阅读说明：本技术 5-碘代杀结核菌素用于制备抗真菌药物的用途 (Use of 5-iodotubercidin for preparing antifungal medicine ) 是由 刘伟 王苗苗 倪萍 韩研春 温芝潼 于 2020-05-19 设计创作，主要内容包括：本发明提供5-Itu用于制备抗真菌药物的用途,通过体外细胞实验表明,5-Itu具有广谱抗真菌活性,对耐药白念珠菌103、敏感白念珠菌SC5314、新生隐球菌32609、克柔念珠菌ATCC2340、近平滑念珠菌22019、光滑念珠菌ATCC2281、耐药热带念珠菌具有不同程度的抗真菌甚至杀真菌作用。因此可将5-Itu用作抗真菌药物,将其用于制备抗真菌药物,为真菌感染治疗提供了新的候选药物,5-Itu的抗真菌谱广且杀真菌活性的特点,为临床高效治疗真菌甚至是耐药真菌的感染,提供新的治疗途径。(The invention provides application of 5-Itu in preparing antifungal drugs, and in vitro cell experiments show that 5-Itu has broad-spectrum antifungal activity and has antifungal and even fungicidal effects to different degrees on drug-resistant candida albicans 103, sensitive candida albicans SC5314, cryptococcus neoformans 32609, candida krusei ATCC2340, candida parapsilosis 22019, candida glabrata ATCC2281 and drug-resistant candida tropicalis. Therefore, 5-Itu can be used as an antifungal drug to prepare the antifungal drug, provides a new candidate drug for treating fungal infection, has the characteristics of wide antifungal spectrum and antifungal activity of 5-Itu, and provides a new treatment way for clinically and efficiently treating fungal infection even drug-resistant fungal infection.)

Use of 1.5-iodotubercidin for the preparation of antifungal agents.

2. The use according to claim 1, wherein the fungi comprise sensitive and resistant fungal strains.

3. The use according to claim 2, wherein said susceptible fungal strains comprise susceptible Candida albicans SC5314, Candida parapsilosis 22019 and Cryptococcus neoformans 32609.

4. The use according to claim 2, wherein said drug-resistant fungal strains comprise drug-resistant Candida albicans 103, drug-resistant Candida tropicalis, Candida krusei ATCC2340, and Candida glabrata ATCC 2281.

5. The use according to claim 1, wherein said 5-Itu has an in vitro antifungal effect.

6. The use according to claim 1, wherein said 5-Itu has an in vitro fungicidal effect.

Technical Field

The invention belongs to the technical field of medicines, and particularly relates to application of 5-iodotubercidin in preparation of antifungal medicines.

Background

5-Iodotubercidin (5-Iodotubercidin, abbreviated as 5-Itu) is a high-efficiency adenosine kinase inhibitor, and modern pharmacological studies show that 5-Itu has the functions of resisting tumor, resisting trypanosoma, resisting virus, resisting convulsion, removing melanin, regulating fatty acid metabolism and the like.

5-Itu has also been reported in recent years to be effective against bacterial infections, but is less studied in the field of antifungal infections. At present, no report of antifungal effect of 5-Itu is found at home and abroad.

Disclosure of Invention

In view of the problems in the prior art, the invention provides the use of 5-Itu for preparing antifungal medicines.

The invention is realized by the following technical scheme:

use of 5-iodotubercidin for the preparation of an antifungal agent.

Preferably, the fungi include sensitive fungal strains and resistant fungal strains.

Further, the sensitive fungal strains include sensitive Candida albicans SC5314, Candida parapsilosis 22019 and Cryptococcus neoformans 32609.

Still further, the drug-resistant fungal strains include drug-resistant Candida albicans 103, drug-resistant Candida tropicalis, Candida krusei ATCC2340, and Candida glabrata ATCC 2281.

Preferably, said 5-Itu has an in vitro antifungal effect.

Preferably, said 5-Itu has an in vitro fungicidal effect.

Compared with the prior art, the invention has the following beneficial technical effects:

the application of the 5-Itu in preparing antifungal drugs shows that the 5-Itu has broad-spectrum antifungal activity and has different degrees of antifungal and even antifungal effects on drug-resistant candida albicans 103, sensitive candida albicans SC5314, cryptococcus neoformans 32609, candida krusei ATCC2340, candida parapsilosis 22019, candida glabrata ATCC2281 and drug-resistant candida tropicalis through in vitro cell experiments. Therefore, 5-Itu can be used as antifungal medicine. The invention opens up a new application of 5-Itu, can be used for preparing antifungal drugs and provides a new candidate drug for treating fungal infection. At present, the clinical antifungal spectrum is wide, the number of drugs with antifungal activity is very small, and under the conditions that the clinical fungal drug resistance is more and more common and the drug resistance degree is more and more serious, the antifungal spectrum of 5-Itu is wide and the antifungal activity is high, so that a new treatment way is provided for the clinical high-efficiency treatment of the infection of fungi and even drug-resistant fungi.

Detailed Description

The present invention will now be described in further detail with reference to specific examples, which are intended to be illustrative, but not limiting, of the invention.