阅读说明：本技术 一种易于实现产业化的治疗鸡呼吸道混合型感染的复方制剂及其制备方法 (Compound preparation easy to realize industrialization and used for treating chicken respiratory tract mixed infection and preparation method thereof ) 是由 朱术会 郭华亮 孙向兰 李法红 李贺东 张忠华 于 2016-07-29 设计创作，主要内容包括：本发明公开了一种易于实现产业化的治疗鸡呼吸道混合型感染的复方制剂及其制备方法,每100Kg制剂由以下原料制备而成,盐酸阿比多尔5Kg,盐酸多西环素8Kg,海藻酸钠2Kg,无水葡萄糖85Kg。采用盐酸阿比多尔和盐酸多西环素,添加矫味剂和助溶剂,制备成复方制剂,发挥二者抗菌和抗病毒的协调作用,适口性好,对鸡细菌和病毒引起的呼吸道混合型感染具有较好的预防和治疗作用；同时其生产工艺简单,无需昂贵的设备和较高要求的专业技术人员,耗能低,环保,总成本较低,易于实现产业化,使得药物能够得到更大的推广和使用。(The invention discloses a compound preparation for treating chicken respiratory tract mixed infection and a preparation method thereof, wherein each 100Kg of the preparation is prepared from 5Kg of arbidol hydrochloride, 8Kg of doxycycline hydrochloride, 2Kg of sodium alginate and 85Kg of anhydrous glucose. The compound preparation is prepared by adding the flavoring agent and the cosolvent into the arbidol hydrochloride and the doxycycline hydrochloride, plays the role of coordinating antibacterial action and antiviral action of the arbidol hydrochloride and the doxycycline hydrochloride, has good palatability, and has better prevention and treatment effects on respiratory tract mixed infection caused by chicken bacteria and viruses; meanwhile, the production process is simple, expensive equipment and professional technicians with high requirements are not needed, the energy consumption is low, the environment is protected, the total cost is low, the industrialization is easy to realize, and the medicine can be popularized and used more greatly.)

1. Every 100Kg of the compound preparation for treating the chicken respiratory tract mixed infection is prepared by the following raw materials of 5Kg of arbidol hydrochloride, 8Kg of doxycycline hydrochloride, 2Kg of sodium alginate and 85Kg of anhydrous glucose.

2. A process for preparing a compound formulation as claimed in claim 1, wherein: the method comprises the following specific steps:

weighing the abidol hydrochloride, the doxycycline hydrochloride and the sodium alginate according to the formula proportion, uniformly mixing by adopting a three-dimensional motion mixer, mixing the anhydrous glucose with the mixture in an equivalent incremental mode for 30-40 min, and finally subpackaging to obtain yellow powder.

Technical Field

The invention belongs to the field of veterinary drug application, and particularly relates to a compound preparation for treating chicken respiratory tract mixed infection, which is easy to realize industrialization, and a preparation method thereof.

Background

The mixed infection of respiratory bacteria and virus of chicken is mainly manifested by nasal discharge, asthma, cough, hemoptysis mucus, pulmonary congestion in severe cases, dyspnea, slow development of young poultry infected with the disease, low feed conversion rate, egg laying reduction of laying poultry, and high mortality rate. Recent research shows that the respiratory tract infection of the chicken is difficult to prevent and treat by a method for treating a single pathogen, the disease is more common and extensive, the harm to the chicken industry is greatest, and the loss is also the most serious. In recent years, the disease is more and more serious, the treatment difficulty and the treatment cost are more and more, so that the research, the application and the clinical application of a preparation for treating and preventing the respiratory tract bacterial and viral mixed infection of the chicken are urgent and necessary.

Disclosure of Invention

The invention provides a compound preparation for treating chicken respiratory tract mixed infection and a preparation method thereof, which are easy to realize industrialization, wherein the compound preparation is prepared by adding corrective and cosolvent into arbidol hydrochloride and doxycycline hydrochloride, and the coordination effect of the antibacterial and antiviral effects of the arbidol hydrochloride and doxycycline hydrochloride is exerted, so that the compound preparation has good palatability and has better prevention and treatment effects on the chicken respiratory tract mixed infection caused by bacteria and viruses; meanwhile, the production process is simple, expensive equipment and professional technicians with high requirements are not needed, the energy consumption is low, the environment is protected, the total cost is low, the industrialization is easy to realize, and the medicine can be popularized and used more greatly.

The specific technical scheme provided by the invention is as follows:

every 100g of the compound preparation is prepared from 3-8 g of arbidol hydrochloride, 3-10 g of doxycycline hydrochloride, 2-10 g of flavoring agent and 72.0-91.0 g of cosolvent;

the flavoring agent is one or two of sodium alginate and mannitol;

the cosolvent is one or two of anhydrous glucose or soluble starch.

Every 100g of the compound preparation is prepared from 4-7 g of arbidol hydrochloride, 5-8 g of doxycycline hydrochloride, 4-7 g of flavoring agent and 78.0-85.0 g of cosolvent;

the flavoring agent is one or two of sodium alginate and mannitol;

the cosolvent is one or two of anhydrous glucose or soluble starch.

Every 100g of the compound preparation is prepared from 6g of arbidol hydrochloride, 7g of doxycycline hydrochloride, 5g of flavoring agent and 82.0g of cosolvent;

the flavoring agent is one or two of sodium alginate and mannitol;

the cosolvent is one or two of anhydrous glucose or soluble starch.

The flavoring agent is preferably mannitol; the cosolvent is preferably anhydrous glucose, so that the prepared compound preparation has good cosolvent and palatability.

The medicines and equipment used in the invention are all commercial products, and the medicines are all solid powder.

The preparation method of the compound preparation comprises the following specific steps:

weighing the abidol hydrochloride, the doxycycline hydrochloride and the flavoring agent according to the formula proportion, uniformly mixing by adopting a three-dimensional motion mixer, mixing the cosolvent with the mixture in an equivalent incremental mode for 30-40 min, and finally subpackaging to obtain the compound preparation. The compound preparation is light yellow powder, has good water solubility, can be administered by drinking water, and is convenient to take.

The compound preparation is prepared by adding the flavoring agent and the cosolvent into the arbidol hydrochloride and the doxycycline hydrochloride, plays the synergistic action of the antibacterial action and the antiviral action of the arbidol hydrochloride and the doxycycline hydrochloride, has good palatability, and has better prevention and treatment effects on respiratory tract mixed infection caused by chicken bacteria and viruses; meanwhile, the production process is simple, expensive equipment and professional technicians with high requirements are not needed, the energy consumption is low, the environment is protected, the total cost is low, the industrialization is easy to realize, and the medicine can be popularized and used more greatly.

Detailed Description