阅读说明：本技术 一种液相色谱接头和液相色谱系统 (Liquid chromatography connects and liquid chromatography system ) 是由 石迪娟 魏伟 张翠英 俄晓 雷晓强 于 2020-07-03 设计创作，主要内容包括：本发明公开了一种液相色谱接头,包括依次设置的调节帽、螺接件、密封环、连接环；还包括毛细管和档环；档环设置于螺接件中,并可沿螺接件内壁轴向移动；毛细管穿过调节帽、螺接件、密封环、连接环以及档环；其中,调节帽包括调节部和连接部,连接部插入螺接件内,并可沿螺接件内壁轴向移动；档环内壁与毛细管外壁固定连接,且调节帽沿螺接件内壁向密封环一侧移动,推动档环向密封环一侧移动,联动毛细管移动。本发明提供的液相色谱接头,可通过调节调节帽来确保毛细管插入到底,防止产生死体积。本发明还提供一种包括该液相色谱接头的液相色谱系统。(The invention discloses a liquid chromatography joint, which comprises an adjusting cap, a screw connector, a sealing ring and a connecting ring which are arranged in sequence; also comprises a capillary tube and a baffle ring; the baffle ring is arranged in the screw connector and can axially move along the inner wall of the screw connector; the capillary tube penetrates through the adjusting cap, the screw connector, the sealing ring, the connecting ring and the baffle ring; the adjusting cap comprises an adjusting part and a connecting part, and the connecting part is inserted into the screw connector and can axially move along the inner wall of the screw connector; the inner wall of the baffle ring is fixedly connected with the outer wall of the capillary tube, and the adjusting cap moves towards one side of the sealing ring along the inner wall of the screw connector to push the baffle ring to move towards one side of the sealing ring to link the movement of the capillary tube. The liquid chromatography joint provided by the invention can ensure that the capillary is inserted to the bottom by adjusting the adjusting cap, and prevent dead volume. The invention also provides a liquid chromatography system comprising the liquid chromatography joint.)

1. A liquid chromatography joint is characterized by comprising an adjusting cap, a screw connector, a sealing ring and a connecting ring which are arranged in sequence; also comprises a capillary tube and a baffle ring; the baffle ring is arranged in the screw connector and can axially move along the inner wall of the screw connector; the capillary tube penetrates through the adjusting cap, the screw connector, the sealing ring, the connecting ring and the baffle ring; wherein the content of the first and second substances,

the adjusting cap comprises an adjusting part and a connecting part, and the connecting part is inserted into the screw connector and can axially move along the inner wall of the screw connector;

the inner wall of the baffle ring is fixedly connected with the outer wall of the capillary tube, the cap edge is adjusted, the inner wall of the screw connector moves towards one side of the sealing ring, the baffle ring is pushed to move towards one side of the sealing ring, and the capillary tube is linked to move.

2. The liquid chromatography fitting of claim 1 further comprising a spring disposed on an outer wall of said capillary tube and between said adjustment cap and said stop ring.

3. A liquid chromatography joint as claimed in claim 2, wherein the outer wall of said connecting portion is provided with external threads and the inner wall of said threaded member is provided with matching internal threads, whereby said connecting portion is threadedly connected to said threaded member.

4. The liquid chromatography fitting of claim 3, wherein said adjustment portion is circumferentially peripherally and peripherally provided with a relief.

5. The liquid chromatography fitting of claim 2 wherein said connector portion outer wall is slidably connected to said threaded connector inner wall; the liquid chromatography joint further comprises a locking mechanism for locking the relative positions of the connecting part and the screw connector when the connecting part is inserted into the deepest part in the screw connector.

6. The liquid chromatography joint of claim 5, further comprising a sliding block disposed on an outer wall of the connecting portion, and a sliding groove extending in an axial direction and matching with the sliding block and disposed on an inner wall of the screw member;

the locking mechanism comprises a locking groove which is arranged on one side of the sliding groove close to the sealing ring and extends along the circumferential direction of the inner wall of the screw connector.

7. The liquid chromatography joint of claim 6, wherein the two sliders are respectively arranged on two opposite sides of the outer wall of the connecting portion; the spout that matches is two, the locking groove is two.

8. The liquid chromatography fitting of claim 5 wherein said threaded member includes a circumferential bead adjacent one side of said adjustment portion;

the locking mechanism is arranged on the adjusting part and extends along the radial direction of the adjusting part;

the locking mechanism comprises a rotating shaft, a rotating part and a locking key, the rotating part is a part of the locking mechanism from the rotating shaft to one end far away from the adjusting part, and the rotating part can rotate around the rotating shaft to the screw connector through the rotating shaft;

the locking key is arranged on the rotating part, and the rotating part rotates towards the screw connector to enable the locking key to be abutted against the flanging bottom.

9. The liquid chromatography fitting of any one of claims 1-8 wherein said capillary tube is threadably connected to said collar.

10. A liquid chromatography system comprising a liquid chromatography joint as claimed in any one of claims 1 to 9.

Technical Field

The invention relates to the field of liquid chromatography detection, in particular to a liquid chromatography joint and a liquid chromatography system comprising the same.

Background

The high performance liquid chromatography is an important analysis method, when in use, a liquid object to be detected is injected into a chromatographic column, moves in a stationary phase through pressure, different substances sequentially leave the chromatographic column according to different interaction of different substances of the object to be detected and the stationary phase, different peak signals are obtained through a detector, and finally the substances contained in the object to be detected are judged through analyzing and comparing the signals.

The liquid chromatography joint is a member for connecting a column to a capillary tube through which a liquid is introduced, and the connection of the capillary tube to the column affects the effect of chromatography. The good sealing performance of the joint is required for achieving a good analysis effect, and the dead volume of the joint is small. The dead volume refers to the volume of the mobile phase in the chromatographic column, including the dead volume outside the column, i.e. including the space between the pipeline and the connector in the chromatograph. The increase in dead volume will cause significant interference in the chromatographic analysis, making peak analysis and determination inaccurate.

In the existing common liquid chromatography joint, in the installation process of a chromatographic column, a capillary tube needs to be inserted through a joint part, and after the capillary tube is completely sensed, a screw joint part is screwed down. The chromatographic joint can only be operated by feel and experience, and cannot ensure that the capillary is inserted to the bottom, and if the capillary is not inserted to the bottom, dead volume is generated, so that the analysis effect is influenced.

Disclosure of Invention

The invention aims to solve the problems that the existing liquid chromatography joint cannot ensure that a capillary tube is inserted to the bottom in the installation process of a chromatographic column, so that dead volume is possibly generated and the analysis effect is influenced. The invention provides a liquid chromatography joint, which can ensure that a capillary is inserted to the bottom by adjusting an adjusting cap and prevent dead volume.

In order to solve the technical problem, the invention provides a liquid chromatography joint which comprises an adjusting cap, a screwed piece, a sealing ring and a connecting ring which are arranged in sequence; also comprises a capillary tube and a baffle ring; the baffle ring is arranged in the screw connector and can axially move along the inner wall of the screw connector; the capillary tube passes through the adjusting cap, the screw connector, the sealing ring, the connecting ring and the baffle ring.

The adjusting cap comprises an adjusting part and a connecting part, and the connecting part is inserted into the screw connector and can axially move along the inner wall of the screw connector; the inner wall of the baffle ring is fixedly connected with the outer wall of the capillary tube, and the adjusting cap moves towards one side of the sealing ring along the inner wall of the screw connector to push the baffle ring to move towards one side of the sealing ring to link the movement of the capillary tube.

By adopting the scheme, the adjusting cap is arranged on the liquid chromatography joint, and in the process of installing the chromatographic column, after the capillary tube is connected with the chromatographic column, the capillary tube can be pushed by the matching of the adjusting cap and the retaining ring so as to ensure that the capillary tube is inserted to the bottom, no gap exists in the position of the liquid chromatography joint, and thus the influence of dead volume on the analysis effect is prevented.

According to another specific embodiment of the present invention, the liquid chromatography joint further comprises a spring disposed on an outer wall of the capillary tube and between the adjustment cap and the stop ring.

Adopt above-mentioned scheme, can prevent to adjust the cap and promote the capillary excessively.

According to another specific embodiment of the invention, the liquid chromatography joint disclosed in the embodiment of the invention is characterized in that the outer wall of the connecting part is provided with external threads, the inner wall of the screw joint is provided with matched internal threads, and the connecting part and the screw joint are in threaded connection through the external threads and the internal threads.

Adopt above-mentioned scheme, through twisting the regulation portion of adjusting the cap, make connecting portion move downwards or upwards along the screw thread to threaded connection makes adjusting cap and screw connector be connected stably, and can twist the position that needs were adjusted as required, and the regulation position after the regulation is stable.

According to another specific embodiment of the invention, the liquid chromatography joint disclosed in the embodiment of the invention, the circumferential periphery of the adjusting part is provided with concave-convex lines.

Adopt above-mentioned scheme, increase the frictional force of regulating part, the person of being convenient for twists the regulating part.

According to another specific embodiment of the present invention, the liquid chromatography joint disclosed in the embodiments of the present invention, the outer wall of the connecting portion is slidably connected to the inner wall of the screw member; the liquid chromatography joint further comprises a locking mechanism for locking the relative positions of the connecting portion and the threaded member when the connecting portion is inserted innermost in the threaded member.

By adopting the scheme, the capillary position adjusting process is simple and easy to operate by means of the locking mechanism. And the connection is stable.

According to another specific embodiment of the invention, the liquid chromatography joint disclosed in the embodiment of the invention further comprises a sliding block arranged on the outer wall of the connecting part, and a sliding groove which is arranged on the inner wall of the screw connector and extends along the axial direction and is matched with the sliding block; locking mechanism is including setting up in the spout and being close to the locking groove that extends along spiro union piece inner wall circumference one side.

By adopting the scheme, the locking mechanism is simple in structure and easy to operate.

According to another specific embodiment of the invention, the liquid chromatography joint disclosed in the embodiment of the invention comprises two sliding blocks respectively arranged on two opposite sides of the outer wall of the connecting part; the spout that matches is two, and the locking groove is two.

By adopting the scheme, the sliding block is balanced after being inserted into the sliding groove and is relatively stable after being locked.

According to another specific embodiment of the present invention, the liquid chromatography joint disclosed in the embodiments of the present invention, the screw member includes a flange on a side thereof adjacent to the adjustment portion in a circumferential direction; the locking mechanism is arranged on the adjusting part and extends along the radial direction of the adjusting part; the locking mechanism comprises a rotating shaft, a rotating part and a locking key, the rotating part is a part of the locking mechanism from the rotating shaft to one end far away from the adjusting part, and the rotating part can rotate around the rotating shaft to the screw connector through the rotating shaft; the locking key sets up on the rotating part to the rotating part can make locking key and turn-ups bottom butt to the rotation of spiro union piece.

By adopting the scheme, the locking position is easy to master, and the locking mechanism is easy to operate.

According to another embodiment of the present invention, a liquid chromatography fitting is disclosed wherein the capillary tube is threadably connected to the collar.

By adopting the scheme, the capillary tube and the baffle ring are easy to connect and disassemble and are stably connected. And the length of the external thread on the periphery of the capillary tube can be set according to the requirement, so that the position of the stop ring can be adjusted.

The invention also provides a liquid chromatography system which is characterized by comprising the liquid chromatography joint.

By adopting the scheme, the capillary can be ensured to be inserted to the bottom when the chromatographic column is installed, so that the influence on the analysis effect due to the dead volume is prevented.

Drawings

FIG. 1 is a schematic cross-sectional view of one embodiment of a liquid chromatography joint according to example 1 of the present invention;

FIG. 2 is a schematic cross-sectional view of a liquid chromatography joint according to example 1 of the present invention in an unlocked state;

FIG. 3 is a schematic cross-sectional view of a liquid chromatography joint of example 1 of the present invention in a locked state in accordance with another embodiment.

Description of reference numerals:

10: an adjusting cap;

11: an adjustment section; 12: a connecting portion; 121: an external thread;

20: a screw member;

21: an internal thread; 22: flanging;

30: a seal ring;

40: a connecting ring;

50: a capillary tube;

60: a retainer ring;

70: a spring;

80: a locking mechanism;

81: a rotating shaft; 82: a rotating part; 83: and a locking key.

Detailed Description

The following description of the embodiments of the present invention is provided for illustrative purposes, and other advantages and effects of the present invention will become apparent to those skilled in the art from the present disclosure. While the invention will be described in conjunction with the preferred embodiments, it is not intended that features of the invention be limited to these embodiments. On the contrary, the invention is described in connection with the embodiments for the purpose of covering alternatives or modifications that may be extended based on the claims of the present invention. In the following description, numerous specific details are set forth in order to provide a thorough understanding of the present invention. The invention may be practiced without these particulars. Moreover, some of the specific details have been left out of the description in order to avoid obscuring or obscuring the focus of the present invention. It should be noted that the embodiments and features of the embodiments may be combined with each other without conflict.

It should be noted that in this specification, like reference numerals and letters refer to like items in the following drawings, and thus, once an item is defined in one drawing, it need not be further defined and explained in subsequent drawings.

In the description of the present embodiment, it should be noted that the terms "upper", "lower", "inner", "bottom", and the like indicate orientations or positional relationships based on the orientations or positional relationships shown in the drawings or orientations or positional relationships that are conventionally placed when the products of the present invention are used, and are only used for convenience in describing the present invention and simplifying the description, but do not indicate or imply that the devices or elements indicated must have specific orientations, be configured in specific orientations, and operate, and thus, should not be construed as limiting the present invention.

The terms "first," "second," and the like are used solely to distinguish one from another and are not to be construed as indicating or implying relative importance.

In the description of the present embodiment, it should be further noted that, unless explicitly stated or limited otherwise, the terms "disposed," "connected," and "connected" are to be interpreted broadly, e.g., as a fixed connection, a detachable connection, or an integral connection; can be mechanically or electrically connected; they may be connected directly or indirectly through intervening media, or they may be interconnected between two elements. The specific meanings of the above terms in the present embodiment can be understood in specific cases by those of ordinary skill in the art.

In order to make the objects, technical solutions and advantages of the present invention more apparent, embodiments of the present invention will be described in detail with reference to the accompanying drawings.