阅读说明：本技术 柠檬烯在制备抗过敏性皮炎药物中的应用 (Application of limonene in preparation of anti-allergic dermatitis medicine ) 是由 孙东杰 于 2020-04-15 设计创作，主要内容包括：本发明公开柠檬烯在制备抗过敏性皮炎药物中的应用,属于生物医药技术领域。本发明所述柠檬烯可以抑制DNCB丙酮溶液诱导的接触性皮炎,同时具有抑制被动皮肤过敏反应及肥大细胞脱颗粒的效应；因此,所述柠檬烯可以用于治疗多种原因引起的过敏性皮炎,且具有较好的治疗效果。(The invention discloses an application of limonene in preparing an anti-allergic dermatitis medicine, and belongs to the technical field of biological medicines. The limonene can inhibit contact dermatitis induced by DNCB acetone solution, and has the effects of inhibiting passive skin anaphylaxis and mast cell degranulation; therefore, the limonene can be used for treating allergic dermatitis caused by various reasons and has a good treatment effect.)

1. Application of limonene in preparing medicine for resisting allergic dermatitis is disclosed.

2. Use of limonene according to claim 1 for the manufacture of a medicament for anti-atopic dermatitis, wherein: the limonene and other auxiliary materials acceptable by other human bodies are prepared into solution, dressing, cream or emulsion.

Technical Field

The invention relates to an application of limonene in preparing an anti-allergic dermatitis medicine, and belongs to the technical field of biological medicines.

Background

Limonene is referred to as limonene, a monoterpene compound, a colorless oily liquid, and has a lemon-like fragrance. Has good effects of relieving cough, eliminating phlegm and inhibiting bacteria. Its dextrogyra is commonly used as raw material for preparing artificial orange flower, sweet flower, lemon and bergamot oil. It can also be used as a fresh top-scent perfume for cosmetic, soap and daily-use chemical essence, and is suitable for flos Jasmini sambac type and Lavender type in cologne type and flower fragrance, and pine, aldehyde, radix aucklandiae, fruit or delicate fragrance type. The edible essence is used as a modifier for white lemon, fruit flavor, spicy flavor and other formulas.

Allergic dermatitis is a large group of diseases, which are commonly characterized by pruritus and rash, and mainly comprises I-type allergic reaction represented by urticaria and IV-type allergic reaction represented by eczema and contact dermatitis. Urticaria is also called rubella, which is indefinite in walking, regresses without traces, attacks repeatedly after chronic urticaria and severe pruritus, and brings great pain to patients. Eczema is also called eczema, the cause of eczema is unknown, contact with allergens and internal constitutional factors are related to the onset of diseases, the main characteristics are repeated attacks of diseases, symmetric skin lesions, generalized diseases, obvious pruritus and exudation of running water when the diseases are serious, the morbidity of people is high, and the people are difficult to radically cure. Contact dermatitis, also known as toxic dermatitis, is an inflammatory reaction that occurs when the skin or mucous membrane is contacted with certain external irritants or allergens; the patent refers to the field of 'pharmaceutical preparations'. The symptoms are: the patient feels burning and itching and has pain in severe cases. The skin lesions are generally limited to the contact area, and have clear boundaries and generally consistent shapes with the contact objects. However, it may also be generalized to the whole body due to scratching. The progression of the disease becomes chronic dermatitis due to scratching or mishandling, infection or failure to remove irritants in a timely manner.

At present, allergic dermatitis treatment is mainly based on anti-allergy and itching relief, oral anti-allergic drugs comprise antihistamines and the like, and external drugs are used according to the basic principle: adopts proper dosage forms and medicines, takes the principles of diminishing inflammation, astringing and relieving as well as avoids using irritative or easily sensitized medicines.

In the treatment of allergic dermatitis, external anti-allergic drugs are one of the main treatment means, including: glucocorticoids can resist allergy and relieve itching to a certain extent, but adverse reactions such as local skin atrophy, infection, pigment abnormality and the like exist after long-term external application, and patients generally smell 'hormone' color change, which limits the use of the glucocorticoids; in addition, other non-glucocorticoid medicaments, such as calcineurin inhibitors and various traditional Chinese medicine monomers or compound components, have certain effects, and have the defects of weak curative effect, high price, local stimulation and the like more or less. In general, external use drugs against allergic dermatitis have poor therapeutic effects on a significant part of patients with allergic dermatitis. Therefore, there is a need to find and develop an anti-allergic dermatitis topical drug with good anti-allergic effect, economy and safety.

Disclosure of Invention

The invention aims to provide application of limonene in preparation of an anti-allergic dermatitis medicament.

The limonene can be prepared into a solution, a dressing cream or an emulsion together with other auxiliary materials acceptable to other human bodies.

In practical application, the traditional Chinese medicine is generally prepared into solution, cream, dressing or emulsion by a conventional method for use, and the solution, the cream, the dressing or the emulsion is respectively sprayed, wet-applied and smeared on an affected part, and 0.5 g of medicine is evenly smeared on a palm of a hand twice a day.

The limonene is commercially available limonene or limonene prepared by the existing method.

The allergic dermatitis is inflammatory reaction generated by contacting skin or mucous membrane with some external irritants or allergens, and is characterized by pruritus and rash in common, including I and IV type skin allergic reactions caused by the allergens and diseases characterized by pruritus and rash caused by unknown reasons.

The invention has the beneficial effects that: the limonene has a good treatment effect on allergic dermatitis caused by various reasons, and animal experiments show that the limonene can inhibit contact dermatitis induced by DNCB acetone solution and has the effects of inhibiting passive skin allergic reaction and mast cell degranulation.

Detailed Description

The present invention is further described in detail with reference to the following specific examples, but the scope of the present invention is not limited to the above description.