阅读说明：本技术 方法和医疗用途 (Method and medical use ) 是由 莱斯利-安·马丁 乔安娜·尼基托罗维奇-布尼亚克 于 2018-06-19 设计创作，主要内容包括：本文描述的发明提供了一种用于治疗有相应需要的受试者中的雌激素受体阳性乳腺癌的方法,该方法包括向所述受试者施用治疗有效量的MPS1抑制剂,其中：(i)所述受试者先前已经用内分泌疗法治疗；和/或(ii)所述乳腺癌对内分泌疗法耐受。(The invention described herein provides a method for treating estrogen receptor positive breast cancer in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of an MPS1 inhibitor, wherein: (i) the subject has been previously treated with endocrine therapy; and/or (ii) the breast cancer is resistant to endocrine therapy.)