阅读说明：本技术 用于预防和治疗幽门螺杆菌轻、中度感染的组合物 (Composition for preventing and treating mild and moderate helicobacter pylori infection ) 是由 王世国 程维佳 于 2020-08-31 设计创作，主要内容包括：用于预防和治疗幽门螺杆菌轻、中度感染的组合物,涉及医疗及食品技术领域,特别是属于一种预防和治疗幽门螺杆菌轻、中度感染的组合物。其特征在于,包含载体、维生素E和抗坏血酸棕榈酸酯,所述载体为含有不饱和脂肪酸的植物油；所述抗坏血酸棕榈酸酯为维生素C的酯化衍生物。按照食品安全规定限量添加相应组分,既有利于杀灭幽门螺杆菌,又不会对人体产生一定的副作用,解决了目前临床上日益严重的耐药性顽疾,且可作为预防和治疗轻、中度幽门螺杆菌感染的药物长期服用。(A composition for preventing and treating helicobacter pylori mild and moderate infection relates to the technical field of medical treatment and food, in particular to a composition for preventing and treating helicobacter pylori mild and moderate infection. The vitamin E-vitamin D compound is characterized by comprising a carrier, vitamin E and ascorbyl palmitate, wherein the carrier is vegetable oil containing unsaturated fatty acid; the ascorbyl palmitate is an esterified derivative of vitamin C. The corresponding components are added in a limited amount according to food safety regulations, which is not only beneficial to killing the helicobacter pylori, but also does not generate certain side effect on human body, solves the problem of the current clinically increasingly serious drug resistance stubborn diseases, and can be taken as a medicament for preventing and treating the infection of the mild and moderate helicobacter pylori for a long time.)

1. A composition for preventing and treating helicobacter pylori mild-moderate infection is characterized by comprising a carrier, vitamin E and ascorbyl palmitate, wherein the carrier is vegetable oil containing unsaturated fatty acid; the ascorbyl palmitate is an esterified derivative of vitamin C.

2. The composition for the prevention and treatment of mild to moderate infection of helicobacter pylori according to claim 1, further characterized in that the composition further comprises any one or more of beta-carotene, vitamin C and vitamin a.

3. The composition for preventing and treating mild-to-moderate infection of helicobacter pylori according to claim 1, wherein the vegetable oil is composed of at least one of soybean oil, hemp oil, linseed oil and palm oil.

4. The composition for preventing and treating the mild and moderate infection of helicobacter pylori according to claim 1 or 2, wherein the composition comprises, by mass, 0.0005 to 0.145% of vitamin E, 0.001 to 0.02% of ascorbyl palmitate, 0.0003 to 0.0006% of beta-carotene, 0.00003 to 0.0017% of vitamin A, and 0.005 to 1.3% of vitamin C, with vegetable oil as a carrier.

Technical Field

The invention relates to the technical field of medical treatment and food, in particular to a composition for preventing and treating mild and moderate helicobacter pylori infection.

Background

Helicobacter pylori is prevalent in the stomach and duodenum or oral cavity of humans and animals (macaque, rat, pig, dog, etc.). Helicobacter pylori includes helicobacter pylori of canine, helicobacter pylori of gastric, helicobacter hei, helicobacter lapenii, and helicobacter sori, and is a gram-negative bacterium, and is a spiroid, microaerophilic, and very demanding in terms of growth conditions. The tissue is successfully separated from the biopsy tissue of the gastric mucosa of the chronic active gastritis for the first time in 1983. According to incomplete statistics, helicobacter pylori is prevalent in the stomach of about 50-60% of people, and almost 90% of people in some countries are infected with this bacterium. People are often infected at young age, reaching 50% under 5 years of age. The bacterial infection firstly causes chronic gastritis, gastric ulcer and gastric atrophy, and severe patients develop gastric cancer, even the gastric cancer is listed in a carcinogen list, and the health and life safety of people are seriously affected.

According to statistics, the incidence rate of atrophic gastritis and gastric cancer of people with early age of the initial helicobacter pylori infection is high, and the helicobacter pylori infection and the death rate of gastric cancer are in parallel. Helicobacter pylori parasitizes in gastric mucosal tissues and oral cavity, and 67-80% of gastric ulcer and 95% of duodenal ulcer are caused by helicobacter pylori. The common symptoms of patients with chronic gastritis and peptic ulcer are: after eating, the upper abdomen is full, uncomfortable or painful, often accompanied by other adverse symptoms such as belching, abdominal distension, acid regurgitation, anorexia, etc. Some patients may also have recurrent severe abdominal pain, minor upper gastrointestinal bleeding, etc.

Helicobacter pylori survives in the stomach of people or animals, and although the pH value of gastric acid reaches about 2-3 and has strong acidity, the helicobacter pylori cannot survive but cannot be killed by the gastric acid. Because helicobacter pylori can not only secrete superoxide dismutase (SOD) and catalase per se to protect bacteria from being killed by human leukocytes, but also secrete urease (urease) which decomposes urea water in the stomach to generate ammonia. The pH value of ammonia reaches about 11.3, and the ammonia has strong alkalinity. Ammonia is neutralized with gastric acid around helicobacter pylori, so that the helicobacter pylori can normally survive without being influenced by gastric acid. Ammonia gas is released in the process of decomposing urea by urease. The ammonia gas is toxic, causes halitosis to patients, can not only damage gastric and duodenal mucous membranes to form ulcers, but also has harmful effect on respiratory tracts, is very easy to combine with hemoglobin, weakens oxygen transportation function and weakens the resistance of human bodies to diseases.

In order to eliminate the harm of helicobacter pylori to the health of human body, triple therapy or quadruple therapy is generally adopted. Currently, six common drugs are used for treating diseases caused by helicobacter pylori: two anti-inflammatory drugs, a proton pump inhibitor and a bismuth agent, and common anti-inflammatory penicillin drugs, including amoxicillin, clarithromycin, metronidazole, tetracycline, furazolidone, cefminox, etc. Although these drugs play an important role in the treatment of diseases caused by helicobacter pylori infection, after the treatment, the drug efficacy of helicobacter pylori gradually decreases due to the drug resistance when the same drug is used for the second time, such as the first time, because the drug resistance is very strong because of the easy re-infection of helicobacter pylori. In addition, the side effect of the treatment medicine is large, the antibiotics also have accidental injury to beneficial bacteria of a human body, and particularly, the main medicine bismuth agent of the treatment medicine can not reverse the injury to the digestive function, the urinary system, the nervous system and the skeletal muscle of the human body. Therefore, the conventional treatment methods and the treatment means using the above drugs are not complete.

Disclosure of Invention

The invention aims to provide a composition for preventing and treating mild and moderate helicobacter pylori infection, so as to achieve the purposes of effectively inhibiting and killing the helicobacter pylori, generating no drug resistance and having no toxic or side effect on a human body.

The composition for preventing and treating the helicobacter pylori mild and moderate infection is characterized by comprising a carrier, vitamin E and ascorbyl palmitate, wherein the carrier is vegetable oil containing unsaturated fatty acid; the ascorbyl palmitate is an esterified derivative of vitamin C.

Further, the composition may also comprise any combination of beta-carotene, vitamin C, and vitamin a.

Further, the vegetable oil is composed of at least one of soybean oil, hemp oil, linseed oil and palm oil.

Furthermore, the composition takes vegetable oil as a carrier, and comprises the following components, by mass, 0.0005-0.145% of vitamin E, 0.001-0.02% of ascorbyl palmitate, 0.0003-0.0006% of beta-carotene, 0.00003-0.0017% of vitamin A and 0.005-1.3% of vitamin C.

Vitamin E is a clear oily liquid, colorless or nearly colorless or pale yellow or pale yellowish green. There are 8 forms of fat-soluble vitamins, the hydrolysis products of which are tocopherols, one of the most important antioxidants. Vitamin E includes alpha, beta, gamma, tocopherol and alpha, beta, gamma, tocotrienol, alpha-tocopherol is the most widely distributed, abundant, most active form of vitamin E in nature. The antioxidant properties of vitamin E protect the body cells from free radical poisoning. Through medical research and clinical practice, the triple or quadruple therapy assisted by vitamin E, which is a strong antioxidant, is proved to be capable of effectively treating the helicobacter pylori in the stomach, treating gastric and duodenal ulcers, eradicating the helicobacter pylori and playing a role in inflammatory factors. Vitamin E can directly remove free radicals and protect gastric epithelial cell cables. Vitamin E can also transmit electrons to free radicals, thereby reducing lipid peroxidation in mucosa caused by free radicals, relieving the effects of superoxide dismutase (SOD) and catalase secreted by helicobacter pylori, and protecting gastric mucosa; meanwhile, vitamin E can maintain the integrity of the nerve biomembrane and prevent the peripheral neuron in the gastric and duodenal mucosa from being damaged by toxicity and free radical attack.

The vitamin C is a strong antioxidant, is water-soluble, has short retention time in vivo, can form fat-soluble ascorbyl palmitate and the like by esterification, can be retained in vivo for more than 24 hours, and slowly releases the vitamin C. The vitamin C can remove free radicals such as super negative oxygen ion (O2-), hydroxyl free radical (OH-), organic free radical (R-) and organic peroxy radical (ROO-) in vivo through the process of gradually supplying electrons to convert into semi-dehydroascorbic acid and dehydroascorbic acid, can block the synthesis of carcinogen N-nitroso compound, reduce ammonia generation, reduce the pH value of gastric juice, and neutralize the alkaline environment generated by ammonia. The tocopherol free radical is reduced into the tocopherol again, and the ascorbic acid free radical generated by the reaction can be reduced into the ascorbic acid under the action of systematic enzyme of NADH2 under certain conditions. The high concentration of vitamin C helps to reduce cystine in food proteins to cysteine, which in turn synthesizes antibodies and prevents cancer. Vitamin C is suitable for administration on an empty stomach. Ascorbyl palmitate is white or white-like powder, has slight orange smell, is esterified product of vitamin C, and can be dissolved in vegetable oil.

Beta-carotene is also a strong antioxidant, an orange-colored, fat-soluble compound, soluble in vegetable oils and converted to vitamin a in vivo to 50%. The oxidation resistance of the beta-carotene is mainly shown in that the beta-carotene has the capability of removing free radicals, contains a plurality of double bonds in the beta-carotene molecule, and is easy to oxidize in the presence of light, heat, oxygen and free radical ions with strong activity, thereby protecting the organism from being damaged. Lipid peroxidation and free radical reaction exist in organisms in a large quantity, so that cell function is reduced, the organism is aged and diseases occur, and the existence of beta-carotene can reduce the lipid peroxidation. Thus, β -carotene can scavenge free radicals and quench the activity of singlet oxygen. Vitamin A converted from beta-carotene can be used for treating peptic ulcer and stress ulcer, and is involved in normal metabolism of gastric epithelial tissue and synthesis of mucopolysaccharide in epithelial tissue matrix, and has protective effect on gastric mucosa injury.

The hemp seed oil is obtained by squeezing hemp seeds and has extremely high nutritional value. Fructus Cannabis is also called Cannabis or fructus Cannabis, and is dried mature fruit of Cannabis sativa L.of Moraceae. It is sweet in taste and neutral in nature, enters spleen and stomach meridians, and can moisten dryness, smooth intestines, nourish and tonify deficiency. Fructus cannabis contains rich protein unsaturated fatty acid, lecithin, linolenic acid, vitamins, calcium, iron minerals and other trace elements necessary for human bodies, particularly has the natural ratio of 2.4: 1 between omega-6 linoleic acid and omega-3 alpha-linolenic acid, and meets the requirements of international health organization that the ratio is less than or equal to 4: the optimal ratio of 1 is characterized by being the most nutrient-balanced oil and fat and being soluble in water. The oleum Sesami contains unsaturated fatty acids such as linolenic acid and linoleic acid, which can inhibit activity of helicobacter pylori, and has no drug resistance. The food has the effects of moistening intestines and stomach, nourishing yin, tonifying deficiency, promoting digestion, improving eyesight, protecting liver, removing diseases and prolonging life, and has special curative effects on diseases such as constipation, hypertension, hypercholesterolemia and the like. The national ministry of health lists the fructus cannabis as a list of food and medicine (homology of medicine and food).

Linseed oil is prepared from flaxseed, which is the seed of flax of the family of the flax family, which is called flax. The cold pressed linseed oil is rich in plant source omega-3 linolenic acid, omega-6 linoleic acid and other essential fatty acids and other natural components of human body, such as complete types of amino acids, and the content of the essential amino acids is up to 5.16%. The amino acids can inhibit activity of helicobacter pylori, and do not produce drug resistance. The content of alpha-linolenic acid in the linseed oil is 53 percent, the alpha-linolenic acid is essential fatty acid of a human body, and the alpha-linolenic acid has the effects of resisting tumors, resisting thrombus, reducing blood fat, nourishing brain cells, regulating vegetative nerves and the like. The alpha-linolenic acid taken in by human body can be taken in the white blood cells, and released when the white blood cells are stimulated, and the fluidity of the white blood cells is changed, so that the neutral chemotaxis and the endothelial cell adhesion reaction of the white blood cells are inhibited, and the anti-inflammatory effect is good. The main trace nutrient component of the linseed oil is vitamin E, and the linseed oil has the natural composite antioxidant effect.

The three vitamins of vitamin E, vitamin C and beta-carotene are strong antioxidant substances, and have the effects of repairing gastric mucosa, inhibiting proliferation of helicobacter pylori and preventing gastric canceration for stomach. The composition of the antioxidant substances can be used for conditioning the stomach of people with stomach diseases such as chronic gastritis, gastric ulcer, atrophic gastritis, superficial gastritis, erosive gastritis and the like. The antioxidants need to be matched according to a specific proportion, and vitamin E and vitamin A cannot supplement excessive vitamin E or vitamin A, otherwise, the antioxidants are not beneficial to health. Experiments show that the DNA damage induced by hydrogen peroxide can be obviously reduced by continuously taking vitamin E, vitamin C and beta-carotene.

In normal diet, vitamin E, ascorbyl palmitate and beta-carotene are in limited eating amount, so that the single use of one antioxidant can kill helicobacter pylori under the condition of exceeding standard, and certain harm is brought to the body. By complying with the following food safety regulations limits: GB 2760 national food safety standard and GB14880 national food safety standard and food nutrition enhancer standard and related supplementary bulletin form a composition formula according to the food limit of the composition, which is not only beneficial to killing helicobacter pylori, but also does not generate side effect on human body, and the product can be taken healthily and safely for a long time to achieve the prevention effect.

Vegetable oil such as cannabis oil or linseed oil is used as a carrier and a quality reference, and relevant limit values in the formula are as follows: the edible limit of vitamin E is 5-1450 mg/kg, the edible limit of ascorbyl palmitate is 10-200 mg/kg (calculated by ascorbic acid in fat), the edible limit of beta-carotene is 3-20000 mg/kg, the edible limit of vitamin C is 50-13000 mg/kg, and the edible limit of vitamin A is 300-17000 mu g/kg.

The composition for preventing and treating the mild and moderate helicobacter pylori infection has the following positive effects:

1. the composition selects strong antioxidant substances, such as vitamin E, vitamin C and beta-carotene, and has effects of repairing gastric mucosa, inhibiting helicobacter pylori proliferation, and preventing gastric canceration; meanwhile, the DNA damage induced by hydrogen peroxide can be obviously reduced;

2. the composition disclosed by the invention takes vegetable oil as a carrier, and corresponding components are added in a limited amount according to food safety regulations, so that the composition is beneficial to killing helicobacter pylori, does not generate certain side effects on a human body, solves the problem of clinically increasingly serious drug resistance stubborn diseases at present, and can be taken as a medicament for preventing and treating light and moderate helicobacter pylori infection for a long time.

Detailed Description

The composition for preventing and treating the mild and moderate helicobacter pylori infection comprises a carrier, vitamin E and ascorbyl palmitate, wherein the carrier is vegetable oil containing unsaturated fatty acid, and the vegetable oil is at least one of soybean oil, hemp seed oil, linseed oil and palm oil. Ascorbyl palmitate is an esterified derivative of vitamin C. In addition, the composition also comprises any composition of beta-carotene, vitamin C and vitamin A. Since ascorbyl palmitate slowly decomposes vitamin C in the human body, beta-carotene is converted to vitamin A in the human body by about 50%, i.e., beta-carotene, vitamin C and vitamin A are used as supplementary substances.

The composition comprises vegetable oil as carrier, and vitamin E0.0005-0.145%, ascorbyl palmitate 0.001-0.02%, beta-carotene 0.0003-0.0006%, vitamin A0.00003-0.0017%, and vitamin C0.005-1.3%. The mass percentage is the ratio of the mass of the additive to the mass of the carrier.

The invention will be better understood from the following examples. However, those skilled in the art will readily appreciate that the description of the embodiments is only for illustrating the present invention and should not be taken as limiting the invention as detailed in the claims.