阅读说明：本技术 一种壳寡糖与姜黄素的复合物及应用 (Chitosan oligosaccharide and curcumin compound and application thereof ) 是由 郭占勇 秦荣基 谭文强 秦荣珍 董方 姜峰 于 2019-12-04 设计创作，主要内容包括：本发明涉及功能食品及医药行业,具体是一种壳寡糖与姜黄素的复合物及应用。壳寡糖与姜黄素的质量比为1:9-9:1；其中,壳寡糖分子量为1000-8000。本发明把壳寡糖增强免疫功能、改善肝脏和心肺功能等作用与姜黄素抗肿瘤、保肝利胆的功效相互结合,并对肝癌和肺癌细胞具有一定的协同增效的抑制作用,是一种有助于增强免疫功能、抗肿瘤、抗肝纤维化等的功能性食品复合物。壳寡糖与姜黄素都可以作为食品或者食品添加剂使用,易于推广,可以广泛应用于功能食品及医药领域。(The invention relates to the functional food and medicine industries, in particular to a compound of chitosan oligosaccharide and curcumin and application thereof. The mass ratio of the chitosan oligosaccharide to the curcumin is 1:9-9: 1; wherein the molecular weight of the chitosan oligosaccharide is 1000-8000. The chitosan oligosaccharide-containing functional food compound combines the functions of enhancing the immune function, improving the liver and the heart and lung functions and the like with the functions of resisting tumor, protecting the liver and benefiting the gallbladder of curcumin, has a certain synergistic inhibition effect on liver cancer cells and lung cancer cells, and is a functional food compound which is beneficial to enhancing the immune function, resisting tumor, resisting hepatic fibrosis and the like. The chitosan oligosaccharide and the curcumin can be used as food or food additives, are easy to popularize and can be widely applied to the fields of functional foods and medicines.)

1. A compound of chitosan oligosaccharide and curcumin is characterized in that: the mass ratio of the chitosan oligosaccharide to the curcumin is 1:9-9: 1; wherein the molecular weight of the chitosan oligosaccharide is 1000-8000.

2. The complex of chitosan oligosaccharide and curcumin as claimed in claim 1, wherein: the mass ratio of the chitosan oligosaccharide to the curcumin is 4:6-5: 5.

3. The complex of chitosan oligosaccharide and curcumin as claimed in claim 1, wherein: the mass ratio of the chitosan oligosaccharide to the curcumin is 3:7-4: 6.

4. Use of a complex of chitosan oligosaccharide and curcumin as claimed in claim 1, wherein: the compound of chitosan oligosaccharide and curcumin is applied to preparation of liver cancer or lung cancer cell inhibition.

5. The use of a complex of chitosan oligosaccharide and curcumin as claimed in claim 5, wherein: the application of the compound with the mass ratio of chitosan oligosaccharide to curcumin being 4:6-5:5 in preparation of liver cancer cell inhibition is provided.

6. The use of a complex of chitosan oligosaccharide and curcumin as claimed in claim 5, wherein: the compound with the mass ratio of chitosan oligosaccharide to curcumin being 3:7-4:6 is applied to preparation of lung cancer cell inhibition.

7. Use of a complex of chitosan oligosaccharide and curcumin as claimed in any one of claims 5 to 7, wherein: the inhibitor is capsule, tablet, powder or granule.

Technical Field

The invention relates to the functional food and medicine industries, in particular to a compound of chitosan oligosaccharide and curcumin and application thereof.

Background

Cancer is the second leading cause of death in the world, second only to heart disease. According to the World Health Organization (WHO) report, there are currently about 1409 million new annual cancer cases in the world. The recently updated data shows that two thirds of new cancer cases worldwide are in china. According to the World Health Organization (WHO) statistics, the increase of cases of cancer is most obvious in rural areas in china. The annual cancer mortality rate in china is one quarter of all cancer deaths worldwide. Liver cancer and lung cancer are malignant diseases seriously threatening human life and health, and the onset of the malignant diseases is a complex process of multiple factors and multiple steps and is influenced by dual factors of environment and genes. However, the causes of liver cancer and lung cancer are different, and the main risk factors of primary liver cancer are hepatitis B and hepatitis C, food contamination by aflatoxin, familial genetic factors, drinking water contamination, smoking, drinking and other factors. The main risk factors for lung cancer are viral pneumonia, long-term smoking, atmospheric pollution, occupational and environmental exposure, ionizing radiation, and genetics. The liver cells are invaded by the cancer cells, so that the normal detoxification function of the liver cells can be influenced, the normal metabolism of a human body is influenced, and liver rupture bleeding is easy to occur in liver cancer patients. However, lung cancer refers to the condition that cancer cells invade cells of the lung, affect the normal breathing of people, and cause hemoptysis and even dyspnea. Meanwhile, the treatment process and treatment mode of liver cancer and lung cancer are different due to different pathogenesis, action mode, action target and the like.

Chitosan (chitosan) is mainly an amino-containing polysaccharide obtained by removing part or all acetyl groups from chitin extracted from marine aquatic waste such as shrimp and crab shells, and is a covalent polymer formed by connecting D-glucosamine monomers together through β -1, 4-glycosidic bonds, chitosan has a plurality of unique physiological and pharmacological functional properties, such as good biocompatibility, biodegradability and film-forming property, is green and non-toxic, and the like, chitosan is also called chitosan oligosaccharide and chitosan oligosaccharide, is glucosamine oligosaccharide obtained by degrading chitosan through a special biological enzyme technology (reports of chemical degradation and microwave degradation technologies), is a low molecular weight product with good water solubility, large functional effect and high biological activity, has certain bacteriostatic, antioxidant and anticancer activities, has high solubility of chitosan, is easy to dissolve in water, is easy to be absorbed by organisms, can stimulate the number of osmophilic cells, is easy to be utilized, has high biological activity, has a plurality of unique functions of chitosan oligosaccharide such as high solubility, is easy to be absorbed by organisms, is easy to be utilized, is easily absorbed by the organisms, has high biological activity, can stimulate the number of the cells of the chitosan oligosaccharide, can be easily absorbed by the macrophages and can further activate macrophages to activate macrophages, so that the macrophage activation of macrophage and macrophage activation of macrophage, macrophage activation of macrophage, macrophage activation, and macrophage activation of macrophage activation, and cell activation, macrophage activation, and.

Curcumin is a chemical component extracted from rhizomes of some plants in Zingiberaceae and Araceae, is a pigment with diketone which is rare in plant world, and is a diketone compound. Curcumin has wide pharmacological activities of anti-inflammation, antioxidation, lipid regulation, antivirus, anti-infection, anti-tumor, anticoagulation, anti-hepatic fibrosis, anti-atherosclerosis and the like, is possibly related to the activation and expression of transcription factors such as nuclear factor-kB, activin-1 and the like, has no obvious toxic or side effect and has small adverse reaction. Particularly, the curcumin compound plays an anticancer role by inducing differentiation of malignant tumor cells, inducing apoptosis of tumor cells and inhibiting effects on various growth stages of tumors, and has very wide clinical application. Curcumin is one of the natural food pigments with the largest sale amount in the world at present, and is a food additive which is approved by the world health organization, the U.S. food and drug administration and multiple countries. Attracting researchers is that not only is curcumin used as a non-steroidal anti-inflammatory drug, but also the curcumin has chemopreventive properties, and curcumin has wide preventive properties on diseases. In view of the fact that modern medical research finds that the occurrence of a plurality of diseases of human bodies is related to the formation of free radicals and the participation of inflammatory reaction, the anti-oxidation activity and the anti-inflammatory effect of curcumin have attracted extensive attention of scholars at home and abroad.

Disclosure of Invention

The invention aims to provide preparation and application of a compound of chitosan oligosaccharide and curcumin, which is helpful for enhancing immune function and improving liver and heart-lung functions and has a synergistic effect on anticancer activity.

In order to achieve the purpose, the technical scheme adopted by the invention is as follows:

a compound of chitosan oligosaccharide and curcumin has a mass ratio of 1:9-9: 1; wherein the molecular weight of the chitosan oligosaccharide is 1000-8000.

The mass ratio of the chitosan oligosaccharide to the curcumin is 4:6-5: 5.

The mass ratio of the chitosan oligosaccharide to the curcumin is 3:7-4: 6.

An application of a compound of chitosan oligosaccharide and curcumin in preparation of liver cancer or lung cancer cell inhibition.

The application of the compound with the mass ratio of chitosan oligosaccharide to curcumin being 4:6-5:5 in preparation of liver cancer cell inhibition is provided.

The compound with the mass ratio of chitosan oligosaccharide to curcumin being 3:7-4:6 is applied to preparation of lung cancer cell inhibition.

The inhibitor is capsule, tablet, powder or granule.

The invention has the advantages that:

(1) according to the invention, chitosan oligosaccharide with the functions of enhancing the immunity and improving the liver and heart and lung functions and curcumin with the effects of resisting tumor, protecting liver and benefiting gallbladder are combined with each other, so that canceration can be prevented by enhancing the immunity, early liver cancer and lung cancer can be treated, and the prevention and treatment of related diseases of consumer groups are facilitated;

(2) the chitosan oligosaccharide and the curcumin both have certain anticancer activity, can effectively inhibit the growth of cancer cells, and are beneficial to preventing the occurrence or recurrence of tumor cells, and the compound product of the chitosan oligosaccharide and the curcumin has a synergistic effect.

(3) Both chitosan oligosaccharide and curcumin belong to food or food additives and have good foundation for medical food development.

Detailed Description

The following examples are further illustrative of the present invention, but the present invention is not limited to the compositions and uses of the present embodiments.