阅读说明：本技术 一种壳聚糖米诺地尔生发凝露及其制备方法 (chitosan minoxidil hair-growing gel and preparation method thereof ) 是由 贾承政 杨苗蕾 于 2019-09-25 设计创作，主要内容包括：本发明提供了一种壳聚糖米诺地尔生发凝露,包括：米诺地尔、去离子水、润肤剂、杀菌抑菌剂、pH调节剂以及助剂,其中,杀菌抑菌剂包括壳聚糖、变性乙醇和柠檬酸钠,润肤剂包括丙二醇、乙二醇、甘油和双丙甘醇,pH调节剂为三乙醇胺,助剂包括卡波姆、丙烯酰二甲基牛磺酸铵/VP共聚物、香茅醇和精油,米诺地尔、甘油、乙二醇、丙二醇、壳聚糖、双丙甘醇、卡波姆、丙烯酰二甲基牛磺酸铵/VP共聚物、三乙醇胺、柠檬酸钠、精油、变性乙醇、香茅醇和去离子水的质量比例是：0.1-10：1-5：1-5：0.1-1：0.1-1：0.1-1：0.1-1：0.1-1：0.1-1：0.1-1：0.1-1：0.1-1：0.1-1：30-40。本发明还提供了一种壳聚糖米诺地尔生发凝露的制备方法来制备壳聚糖米诺地尔生发凝露。(The invention provides a chitosan minoxidil hair-growing gel, which comprises the following components: the disinfectant comprises minoxidil, deionized water, an emollient, a bactericidal bacteriostatic agent, a pH regulator and an auxiliary agent, wherein the bactericidal bacteriostatic agent comprises chitosan, denatured ethanol and sodium citrate, the emollient comprises propylene glycol, ethylene glycol, glycerol and dipropylene glycol, the pH regulator is triethanolamine, the auxiliary agent comprises carbomer, acryloyl dimethyl ammonium taurate/VP copolymer, citronellol and essential oil, and the mass ratio of minoxidil, glycerol, ethylene glycol, propylene glycol, chitosan, dipropylene glycol, carbomer, acryloyl dimethyl ammonium taurate/VP copolymer, triethanolamine, sodium citrate, essential oil, denatured ethanol, citronellol and deionized water is as follows: 0.1-10: 1-5: 1-5: 0.1-1: 0.1-1: 0.1-1: 0.1-1: 0.1-1: 0.1-1: 0.1-1: 0.1-1: 0.1-1: 0.1-1: 30-40. The invention also provides a preparation method of the chitosan minoxidil hair-growing gel.)

1. The chitosan minoxidil hair-growing gel is characterized by comprising the following components:

Minoxidil, deionized water, an emollient, a bactericidal bacteriostatic agent, a pH regulator and an auxiliary agent,

Wherein the bactericidal bacteriostatic agent comprises chitosan, denatured ethanol and sodium citrate,

The emollient includes propylene glycol, ethylene glycol, glycerin and dipropylene glycol,

The pH regulator is triethanolamine and is used as a pH regulator,

The auxiliary agent comprises carbomer, acryloyl dimethyl ammonium taurate/VP copolymer, citronellol and essential oil,

The mass ratio of said minoxidil, said glycerol, said ethylene glycol, said propylene glycol, said chitosan, said dipropylene glycol, said carbomer, said ammonium acryloyldimethyl taurate/VP copolymer, said triethanolamine, said sodium citrate, said essential oil, said denatured ethanol, said citronellol, and said deionized water is: 0.1-10: 1-5: 1-5: 0.1-1: 0.1-1: 0.1-1: 0.1-1: 0.1-1: 0.1-1: 0.1-1: 0.1-1: 0.1-1: 0.1-1: 30-40.

2. A method for preparing the chitosan minoxidil hair-growing gel according to claim 1, which comprises the following steps:

Step 1, adding the minoxidil, the glycerol, the ethylene glycol, the propylene glycol, the chitosan, the dipropylene glycol, the triethanolamine, the sodium citrate, the essential oil and the citronellol into the deionized water in proportion to obtain a mixed solution I;

Step 2, uniformly stirring the mixed solution I at the temperature of 40-60 ℃, and then cooling to a specified temperature to obtain a mixed solution II;

step 3, adding the carbomer, the acryloyl dimethyl ammonium taurate/VP copolymer and the denatured ethanol into the mixed solution II to obtain a primary product;

And 4, adding the triethanolamine into the primary product until the pH value of the primary product is 7, and then cooling to room temperature to obtain a finished product.

3. The method for preparing the chitosan minoxidil hair-growing gel according to claim 2, which is characterized in that:

Wherein the predetermined temperature in step 2 is 35 ℃.

Technical Field

The invention belongs to the technical field of biological medicines, and particularly relates to chitosan minoxidil hair-growing gel and a preparation method thereof.

background

Alopecia is a common skin disease. With the development of society and the acceleration of life rhythm, the pressure in all aspects makes the alopecia crowd gradually increase, and in the prior art, the common treatment means for alopecia is to smear external medicines which have certain irritation and have no good antibacterial and bactericidal functions, and the improvement of scalp environment by inhibiting the reproduction of dermatophytes plays an important role in helping hair growth.

Disclosure of Invention

the present invention has been made to solve the above problems, and an object of the present invention is to provide a chitosan minoxidil hair growth lotion.

the invention provides a chitosan minoxidil hair-growing gel, which is characterized by comprising the following components: the disinfectant comprises minoxidil, deionized water, an emollient, a bactericidal bacteriostatic agent, a pH regulator and an auxiliary agent, wherein the bactericidal bacteriostatic agent comprises chitosan, denatured ethanol and sodium citrate, the emollient comprises propylene glycol, ethylene glycol, glycerol and dipropylene glycol, the pH regulator is triethanolamine, the auxiliary agent comprises carbomer, acryloyl dimethyl ammonium taurate/VP copolymer, citronellol and essential oil, and the mass ratio of minoxidil, glycerol, ethylene glycol, propylene glycol, chitosan, dipropylene glycol, carbomer, acryloyl dimethyl ammonium taurate/VP copolymer, triethanolamine, sodium citrate, essential oil, denatured ethanol, citronellol and deionized water is as follows: 0.1-10: 1-5: 1-5: 0.1-1: 0.1-1: 0.1-1: 0.1-1: 0.1-1: 0.1-1: 0.1-1: 0.1-1: 0.1-1: 0.1-1: 30-40.

The invention also provides a preparation method of the chitosan minoxidil hair-growing gel, which is characterized by comprising the following steps: step 1, adding minoxidil, glycerol, ethylene glycol, propylene glycol, chitosan, dipropylene glycol, triethanolamine, sodium citrate, essential oil and citronellol into deionized water according to a proportion to obtain a mixed solution I;

Step 2, uniformly stirring the mixed solution I at the temperature of 40-60 ℃, and then cooling to a specified temperature to obtain a mixed solution II;

step 3, adding carbomer, acryloyl dimethyl ammonium taurate/VP copolymer and denatured ethanol into the mixed solution II to obtain a primary product;

And 4, adding triethanolamine into the primary product until the pH value of the primary product is 7, and then cooling to room temperature to obtain a finished product.

The invention also provides a preparation method of the chitosan minoxidil hair-growing gel, which is also characterized in that the specified temperature in the step 2 is 35 ℃.

action and Effect of the invention

according to the chitosan minoxidil hair-growing gel, the sterilization bacteriostat formed by mixing the chitosan, the denatured ethanol and the sodium citrate has stronger antibacterial and bactericidal capability and good antibacterial effect on head skin, and meanwhile, the chitosan minoxidil hair-growing gel also contains the minoxidil which can promote venous reflux and has better effect on treating androgenetic alopecia, alopecia areata and alopecia totalis. Therefore, the chitosan minoxidil hair-growing gel disclosed by the invention can inhibit hair loss and effectively grow hair, can realize effective bacteriostasis, has no stimulation to skin and hair, and is safer and healthier to use.

Drawings

Fig. 1 is a flow chart of a preparation method of chitosan minoxidil hair-growth condensation cream in an embodiment of the present invention.

Detailed Description

in order to make the technical means and functions of the present invention easy to understand, the present invention is specifically described below with reference to the embodiments and the accompanying drawings.

The embodiment provides a chitosan minoxidil hair-growing gel, which comprises: minoxidil, deionized water, an emollient, a bactericidal bacteriostatic agent, a pH regulator and an auxiliary agent.

Minoxidil is used as potassium ion channel opener in clinic, can directly relax vascular smooth muscle, has strong arteriolar expansion effect, reduces peripheral resistance and blood pressure, has no influence on volumetric blood vessels, can promote venous return, and has better clinical effect on treating androgenetic alopecia, alopecia areata and alopecia totalis.

The antibacterial agent comprises chitosan, denatured ethanol and sodium citrate.

The chitosan has the characteristics of no toxicity, no smell and easy degradation and has good biocompatibility, the chitosan can be used as a carrier of a medicament while killing parasites and inhibiting the activity of bacteria, and has special effects on slow release and anticoagulation.

Emollients include propylene glycol, ethylene glycol, glycerin, and dipropylene glycol.

the pH regulator is triethanolamine.

The auxiliary agent comprises carbomer, acryloyl dimethyl ammonium taurate/VP copolymer, citronellol and essential oil.

The mass ratio of minoxidil, glycerol, ethylene glycol, propylene glycol, chitosan, dipropylene glycol, carbomer, acryloyl dimethyl ammonium taurate/VP copolymer, triethanolamine, sodium citrate, essential oil, denatured ethanol, citronellol and deionized water is as follows: 0.1-10: 1-5: 1-5: 0.1-1: 0.1-1: 0.1-1: 0.1-1: 0.1-1: 0.1-1: 0.1-1: 0.1-1: 0.1-1: 0.1-1: 30-40.

fig. 1 is a flow chart of a preparation method of chitosan minoxidil hair-growth condensation cream in an embodiment of the present invention.

as shown in fig. 1, the embodiment also provides a preparation method of chitosan minoxidil hair-growth condensation cream, which comprises the following steps:

Step 1, adding minoxidil, glycerol, ethylene glycol, propylene glycol, chitosan, dipropylene glycol, triethanolamine, sodium citrate, essential oil and citronellol into deionized water according to a proportion to obtain a mixed solution I.

And 2, uniformly stirring the mixed solution I at the temperature of 40-60 ℃, and then cooling to a specified temperature to obtain a mixed solution II.

The prescribed temperature in step 2 was 35 ℃.

And 3, adding carbomer, acryloyl dimethyl ammonium taurate/VP copolymer and denatured ethanol into the mixed solution II to obtain a primary product.

and 4, adding triethanolamine into the primary product until the pH value of the primary product is 7, and then cooling to room temperature to obtain a finished product.