阅读说明：本技术 一种适用于肥胖人群高效降脂补钙的制剂 (Preparation suitable for obese people to efficiently reduce blood fat and supplement calcium ) 是由 王宝维 刘亚楠 谢玉娥 葛文华 张名爱 岳斌 于 2019-09-27 设计创作，主要内容包括：本发明提供了一种适用于肥胖人群高效降脂补钙的制剂,即使用鸭油甘油二酯、维生素D和纳米级葡萄糖酸钙组合物用于降脂、提高钙利用率预防骨质疏松；从而弥补现有药物对身体伤害较大、单一效果差的不足。本发明的制剂对肥胖大鼠具有降低体重和体脂比、降低甘油三酯、胆固醇和低密度脂蛋白水平,提高高密度脂蛋白水平,增加血液中25羟基维生素D<Sub>3</Sub>的含量,降低骨源性碱性磷酸酶以增加骨质的钙盐沉积,提高骨密度和骨强度；增加肥胖大鼠对钙的利用率。有望开发一种新型高效的降脂补钙缓解骨质疏松的保健品。(The invention provides a preparation suitable for fat people to efficiently reduce blood fat and supplement calcium, which is used for reducing blood fat and improving the utilization rate of calcium to prevent osteoporosis by using a duck oil diglyceride, vitamin D and nano-scale calcium gluconate composition; thereby making up the defects of large damage to the body and poor single effect of the existing medicines. The preparation of the invention has the functions of reducing the body weight and body fat ratio, reducing the levels of triglyceride, cholesterol and low-density lipoprotein, increasing the levels of high-density lipoprotein and increasing the levels of fat in obese ratsAdding 25 hydroxy vitamin D in blood 3 Reducing bone-derived alkaline phosphatase to increase calcium salt deposition of bone, increasing bone density and bone strength; increasing the utilization rate of calcium in obese rats. Is expected to develop a novel high-efficiency health care product for reducing blood fat, supplementing calcium and relieving osteoporosis.)

1. A composition is characterized by comprising duck oil diglyceride, vitamin D and nano calcium gluconate.

2. The composition of claim 1, wherein the mass ratio of the diglyceride of duck oil to the VD to the nano-sized calcium gluconate is 1: 1.5 to 3.0 x 10^-6：0.18。

3. Use of the composition of claim 1 or 2 for preparing a preparation for highly effective lipid-lowering and calcium-supplementing for obese people.

4. A highly effective lipid-lowering calcium-supplementing preparation for obese people, which is prepared from the composition of claim 1 or 2.

5. The preparation of claim 4, wherein the preparation is prepared by dissolving the diglyceride of duck oil at a temperature of 25-40 deg.C; according to the mass ratio of the duck oil diglyceride to VD to the nano-scale calcium gluconate of 1: 1.5 to 3.0 x 10^-6: 0.18 mixing the three components, stirring for 0.5-2 min, adding a carrier in a proper proportion, diluting, stirring uniformly, subpackaging by adopting medical capsules, sterilizing and bottling to finish the preparation.

Technical Field

The invention belongs to the technical field of nutrition and health care, and particularly relates to a product which is suitable for fat people to efficiently reduce blood fat and supplement calcium, namely a composition prepared from duck oil diglyceride, Vitamin D (VD) and nano-scale calcium gluconate; is used for increasing vitamin D absorption, reducing blood lipid and improving calcium utilization rate, thereby playing a role in preventing and relieving osteoporosis caused by obesity. Thereby relieving obesity and induced osteoporosis complications

Background

By 2016, 19 billion adults are overweight globally, with 6.5 billion people obese, more than 3.4 billion children and adolescents being overweight or obese according to World Health Organization (WHO) statistics. Obesity also causes many other complications, and obesity is closely related to the occurrence of osteoporosis. Because the vitamin D level in the body of the obese people is low, the diseases such as osteoporosis and the like are easily caused. At present, a plurality of weight-reducing medicines appear in the market, such as sibutramine capable of suppressing appetite, orlistat capable of blocking lipid absorption and other medicines, and long-term administration can cause insufficient absorption of fat-soluble vitamins required in a body to cause endocrine dyscrasia and cause various damages to the body. Therefore, the research of the novel preparation for reducing blood fat and supplementing calcium has important clinical significance for relieving obesity and induced osteoporosis complications.

Obese people have high blood fat, poor lipid metabolism and lower in vivo vitamin D level than normal people, but the obese people also need to supplement vitamin D to supplement insufficient in vivo vitamin D level and relieve obesity-caused complication, namely osteoporosis. Currently, vitamin D formulations are single in form, either by dissolving vitamin D in oil or by combining vitamin D with calcium to act as a facilitator for both. Calcium carbonate commonly used in calcium preparations in the market is inorganic calcium, and is not easy to dissolve, digest and absorb.

Disclosure of Invention

The invention provides a preparation suitable for fat people to efficiently reduce blood fat and supplement calcium, which is used for reducing blood fat and improving the utilization rate of calcium to prevent osteoporosis by using a duck oil diglyceride, vitamin D and nano-scale calcium gluconate composition; thereby making up the defects of large damage to the body and poor single effect of the existing medicines.

The invention firstly provides a composition, which comprises duck oil diglyceride, Vitamin D (VD) and nano calcium gluconate;

the mass ratio (g) of the duck oil diglyceride to the VD to the nano-scale calcium gluconate is 1: 1.5 to 3.0 x 10^-6：0.18；

The composition is used for preparing a preparation for efficiently reducing blood fat and supplementing calcium for obese people.

The invention also provides a high-efficiency lipid-lowering calcium-supplementing preparation for obese people, which is prepared by using the composition;

the specific preparation method comprises the steps of dissolving the diglyceride of the duck oil, and adjusting the temperature to be 25-40 ℃; according to the mass ratio (g) of the duck oil diglyceride to the VD to the nano-scale calcium gluconate of 1: 1.5 to 3.0 x 10^-6: 0.18 of; mixing the three components, stirring for 0.5-2 min, adding a carrier in a proper proportion for dilution, uniformly stirring, subpackaging by adopting medical capsules, sterilizing and bottling to finish the preparation.

The preparation of the invention has the effects of reducing weight and body fat ratio, reducing triglyceride, cholesterol and low-density lipoprotein level, increasing high-density lipoprotein level and increasing 25-hydroxy vitamin D in blood of obese rats₃Reducing bone-derived alkaline phosphatase to increase calcium salt deposition of bone, increasing bone density and bone strength; increasing the utilization rate of calcium in obese rats. Is expected to develop a novel high-efficiency health care product for reducing blood fat, supplementing calcium and relieving osteoporosis.

Detailed Description

In order to reduce the possibility of blood fat increase and promote the absorption of vitamin D caused by eating unnecessary triglyceride due to the supplement of a vitamin D preparation, the duck oil diglyceride with the functions of reducing fat and losing weight is added to replace triglyceride to dissolve the vitamin D and is compounded with the nano-scale calcium gluconate to prepare the preparation, so that the effects of supplementing the vitamin D, reducing fat and losing weight and relieving osteoporosis complications are achieved.

The present invention will be described in detail with reference to examples.