to an excipient used to administer a pharmaceutical agent (e.g., a compound described herein). The term refers to any pharmaceutical excipient that can be administered without undue toxicity. Pharmaceutically acceptable excipients may be determined, in part, by the particular composition being administered and the particular mode and/or dosage form being administered. Non-limiting examples of pharmaceutically acceptable excipients include carriers, solvents, stabilizers, adjuvants, diluents, and the like. Thus, there are a variety of suitable formulations for Pharmaceutical compositions of the compounds of the invention described herein (see, e.g., Remington's Pharmaceutical Sciences).

Suitable excipients may be carrier molecules which include large, slowly metabolised macromolecules such as proteins, polysaccharides, polylactic acids, polyglycolic acids, polymeric amino acids, amino acid copolymers and inactive antibodies. Other exemplary excipients include antioxidants, such as ascorbic acid; chelating agents, such as EDTA; carbohydrates, such as dextrin, hydroxyalkyl cellulose, hydroxyalkyl methyl cellulose (e.g., hydroxypropyl methyl cellulose, also known as HPMC), stearic acid; liquids, such as oil, water, saline, glycerol and ethanol; a wetting or emulsifying agent; a pH buffering substance; and so on. Liposomes are also included within the definition of pharmaceutically acceptable excipients.

The pharmaceutical compositions described herein may be formulated in any form suitable for the intended use described herein. Suitable formulations for oral administration include solids, liquid solutions, emulsions and suspensions, while suitable inhalable formulations for pulmonary administration include liquids and powders. Alternative formulations include syrups, creams, ointments, tablets, and lyophilized solids that can be reconstituted with a physiologically compatible solvent prior to administration.

When intended for oral use, for example, tablets, troches (troche), lozenges (lozenge), aqueous or oily suspensions, non-aqueous solutions, dispersible powders or granules (including micronized granules or nanoparticles), emulsions, hard or soft capsules, syrups or elixirs may be prepared. Compositions intended for oral use may be prepared according to any method known to the art for the manufacture of pharmaceutical compositions and such compositions may contain one or more agents, including sweetening agents, flavouring agents, colouring agents and preserving agents, in order to provide palatable preparations.

Pharmaceutically acceptable excipients suitable for use in conjunction with tablets include, for example, inert diluents such as cellulose, calcium or sodium carbonate, lactose, calcium or sodium phosphate; disintegrants, for example croscarmellose sodium, crospovidone, corn starch, or alginic acid; binders, such as povidone, starch, gelatin or acacia; and lubricating agents, such as magnesium stearate, stearic acid or talc. The tablets may be uncoated or they may be coated by known techniques, including microencapsulation to delay disintegration and absorption in the gastrointestinal tract, to provide a sustained action over a longer period. For example, a time delay material (e.g., glyceryl monostearate or glyceryl distearate) may be employed alone or with a wax.

Formulations for oral use may also be presented as hard gelatin capsules wherein the active ingredient is mixed with an inert solid diluent, for example, cellulose, lactose, calcium phosphate or kaolin, or as soft gelatin capsules wherein the active ingredient is mixed with a non-aqueous or oily medium, for example glycerol, propylene glycol, polyethylene glycol, peanut oil, liquid paraffin or olive oil.

In other embodiments, the pharmaceutical compositions described herein may be formulated as a suspension comprising a compound of formula (I) or a form thereof admixed with one or more pharmaceutically acceptable excipients suitable for the manufacture of suspensions. In other embodiments, the pharmaceutical compositions described herein may be formulated as dispersible powders and granules suitable for preparation of suspensions by the addition of one or more excipients.

Excipients suitable for use in connection with suspensions include suspending agents, for example, sodium carboxymethylcellulose, methylcellulose, hydroxypropylmethylcellulose, sodium alginate, polyvinylpyrrolidone, gum tragacanth, gum acacia; dispersing or wetting agents, for example, naturally occurring phosphatides (e.g., lecithin), condensation products of alkylene oxides with fatty acids (e.g., polyoxyethylene stearate), condensation products of ethylene oxide with long chain aliphatic alcohols (e.g., heptadecaalkoxyethanol), condensation products of ethylene oxide with partial esters derived from fatty acids and hexitol anhydrides (e.g., polyoxyethylene sorbitan monooleate); and thickeners, for example, carbomer, beeswax, hard paraffin or cetyl alcohol. The suspension may also contain one or more preservatives, such as acetic acid, methyl paraben and/or n-propyl paraben; one or more colorants; one or more flavoring agents; and one or more sweetening agents, such as sucrose or saccharin.

The pharmaceutical compositions described herein may also be in the form of oil-in-water emulsions. The oily phase may be a vegetable oil, for example olive oil or arachis oil, a mineral oil, for example liquid paraffin, or a mixture of these. Suitable emulsifying agents include naturally-occurring gums, for example, gum acacia and gum tragacanth; naturally occurring phospholipids, such as soy lecithin, derived from fatty acids or ester partial esters; hexitol anhydrides such as hexitol monooleate; condensation products of these partial esters with ethylene oxide, such as polyoxyethylene sorbitan monooleate. The emulsion may also contain sweetening and flavoring agents. Syrups and elixirs may be formulated with sweetening agents, for example glycerol, sorbitol or sucrose. Such formulations may also contain a demulcent, a preservative, a flavouring or a colouring agent.

In addition, the pharmaceutical compositions described herein may be in the form of a sterile injectable preparation, such as a sterile injectable aqueous emulsion or oily suspension. Such emulsions or suspensions may be formulated according to the known art using those suitable dispersing or wetting agents and suspending agents which have been mentioned above. The sterile injectable preparation may also be a sterile injectable solution or suspension in a non-toxic parenterally-acceptable diluent or solvent, for example as a solution in 1, 2-propanediol. Sterile injectable formulations may also be prepared as lyophilized powders. Acceptable carriers and solvents that may be employed include water, ringer's solution and isotonic sodium chloride solution. In addition, sterile fixed oils may be employed as a solvent or suspending medium. For this purpose, any bland fixed oil may be employed including synthetic mono-or diglycerides. In addition, fatty acids (e.g., oleic acid) may likewise be used in the preparation of injectables.

The compounds described herein may be substantially water insoluble and sparingly soluble in most pharmaceutically acceptable protic solvents and vegetable oils, but are generally soluble in medium chain fatty acids (e.g. caprylic and capric acid) or in triglycerides and propylene glycol esters of medium chain fatty acids. Thus, contemplated in the present invention are compounds modified by substitution or addition of chemical or biochemical moieties that make them more suitable for delivery (e.g., increase solubility, biological activity, palatability, reduce adverse reactions, etc.), such as by esterification, glycosylation, pegylation, and the like.

In some embodiments, the compounds described herein are formulated for oral administration in a lipid-based composition suitable for low solubility compounds. Lipid-based formulations can generally enhance the oral bioavailability of these compounds. Thus, the pharmaceutical compositions described herein may comprise an effective amount of a compound of formula (I) or a form thereof and at least one pharmaceutically acceptable excipient selected from medium chain fatty acids or propylene glycol esters thereof (e.g., propylene glycol esters of edible fatty acids such as caprylic and capric fatty acids) and pharmaceutically acceptable surfactants (e.g., polysorbate 20 or polysorbate 80 (also referred to as polysorbate 20 or polysorbate 80, respectively)20 or80) Or polyoxyethylene 40 hydrogenated castor oil).

In other embodiments, the bioavailability of the low solubility compound may be enhanced using particle size optimization techniques that include preparing nanoparticles or nanosuspensions using techniques known to those skilled in the art. The forms of the compounds present in such formulations include amorphous, partially crystalline or crystalline forms.

In an alternative embodiment, the pharmaceutical composition may further comprise one or more water solubility enhancing agents, such as cyclodextrins. Non-limiting examples of cyclodextrins include hydroxypropyl, hydroxyethyl, glucosyl, maltosyl and maltotriosyl derivatives of alpha-cyclodextrin, beta-cyclodextrin and gamma-cyclodextrin, and hydroxypropyl-beta-cyclodextrin (HPBC). In some embodiments, the pharmaceutical composition further comprises HPBC in a range of about 0.1% to about 20%, about 1% to about 15%, or about 2.5% to about 10%. The amount of solubility enhancer used may depend on the amount of compound in the composition.

Preparation of the Compounds

The compounds provided herein can be prepared by one of ordinary skill in the art, for example, by the synthetic methods set forth in international application publication No. WO2014/028459a1, published on 7/31 2014, international application publication No. WO2014/116845a1, published on 2/5 2014, international application publication No. WO2015/017589a1, each of which is incorporated herein by reference.

General scheme

The following reaction schemes illustrate methods of making the compounds described herein. It is understood that one skilled in the art would be able to prepare these compounds by analogous methods or by methods known to those skilled in the art.

In general, starting components and reagents can be obtained commercially from various sources (e.g., commercial suppliers), synthesized according to methods known to those skilled in the art, or prepared as described herein. It is to be understood that in the following description, combinations of substituents and/or variants of the formulae depicted are permitted only if the result yields a stable compound.

In general, the compounds of formula (I) described herein can be synthesized according to the general scheme of scheme 1 below.

Scheme 1

General procedure for scheme 1

The starting materials for the above reaction schemes are commercially available or can be prepared according to methods known to those skilled in the art or by the methods disclosed herein. Generally, the compounds described herein are prepared in reaction scheme 1 above as follows: using a metathesis or metal-mediated cross-coupling reaction (e.g. Buchwald reaction), a halo compound Ia (where Hal is a halogen selected from bromo or chloro) is reacted with a compound 1B (where H is a reactive hydrogen atom in an amine or alcohol X functional group, where X and B of the compound of formula (I) are as described herein) to provide an intermediate compound 1 c. Compound 1c is continued and reacted with a boronic acid or boronic ester compound 1d (wherein B represents a boron atom and R represents an acid or ester functional group or forms a ring system (when taken together with boron) using a transition metal mediated cross-coupling reaction (e.g. a Suzuki reaction) to provide the compound of formula (I) a.

In a complementary manner, the compounds of formula (I) can also be synthesized in the reverse order, wherein the boronic ester compound 1d is first reacted with compound 1a, and then the intermediate is reacted with the amine compound 1 b. Other variations (representing different combinations of one or both of the boronic ester compound 1d and the amine compound 1b used in place of the compound 1 a) are intended to be included within the scope of the synthetic methods described herein.

DETAILED DESCRIPTION OF EMBODIMENT (S) OF INVENTION

The following specific examples are included to aid in the understanding of the invention. Of course, experimentation in connection with the present invention should not be construed as specifically limiting the invention, and variations now known or later developed that are within the purview of one skilled in the art are considered to fall within the scope of the invention as described herein and hereinafter claimed.

Except in the working examples, all numbers expressing quantities of materials, reagents, reaction conditions, experimental data, and so forth, used in the specification and claims are to be understood as being modified by the term "about" unless otherwise indicated. Accordingly, all of these numbers represent approximations that may vary depending upon the desired properties sought to be obtained by the reaction or as a result of variable experimental conditions. Thus, within the expected range of experimental reproducibility, in the context of the resulting data, the term "about" refers to the range of data provided that may vary according to standard deviation from the mean. Likewise, for the experimental results provided, the resulting data can be rounded up or down to consistently present the data without loss of significant digits. At the very least, and not as an attempt to limit the application of the doctrine of equivalents to the scope of the claims, each numerical parameter should at least be construed in light of the number of significant digits and by applying ordinary rounding techniques.

Notwithstanding that the numerical ranges and parameters setting forth the broad scope of the invention are approximations, the numerical values set forth in the working examples are reported as precisely as possible. Any numerical value, however, inherently contains certain errors necessarily resulting from the standard deviation found in their respective testing measurements.

The column chromatography system used for product purification is ISCO CombiFlash^TMA brand chromatography system (manufactured by Teledyne Isco).

Synthetic examples

Further details of the invention are provided with reference to the following non-limiting examples, which are provided to more fully illustrate the invention, but should not be construed as limiting its scope. The examples illustrate the preparation of certain compounds described herein, and the testing of such compounds in vitro and/or in vivo. It will be appreciated by those of skill in the art that the techniques described in these examples represent techniques described by the inventors that function well in the practice of the invention, and thus constitute preferred modes for its practice. However, those of skill in the art should, in light of the present disclosure, appreciate that many changes can be made in the specific methods which are disclosed and still obtain a like or similar result without departing from the spirit and scope of the invention.

As used above, and throughout the specification, unless otherwise indicated, the following abbreviations shall be understood to have the following meanings:

example 1(Compound 411)

2- {6- [ 8-azabicyclo [3.2.1] oct-3-yl (methyl) amino ] pyridazin-3-yl } -5- (1H-pyrazol-4-yl) phenol hydrochloride

Step 1:the reaction mixture was cooled and dried over sodium sulfate, and 3, 6-dibromopyridazine (133.7mg, 0.56mmol), (1R,5S) -3- (methylamino) -8-azabicyclo [3.2.1]Octane-8-carboxylic acid tert-butyl ester (85mg, 0.28mmol) and DIPEA (0.15mL, 0.84mmol) were mixed in 1mL ACN and heated to 100 ℃ for 1 hour until LC-MS showed complete consumption of the starting material. The reaction mixture was concentrated and purified by column chromatography: by CH₂Cl₂A gradient of/MeOH (0% to 30% MeOH) elution, column: silica 4g to give (1S,5R) -3- [ (6-bromopyridazin-3-yl) -methyl-amino]-8-azabicyclo [3.2.1]Octane-8-carboxylic acid tert-butyl ester (55mg, yield 49.25%).

Step 2:reacting 3- [ (6-bromopyridazin-3-yl) -methyl-amino]-8-azabicyclo [3.2.1]Octane-8-carboxylic acid tert-butyl ester (55mg, 0.14mmol), 4- [3- (methoxymethyloxy) -4- (4,4,5, 5-tetramethyl-1, 3, 2-dioxaborolan-2-yl) phenyl]-1-tetrahydropyran-2-yl-pyrazole (68.82mg, 0.17mmol), Pd (dppf) Cl₂(10.34mg，0.01mmol)、K₂CO₃(57.98mg, 0.42mmol) were mixed in a schlenk tube. Reacting with N₂Degassed for 15 min, dioxane (2mL) and water (0.5mL) were added and the reaction heated to 90 ℃ for 16 h. The reaction was cooled to rt and partitioned between EtOAc and water. Subjecting the organic layer to Na₂SO₄Dried, concentrated under vacuum, purified by column chromatography: by CH₂Cl₂EtOAc (0% to 80%) gradient elution, column: silica 4g to give (1S,5R) -3- [ [6- [2- (methoxymethyloxy) -4- (1-tetrahydropyran-2-ylpyrazol-4-yl) phenyl ] as a tan solid]Pyridazin-3-yl radicals]-methyl-amino]-8-azabicyclo [3.2.1]Octane-8-carboxylic acid tert-butyl ester (52mg, 62%).

And step 3:to (1S,5R) -3- [ [6- [2- (methoxymethyloxy) -4- (1-tetrahydropyran-2-ylpyrazol-4-yl) phenyl ] methyl]Pyridazin-3-yl radicals]-methyl-amino]-8-azabicyclo [3.2.1]Octane-8-carboxylic acid tert-butyl ester (52mg, 0.086mmol) in 1mL CH₂Cl₂And 0.5mL of MeOH mixture solution to HCl (4mol/L) in 1, 4-dioxane (0.06mL) was added. The reaction was stirred overnight. The precipitate was filtered and then dried in vacuo to give 2- [6- [ 8-azabicyclo [3.2.1] as a yellow solid]Oct-3-yl (methyl) amino]Pyridazin-3-yl radicals]-5- (1H-pyrazol-4) yl) phenol hydrochloride (15mg, yield 42.25%).

LC-MS:377[M+H]⁺.¹H NMR(500MHz,DMSO-d₆)δ:9.37-9.51(m,IH),8.87-8.96(m,IH),8.31(d,J＝9.8Hz,IH),8.12(s,2H),7.74(d,J＝8.2Hz,2H),7.19-7.27(m,2H),4.80-4.92(m,IH),4.08-4.14(m,3H),3.07(s,3H),2.30(td,J＝12.6,2.8Hz,2H),1.99-2.15(m,4H),1.74-1.87(m,2H)

Using the procedure described in example 1 above, additional compounds described herein can be prepared by substituting the appropriate starting reagents and reaction conditions to yield, for example, a compound selected from the following:

example 2(Compound 416)

5- (5-methyl-1H-pyrazol-4-yl) -2- {6- [ methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino ] pyridazin-3-yl) phenol

Step 1:3-methoxy-4- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) phenyltriflate (80mg, 0.16mmol), (3-methyl-4- (4,4,5, 5-tetramethyl-1, 3, 2-dioxaborolan-2-yl) -1H-pyrazole-1-carboxylic acid tert-butyl ester (59mg, 0.19mmol), Pd (dppf) Cl₂(7mg，0.01mmol)、K₂CO₃(66mg, 0.48mmol) were mixed in a schlenk tube. Reacting with N₂Degassed for 15 min, dioxane (2mL) and water (0.5mL) were added and the reaction heated to 90 ℃ for 16 h. The reaction was cooled to room temperature and the reaction was cooled to room temperature in EtOAc and waterAnd (5) interlayer layering. The organic layer was washed with Na₂SO₄Dried, concentrated under vacuum and then purified by column chromatography: by CH₂Cl₂A gradient of/MeOH (0% to 30% MeOH) elution, column: silica 4g to give 4- (3-methoxy-4- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) phenyl) -3-methyl-1H-pyrazole-1-carboxylic acid tert-butyl ester (46mg, 54%) as a pale brown solid.

Step 2:2mL of anhydrous CH containing 4- (3-methoxy-4- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) phenyl) -3-methyl-1H-pyrazole-1-carboxylic acid tert-butyl ester (46mg, 0.09mmol)₂Cl₂The solution was cooled in an ice-water bath. Adding CH₂Cl₂1.0M boron tribromide (0.45mL, 0.45mmol), the reaction mixture was stirred at room temperature for 16 h. The reaction was quenched with 2mL MeOH, stirred for 30 min, then concentrated and purified by column chromatography: by CH₂Cl₂/MeOH (2.5% NH)₄OH) (0% to 30% MeOH/NH)₄OH) gradient elution, column: silica 4g to give 2- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) -5- (3-methyl-1H-pyrazol-4-yl) tert-butylphenol (20mg, 55%) as a yellow solid.

LC-MS:421[M+H]⁺.¹H NMR(500MHz,DMSO-d₆)δ:13.74(s,1H),12.63-12.71(m,1H),8.20(d,J＝9.5Hz,1H),8.03-8.04(m,1H),7.86(d,J＝8.0Hz,1H),7.73-7.75(m,1H),7.36(d,J＝9.5Hz,1H),7.03-7.06(m,2H),4.90-5.05(m,1H),2.92(s,3H),2.43(s,3H),1.43-1.54(m,2H),1.15-1.43(m,2H),1.14(s,6H),1.09(s,6H)

Using the procedure described in example 2 above, additional compounds described herein can be prepared by substituting the appropriate starting reagents and reaction conditions to yield, for example, a compound selected from the following:

example 3(Compound 419)

2- {6- [ methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino ] pyridazin-3-yl } -5- (4-nitro-1H-pyrazol-1-yl) phenol dihydrochloride

Step 1:3-methoxy-4- (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) phenyltriflate (335mg, 0.67mmol), 4-nitro-lH-pyrazole (340mg, 4.5mmol), Pd₂(dba)₃(67mg，0.07mmol)、Me₄tBu-XPhos(35mg，0.07mmol)、K₃PO₄(368mg, 1.73mmol) were mixed in a schlenk tube. Reacting with N₂Degassed for 15 min, dioxane (8mL) was added and the reaction heated to 90 ℃ for 16 h. The reaction was cooled to room temperature, filtered through celite, concentrated, and purified by column chromatography: by CH₂Cl₂A gradient of/MeOH (0% to 30% MeOH) elution, column: silica 12g, 6- (2-methoxy-4- (4-nitro-1H-pyrazol-1-yl) phenyl) -N-methyl-N- (2,2,6, 6-tetramethylpiperidin-4-yl) pyridazin-3-amine (202mg, 65%) was obtained.

LC-MS:466[M+H]⁺.¹H NMR(500MHz,DMSO-d₆) δ 9.81-9.85(m, IH),8.61(d, J ═ 0.6Hz, IH),7.91(d, J ═ 8.5Hz, IH),7.81(d, J ═ 9.8Hz, IH),7.73(d, J ═ 1.9Hz, IH),7.68(dd, J ═ 8.2,2.2Hz, IH),7.10-7.21(m, IH),5.08-5.26(m, IH),3.96(s,3H),2.95(s,3H),1.59-1.75(m,4H),1.40(s,6H),1.33, (s,6H), (1H corresponding to OH or NH was not observed)

Step 2:mixing 6- (2-methoxy-4- (4-nitro-1H-pyrazol-1-yl) phenyl) -N-methyl-N- (2,2,6, 6-tetramethylpiperidin-4-yl) pyridazin-3-amine (150mg, 0.32mmol), thiophenol (33. mu.L, 0.32mmol) and K₂CO₃(44mg, 0.32mmol) were mixed in a microwave tube. Reacting with N₂Degassed for 15 min and dry NMP (1.5mL) was added. The reaction was heated in a Biotage microwave at 190 ℃ for 20 minutes, then diluted with 10mL EtOAc and washed with water and brine. Subjecting the product to Na₂SO₄Dried, concentrated under vacuum and then purified by column chromatography: by CH₂Cl₂A gradient of/MeOH (0% to 30% MeOH) elution, column: silica 4g to give 2- (6- (methyl) (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) -5- (4-nitro-1H-pyrazol-1-yl) phenol (60mg, 42%) as a brown solid.

LC-MS:452[M+H]⁺.¹H NMR(500MHz,DMSO-d₆) δ 9.77(s,1H),8.68(d, J ═ 9.8Hz,1H),8.62(s,1H),8.27(d, J ═ 8.8Hz,1H),7.87-7.94(m,1H),7.66(dd, J ═ 8.5,2.6Hz,1H),7.64(d, J ═ 2.6Hz,1H),5.03-5.22(m,1H),3.01(s,3H),1.84-1.94(m,2H),1.70-1.77(m,2H),1.53(s,6H),1.43(s,6H), (2 hydrogens corresponding to OH and NH not observed)

Using the procedure described in example 3 above, additional compounds described herein can be prepared by substituting the appropriate starting reagents and reaction conditions to yield, for example, a compound selected from the following:

example 4(Compound 424)

5- (1H-pyrazol-4-yl) -2- [6- (1,2,3, 6-tetrahydropyridin-4-yl) pyridazin-3-yl ] phenol trihydrochloride

Step 1:3-bromo-6- (2-methoxy-4- (1- (tetrahydro-2H-pyran-2-yl) -1H-pyrazol-4-yl) phenyl) pyridazine (100mg, 0.24mmol), (1- (tert-butoxycarbonyl) -1,2,3, 6-tetrahydropyridin-4-yl) boronic acid (66mg, 0.29mmol), PdpfCl₂(8mg，0.012mmol)、K₂CO₃(99mg, 0.72mmol) were mixed in a schlenk tube. Reacting with N₂Degassed for 15 min, dioxane (2mL) and water (0.5mL) were added and the reaction heated to 90 ℃ for 16 h. The reaction was cooled to rt and partitioned between EtOAc and water. Subjecting the organic layer to Na₂SO₄Dried and then concentrated under vacuum and purified by column chromatography: by CH₂Cl₂A gradient of/MeOH (0% to 20% MeOH) elution, column: silica 4g to give 5- (1H-pyrazol-4-yl) -2- (6- (1,2,3, 6-tetrahydropyridin-4-yl) pyridazin-3-yl) phenol as an off-white solid (102mg, 82%).

Step 2:2mL of anhydrous CH with 5- (1H-pyrazol-4-yl) -2- (6- (1,2,3, 6-tetrahydropyridin-4-yl) pyridazin-3-yl) phenol (102mg, 0.196mmol)₂Cl₂The solution was cooled in an ice-water bath. CH with addition of 1.0M bromotribromide₂Cl₂Solution (0.98mL, 0.98mmol) and the reaction mixture was stirred at room temperature for 16 h. The reaction was quenched with 2mL MeOH, stirred for 30 min, then concentrated and purified using preparative HPLC to give 5- (1H-pyrazol-4-yl) -2- (6- (1,2,3,6-) tetrahydropyridin-4-yl) pyridazin-3-yl) phenol (41mg, 66%) as an off-white solid.

LC-MS:320[M+H]⁺.¹H NMR(500 MHz,DMSO-d₆) δ 9.19(br S,2H),8.54(d, J ═ 9.6Hz,1H),8.22, (d, J ═ 9.6Hz,1H),8.18(S,1H),8.05(d, J ═ 8.8Hz,1H),7.25-7.29(m,2H),6.92(S,1H),3.85-3.92(m,2H),3.38-3.41(m,2H),2.88-2.98(m,2H), (1 hydrogen corresponding to OH or NH not observed)

Using the procedure described in example 4 above, additional compounds described herein can be prepared by substituting the appropriate starting reagents and reaction conditions to yield, for example, a compound selected from the following:

example 5(Compound 427)

2- [6- (piperidin-4-ylamino) pyridazin-3-yl ] -5- (1H-pyrazol-4-yl) phenol tetrahydrochloride salt

Step 1:3, 6-dibromopyridazine (500mg, 2.1mmol), 4- (3-methoxy-4- (4,4,5, 5-tetramethyl-1, 3, 2-dioxaborolan-2-yl) phenyl) -1- (tetrahydro-2H-pyran-2-yl) -1H-pyrazole (970mg, 2.52mmol), Pd (dppf) Cl₂(77mg，0.11mmol)、K₂CO₃(870mg, 6.3mmol) were mixed in a schlenk tube. Reacting with N₂Degassed for 15 min, dioxane (8mL) and water (1mL) were added and the reaction heated to 90 ℃ for 16 h. The reaction was cooled to rt and partitioned between EtOAc and water. Subjecting the organic layer to Na₂SO₄Dried, concentrated under vacuum, purified by column chromatography: with hexane/EtOAc (0% to40% EtOAc) gradient elution, column: silica 4g to give 3-bromo-6- (2-methoxy-4- (1- (tetrahydro-2H-pyran-2-yl) -1H-pyrazol-4-yl) phenyl) pyridazine as an off-white fluffy solid (690mg, 79%).

Step 2:3-bromo-6- (2-methoxy-4- (1- (tetrahydro-2H-pyran-2-yl) -1H-pyrazol-4-yl) phenyl) pyridazine (50mg, 0.12mmol), tert-butyl 4-aminopiperidine-1-carboxylate (36mg, 0.18mmol), potassium tert-butoxide (41mg, 0.36mmol), tBuXPhos-Pd-G3(10mg, 0.012mmol) were mixed in a Schlenk tube. The reaction was degassed with Ar, then anhydrous THF (2mL) was added and the reaction heated to 80 ℃ for 12 hours. The reaction was cooled to room temperature and then partitioned between EtOAc and water. Subjecting the organic layer to Na₂SO₄Dried, concentrated under vacuum, purified by column chromatography: by CH₂Cl₂Gradient elution/MeOH (0% to 15% MeOH), column: silica 4g to give tert-butyl 4- ((6- (2-methoxy-4- (1- (tetrahydro-2H-pyran-2-yl) -1H-pyrazol-4-yl) phenyl) pyridazin-3-yl) amino) piperidine-1-carboxylate (45mg, 70%) as a tan solid.

And step 3:4- ((6- (2-methoxy-4- (1- (tetrahydro-2H-pyran-2-yl) -1H-pyrazol-4-yl) phenyl) pyridazin-3-yl) amino) piperidine-1-carboxylic acid ester (45mg, 0.084mmol) in 2mL anhydrous CH₂Cl₂The solution was cooled in an ice-water bath. Addition of 1.0M boron tribromide CH₂Cl₂Solution (0.42mL, 0.42mmol) and the reaction mixture was stirred at room temperature for 16 h. The reaction was quenched with 2mL MeOH, stirred for 30 min, then concentrated and purified using preparative HPLC to give 2- (6- (piperidin-4-ylamino) pyridazin-3-yl) -5- (1H-pyrazol-4-yl) phenol (21mg, 73%) as a pale yellow solid.

LC-MS:377[M+H]⁺.¹H NMR(500MHz,DMSO-d₆)δ:8.95(s,2H),8.25(d,J＝9.6Hz,1H),8.09(s,2H),7.69(d,J＝8.8Hz,1H),7.49-7.41(m,1H),7.21-7.24(m,2H),4.11-4.15(m,1H),3.34-3.39(m,4H),3.01-3.08(m,2H),2.11-2.17(m,2H),1.79(q,J＝9.2Hz,2H)

Using the procedure described in example 5 above, additional compounds described herein can be prepared by substituting the appropriate starting reagents and reaction conditions to yield, for example, a compound selected from the following:

example 6(Compound 430)

6- [2, 3-difluoro-4- (1H-pyrazol-4-yl) phenyl ] -N-methyl-N- (2,2,6, 6-tetramethylpiperidin-4-yl) pyridazin-3-amine hydrochloride

Step 1:to be provided with N₂Adding the following components into RBF of an inlet: 6-bromo-N-methyl-N- (2,2,6, 6-tetramethyl-4-piperidyl) pyridazin-3-amine (90mg, 0.28mmol), 4- [2, 3-difluoro-4- (4,4,5, 5-tetramethyl-1, 3, 2-dioxaborolan-2-yl) phenyl]-1-tetrahydropyran-2-yl-pyrazole (128.8mg, 0.33mmol), Pd (PPh)₃)₄(31.8mg，0.03mmol)、Na₂CO₃(87.43mg, 0.83 mmol). Reacting with N₂Degassed for 15 min, then dioxane (8mL) and water (2mL) were added. The reaction was heated to 90 ℃ for 16 h, then cooled to room temperature and partitioned between EtOAc and water. Subjecting the organic layer to Na₂SO₄Dried, concentrated on a rotary evaporator and purified by column chromatography: by CH₂Cl₂Gradient elution with MeOH (0% to 30%), column: silica 4g to give 6- (2, 3-difluoro-4- (1- (tetrahydro-2H-pyran-2-yl) -1H-pyrazol-4-yl) phenyl) -N-methyl-N- (2,2,6, 6-tetramethylpiperidin-4-yl) pyridazin-3-amine (88mg, 63%) as a grey solid.

Step 2:reacting 6- [2, 3-difluoro-4- (1-tetrahydropyran-2-yl pyrazol-4-yl) phenyl]-N-methyl-N- (2,2,6, 6-tetramethyl-4-piperidinyl) pyridazin-3-amine (88mg, 0.17mmol) was dissolved in MeOH (2mL), and a 4M HCl solution in dioxane (90 μ L, 0.34mmol) was added dropwise. The reaction mixture was stirred at room temperature for 30 minutes until LC-MS showed complete consumption of starting material. The reaction mixture was concentrated under reduced pressure to give 6- (2, 3-difluoro-4- (1H-pyrazol-4-yl) phenyl) -N-methyl-N- (2,2,6, 6-tetramethylpiperidin) -4-yl) pyridazin-3-amine hydrochloride.

LC-MS:427[M+H]⁺.¹H NMR(500MHz,DMSO-d₆)δ:9.21-9.33(m,IH),8.27-8.43(m,IH),8.20(s,2H),8.01(d,J＝9.8Hz,IH),7.60-7.79(m,3H),5.01-5.14(m,IH),3.05(s,3H),2.10(td,J＝13.2,1.6Hz,2H),1.79(dd,J＝12.9,4.1Hz,2H),1.55(s,6H),1.50(s,6H)

Using the procedure described in example 6 above, additional compounds described herein can be prepared by substituting the appropriate starting reagents and reaction conditions to yield, for example, a compound selected from the following:

example 7(Compound 434)

6- [ 2-methoxy-6- (1H-pyrazol-4-yl) pyridin-3-yl ] -N-methyl-N- (2,2,6, 6-tetramethylpiperidin-4-yl) pyridazin-3-amine hydrochloride

6- (2-methoxy-6- (1- (tetrahydro-2H-pyran-2-yl) -1H-pyrazol-4-yl) pyridin-3-yl) -N-methyl-N- (2,2,6, 6-tetramethylpiperidin-4-yl) pyridazin-3-amine (6mg) was dissolved in 1mL of 4N HCl/dioxane, and the resulting mixture was stirred at room temperature for 20 minutes. The mixture was evaporated and triturated with ether to give 6- (2-methoxy-6- (1H-pyrazol-4-yl) pyridin-3-yl) -N-methyl-N- (2,2,6,6-) tetramethylpiperidin-4-yl) pyridazin-3-amine (4mg, 75%).

LC-MS:422[M+H]⁺.¹H NMR (500MHz, methanol-d)₄)δ:8.42-8.47(m,1H),8.33-8.42(m,2H),8.09-8.17(m,1H),7.99-8.08(m,1H),7.50-7.56(m,1H),5.0(m,1H),4.16(s,3H),3.20(s,3H),1.94-2.15(m,4H),1.65(s,6H),1.57(s,6H)

Example 8(Compound 460)

3- {6- [ methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino ] pyridazin-3-yl } -6- (lH-pyrazol-4-yl) pyridin-2-ol hydrochloride

Step 1:6-chloro-N-methyl-N- (2,2,6, 6-tetramethylpiperidin-4-yl) pyridazin-3-amine (280mg, 1.0mmol) was dissolved in a mixture of 10mL dioxane and water (4: 1). To this solution was added sodium carbonate (190mg, 3 equiv), (6-chloro-2-methoxypyridin-3-yl) boronic acid (190mg, 1 equiv) and Pd (Ph)₃P)₄(70mg, 0.1 equiv.). The reaction mixture was stirred at 90 ℃ for 16 h, then applied to a column and purified using DCM/MeOH to give (133mg, 55%) 6- (6-chloro-2-methoxypyridin-3-yl) -N-methyl-N- (2,2,6, 6-tetramethylpiperidin-4-yl) pyridazin-3-amine.

LC-MS:390[M+H]⁺.¹H NMR(500MHz,DMSO-d₆)δ:8.25(d,J＝7.88Hz,1H),7.83(d,J＝9.77Hz,1H),7.24(d,J＝7.88Hz,1H),7.11(d,J＝9.77Hz,1H),5.00-5.24(m,1H),3.93(s,3H),2.87-2.96(m,3H),1.40-1.57(m,4H),1.21-1.29(m,7H),1.10(br s,6H)

Step 2:6- (6-chloro-2-methoxypyridin-3-yl) -N-methyl-N- (2,2,6, 6-tetramethylpiperidin-4-yl) pyridazin-3-amine (90mg) was dissolved in a mixture of dioxane and water (4:1, 5 mL). To this solution was added sodium carbonate (100mg, 3 equivalents), 1- (tetrahydro-2H-pyran-2-yl) -4- (4,4,5, 5-tetramethyl-1, 3, 2-dioxaborolan-2-yl) -1H-pyrazole (70mg, 1.1 equivalents), and Pd (Ph)₃P)₄(27mg, 0.1 equiv.). The reaction mixture was stirred at 90 ℃ for 16H, then purified by column chromatography using DCM/MeOH to give 80mg (68%) of 6- (2-methoxy-6- (1- (tetrahydro-2H-pyran) -2-yl) -1H-pyrazol-4-yl) pyridin-3-yl) -N-methyl-N- (2,2,6, 6-tetramethylpiperidin-4-yl) pyridazin-3-amine.

And step 3:6- (2-methoxy-6- (1- (tetrahydro-2H-pyran-2-yl) -1H-pyrazol-4-yl) pyridin-3-yl) -N-methyl-N- (2,2,6, 6-tetramethylpiperidin-4-yl) pyridazin-3-amine (45mg) was dissolved in 4mL of 4N HCl/dioxane, and the resulting mixture was heated at 60 ℃ F. for 2 hours. The resulting mixture was evaporated and triturated with ether to give 3-, (6- (methyl (2,2,6, 6-tetramethylpiperidin-4-yl) amino) pyridazin-3-yl) -6- (1H-pyrazol-4-yl) pyridin-2-ol (24mg, 61%).

LC-MS:408[M+H]⁺；¹H NMR (500MHz, methanol-d)₄)δ:8.62-8.69(m,1H),8.55-8.61(m,1H),8.39(s,2H),7.95-8.06(m,1H),7.04-7.14(m,1H),5.02-5.24(m,1H),3.18(s,3H),2.03(s,4H),1.67(s,6H),1.57(s,6H)

Using the procedure described in example 8 above, additional compounds described herein can be prepared by substituting the appropriate starting reagents and reaction conditions to yield, for example, a compound selected from the following:

biological examples

The effectiveness of the compounds of the invention for treating huntington's disease is demonstrated in the following in vitro biological examples.

In order to describe and facilitate a more detailed understanding of the present invention, the following non-limiting biological examples are provided to more fully illustrate the scope of the present invention and are not to be construed as specifically limiting the scope thereof. Such variations of the invention, now known or later developed, which would be within the knowledge of those skilled in the art, are considered to fall within the scope of the invention and are claimed below.

Example 1

Development and validation of Meso Scale Discovery (MSD) assay to quantify best-pair analysis of mutant huntingtin and total Huntingtin (HTT) -endogenous HTT detection

To determine orally bioavailable small molecules for HTT reduction, a high-throughput ELISA method is required to detect and measure total HTT (wild-type and mutant) (tHTT) and mutant HTT (mhtt) in cells and tissues from HD patients and animal models. The methods described herein allow for relatively high throughput protein measurements of the levels of tHTT and mHTT in cells and tissues from HD patients and in HD animal models. The ELISA methods described herein enable screening of molecules for their ability to reduce HTT levels and to identify and optimize small molecules for the treatment of HD.

To determine the combination of antibodies that detect HTT (wild type and mutant) in a sensitive, high throughput format, a number of commercially available antibodies for the capture/detection combination were screened (table 1).

Optimal pairing assay protocol for antibody comparison to detect total and mutant HTTs in cells

1. Cells were cultured in cell culture compatible 96-well plates.

2. The medium was removed and 50 to 100 μ l lysis buffer (composition described below) per well was added to the cells to provide a "cell lysate". Plates were placed on a shaker at 4 ℃ for 30 minutes and then stored at-20 ℃.

3. As described in the plate layout, a capture antibody dilution was prepared by diluting the capture antibody for the standard plate in PBS, and then 30 μ l of the capture antibody dilution was added per well. The plates were sealed and incubated overnight at 4 ℃.

4. The plate was washed 3 times with 200. mu.l of wash buffer. Blocking buffer (150. mu.l per well) was added, then the plate was sealed and incubated at Room Temperature (RT) for 3 to 4 hours on a plate shaker.

5. The blocking buffer was poured off and the plate was washed 3 times with 200. mu.l of wash buffer. Cell lysate (25 μ L per well) was then added. The plates were sealed and incubated overnight at 4 ℃.

6. A first assay antibody dilution is prepared by diluting the first assay antibody for pairing in an assay antibody dilution. The plate was washed 3 times with 200. mu.l of wash buffer, then 25. mu.l of the first detection antibody dilution was added per well. The plates were sealed and incubated for 1 hour at room temperature on a plate shaker.

7. A second assay antibody dilution is prepared by diluting the second assay antibody for pairing in the assay antibody dilution. The plate was washed 3 times with 200. mu.L of wash buffer, then 25. mu.l of a second detection antibody dilution was added per well. The plates were sealed and incubated for 1 hour at room temperature on a plate shaker.

8. The read buffer was diluted 4-fold. The plate was washed 3 times with 200. mu.l wash buffer and then 150. mu.L of read buffer was added per well. The plate was then read immediately.

Various commercially available antibodies screened in the best-pair assay are shown in table 1, providing different capture/detection combinations. The capture/detection antibody pairs evaluated are shown in table 2. The two antibody pairs that gave the greatest transmission value (higher signal-to-noise ratio) were selected for extended polyglutamine (mHTT) and fully human HTT detection.

TABLE 1

TABLE 2

To pair	HTT MSD	ID	Signal to noise ratio
				Capture/detection	General assembly	MAB2166/MAB2174	95
Capture/detection	General assembly	MAB2166/sc-8767	6
				Capture/detection	General assembly	sc-8767/#5656	5
Capture/detection	General assembly	MAB2166/#5656S	483
				Capture/detection	Mutant forms	MAB5374/#5656S	8
Capture/detection	Mutant forms	MAB1574/#5656S	25
				Capture/detection	Mutant forms	P1874/#5656S	20
Capture/detection	Mutant forms	MW1/#5656S	45

The best-paired capture/detection antibody pairs are characterized by those combinations that provide the least background and the greatest signal. This highly sensitive ELISA assay can be used to detect HTTs in the context of drug discovery of screening agents (small and large molecules and gene therapy) and to detect HTTs as biomarkers in clinical studies. This capture/detection antibody pair for quantification of total HTT is selected from MAB2166/MAB2174 and MAB2166/# 5656S. This capture/detection antibody pair for quantification of mutant HTTs was selected from MAB1574/#5656S, P1874/#5656S and MW1/# 5656S. The antibody pair for mHTT (MW1/#5656S) and the other antibody pair for total HTT (MAB2166/#5656S) from this assay were further optimized and validated to provide a high throughput assay capable of HTT detection in patient fibroblasts and lymphocytes.

The endogenous huntingtin protein assay used in example 2 was developed using the best-paired antibodies identified in table 2, which provides a high-sensitivity, high-throughput detection assay for extended polyglutamine (mHTT) and total human HTT in a multicellular system. The platform used for the assay was an ELISA-based Meso Scale Discovery (MSD) electrochemiluminescence assay platform.

Example 2

Endogenous huntingtin protein assay

Meso Scale Discovery (MSD) 96-well plates or 384-well plates were coated overnight at 4 ℃ with MW1 (extended polyglutamine) or MAB2166 monoclonal antibody (for capture) at a concentration of 1 μ g/mL in PBS (30 μ L per well). The plate was then washed three times with 300. mu.l of wash buffer (0.05% Tween-20 in PBS), blocked by rotary shaking (100. mu.l of blocking buffer; 5% BSA in PBS) at room temperature for 4 to 5 hours, and then washed three times with wash buffer.

Samples (25 μ L) were transferred to antibody-coated MSD plates and incubated overnight at 4 ℃. After removal of the lysate, the plates were washed three times with wash buffer and 25 μ L of #5656S (cell signaling; rabbit monoclonal) secondary antibody (diluted to 0.25 μ g/mL in 0.05% Tween-20 blocking buffer) was added to each well and incubated with shaking at room temperature for 1 hour. After incubation with secondary antibody, wells were washed with wash buffer before 25 μ L of goat anti-rabbit sulflo TAG secondary detection antibody (an essential aspect of the MSD system) (diluted to 0.25 μ g/mL in 0.05% Tween-20 blocking buffer) was added to each well and incubated for 1 hour at room temperature with shaking. After three washes with wash buffer, 150 μ L of read buffer T with surfactant (MSD) was added to each empty well, and the plate was imaged on a SI 6000 imager (MSD) according to the provided 96-well plate or 384-well plate manufacturer's instructions. Compounds to be testedObtained IC of₅₀The values (. mu.M) are shown in Table 3.

As shown in table 3, the test compounds described herein have the following IC₅₀Values, single star (.)>IC between 3 mu M and less than or equal to 9 mu M₅₀Values, two stars are indicated in>IC between 1 μ M and ≤ 3 μ M₅₀Values, three stars (. X.) are indicated in>IC between 0.5 mu M and less than or equal to 1 mu M₅₀The values, four stars (. multidot.. multidot.) are indicated in>IC between 0.1 mu M and less than or equal to 0.5 mu M₅₀The value, five stars (. times.. times.) represents an IC of 0.1. mu.M or less₅₀The value is obtained.

TABLE 3

All documents referred to herein are incorporated by reference into this application for any and all purposes to the same extent as if each individual reference were specifically and individually indicated to be incorporated by reference herein.

Having now fully described the subject matter of the claims, it will be understood by those skilled in the art that the same operations can be performed within a wide range of equivalents without affecting the scope of the subject matter or embodiments described herein. It is intended that the following claims be interpreted to include all such equivalents.