阅读说明：本技术 一种促进烧伤皮肤愈合的药物 (Medicine for promoting healing of burned skin ) 是由 满汉云 满意 满孜孜 于 2019-12-07 设计创作，主要内容包括：本发明公开了一种促进烧伤皮肤愈合的药物,本发明以博落回生物总碱为主要提取物,辅以医学上常用的小分子硅酮成膜剂、组合而成博落回生物总碱凝胶剂。现代中药生产方法制备皮肤促进剂,能迅速止痒消炎止痛,改善局部血液循环和新陈代谢,增强白细胞吞噬能力,促进炎性渗出物的吸收和消遗,迅速改善局部血液循环,适用于因皮肤烧伤引起的剧烈疼痛,防止疤痕增殖,减轻患者疼苦,早日康复。皮肤促进剂尽快愈合,配方简单易于批量生产。(The invention discloses a medicine for promoting the healing of burned skin, which is a macleaya cordata total alkaloid gel prepared by using macleaya cordata total alkaloid as a main extract and assisting with a medically common small-molecule silicone film-forming agent. The skin promoter prepared by the modern Chinese medicine production method can quickly relieve itching, diminish inflammation, relieve pain, improve local blood circulation and metabolism, enhance phagocytic capacity of white blood cells, promote absorption and elimination of inflammatory exudates, and quickly improve local blood circulation, is suitable for severe pain caused by skin burn, prevents scar proliferation, relieves pain of patients, and recovers early. The skin promoter can heal as soon as possible, and has simple formula and easy batch production.)

1. A medicine for promoting the healing of burned skin is characterized by comprising 8-10 parts by weight of macleaya cordata alkaloid; 2-10 parts of gel; 8-25 parts of a humectant; 2-10 parts of methyl glycine; 6-12 parts of antioxidant; 20-30 parts of lubricant.

2. A medicament for promoting the healing of burned skin as in claim 1 wherein the gelling agent is a small molecule silicone having a molecular weight of less than 2000.

3. The medicament for promoting healing of burned skin according to claim 1, wherein the humectant is medical glycerin and the medical glycerin is 8 to 20 parts by weight.

4. The medicament for promoting healing of burned skin according to claim 1, wherein the broad spectrum preservative is methylglycine.

5. A medicament for promoting the healing of burned skin according to claim wherein the antioxidant is medicinal tea oil.

6. The medicament for promoting healing of burned skin according to claim, wherein the lubricant is white vaseline for medical use 20-30 parts by weight.

7. The medicament for promoting healing of burned skin according to claim 1, wherein the medicament is an ointment.

8. The medicament for promoting healing of burned skin of claim 1 wherein the macleaya cordata alkaloid is protopine.

9. The medicament for promoting healing of burned skin according to claim 6, wherein the protopine is extracted by the following method:

ultrasonically extracting 50g of macleaya cordata total alkaloids by using 90% ethanol 9 times the amount of the macleaya cordata for 30-60 minutes, filtering by using a 0.25 organic microporous membrane, recovering ethanol by ultrafiltration until the ethanol in the solution is free from ethanol, diluting the concentrated solution to 0.8-12 ug/mL by using pure clean water, adsorbing and enriching free form biological protopine in an alkaline silica gel column, soaking in 0.2% sodium hydroxide aqueous solution for 30 minutes, cleaning with ultrapure water until the pH is neutral, soaking in 0.2 hydrochloric acid aqueous solution for 30 minutes, cleaning with ultrapure water until the pH is neutral, taking a chloroform-methanol system as eluent, desorbing according to a methanol-chloroform volume ratio of 200:1, drying in vacuum at a temperature of <40 ℃ to obtain a crude protopine product, heating and dissolving the eluent, filtering while hot, carrying out vacuum filtration, concentrating under reduced pressure and suction filtration, standing, recrystallizing methanol, filtering to obtain crystals, and drying at a temperature of <.

Technical Field

The invention relates to the field of medicines, in particular to a medicine for promoting burn skin healing.

Background

Burn mainly refers to scald caused by hot water vapor, flame burn, arc burn, explosion burn, chemical burn, etc. Various diseases and disasters are frequently encountered in life, burn is a common one, the burn refers to a phenomenon that skin is changed when being contacted with high temperature or high-intensity radiation, different burn degrees are different from each other for the expressed symptoms, the higher the burn degree is, after a patient who is more concerned about life and is in danger is burned, the wound is not easy to heal, painful and itchy due to different age, individual difference, burn area size and wound depth, the leukocyte phagocytic capacity is poor, the absorption and dissipation of medicines are not easy, and the pain is severe. Skin may have different degrees of pigmentation and scar proliferation after the wound surface is healed. The macleaya cordata extract protopine has local anesthetic effect, the sulfate of the macleaya cordata extract protopine has equivalent efficacy with hydrochloride procaine, and can paralyze sensory nerve endings for local external application to eliminate touch and pain Zhe, so that the pain can be quickly relieved, local blood circulation and metabolism can be quickly improved, the phagocytic capacity of white cells can be enhanced, and the absorption and the disappearance of inflammatory exudates can be promoted. It is indicated for severe pain.

Macleaya cordata (Willd.) r.br.), also known as ramose pith, paulownia stem, bolenia, sanda mazao, yellow mint, yellow boyer, sanqian, fructus cannabis, and boehmeria herb, is a perennial high herb of Macleaya genus of papaveraceae family, and has a long history in China for treating scabies, furunculosis, killing worms, etc. The earliest recorded herbal literature of macleaya cordata is 'herbal Shi Yi'. The macleaya cordata is uniformly named and widely used as raw materials of medicines, biological pesticides, veterinary drugs for veterinary medicine and fine chemical products.

The alkaloid components of macleaya cordata include Sanguinarine (Sanguinarine), chelerythrine (chelerythrine), protopine (protopine), alpha-Allocryptopine (alpha-Allocryptopine) and beta-Allocryptopine (beta-Allocrytopine). The effective chemical components of macleaya cordata mainly comprise sanguinarine and chelerythrine, and the content of the effective chemical components in the macleaya cordata is the highest. Macleaya cordata is a perennial herb. The stem is up to 2 meters. The leaves are round and heart-shaped, the edge lines are split, the split pieces have thick teeth, the back surfaces of the leaves are white, and the leaves often have short hairs; branching a plurality of small flowers from the stem top in summer, and arranging the small flowers into a big cone inflorescence; sepals 2, white sometimes with red color, no petals, most stamens and 1 pistil; prolate capsule after blossom. The dry root, stem and leaf of macleaya cordata are ground into powder for curing burn in China, but the main effective cost is uncertain, so the curing efficiency is not high, and other impurities in macleaya cordata easily cause symptoms such as allergy in the medication process.

Disclosure of Invention

The invention aims to overcome the defects of the prior art, and the macleaya cordata total alkaloid gel is prepared by taking macleaya cordata total alkaloid as a main extract and assisting a small molecular silicone film-forming agent commonly used in medicine. The skin promoter prepared by the modern Chinese medicine production method can quickly relieve itching, diminish inflammation, relieve pain, improve local blood circulation and metabolism, enhance phagocytic capacity of white blood cells, promote absorption and elimination of inflammatory exudates, and quickly improve local blood circulation, is suitable for severe pain caused by skin burn, prevents scar proliferation, relieves pain of patients, and recovers early. The skin promoter can heal as soon as possible, and has simple formula and easy batch production.

In order to achieve the purpose, the technical scheme adopted by the invention is as follows:

a medicine for promoting healing of burn skin comprises Macleaya cordata alkaloid 8-10 weight parts; 2-10 parts of gel; 8-25 parts of a humectant; 2-10 parts of methyl glycine; 6-12 parts of antioxidant; 20-30 parts of lubricant.

In a further improvement, the gelling agent is small molecule silicone, and the molecular weight of the small molecule silicone is less than 2000.

In a further improvement, the humectant is medical glycerin and the weight part of the medical glycerin is 8-20.

In a further improvement, the broad spectrum preservative is methylglycine.

In a further improvement, the antioxidant is medicinal tea oil.

In a further improvement, the lubricant is medical white vaseline 20-30 parts by weight.

In a further improvement, the medicine is an ointment.

In a further improvement, the macleaya cordata alkaloid is protopine.

In a further improvement, the extraction method of the protopine comprises the following steps:

ultrasonically extracting 50g of macleaya cordata total alkaloids by using 90% ethanol 9 times the amount of the macleaya cordata for 30-60 minutes, filtering by using a 0.25 organic microporous membrane, recovering ethanol by ultrafiltration until the ethanol in the solution is free from ethanol, diluting the concentrated solution to 0.8-12 ug/mL by using pure clean water, adsorbing and enriching free form biological protopine in an alkaline silica gel column, soaking in 0.2% sodium hydroxide aqueous solution for 30 minutes, cleaning with ultrapure water until the pH is neutral, soaking in 0.2 hydrochloric acid aqueous solution for 30 minutes, cleaning with ultrapure water until the pH is neutral, taking a chloroform-methanol system as eluent, desorbing according to a methanol-chloroform volume ratio of 200:1, drying in vacuum at a temperature of <40 ℃ to obtain a crude protopine product, heating and dissolving the eluent, filtering while hot, carrying out vacuum filtration, concentrating under reduced pressure and suction filtration, standing, recrystallizing methanol, filtering to obtain crystals, and drying at a temperature of <.

Detailed Description