阅读说明：本技术 归一化肿瘤突变负荷 (Normalization of tumor mutational burden ) 是由 达里娅·丘多瓦 于 2018-11-02 设计创作，主要内容包括：通过归一化方案可以使来自不同样品的肿瘤突变负荷的值彼此或与对照标准更可比较,所述归一化方案考虑了样品中高评级突变(highly rated mutations)的次要等位基因分数(minor allele fraction)。这样的分析可以提供一种指示,其中测试样品的肿瘤突变负荷依赖于对照群体中肿瘤突变负荷的分布,并且因此,指示提供测试样品的个体是否可能顺从于免疫疗法以治疗癌症。(The values of tumor mutation burden from different samples can be made more comparable to each other or to control standards by a normalization scheme that takes into account the minor allele fraction (minor allele fraction) of high-rated mutations (high rated mutations) in the samples. Such an analysis may provide an indication that the tumor mutational burden of the test sample is dependent on the distribution of tumor mutational burden in the control population and, thus, whether the individual providing the test sample is likely to be amenable to immunotherapy to treat cancer.)