阅读说明：本技术 使用中间体化合物2-氯-5-甲基-4-吡啶胺从2-氯-5-甲基-4-硝基-吡啶-1-氧化物开始合成4-氨基-5-甲基-1h-吡啶-2(1h)-酮（用于合成mr拮抗剂非奈利酮的中间体化合物）的方法 (Method for the synthesis of 4-amino-5-methyl-1H-pyridin-2 (1H) -one (intermediate compound for the synthesis of MR antagonist non-neferitone) starting from 2-chloro-5-methyl-4-nitro-pyridin-1-oxide us) 是由 J·普拉策克 K·洛维斯 于 2020-02-28 设计创作，主要内容包括：本发明涉及一种通过使式2的2-氯-5-甲基-4-吡啶胺与KOH在甲醇中在压力反应器中反应来制备式(I)的4-氨基-5-甲基-2(1H)-吡啶酮的方法,以及涉及一种通过使用铂催化剂将式3的2-氯-5-甲基-4-氨基-吡啶-I-氧化物进行氢化来制备式2的2-氯-5-甲基-4-吡啶胺的方法。式(I)的4-氨基-5-甲基-1H-吡啶-2(I)-酮是用于制备MR拮抗剂式(II)的非奈利酮的中间体产物。(The invention relates to a method for producing 4-amino-5-methyl-2 (1H) -pyridones of formula (I) by reacting 2-chloro-5-methyl-4-pyridinamine of formula 2 with KOH in methanol in a pressure reactor, and to a method for producing 2-chloro-5-methyl-pyridones of formula 3 by using a platinum catalystA process for the hydrogenation of a yl-4-amino-pyridine-I-oxide to produce 2-chloro-5-methyl-4-pyridineamine of formula 2. 4-amino-5-methyl-1H-pyridin-2 (I) -ones of formula (I) are intermediate products useful in the preparation of the MR antagonist, non-neferide ketone of formula (II).)