Column oven
阅读说明:本技术 柱温箱 (Column oven ) 是由 石原光 于 2017-09-21 设计创作,主要内容包括:本发明提供了一种柱温箱,具备:大致密闭空间,被由导热材料构成的壁面所包围,用于收容分析柱;加热器,加热由所述导热材料构成的壁面;隔热材料,包围由所述导热材料构成的壁面的外侧。即,本发明通过使收容有分析柱的柱温箱内的空间成为由导热性的壁面包围的大致密闭结构,由加热器加热包围该大致密闭空间的壁面,从而从大致密闭空间的周边方向均匀地加热该大致密闭空间。(The present invention provides a column oven, comprising: a substantially closed space surrounded by a wall surface made of a heat conductive material for accommodating the analytical column; a heater for heating a wall surface made of the heat conductive material; and a heat insulating material surrounding the outside of the wall surface made of the heat conductive material. That is, in the present invention, the space in the column oven in which the analytical column is housed is made into a substantially closed structure surrounded by a heat conductive wall surface, and the wall surface surrounding the substantially closed space is heated by the heater, whereby the substantially closed space is uniformly heated from the peripheral direction of the substantially closed space.)
1. A column oven is characterized by comprising:
a substantially closed space surrounded by a wall surface made of a heat conductive material for accommodating the analytical column;
a heater for heating a wall surface made of the heat conductive material;
and a heat insulating material surrounding the outside of the wall surface made of the heat conductive material.
2. The column oven of claim 1,
the column oven is provided with: an opening/closing cover and a column oven main body having an opening/closing surface opened/closed by the opening/closing cover,
the column oven main body has a recess portion opened on the opening surface side so that the analytical column is fitted into and held in the recess portion from the opening surface side, an inner wall surface of the recess portion is formed of the heat conductive material,
the opening/closing cover includes a heat conductive plate made of the heat conductive material on a surface facing the opening/closing surface of the column oven main body, and when the opening/closing cover closes the opening/closing surface of the column oven main body, the heat conductive plate is in close contact with an edge of the opening made of the heat conductive material of the recess, and the opening is sealed to form the substantially sealed space.
3. The column oven of claim 2,
the analytical column is held by a column holder made of a heat conductive material provided in the recess,
the heat of the heater is directly transferred from the inner wall surface of the recess to the analytical column via the column holder, and the heat of the heater is transferred from the inner wall surface of the recess to the heat conductive plate, thereby heating the analytical column by convection of the heat in the substantially closed space.
4. The column oven according to claim 2 or 3,
the opening/closing cover has an elastic member for biasing the heat conductive plate toward the opening/closing surface.
5. The column oven according to any one of claims 2 to 4,
one end of the opening/closing cover is connected to the column oven main body by a hinge.
Technical Field
The present invention relates to a column oven for adjusting the temperature of an analytical column for a liquid chromatograph.
Background
The liquid chromatography analysis was performed by: the mobile phase is transported through the analysis channel, the sample injected into the analysis channel is transported to the analysis column and separated, and the component separated by the analysis column is detected by the detector. An analytical column for separating a sample is generally an analytical column in which a filler is packed in a capillary. Since the separation ability of the analytical column is temperature-dependent, if the temperature of the analytical column varies, the retention time of the sample component varies, and the reproducibility of the analysis result deteriorates. Therefore, the temperature of the analytical column is adjusted by housing the analytical column in a temperature adjusting device called a column oven.
The column oven comprises: the temperature of the analytical column is adjusted by holding the analytical column by a heat-conductive heating block in a space surrounded by a heat insulating material, and by heating the heating block to transfer heat from the heating block to the analytical column (see patent document 1).
Disclosure of Invention
Technical problem to be solved by the invention
However, the column oven is provided with an opening/closing cover. The arrangement of the analytical column in the column oven requires the following operations: the open-close cover of the column oven is opened, the analytical column is held by the heating block in the column oven main body, and the open-close cover is closed after the pipelines connected to the automatic sample injector and the detector are connected to the two ends of the analytical column. In such an operation, since it is particularly troublesome to connect the line to the analytical column provided in the column oven, it has also been proposed to provide a mechanism for facilitating the attachment and detachment of the line to and from the analytical column in the column oven.
In order to provide such a mechanism in the column oven, a certain degree of space needs to be present in the column oven. However, the space inside the column oven that is opened and closed by the opening and closing cover is not originally a sufficiently sealed space. If the space in the column oven is enlarged in this manner, the temperature of the space in the column oven becomes less likely to follow the temperature of the heating block, and it becomes difficult to uniformly and accurately control the temperature of the analytical column.
Therefore, an object of the present invention is to uniformly and accurately control the temperature of an analytical column even if the internal structure of a column oven is improved and the internal space is enlarged.
Means for solving the technical problem
The column oven of the present invention comprises: a substantially closed space surrounded by a wall surface made of a heat conductive material for accommodating the analytical column; a heater for heating a wall surface made of the heat conductive material; and a heat insulating material surrounding the outside of the wall surface made of the heat conductive material. That is, in the present invention, the space in the column oven in which the analytical column is housed is made into a substantially closed structure surrounded by a heat conductive wall surface, and the wall surface surrounding the substantially closed space is heated by the heater, whereby the heating is performed uniformly from the peripheral direction of the substantially closed space.
In a preferred embodiment, the column oven includes: an opening and closing cover; and a column oven main body having an opening/closing surface opened/closed by the opening/closing cover. In this case, the column oven body has a recess that is open on the opening surface side so that the analysis column is fitted into and held in the recess from the opening surface side, an inner wall surface of the recess is made of the heat conductive material, the opening/closing cover includes a heat conductive plate made of the heat conductive material on a surface facing the opening/closing surface of the column oven body, and when the opening/closing cover closes the opening/closing surface of the column oven body, the heat conductive plate is in close contact with an edge of the opening made of the heat conductive material of the recess, and the opening is sealed to form the substantially closed space.
In a further preferred embodiment, the structure is: the analytical column is held by a column holder made of a heat conductive material provided in the recess, heat of the heater is directly transferred from an inner wall surface of the recess to the analytical column via the column holder, and heat of the heater is transferred from the inner wall surface of the recess to the heat conductive plate, so that the analytical column is heated by heat convection in the substantially closed space.
In this case, the opening/closing cover preferably has an elastic member for biasing the heat conductive plate toward the opening/closing surface. As a result, the heat-conducting plate can be pressed against the edge of the opening of the recess of the column oven main body, and the substantially closed space formed by the recess and the heat-conducting plate can be improved in airtightness, so that the responsiveness to temperature control in the substantially closed space is improved.
One end of the opening/closing cover may be coupled to the column oven main body by a hinge. Thus, the opening/closing cover does not come off from the column oven main body, and the opening/closing cover is easy to handle when the analytical column is attached to and detached from the column oven.
Effects of the invention
In the column oven of the present invention, the space in the column oven in which the analytical column is housed is made into a substantially closed structure surrounded by a heat-conductive wall surface, and the wall surface surrounding the substantially closed space is heated by the heater, so that the heat from the heater is uniformly transferred to the entire substantially closed space, and therefore, the responsiveness of temperature control of the space in which the analytical column is housed is improved. This enables accurate and uniform control of the temperature of the analytical column.
Drawings
Fig. 1 is a perspective view showing a state in which an opening/closing cover of a column oven according to an embodiment is opened.
Fig. 2 is a sectional view showing an internal structure of the column oven of this embodiment in a state where the opening/closing lid is closed.
Detailed Description
An embodiment of the column oven of the present invention will be described below with reference to fig. 1 and 2.
As shown in fig. 1, the
The column oven
A heat
As shown in fig. 2, when the opening/
The
A
Further, the surface portion of the opening/
The
Although not shown in fig. 1 and 2, a temperature sensor is attached to any one of the
Description of the reference numerals
2 column incubator
4 column incubator main body
4a opening and closing surface
6 opening and closing cover
8 hinge
10 recess
12 analytical column
14 column frame
16 heat conducting block
18 heat conducting plate
20 Heat insulation board
22 Heat insulation block
24 heater
The block is held 26.
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