阅读说明：本技术 靶向治疗剂 (Targeted therapeutic agents ) 是由 L·阿兰德 C·西尔斯 R·R·欣德 B·斯韦伊达-克拉维茨 T·P·欧阳 M·T·比洛多 于 2018-06-19 设计创作，主要内容包括：本发明提供了药理学化合物,其包括与结合部分缀合的效应物部分,该结合部分将效应物部分引导至受关注的生物学靶标。类似地,本发明提供了包括该化合物的组合物、试剂盒和方法(例如治疗、诊断和成像)。该化合物可以被描述为蛋白质相互作用结合部分-药物缀合物(SDC-TRAP)化合物,其包括蛋白质相互作用结合部分和效应物部分。例如,在针对治疗癌症的某些实施方案中,SDC-TRAP可包括与作为效应物部分的细胞毒性剂缀合的Hsp90抑制剂。(The present invention provides pharmacological compounds comprising an effector moiety conjugated to a binding moiety that directs the effector moiety to a biological target of interest. Similarly, the invention provides compositions, kits and methods (e.g., therapy, diagnosis and imaging) comprising the compounds. The compounds may be described as protein interaction binding moiety-drug conjugate (SDC-TRAP) compounds, which include a protein interaction binding moiety and an effector moiety. For example, in certain embodiments directed to treating cancer, a SDC-TRAP can comprise an Hsp90 inhibitor conjugated to a cytotoxic agent as an effector moiety.)