新型dna适配体及其用途
阅读说明:本技术 新型dna适配体及其用途 (Novel DNA aptamer and use thereof ) 是由 金润姬 许钧 崔先一 金仁厚 于 2019-08-08 设计创作,主要内容包括:本公开涉及新型DNA适配体及其用途。具体地,本公开涉及使用Cell-SELEX从DNA文库中选择与癌细胞特异性结合的DNA适配体。本公开中经选择和优化以获得与癌细胞高结合亲和力的DNA适配体,由于其具有增强的对靶细胞和组织的靶向效率以及高血清稳定性,可有效用于癌症诊断。(The present disclosure relates to novel DNA aptamers and uses thereof. In particular, the present disclosure relates to the use of Cell-SELEX to select DNA aptamers that specifically bind to cancer cells from DNA libraries. The DNA aptamers selected and optimized in the present disclosure to obtain high binding affinity to cancer cells can be effectively used for cancer diagnosis due to their enhanced targeting efficiency to target cells and tissues and high serum stability.)