阅读说明：本技术 包括烟酰胺核苷的磷衍生物的组合物以及用于调节烟酰胺腺嘌呤二核苷酸的方法 (Compositions comprising phosphorus derivatives of nicotinamide riboside and methods for modulating nicotinamide adenine dinucleotide ) 是由 B·斯潘肯维斯 J·M·麦克瑞 于 2020-03-18 设计创作，主要内容包括：本发明涉及用于调节烟酰胺腺嘌呤二核苷酸(NAD+)的化合物和组合物。本发明还涉及制造这样的化合物和组合物的方法。本发明涉及含有与一种或更多种活性药物成分组合的作为第一成分的一种或更多种NAD+调节化合物的药物组合物。此外,本发明涉及使用这样的化合物或组合物促进细胞和组织中烟酰胺腺嘌呤二核苷酸(NAD+)的细胞内水平的增加以治疗疾病和/或改善细胞和组织存活的方法。(The present invention relates to compounds and compositions for modulating nicotinamide adenine dinucleotide (NAD +). The invention also relates to methods of making such compounds and compositions. The present invention relates to pharmaceutical compositions containing one or more NAD + modulatory compounds as a first ingredient in combination with one or more active pharmaceutical ingredients. Furthermore, the invention relates to methods of using such compounds or compositions to promote an increase in intracellular levels of nicotinamide adenine dinucleotide (NAD +) in cells and tissues to treat diseases and/or improve cell and tissue survival.)