阅读说明：本技术 用于治疗nash/nafld及相关疾病的包含作为glp-1r激动剂的苯并二氧杂环戊烯的组合 (Combinations comprising benzodioxoles as GLP-1R agonists for the treatment of NASH/NAFLD and related diseases ) 是由 G·E·阿斯普内斯 S·W·巴格利 J·M·柯托 M·道林 D·J·埃德蒙斯 D·费尔南多 于 2020-05-15 设计创作，主要内容包括：本发明部分地提供包含(1)GLP-1R激动剂及(2)ACC抑制剂或DGAT2抑制剂、或KHK抑制剂或FXR激动剂的新颖组合。本发明进一步提供例如使用本申请中所述的新颖组合治疗下列疾病和障碍的新颖方法：例如,脂肪肝、非酒精性脂肪肝疾病、非酒精性脂肪性肝炎、伴有肝纤维化的非酒精性脂肪性肝炎、伴有肝硬化的非酒精性脂肪性肝炎以及伴有肝硬化与伴有肝细胞癌或伴有代谢相关疾病的非酒精性脂肪性肝炎、肥胖症和2型糖尿病。(The present invention provides, in part, novel combinations comprising (1) a GLP-1R agonist and (2) an ACC inhibitor or a DGAT2 inhibitor, or a KHK inhibitor or an FXR agonist. The invention further provides novel methods of treating the following diseases and disorders, for example using the novel combinations described in this application: for example, fatty liver, non-alcoholic fatty liver disease, non-alcoholic steatohepatitis with liver fibrosis, non-alcoholic steatohepatitis with cirrhosis, and non-alcoholic steatohepatitis with cirrhosis and with hepatocellular carcinoma or with metabolic-related diseases, obesity, and type 2 diabetes.)