阅读说明：本技术 含有2-氨基-3-（4-溴苯甲酰基）苯乙酸或其盐的滴眼剂 (Eye drops containing 2-amino-3- (4-bromobenzoyl) phenylacetic acid or its salt ) 是由 松本直树 梅崎慎也 井上博行 今井顺也 梅田雅之 于 2018-12-13 设计创作，主要内容包括：本发明的目的在于提供能够长期维持保存效力的含有2-氨基-3-(4-溴苯甲酰基)苯乙酸或其盐的滴眼剂。本发明的滴眼剂为收容于滴眼容器的含有2-氨基-3-(4-溴苯甲酰基)苯乙酸或其盐的滴眼剂,前述滴眼容器进一步被密闭包装。(The purpose of the present invention is to provide an eye drop containing 2-amino-3- (4-bromobenzoyl) phenylacetic acid or a salt thereof, which can maintain the storage efficacy for a long period of time. The eye drops of the present invention are eye drops containing 2-amino-3- (4-bromobenzoyl) phenylacetic acid or a salt thereof in an eye drop container, and the eye drop container is further hermetically packaged.)

1. An eye drop which is contained in an eye drop container and contains 2-amino-3- (4-bromobenzoyl) phenylacetic acid or a salt thereof, wherein the eye drop container is further hermetically packaged.

2. The eye drop according to claim 1, which is hermetically packaged together with a deoxidizer.

3. The eye drop according to claim 1 or 2, wherein the content of 2-amino-3- (4-bromobenzoyl) phenylacetic acid or a salt thereof is 0.05 to 0.2% (w/v).

4. The eye drop according to any one of claims 1 to 3, further comprising a benzalkonium salt.

5. The eye drop according to claim 4, wherein the benzalkonium salt is benzalkonium chloride.

6. The eye drop according to claim 4 or 5, wherein the content of the benzalkonium salt is 0.0001 to 0.01% (w/v).

7. The eye drop according to any one of claims 1 to 6, further comprising a sulfite.

8. The eye drop according to claim 7, wherein the sulfite is sodium sulfite.

9. The eye drop according to claim 7 or 8, wherein the content of sulfite is 0.01 to 0.5% (w/v).

10. The eye drop according to any one of claims 1 to 9, further comprising boric acid, borax, sodium edetate hydrate, povidone, and polysorbate 80.

11. The eye drop according to any one of claims 1 to 10, which has a pH of 7.0 to 9.0.

12. The eye drop according to any one of claims 1 to 11, which is hermetically packaged in a pillow bag.

13. The eye drop according to claim 12, wherein the pillow bag is formed of an aluminum film.

14. The eye drop according to claim 12 or 13, wherein the penetration of the pillow bagOxygen content of 20ml/m²Atm · 24h or less.

15. The eye drop according to any one of claims 2 to 14, wherein the oxygen scavenger is an iron-based oxygen scavenger.

16. An ophthalmic pharmaceutical product comprising:

eye drops containing 2-amino-3- (4-bromobenzoyl) phenylacetic acid or its salt,

An eye drop container containing the eye drop, and

the eye drop container was hermetically packaged.

17. An ophthalmic pharmaceutical product according to claim 16, wherein the package further encloses a deoxidising agent.

18. A method for producing an ophthalmic pharmaceutical product, comprising the steps of: an eye drop containing 2-amino-3- (4-bromobenzoyl) phenylacetic acid or a salt thereof is stored in an eye drop container, and the eye drop container is further hermetically packaged.

19. The method for producing an ophthalmic pharmaceutical product according to claim 18, wherein the ophthalmic pharmaceutical product is hermetically packaged together with a deoxidizer.

20. A package comprising an eye drop container in which an eye drop containing 2-amino-3- (4-bromobenzoyl) phenylacetic acid or a salt thereof is contained, which is sealed.

21. The package of claim 20, further comprising a hermetic seal for the oxygen scavenger.

22. A method for preserving eye drops, comprising the steps of: an eye drop containing 2-amino-3- (4-bromobenzoyl) phenylacetic acid or a salt thereof is stored in an eye drop container, and the eye drop container is further hermetically packaged.

23. The method for preserving eye drops according to claim 22, wherein the eye drops are hermetically packaged together with a deoxidizer.

Technical Field

The present invention relates to eye drops containing 2-amino-3- (4-bromobenzoyl) phenylacetic acid or a salt thereof.

Background

2-amino-3- (4-bromobenzoyl) phenylacetic acid is a compound represented by the following formula (1).

The common name of 2-amino-3- (4-bromobenzoyl) phenylacetic acid is Bromfenac (Bromfenac), which is known as a nonsteroidal anti-inflammatory agent and is used in the ophthalmic field as an eye drop for the treatment of inflammation of the outer eye and anterior segment of the eye.

In general, there are a type in which an eye drop (eye drop) is used a plurality of times within a certain period after being unsealed (multi-dose type eye drop) and a type in which the eye drop is used up 1 time (single-dose type eye drop). In particular, in order to prevent putrefaction of products caused by microbial contamination or the like at the time of use, it is common that multi-dose type eye drops contain a preservative such as benzalkonium chloride.

Patent document 1 reports that an aqueous liquid composition having excellent storage potency and stability is prepared by combining bromfenac and benzalkonium chloride in an aqueous liquid composition containing 2-amino-3- (4-bromobenzoyl) phenylacetic acid. However, no study was made on the storage efficiency of an aqueous liquid composition containing 2-amino-3- (4-bromobenzoyl) phenylacetic acid when stored for a long period of time. Further, there is no description or suggestion of the study of the packaging form.

Disclosure of Invention

Problems to be solved by the invention

There has been no example of studying the storage efficacy of an eye drop containing 2-amino-3- (4-bromobenzoyl) phenylacetic acid or a salt thereof in long-term storage. Further, there has been no example of examining the form of a package of an eye drop containing 2-amino-3- (4-bromobenzoyl) phenylacetic acid or a salt thereof.

The present inventors have studied the storage efficacy of an eye drop containing 2-amino-3- (4-bromobenzoyl) phenylacetic acid or a salt thereof in long-term storage, and as a result, they have found a problem that the storage efficacy of the eye drop deteriorates with time and the storage efficacy cannot be maintained in long-term storage. The present invention addresses the problem of providing eye drops containing 2-amino-3- (4-bromobenzoyl) phenylacetic acid or a salt thereof, which are capable of maintaining the storage efficacy over a long period of time.

Means for solving the problems

The present inventors have conducted intensive studies in order to maintain the storage efficacy of an eye drop containing 2-amino-3- (4-bromobenzoyl) phenylacetic acid or a salt thereof for a long period of time, and as a result, have found that the storage efficacy of an eye drop containing 2-amino-3- (4-bromobenzoyl) phenylacetic acid or a salt thereof can be maintained for a long period of time by storing the eye drop in an eye drop container, further hermetically packaging the eye drop, and further hermetically packaging the eye drop together with a deoxidizer, thereby completing the present invention.

Namely, the present invention relates to the following.

(1) An ophthalmic solution containing 2-amino-3- (4-bromobenzoyl) phenylacetic acid or a salt thereof in an ophthalmic container, wherein the ophthalmic container is further hermetically packaged.

(2) The eye drop according to the above (1), which is hermetically packaged together with a deoxidizer.

(3) The eye drop according to the above (1) or (2), wherein the content of 2-amino-3- (4-bromobenzoyl) phenylacetic acid or its salt is 0.05 to 0.2% (w/v).

(4) The eye drop according to any one of the above (1) to (3), further comprising a benzalkonium salt.

(5) The eye drop according to the above (4), wherein the benzalkonium salt is benzalkonium chloride.

(6) The eye drop according to the above (4) or (5), wherein the content of the benzalkonium salt is 0.0001 to 0.01% (w/v).

(7) The eye drop according to any one of the above (1) to (6), further comprising a sulfite.

(8) The eye drop according to the above (7), wherein the sulfite is sodium sulfite.

(9) The eye drop according to the above (7) or (8), wherein the content of sulfite is 0.01 to 0.5% (w/v).

(10) - (a) the eye drop according to any one of the above (1) to (9), further comprising boric acid, borax, sodium edetate hydrate, povidone, and polysorbate 80.

(10) - (b) the eye drop according to any one of the above (1) to (9), further comprising boric acid, borax, sodium edetate hydrate, povidone, and tyloxapol.

(11) The eye drop according to any one of (1) - (10) - (a) and (10) - (b) above, wherein the pH is 7.0-9.0.

(12) The eye drop according to any one of the above (1) to (11), which is hermetically packaged in a pillow bag.

(13) The eye drop according to the above (12), wherein the pillow bag is formed of an aluminum film.

(14) The eye drops as described in the above (12) or (13)In which the oxygen permeability of the pillow pouch is 20ml/m²Atm · 24h or less.

(15) The eye drop according to any one of the above (2) to (14), wherein the oxygen scavenger is an iron-based oxygen scavenger.

The present invention also relates to the following.

(16) An ophthalmic pharmaceutical product comprising: an ophthalmic solution containing 2-amino-3- (4-bromobenzoyl) phenylacetic acid or a salt thereof, an ophthalmic container containing the ophthalmic solution, and a sealed package of the ophthalmic container.

(17) The pharmaceutical ophthalmic product according to item (16), wherein the package further seals the deoxidizer.

The present invention also relates to the following.

(18) A method for producing an ophthalmic pharmaceutical product, comprising the steps of: an eye drop containing 2-amino-3- (4-bromobenzoyl) phenylacetic acid or a salt thereof is stored in an eye drop container, and the eye drop container is further hermetically packaged.

(19) The method for producing an ophthalmic pharmaceutical product according to item (18), wherein the ophthalmic pharmaceutical product is hermetically packaged together with a deoxidizer.

The present invention also relates to the following.

(20) A package comprising an eye drop container in which an eye drop containing 2-amino-3- (4-bromobenzoyl) phenylacetic acid or a salt thereof is contained, which is sealed.

(21) The package according to (20) above, wherein the oxygen scavenger is further hermetically sealed.

The present invention also relates to the following.

(22) A method for preserving eye drops, comprising the steps of: an eye drop containing 2-amino-3- (4-bromobenzoyl) phenylacetic acid or a salt thereof is stored in an eye drop container, and the eye drop container is further hermetically packaged.

(23) The method for storing an eye drop according to item (22), wherein the eye drop is hermetically packaged together with a deoxidizer.

The respective configurations described in (1) to (23) above may be combined by arbitrarily selecting 2 or more.

ADVANTAGEOUS EFFECTS OF INVENTION

The present invention provides an eye drop containing 2-amino-3- (4-bromobenzoyl) phenylacetic acid or a salt thereof, which can maintain the storage efficacy for a long period of time.

Drawings

Fig. 1 is a graph showing the results of a reference test.

Detailed Description

The present invention will be described in detail below.

In the present specification, unless otherwise specified, the unit "%" of the content means "w/v%" and is synonymous with "g/100 mL".

In the present specification, the term "eye drop container" refers to a container in which an eye drop (aqueous composition) containing 2-amino-3- (4-bromobenzoyl) phenylacetic acid or a salt thereof is previously contained in a pharmaceutically acceptable state, that is, the eye drop (aqueous composition) is accommodated.

In the present specification, "package" means an object for storing (housing) the eye drop container of the present invention, and is distinguished from the aforementioned eye drop container.

In the present specification, "packaging" means housing (containing) an object in the package, and includes housing (containing) an object in a bag formed of a film by wrapping the object with a film, for example. The term "hermetically sealed package" means that an object is hermetically sealed inside the package (in a sealed state), and includes, for example, a case where the object is sealed inside a bag by closing an opening of the bag formed by a film after the object is covered with the film (in a sealed state). Here, the sealed state also includes a case of being an airtight state or a sealed state.

In the present specification, "preservation efficacy" refers to a preservative effect possessed by eye drops, and "maintenance of preservation efficacy" refers to suppression of deterioration of preservation efficacy of eye drops with time. The storage efficacy of the eye drops can be determined by, for example, whether or not the criterion "class IA" in the seventeenth revised japanese pharmacopoeia reference information "storage efficacy test method" is satisfied.

< eye drops >

The eye drop of the present invention contains 2-amino-3- (4-bromobenzoyl) phenylacetic acid or a salt thereof (hereinafter, referred to as the present compound), is contained in an eye drop container, and is hermetically packaged in the package together with the eye drop container. Further, the eye drop of the present invention may be hermetically packaged in a package together with a deoxidizer, for example. The eye drop containing the present compound can maintain its storage efficacy over a long period of time by being stored in an eye drop container, further being hermetically packaged in the package, and further being hermetically packaged in the package together with a deoxidizer. Further, the eye drops of the present invention inhibit the production of substances related to the present compound for a long period of time, and are pharmaceutically stable. The eye drop of the present invention preferably has a reduced dissolved oxygen content as much as possible, and particularly preferably contains substantially no dissolved oxygen.

The eye drop of the present invention may be one in which the storage efficacy is maintained after storage (preservation) for a pharmaceutically acceptable period of time, for example, after 3 to 36 months of storage at 1 to 30 ℃ and 75% RH or less, preferably 6 months of storage at 40 ℃ and 75% RH or less, and/or after 12 months of storage at 25 ℃ and 60% RH or less. The eye drop of the present invention may be, for example, one which is pharmaceutically stable after storage (preservation) for a pharmaceutically acceptable period of time, and may be, for example, one which is pharmaceutically stable after 12 to 36 months of storage at 1 to 30 ℃ and 40% RH or less, preferably 6 months of storage at 40 ℃ and 25% RH or less, and/or 12 months of storage at 25 ℃ and 60% RH or less.

(eye drops (aqueous composition) containing the Compound)

The eye drops of the present invention are ophthalmic compositions, preferably aqueous compositions, containing 2-amino-3- (4-bromobenzoyl) phenylacetic acid or a salt thereof as an active ingredient (active ingredient) and, in some cases, pharmaceutically acceptable additives. The form of the solution may be a liquid such as a solution or a suspension, and is preferably an aqueous solution. When the eye drop of the present invention is an aqueous composition, the aqueous solvent that can be used is not particularly limited as long as it is a solvent containing water, and for example, it may be water or a mixture of a water-soluble solvent such as alcohol and water, and preferably purified water.

In the present invention, the eye drops, the aqueous composition and the aqueous solvent used for producing them are preferably used with the dissolved oxygen amount as reduced as possible, and particularly preferably used in a state substantially free of dissolved oxygen. The method is not particularly limited, and for example, the dissolved oxygen amount of the eye drop, the aqueous composition, or the aqueous solvent used for producing them can be reduced by removing the dissolved oxygen by substitution operation with an inert gas such as nitrogen or argon.

In the eye drops of the present invention, 2-amino-3- (4-bromobenzoyl) phenylacetic acid may be present in a dissolved form in the form of undissociated 2-amino-3- (4-bromobenzoyl) phenylacetic acid itself, a salt of 2-amino-3- (4-bromobenzoyl) phenylacetic acid, zwitterions (carboxyl group forming carboxylate ion and amino group forming ammonium ion), positive plasmons (amino group forming ammonium ion only), negative plasmons (carboxyl group forming carboxylate ion only).

In the eye drops of the present invention, the salt of 2-amino-3- (4-bromobenzoyl) phenylacetic acid is not particularly limited as long as it is a pharmaceutically acceptable salt, and examples of the salt include salts with inorganic acids, salts with organic acids, quaternary ammonium salts, salts with halogen ions, salts with alkali metals, salts with alkaline earth metals, metal salts, and salts with organic amines. Examples of the salt with an inorganic acid include salts with hydrochloric acid, hydrobromic acid, hydroiodic acid, nitric acid, sulfuric acid, phosphoric acid, and the like. Examples of the salt with an organic acid include salts with acetic acid, oxalic acid, fumaric acid, maleic acid, succinic acid, malic acid, citric acid, tartaric acid, adipic acid, gluconic acid, glucoheptonic acid, glucuronic acid, terephthalic acid, methanesulfonic acid, alanine, lactic acid, hippuric acid, 1, 2-ethanedisulfonic acid, hydroxyethanesulfonic acid, lactobionic acid, oleic acid, gallic acid, pamoic acid, polygalacturonic acid, stearic acid, tannic acid, trifluoromethanesulfonic acid, benzenesulfonic acid, p-toluenesulfonic acid, lauryl sulfate, methyl sulfate, naphthalenesulfonic acid, and sulfosalicylic acid. Examples of the quaternary ammonium salt include salts with methyl bromide, methyl iodide and the like. Examples of the salt with a halogen ion include a salt with a chloride ion, a bromide ion, an iodide ion, and the like, examples of the salt with an alkali metal include a salt with lithium, sodium, potassium, and the like, examples of the salt with an alkaline earth metal include a salt with calcium, magnesium, and the like, and examples of the metal salt include a salt with iron, zinc, and the like. Examples of the salt with an organic amine include salts with triethylenediamine, 2-aminoethanol, 2-iminobis (ethanol), 1-deoxy-1- (methylamino) -2-D-sorbitol, 2-amino-2- (hydroxymethyl) -1, 3-propanediol, procaine, and N, N-bis (phenylmethyl) -1, 2-ethylenediamine. In the eye drops of the present invention, the preferred salt of 2-amino-3- (4-bromobenzoyl) phenylacetic acid is the sodium salt.

The concentration of 2-amino-3- (4-bromobenzoyl) phenylacetic acid in the eye drops of the present invention is not particularly limited as long as it is an amount sufficient to exert the desired drug effect, but is preferably 0.01 to 1.0% (w/v), more preferably 0.03 to 0.5% (w/v), still more preferably 0.05 to 0.2% (w/v), and most preferably 0.08 to 0.1% (w/v). In the case of using a salt of 2-amino-3- (4-bromobenzoyl) phenylacetic acid or a hydrate thereof, the mass of 2-amino-3- (4-bromobenzoyl) phenylacetic acid was calculated by using the mass as converted.

The eye drops of the present invention may further contain a benzalkonium salt which is useful as an additive for pharmaceuticals. Examples of the benzalkonium salt include benzalkonium chloride (BAK) and benzalkonium bromide, and benzalkonium chloride is preferable.

The upper limit of the concentration of the benzalkonium salt in the eye drops of the present invention is not particularly limited, and is preferably 0.01% (w/v), more preferably 0.008% (w/v), particularly preferably 0.006% (w/v), and most preferably 0.005% (w/v). On the other hand, the lower limit of the concentration is not particularly limited, but is preferably 0.0001% (w/v), more preferably 0.0005% (w/v), particularly preferably 0.0008% (w/v), most preferably 0.001% (w/v). The concentration range is not particularly limited, but is preferably 0.0001% (w/v) or more and 0.01% (w/v) or less, more preferably 0.0005% (w/v) or more and 0.0008% (w/v) or less, particularly preferably 0.001% (w/v) or more and 0.006% (w/v) or less, and most preferably 0.001% (w/v) or 0.005% (w/v).

The eye drop of the present invention may further contain a sulfite salt which is useful as an additive for pharmaceuticals. Examples of the sulfite include sodium sulfite, potassium sulfite, magnesium sulfite, and calcium sulfite, and sodium sulfite is preferable. Sodium sulfite anhydrous sodium sulfite can be used, for example.

The upper limit of the concentration of the sulfite in the eye drops of the present invention is not particularly limited, but is preferably 0.5% (w/v), more preferably 0.3% (w/v), and particularly preferably 0.25% (w/v). On the other hand, the lower limit of the concentration is not particularly limited, but is preferably 0.01% (w/v), more preferably 0.03% (w/v), and particularly preferably 0.04% (w/v). The concentration range is not particularly limited, but is preferably 0.01% (w/v) to 0.5% (w/v), more preferably 0.03% (w/v) to 0.3% (w/v), and particularly preferably 0.04% (w/v) to 0.25% (w/v).

In the eye drop of the present invention, additives such as a buffer, an isotonic agent, a pH adjuster, a stabilizer, a preservative, a solubilizing agent, a thickener and the like may be added as necessary in addition to the above.

The eye drops of the present invention may contain a buffer agent which is useful as an additive for pharmaceuticals. Examples of the buffer include phosphoric acid or a salt thereof, boric acid or a salt thereof, citric acid or a salt thereof, acetic acid or a salt thereof, carbonic acid or a salt thereof, tartaric acid or a salt thereof, -aminocaproic acid, tromethamine, and the like. Examples of the phosphate include sodium phosphate, sodium dihydrogen phosphate, disodium hydrogen phosphate, potassium dihydrogen phosphate, dipotassium hydrogen phosphate, etc., examples of the borate include borax, sodium borate, potassium borate, etc., examples of the citrate include sodium citrate, disodium citrate, etc., examples of the acetate include sodium acetate, potassium acetate, etc., examples of the carbonate include sodium carbonate, sodium hydrogen carbonate, etc., and examples of the tartrate include sodium tartrate, potassium tartrate, etc. In the present invention, the preferred buffer is boric acid or a salt thereof, for example, boric acid, borax.

The concentration of the buffer in the eye drop of the present invention may be adjusted as appropriate in consideration of the influence on the drug, other additives and/or the osmotic pressure ratio, and the total amount thereof is preferably 0.01 to 15% (w/v), more preferably 0.05 to 10% (w/v), still more preferably 0.1 to 6% (w/v), particularly preferably 0.5 to 5% (w/v), and most preferably 2 to 4% (w/v).

The eye drops of the present invention may be suitably incorporated with an isotonic agent which is useful as an additive for pharmaceuticals. Examples of the isotonic agent include an ionic isotonic agent, a nonionic isotonic agent and the like. Examples of the ionic isotonic agent include sodium chloride, potassium chloride, calcium chloride, and magnesium chloride, and examples of the nonionic isotonic agent include glycerin, propylene glycol, sorbitol, and mannitol. In the present invention, the preferred isotonicity agent is sodium chloride.

The concentration of the isotonic agent in the eye drop of the present invention may be adjusted as appropriate in consideration of the influence on the drug, other additives and/or osmotic pressure ratio, and the total amount thereof is preferably 0.01 to 3% (w/v), more preferably 0.02 to 2.5% (w/v), still more preferably 0.03 to 2% (w/v), particularly preferably 0.05 to 1% (w/v), and most preferably 0.1 to 0.5% (w/v).

The eye drop of the present invention may contain an appropriate amount of a pH adjuster which is useful as an additive for pharmaceuticals. Examples of the pH adjuster include hydrochloric acid, phosphoric acid, citric acid, acetic acid, sodium hydroxide, potassium hydroxide, sodium carbonate, and sodium hydrogen carbonate. In the present invention, hydrochloric acid and sodium hydroxide are preferred as the pH adjuster.

The pH of the eye drop of the present invention is preferably 7.0 to 9.5, more preferably 7.5 to 9.0, even more preferably 8.0 to 8.6, and most preferably 8.2 to 8.4.

The eye drops of the present invention may be suitably incorporated with a stabilizer which is useful as an additive for pharmaceuticals. Examples of the stabilizer include edetic acid, sodium edetate hydrate, sodium citrate, and water-soluble polymer. Examples of the water-soluble polymer include povidone (polyvinylpyrrolidone), polyvinyl alcohol, carboxypropyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, and sodium polyacrylate. In the present invention, preferable stabilizers are sodium edetate hydrate and povidone (preferably povidone (K-30)).

The concentration of the stabilizer in the eye drop of the present invention may be adjusted as appropriate in consideration of the influence on the drug, other additives and/or osmotic pressure ratio, and the total amount thereof is preferably 0.001 to 5% (w/v), more preferably 0.002 to 4% (w/v), still more preferably 0.003 to 3.5% (w/v), particularly preferably 0.005 to 3.0% (w/v), and most preferably 0.01 to 2.2% (w/v).

The eye drops of the present invention may be suitably blended with a preservative which is useful as an additive for pharmaceuticals. Examples of the preservative include benzethonium chloride, sorbic acid, potassium sorbate, methylparaben, propylparaben, chlorobutanol, and the like.

The concentration of the preservative in the eye drop of the present invention may be adjusted as appropriate in consideration of the influence on the drug, other additives and/or osmotic pressure ratio, and the total amount thereof is preferably 0.00005 to 0.01% (w/v), more preferably 0.0001 to 0.005% (w/v), still more preferably 0.0002 to 0.004% (w/v), particularly preferably 0.0005 to 0.003% (w/v), and most preferably 0.001 to 0.002% (w/v).

The eye drop of the present invention may be suitably blended with a cosolvent which is useful as an additive for pharmaceuticals. Examples of the cosolvent include polysorbate 80, tyloxapol, polyoxyethylene hydrogenated castor oil 60, polyoxyethylene hydrogenated castor oil 40, polyoxyethylene castor oil 35, poloxamer 188, poloxamer 407, and polyethylene glycol 4000, and a preferable cosolvent is polysorbate 80 or tyloxapol.

The concentration of the cosolvent in the eye drop of the present invention may be suitably adjusted in consideration of the influence on the drug, other additives and/or osmotic pressure ratio, and the total amount thereof is preferably 0.001 to 1.0% (w/v), more preferably 0.005 to 0.5% (w/v), still more preferably 0.01 to 0.3% (w/v), particularly preferably 0.01 to 0.2% (w/v), and most preferably 0.02 to 0.18% (w/v).

The eye drops of the present invention may be suitably blended with a thickener which is useful as an additive for pharmaceuticals. Examples of the thickener include polyvinyl alcohol, sodium carboxymethylcellulose, hydroxyethyl cellulose, hydroxypropyl methylcellulose, methyl cellulose, glucose, glycerin, polyethylene glycol, and dextran.

The concentration of the thickener in the eye drop of the present invention may be adjusted as appropriate in consideration of the influence on the drug, other additives and/or osmotic pressure ratio, and the total amount thereof is preferably 0.001 to 5.0% (w/v), more preferably 0.01 to 2.0% (w/v), still more preferably 0.05 to 1.0% (w/v), particularly preferably 0.1 to 0.75% (w/v), most preferably 0.2 to 0.5% (w/v).

(eye drop container)

In the present invention, the eye drop container is not particularly limited as long as it can contain an eye drop containing 2-amino-3- (4-bromobenzoyl) phenylacetic acid or a salt thereof and is a pharmaceutically acceptable container. The eye drop container may be formed of 1 member or a plurality of members, and for example, may be a 1-piece (piece) type eye drop container, a 2-piece type eye drop container, or a 3-piece type eye drop container. Here, for example, in the case of a 3-piece type eye drop container, the container body for storing eye drops, 3 members of a middle stopper and a lid are formed, and in the case of an integrally molded container in which blow molding and filling of a liquid medicine (eye drops) are simultaneously performed, the container is included in the eye drop container according to the number of members. When the eye drop container is formed of a plurality of members, the eye drop container may be formed of members made of the same material, or may be formed of members made of different materials. Further, a part or the whole of the member may be constituted by a material, or a part or the whole of the member may be coated.

As the material of the eye drop container, for example, polyethylene (including LDPE, MDPE, HDPE), polypropylene, polyethylene terephthalate, polybutylene terephthalate, polypropylene-polyethylene copolymer, polyvinyl chloride, acrylic resin, polystyrene, and the like can be used, and preferably, polyethylene can be used.

In the present invention, the amount of oxygen in the eye drop container containing the eye drops is preferably reduced as much as possible, and particularly preferably substantially no oxygen is contained. The method is not limited, and for example, the oxygen in the eye drop container can be removed by a replacement operation with an inert gas such as nitrogen or argon, thereby reducing the oxygen content in the eye drop container.

(Package)

In the present invention, the package is not particularly limited as long as it is a pharmaceutically acceptable package, and may be a shaped container such as a bottle, a can, a box, or an unshaped container such as a bag. In the present invention, the preferred package is a bag. Examples of the bag include a three-side seal bag, a four-side seal bag, a gusset bag (gusset bag), and a pillow bag is preferable. The package is not limited to a package having a single-layer structure, and may have a multilayer structure such as a multilayer film.

In the present invention, the package may be a closed container, an airtight container, or a sealed container, for example. Here, the closed container is a container that can prevent solid foreign matter from being mixed and prevent the loss of internal materials in a normal handling, transportation, or storage state. The airtight container is a container that can prevent the intrusion of solid or liquid foreign matter and prevent the loss of contents, deliquescence, or evaporation in a normal handling, transportation, or storage state. The sealed container is a container into which gas does not enter in a normal handling, transportation, or storage state.

In the present invention, the oxygen content in the package is preferably reduced as much as possible during or for a certain period after the sealed packaging, and particularly preferably substantially no oxygen is contained. The method is not limited, and for example, the oxygen in the package can be reduced by sealing a deoxidizer in the package, or by removing oxygen in the package by a replacement operation with an inert gas such as nitrogen or argon before sealing.

In the present specification, "substantially no oxygen in the package (container)" means that the oxygen concentration in the gas in the package (container) is 0 or very low, and means that the oxygen concentration in the gas in the package (container) is, for example, 5% by volume or less, 1% by volume or less, 0.1% by volume or less, 0.01% by volume or less, 0.001% by volume or less, 0.0001% by volume or less, or 0.00001% by volume or less. In the present specification, "substantially no dissolved oxygen is contained in the solution" means that the oxygen concentration in the solution is 0 or very low, and means that the oxygen concentration in the gas is, for example, 5% by volume or less, 1% by volume or less, 0.1% by volume or less, 0.01% by volume or less, 0.001% by volume or less, 0.0001% by volume or less, or 0.00001% by volume or less when the oxygen in the solution and the oxygen present in the gas are in equilibrium.

Here, the method of measuring the oxygen concentration in the gas in the package (container) or the dissolved oxygen concentration in the solution is not particularly limited, and the measurement can be performed by a generally known method, and for example, can be performed by a method of using a commercially available measuring instrument. Specifically, the oxygen concentration in the gas in the package (container) can be measured by using an oxygen concentration meter of a diaphragm electrode type, a magnet type, a zirconia type or the like, and the dissolved oxygen concentration in the solution can be measured by a measuring method such as a titration method or a diaphragm electrode method.

The material of the package is not particularly limited as long as it is a pharmaceutically acceptable material, and for example, paper, glass, resin and resin film, metal and metal film, and the like, or a combination thereof may be used. As a material of the package, for example, a package formed only of paper may be excluded. Specifically, aluminum films such as aluminum foil, aluminum vapor deposited film, and aluminum laminated film are exemplified. In addition, the package may be any of transparent, translucent, and opaque.

The material of the package is preferably a material having low oxygen permeability, for example, in order to suppress the inflow of oxygen into the package, and more specifically, the oxygen permeability is preferably 20ml/m²Atm · 24h or less, more preferably 5ml/m²Atm.24 h or less, most preferably 1.5ml/m²Atm · 24h or less.

In the present invention, the package may be such that the eye drop container containing the present compound and optionally the oxygen scavenger are sealed inside, and other substances may be further sealed inside, and for example, other drugs and medical supplies, a desiccant such as silica gel, an antioxidant, an insect repellent, and the like may be sealed inside.

(deoxidizing agent)

In the present invention, the oxygen scavenger is not particularly limited as long as it can reduce the concentration of oxygen in the surroundings by absorbing oxygen in the surroundings or reacting with oxygen, and for example, a metal-based oxygen scavenger such as an iron-based oxygen scavenger, an organic oxygen scavenger, or the like can be used, and preferably an iron-based oxygen scavenger can be used. Specific examples of the iron-based deoxidizer include WonderKeep model, RP-30 (registered trademark: Powdertech Co., Ltd.), Ageless model, ZP-32RY (registered trademark: Mitsubishi gas chemical Co., Ltd.), EVERFRESH model, and Q-30 (registered trademark: bird industries, Ltd.).

In the present invention, the oxygen scavenger is sealed inside the package together with, for example, the eye drop container in which the present compound is stored, and in this case, the oxygen scavenger may be disposed inside the package so as to be separated from the package, or may be disposed so as to be in contact with the package. Here, the case where the package is disposed in contact with the package also includes a case where the package and the deoxidizer are integrated, and for example, the case where the surface of the interior of the package is coated with the deoxidizer, the case where the package has a multilayer structure and the inner layer or the intermediate layer contains the deoxidizer, and the like are included.

< ophthalmic medicinal product and Process for producing the same >

The ophthalmic pharmaceutical product of the present invention comprises: an eye drop containing 2-amino-3- (4-bromobenzoyl) phenylacetic acid or a salt thereof, an eye drop container containing the eye drop, and a package in which the eye drop container is hermetically sealed, more preferably comprise: an ophthalmic solution containing 2-amino-3- (4-bromobenzoyl) phenylacetic acid or a salt thereof, an ophthalmic container containing the ophthalmic solution, a deoxidizer, and a hermetically sealed package containing the ophthalmic container and the deoxidizer. The method of the present invention for producing the same comprises storing an eye drop containing 2-amino-3- (4-bromobenzoyl) phenylacetic acid or a salt thereof in an eye drop container and hermetically packaging the eye drop container, and more preferably comprises storing an eye drop containing 2-amino-3- (4-bromobenzoyl) phenylacetic acid or a salt thereof in an eye drop container and hermetically packaging the eye drop container together with a deoxidizer. The ophthalmic pharmaceutical preparation of the present invention can provide an ophthalmic pharmaceutical preparation containing an eye drop containing 2-amino-3- (4-bromobenzoyl) phenylacetic acid or a salt thereof, which can maintain the storage efficacy for a long period of time, and the production method of the present invention can produce an ophthalmic pharmaceutical preparation containing an eye drop containing 2-amino-3- (4-bromobenzoyl) phenylacetic acid or a salt thereof, which can maintain the storage efficacy for a long period of time. The above-mentioned eye drops can be cited as the ophthalmic pharmaceutical product and the method for producing the same.

< packaging >

The package of the present invention is a sealed package in which an eye drop container containing an eye drop containing 2-amino-3- (4-bromobenzoyl) phenylacetic acid or a salt thereof is sealed, and more preferably, an eye drop container containing an eye drop containing 2-amino-3- (4-bromobenzoyl) phenylacetic acid or a salt thereof and a deoxidizer are sealed. The package of the present invention can provide a hermetically sealed package for an eye drop containing 2-amino-3- (4-bromobenzoyl) phenylacetic acid or a salt thereof, which can maintain the storage efficacy for a long period of time. The aforementioned eye drop-related description may be directly cited in the package.

< storage method >

The storage method of the present invention is a method of storing an eye drop containing 2-amino-3- (4-bromobenzoyl) phenylacetic acid or a salt thereof in an eye drop container and hermetically packaging the eye drop container, and more preferably a method of storing an eye drop containing 2-amino-3- (4-bromobenzoyl) phenylacetic acid or a salt thereof in an eye drop container and hermetically packaging the eye drop container together with a deoxidizer. By this method, the eye drops maintain the preservation efficacy after storage (preservation) for a pharmaceutically acceptable period. The storage method of the present invention is also a method for suppressing deterioration of the storage efficacy of eye drops, or a method for maintaining the storage efficacy of eye drops, for example. The above-mentioned eye drop-related description can be directly cited in the preservation method of the present invention.