阅读说明：本技术 一种液相色谱柱及液相色谱系统 (Liquid chromatographic column and liquid chromatographic system ) 是由 李莹 马金蝉 魏伟 高艳华 雷晓强 于 2020-07-03 设计创作，主要内容包括：本发明公开了一种液相色谱柱,包括柱管、设置于柱管端部的连接接头,设置于连接接头中并位于柱管端面的筛板,柱管包括主体和设置于主体两端的连接部,连接部外周壁厚小于主体的壁厚；连接接头包括盖部和套接部,套接部内与盖部连接的一端设置筛板,且套接部紧密套设于连接部的外周；液相色谱柱还包括具有弹性的套环,套环的一部分套设于套接部的外周,另一部分套设于主体外周。本发明提供的液相色谱柱,连接接头与柱管采用套接的方式,便于拆卸与连接,避免发生紧固过度的情况。本发明还公开了一种液相色谱系统。(The invention discloses a liquid chromatographic column, which comprises a column tube, a connecting joint arranged at the end part of the column tube and a sieve plate arranged in the connecting joint and positioned on the end surface of the column tube, wherein the column tube comprises a main body and connecting parts arranged at the two ends of the main body, and the peripheral wall thickness of the connecting parts is less than that of the main body; the connecting joint comprises a cover part and a sleeving part, a sieve plate is arranged at one end of the sleeving part connected with the cover part, and the sleeving part is tightly sleeved on the periphery of the connecting part; the liquid chromatographic column further comprises an elastic lantern ring, one part of the lantern ring is sleeved on the periphery of the sleeving part, and the other part of the lantern ring is sleeved on the periphery of the main body. According to the liquid chromatographic column provided by the invention, the connecting joint and the column tube are in a sleeved connection mode, so that the liquid chromatographic column is convenient to disassemble and connect, and the condition of over-fastening is avoided. The invention also discloses a liquid chromatography system.)

1. A liquid chromatographic column comprises a column tube, a connecting joint arranged at the end part of the column tube, and a sieve plate arranged in the connecting joint and positioned at the end surface of the column tube, and is characterized in that,

the column tube comprises a main body and a connecting part arranged at the end part of the main body, and the wall thickness of the periphery of the connecting part is smaller than that of the main body;

the connecting joint comprises a cover part and a sleeve joint part, the sieve plate is arranged at one end connected with the cover part in the sleeve joint part, and the sleeve joint part is tightly sleeved on the periphery of the connecting part;

the liquid chromatographic column further comprises an elastic lantern ring, one part of the lantern ring is sleeved on the periphery of the sleeved part, and the other part of the lantern ring is sleeved on the periphery of the main body.

2. The liquid chromatography column as claimed in claim 1, wherein the connecting portion is provided with an outward protrusion on an outer wall surface close to the main body, and a clamping groove matched with the protrusion is provided on an inner wall of the socket portion, and the clamping groove is L-shaped; wherein the content of the first and second substances,

in the process that the sleeve joint part is sleeved on the connecting part, the protrusion is inserted from one end of the clamping groove; the sleeve joint part rotates along the circumferential direction, so that when the protrusion reaches the other end of the clamping groove, the sleeve joint part is limited to move in the axial direction relative to the connecting part.

3. The liquid chromatography column of claim 2, wherein the number of protrusions is 4, evenly distributed circumferentially along the connecting portion; the number of the corresponding clamping grooves is 4, and the clamping grooves are uniformly distributed along the circumferential direction of the sleeving part.

4. The liquid chromatography column of claim 1, wherein the collar comprises an inner, resilient portion and an outer, peripheral, fastening portion; the elasticity of the elastic part enables the elastic part to be tightly abutted against the peripheries of the sleeve joint part and the main body; the fastening portion restricts elasticity of an outer periphery of the elastic portion.

5. The liquid chromatography column of claim 4, wherein the collar is formed as two semi-annular joints and one of the joint locations of the two semi-annular joints is a swivel joint.

6. A liquid chromatography column as claimed in claim 5 wherein the other of said semi-annular connection locations is a pin connection.

7. The liquid chromatography column of any of claims 1-6, further comprising a first seal disposed on an outer periphery of the frit.

8. The liquid chromatography column of claim 7, further comprising a second seal ring disposed between an end of the socket portion distal from the cap portion and the main body.

9. The liquid chromatography column of any of claims 1-6, wherein a wall thickness of the socket portion plus a wall thickness of the connecting portion is equal to a wall thickness of the body.

10. A liquid chromatography system comprising a liquid chromatography column according to any of claims 1 to 9.

Technical Field

The invention relates to the field of liquid chromatography detection, in particular to a liquid chromatography column and a liquid chromatography system comprising the same.

Background

The liquid chromatographic column is an important component of a liquid chromatographic system, wherein a fixed phase filler is filled, a sample solution enters a mobile phase through a sample injector and is loaded into the chromatographic column by the mobile phase, and because each component in the sample solution has different distribution coefficients in two phases, the components are separated into single components and sequentially flow out of the column through the distribution process of repeated adsorption and desorption when the components move relatively in the two phases.

The chromatographic column is composed of column joint, column tube and sieve plate. The general column joint is a threaded component at two ends, a pressing ring is arranged in the middle of the column joint for sealing, and a sieve plate is arranged in the column joint for plugging column packing, so that the column packing is not flushed out of a column by a mobile phase and is lost. In the operation process of the liquid chromatography, the sieve plate can be blocked or polluted, the filler of the column head can be polluted, and the like, thereby causing the problems of high column pressure, low column efficiency and the like. At this time, after the column cap is required to be disassembled, the sieve plate is taken out and cleaned, and then the sieve plate is installed again or replaced; or replacing clean column packing; the stud is then reinstalled. However, the existing stud threaded connection structure is inconvenient to disassemble and assemble, and excessive fastening is easy to occur during assembly.

Disclosure of Invention

The invention aims to solve the problems that in the prior art, the column heads of liquid chromatographic columns are connected by screw threads, are inconvenient to disassemble and are easy to damage the connection due to excessive fastening. The invention provides a liquid chromatographic column, wherein a connecting joint and a column tube are in a sleeved connection mode, so that the liquid chromatographic column is convenient to disassemble and connect, and the situation of over-fastening is avoided.

In order to solve the technical problem, the invention provides a liquid chromatography column which comprises a column tube, a connecting joint arranged at the end part of the column tube and a sieve plate arranged in the connecting joint and positioned on the end surface of the column tube, wherein the column tube comprises a main body and a connecting part arranged at the end part of the main body, and the peripheral wall thickness of the connecting part is smaller than that of the main body.

The connecting joint comprises a cover part and a sleeving part, a sieve plate is arranged at one end of the sleeving part connected with the cover part, and the sleeving part is tightly sleeved on the periphery of the connecting part; the liquid chromatographic column further comprises an elastic lantern ring, one part of the lantern ring is sleeved on the periphery of the sleeving part, and the other part of the lantern ring is sleeved on the periphery of the main body.

Adopt above-mentioned scheme, rely on the mode that cup joints to make attach fitting be connected with the column casing, utilize again to have elastic lantern ring to strengthen connecting, convenient to detach and connection to can avoid taking place the excessive condition of fastening.

According to another specific embodiment of the invention, the liquid chromatography column provided by the invention is characterized in that the outer wall surface of the connecting part close to the main body is provided with an outward protrusion, the inner wall of the sleeve part is provided with a clamping groove matched with the protrusion, and the clamping groove is L-shaped; wherein, in the process that the sleeve joint part is sleeved on the connecting part, the protrusion is inserted from one end of the clamping groove; the sleeve joint part rotates along the circumferential direction, and when the protrusion reaches the other end of the clamping groove, the sleeve joint part is limited to move in the axial direction relative to the connecting part.

By adopting the scheme, after the connecting joint is sleeved with the column tube, the relative movement of the connecting joint and the column tube is limited by clamping, so that the connection is stable.

According to another embodiment of the present invention, the liquid chromatography column provided by the present invention has 4 protrusions uniformly distributed along the circumferential direction of the connecting portion; the number of the corresponding clamping grooves is 4, and the clamping grooves are uniformly distributed along the circumferential direction of the sleeving part.

By adopting the scheme, the protrusions and the clamping grooves are uniformly and symmetrically distributed, so that the connection is balanced and stable.

According to another embodiment of the present invention, there is provided a liquid chromatography column, the collar comprising an inner flexible portion and an outer peripheral fastening portion; the elasticity of the elastic part enables the elastic part to be tightly abutted against the peripheries of the sleeve joint part and the main body; the fastening portion restricts the elasticity of the outer periphery of the elastic portion.

By adopting the scheme, the elastic part of the lantern ring strengthens the connection between the sleeve joint part and the connecting part, the elasticity can strengthen the sealing property of the connection and ensure that the lantern ring cannot be too tight to damage the chromatographic column; the elasticity of fastening portion restriction elasticity portion is inside the lantern ring, strengthens being connected of cup joint portion and connecting portion.

According to another embodiment of the present invention, there is provided a liquid chromatography column wherein the collar is formed by joining two half rings, and one of the joining locations of the two half rings is a pivot joint.

By adopting the scheme, the lantern ring is convenient to open or close, and the connecting joint and the column tube are convenient to detach and connect.

According to another embodiment of the present invention, the present invention provides a liquid chromatography column, wherein the other connection position of the two semi-rings is a pin joint.

By adopting the scheme, the connection is stable after the lantern ring is closed, and the tightness of the connection can be adjusted.

According to another specific embodiment of the present invention, the liquid chromatography column further includes a first sealing ring disposed on an outer periphery of the sieve plate.

By adopting the scheme, the connection sealing performance of the sleeve joint part and the connecting part is ensured, and liquid is prevented from leaking.

According to another specific embodiment of the present invention, the liquid chromatography column further includes a second sealing ring disposed between the end of the sleeve portion away from the cap portion and the main body.

By adopting the scheme, the connection sealing performance of the socket joint part and the connecting part is further ensured.

According to another embodiment of the present invention, the wall thickness of the socket portion and the wall thickness of the connecting portion are equal to the wall thickness of the main body.

By adopting the scheme, the sleeving part is consistent with the outer wall of the main body after being connected with the connecting part, so that the whole outer wall of the chromatographic column is smooth, and the sleeving of the lantern ring is facilitated.

The invention also provides a liquid chromatography system comprising the liquid chromatography column.

By adopting the scheme, the chromatographic column connecting joint can be conveniently detached and connected, and the sieve plate can be conveniently cleaned or replaced in the operation of a chromatographic system.

Drawings

FIG. 1 is a schematic partial cross-sectional view of one embodiment of a liquid chromatography column according to example 1 of the present invention;

FIG. 2 is a schematic diagram of a partially enlarged cross-sectional structure of a joint portion of a coupling portion of a liquid chromatography column according to an embodiment of the invention;

FIG. 3 is a schematic cross-sectional view of a socket section of one embodiment of a liquid chromatography column according to example 1 of the present invention; .

FIG. 4 is a schematic top view of a collar according to one embodiment of the liquid chromatography column of example 1 of the present invention.

Description of reference numerals:

10: a column tube;

11: a main body; 12: a connecting portion; 121: a protrusion;

20: connecting a joint;

21: a cover portion; 22: a socket joint part; 221: a clamping groove;

30: a sieve plate;

40: a collar;

41: an elastic portion; 42: a fastening section; 43: a rotating shaft; 44: a pin;

50: a first seal ring;

60: and a second seal ring.

Detailed Description

The following description of the embodiments of the present invention is provided for illustrative purposes, and other advantages and effects of the present invention will become apparent to those skilled in the art from the present disclosure. While the invention will be described in conjunction with the preferred embodiments, it is not intended that features of the invention be limited to these embodiments. On the contrary, the invention is described in connection with the embodiments for the purpose of covering alternatives or modifications that may be extended based on the claims of the present invention. In the following description, numerous specific details are set forth in order to provide a thorough understanding of the present invention. The invention may be practiced without these particulars. Moreover, some of the specific details have been left out of the description in order to avoid obscuring or obscuring the focus of the present invention. It should be noted that the embodiments and features of the embodiments may be combined with each other without conflict.

It should be noted that in this specification, like reference numerals and letters refer to like items in the following drawings, and thus, once an item is defined in one drawing, it need not be further defined and explained in subsequent drawings.

In the description of the present embodiment, it should be noted that the terms "upper", "lower", "inner", "bottom", and the like indicate orientations or positional relationships based on the orientations or positional relationships shown in the drawings or orientations or positional relationships that are conventionally placed when the products of the present invention are used, and are only used for convenience in describing the present invention and simplifying the description, but do not indicate or imply that the devices or elements indicated must have specific orientations, be configured in specific orientations, and operate, and thus, should not be construed as limiting the present invention.

The terms "first," "second," and the like are used solely to distinguish one from another and are not to be construed as indicating or implying relative importance.

In the description of the present embodiment, it should be further noted that, unless explicitly stated or limited otherwise, the terms "disposed," "connected," and "connected" are to be interpreted broadly, e.g., as a fixed connection, a detachable connection, or an integral connection; can be mechanically or electrically connected; they may be connected directly or indirectly through intervening media, or they may be interconnected between two elements. The specific meanings of the above terms in the present embodiment can be understood in specific cases by those of ordinary skill in the art.

In order to make the objects, technical solutions and advantages of the present invention more apparent, embodiments of the present invention will be described in detail with reference to the accompanying drawings.