阅读说明：本技术 一种治疗意识障碍的药物及其制备方法 (Medicine for treating disturbance of consciousness and preparation method thereof ) 是由 王立艳 刘培伟 周萍 高曈 张宇宏 李佳琳 于 2020-12-25 设计创作，主要内容包括：本发明属于药物制备技术领域,具体的说是一种治疗意识障碍的药物及其制备方法,S1：往容器中A加入注射用水,并将处方量胞磷胆碱钠加入,温度保持5-100℃,再加入注射用水制成胞磷胆碱钠浓配液后,用0.1-3mol/L的盐酸或氢氧化钠溶液调pH值,然后加入活性炭,保持温度5-55分钟后利用过滤装置进行过滤脱炭；S2：往容器中B加入注射用水,并且将其加热至5-100℃,然后加入处方量甘露醇,边加热边搅拌至全部溶解,再加入注射用水,温度为5-100℃,按甘露醇溶液总体积的0.3-3‰(w/v)加入活性炭,保持温度5-55分钟后利用过滤装置进行过滤脱炭；降低了pH值和温度对药品的稳定及作用产生的影响,能够提高治疗急性颅脑外伤及脑手术后意识障碍的疗效。(The invention belongs to the technical field of medicine preparation, in particular to a medicine for treating disturbance of consciousness and a preparation method thereof, S1: adding water for injection into the container A, adding the prescription amount of citicoline sodium, keeping the temperature at 5-100 ℃, adding the water for injection to prepare a citicoline sodium concentrated solution, adjusting the pH value with 0.1-3mol/L hydrochloric acid or sodium hydroxide solution, adding activated carbon, keeping the temperature for 5-55 minutes, and filtering and decarburizing by using a filtering device; s2: adding water for injection into the container B, heating the container B to 5-100 ℃, then adding mannitol with a prescription amount, heating and stirring the mixture until the mannitol is completely dissolved, then adding water for injection at the temperature of 5-100 ℃, adding activated carbon according to 0.3-3 per mill (w/v) of the total volume of the mannitol solution, keeping the temperature for 5-55 minutes, and then filtering and decarburizing the mixture by using a filtering device; reduces the influence of pH value and temperature on the stability and action of the medicine, and can improve the curative effect of treating acute craniocerebral trauma and conscious disturbance after brain surgery.)

1. A medicament for treating disturbance of consciousness and a preparation method thereof are characterized in that: the method comprises the following steps:

s1: adding water for injection into the container A, adding the prescription amount of citicoline sodium, keeping the temperature at 5-100 ℃, adding the water for injection to prepare a citicoline sodium concentrated solution, adjusting the pH value with 0.1-3mol/L hydrochloric acid or sodium hydroxide solution, adding activated carbon, keeping the temperature for 5-55 minutes, and filtering and decarburizing by using a filtering device;

s2: adding water for injection into the container B, heating the container B to 5-100 ℃, then adding mannitol with a prescription amount, heating and stirring the mixture until the mannitol is completely dissolved, then adding water for injection at the temperature of 5-100 ℃, adding activated carbon according to 0.3-3 per mill (w/v) of the total volume of the mannitol solution, keeping the temperature for 5-55 minutes, and then filtering and decarburizing the mixture by using a filtering device;

s3: mixing the concentrated solution subjected to carbon removal by filtration in S1 and the mannitol solution in S2, adding water for injection, opening a valve of the water for injection of the concentrated solution tank, flushing a pipeline of the concentrated solution tank with the water for injection to a diluted solution tank, merging a washing solution into a filtrate, issuing an intermediate product inspection report form by a laboratory of the quality assurance department after the intermediate product is qualified, calculating the weight of the water for injection supplement by a preparation group leader according to the content of the intermediate product, filtering by a 0.1-1.0 mu microporous membrane filter, and finally filling.

2. A medicament for treating disturbance of consciousness and its preparation method as claimed in claim 1, wherein: the filtering device comprises a base (1), a box body (2) and a filtering unit (3); the box body (2) is fixedly connected to the top of the base (1); the top of the box body (2) is arranged in an opening manner; the filtering unit (3) is arranged inside the box body (2); the filtering unit (3) comprises a motor (31), a U-shaped rod (32), a first rod (33), a filtering plate (34), a rectangular groove (35) and a filtering screen (36); the motors (31) are symmetrically and fixedly connected to the side wall of the box body (2); the U-shaped rod (32) is fixedly connected to an output shaft of the motor (31); the rectangular groove (35) is fixedly connected with the inner side wall of the box body (2); the filter plate (34) is rotatably connected to the inner side wall of the rectangular groove (35); one end of the first rod (33) is connected to the outer wall of the U-shaped rod (32) through a lantern ring (37), and the other end of the first rod is connected to the filter plate (34) in a ball joint mode; a through groove (38) is formed in the bottom of the rectangular groove (35); the filter screen (36) is fixedly connected with the inner side wall of the through groove (38).

3. A medicament for treating disturbance of consciousness and its preparation method as claimed in claim 2, wherein: a cavity (21) is arranged in the wall body of the box body (2); a vibration mechanism is arranged in the cavity (21); the vibration mechanism comprises a cam (41), a first push plate (42), a second rod (43) and a third rod (44); the cam (41) is fixedly connected with an output shaft of the motor (31); the first push plate (42) is connected to the inner wall of the cavity (21) in a sliding manner; one end of the third rod (44) is hinged to the bottom of the cavity (21), and the other end of the third rod is in contact with the filter screen (36); one end of the second rod (43) is in ball joint with the first push plate (42), and the other end of the second rod is in ball joint with the third rod (44).

4. A medicament for treating disturbance of consciousness and its preparation method as claimed in claim 3, wherein: a scraping mechanism is further arranged inside the cavity (21); the scraping mechanism comprises an L-shaped plate (51), a stacked air bag (52), a piston cylinder (53), a push rod (54), a second push plate (55), a guide rod (56) and a scraper (57); the piston cylinder (53) is fixedly connected to the bottom of the cavity (21); the overlapped air bag (52) is fixedly connected to the top of the piston cylinder (53), and the overlapped air bag (52) is communicated with the overlapped air bag (52) of the piston cylinder (53); the top of the L-shaped plate (51) is fixedly connected to the bottom of the first push plate (42), and the bottom of the L-shaped plate is arranged at the top of the stacked air bag (52); a groove (58) is formed in the inner side wall of the box body (2); the guide rod (56) is fixedly connected with the inner wall of the groove (58); the second push plate (55) is sleeved on the guide rod (56) and is in sliding connection with the guide rod (56); one end of the push rod (54) is fixedly connected to a piston rod of the piston cylinder (53), and the other end of the push rod is fixedly connected to the top of the second push plate (55); the scraping plate (57) is fixedly connected to the side wall of the second push plate (55).

5. A medicament for the treatment of disturbance of consciousness and process for its preparation as claimed in claim 4, wherein: drainage plates (61) are symmetrically and fixedly connected to the bottom of the box body (2); the cross section of the drainage plate (61) is in a right-angled triangle shape; a discharge pipe (62) is fixedly connected to the bottom of the base (1); the top end of the discharge pipe (62) is opened in the box body (2); the top of the base (1) is also fixedly connected with a supporting plate (63); the top of the supporting plate (63) is provided with a funnel (64) in a penetrating way.

6. A medicament for the treatment of disturbance of consciousness and process for its preparation as claimed in claim 5, wherein: an opening of the groove (58) is fixedly connected with an elastic cloth (71); the outer surface of the elastic cloth (71) is fixedly connected with a waterproof membrane (72).

Technical Field

The invention belongs to the technical field of medicine preparation, and particularly relates to a medicine for treating disturbance of consciousness and a preparation method thereof.

Background

Consciousness refers to the confirmation of the external environment, the self condition and the mutual connection of the external environment and the self condition, consciousness activities comprise two aspects of arousal and consciousness content, when the upper reticular activating system and the extensive damage of cerebral cortex can cause the disturbance of different degrees of arousal level, and the change of consciousness content is mainly caused by the pathological changes of cerebral cortex, and the consciousness disturbance seriously influences the life of people, so the medicine is usually adopted in clinic to treat the consciousness disturbance.

Some technical schemes related to consciousness disorder medicines also appear in the prior art, for example, a Chinese patent with the application number of CN200610003127.4 discloses a compound coenzyme Q10 pharmaceutical preparation, a preparation method and application thereof, wherein the compound coenzyme Q10 pharmaceutical preparation is prepared from coenzyme Q10 and citicoline; the product can be used as adjuvant treatment medicine for heart failure, coronary heart disease, hypertension, arrhythmia and conscious disturbance caused by craniocerebral injury, craniocerebral operation and acute cerebral infarction, and is suitable for treating conscious disturbance caused by congestive heart failure, coronary heart disease, hypertension, arrhythmia, craniocerebral injury, craniocerebral operation and acute cerebral infarction, and can be applied to subacute stage and recovery stage of cerebrovascular diseases; however, the preparation method has poor control on the pH value and the temperature, so that the stability of the medicine is reduced and the effect of the medicine is not obvious.

Therefore, the invention provides a medicament for treating disturbance of consciousness and a preparation method thereof.

Disclosure of Invention

In order to make up for the defects of the prior art and solve the problems that the stability of the medicine is reduced and the action effect of the medicine is not obvious because the pH value and the temperature are not controlled in place by the conventional preparation method, the invention provides the medicine for treating the disturbance of consciousness and the preparation method thereof.

The technical scheme adopted by the invention for solving the technical problems is as follows: the invention relates to a medicine for treating disturbance of consciousness and a preparation method thereof, wherein the method comprises the following steps:

s1: adding water for injection into the container A, adding the prescription amount of citicoline sodium, keeping the temperature at 5-100 ℃, adding the water for injection to prepare a citicoline sodium concentrated solution, adjusting the pH value with 0.1-3mol/L hydrochloric acid or sodium hydroxide solution, adding activated carbon, keeping the temperature for 5-55 minutes, and filtering and decarburizing by using a filtering device;

s2: adding water for injection into the container B, heating the container B to 5-100 ℃, then adding mannitol with a prescription amount, heating and stirring the mixture until the mannitol is completely dissolved, then adding water for injection at the temperature of 5-100 ℃, adding activated carbon according to 0.3-3 per mill (w/v) of the total volume of the mannitol solution, keeping the temperature for 5-55 minutes, and then filtering and decarburizing the mixture by using a filtering device;

s3: mixing the concentrated solution subjected to carbon removal by filtration in S1 and the mannitol solution in S2, adding water for injection, opening a valve of the water for injection of the concentrated solution tank, flushing a pipeline of the concentrated solution tank with the water for injection to a diluted solution tank, merging a washing solution into a filtrate, issuing an intermediate product inspection report form by a laboratory of the quality assurance department after the intermediate product is qualified, calculating the weight of the water for injection supplement by a preparation group leader according to the content of the intermediate product, filtering by a 0.1-1.0 mu microporous membrane filter, and finally filling.

Further, the filtering device comprises a base, a box body and a filtering unit; the box body is fixedly connected to the top of the base; the top of the box body is provided with an opening; the filtering unit is arranged inside the box body; the filtering unit comprises a motor, a U-shaped rod, a first rod, a filtering plate, a rectangular groove and a filtering screen; the motors are symmetrically and fixedly connected to the side wall of the box body; the U-shaped rod is fixedly connected to an output shaft of the motor; the rectangular groove is fixedly connected to the inner side wall of the box body; the filter plate is rotatably connected to the inner side wall of the rectangular groove; one end of the first rod is connected to the outer wall of the U-shaped rod through a lantern ring, and the other end of the first rod is connected to the filter plate in a ball joint mode; the bottom of the rectangular groove is provided with a through groove; the filter screen is fixedly connected to the inner side wall of the through groove; the during operation, pour the concentrated liquid of joining in marriage of citicoline sodium into the funnel, the starter motor simultaneously, make the motor drive U-shaped pole and rotate, and the outer wall at the U-shaped pole is passed through the lantern ring connection to the one end of a pole of one number of pole, the other end ball connects in the filter, make the motor through a pole intermittent type nature extrusion filter, because the filter rotates to be connected in the rectangular channel, will make the filter produce the swing, the filter has been avoided the active carbon granule to block up, and then accelerate the filtration of joining in marriage the concentrated liquid of citicoline sodium, and the concentrated liquid of joining in marriage of citicoline sodium after being filtered by the filter will fall into the rectangular channel in, then the inside of filtration entering box through the filter screen, avoid taking place the phenomenon that the active carbon granule falls into the box inside, thereby make the filter effect of joining in marriage the concentrated.

Further, a cavity is arranged in the wall body of the box body; a vibration mechanism is arranged in the cavity; the vibration mechanism comprises a cam, a first push plate, a second rod and a third rod; the cam is fixedly connected to an output shaft of the motor; the first push plate is connected to the inner wall of the cavity in a sliding manner; one end of the third rod is hinged to the bottom of the cavity, and the other end of the third rod is in contact with the filter screen; one end of the second rod is in ball joint with the first push plate, and the other end of the second rod is in ball joint with the third rod; when the motor works, the motor drives the cam on the output shaft of the motor to rotate, so that the cam intermittently extrudes the first push plate, the first push plate further slides downwards along the inner wall of the cavity, the second rod is extruded, the third rod is extruded due to the fact that the second rod is connected with the third rod in a ball-joint mode, and the third rod rotates; and when the push pedal was not extruded to the cam, because No. three pole lateral walls pass through spring coupling in the bottom of cavity, will make No. three poles get back to initial position, and then make No. three poles pat the filter screen to realize the function of vibrations filter screen, be convenient for shake off remaining citicoline sodium concentrated solution of joining in marriage on the filter screen, realize the recovery to citicoline sodium concentrated solution of joining in marriage, and then avoid citicoline sodium concentrated waste of joining in marriage the solution.

Furthermore, a scraping mechanism is arranged inside the cavity; the scraping mechanism comprises an L-shaped plate, a stacked air bag, a piston cylinder, a push rod, a second push plate, a guide rod and a scraper; the piston cylinder is fixedly connected to the bottom of the cavity; the overlapped air bag is fixedly connected to the top of the piston cylinder and is communicated with the overlapped air bag of the piston cylinder; the top of the L-shaped plate is fixedly connected to the bottom of the first push plate, and the bottom of the L-shaped plate is arranged at the top of the stacked air bag; a groove is formed in the inner side wall of the box body; the guide rod is fixedly connected to the inner wall of the groove; the second push plate is sleeved on the guide rod and is in sliding connection with the guide rod; one end of the push rod is fixedly connected to a piston rod of the piston cylinder, and the other end of the push rod is fixedly connected to the top of the second push plate; the scraping plate is fixedly connected to the side wall of the second push plate; the during operation, after the motor drives the cam and rotates, will make the push pedal of cam intermittent type nature extrusion No. one, and then make the L shaped plate downstream of push pedal bottom, thereby make the folded air bag receive the extrusion, the folded air bag is receiving the extrusion back, its inside gas will get into the piston cylinder, and promote the push rod downstream, thereby make push rod extrusion No. two push pedals, so No. two push pedals will be along guide arm downstream, then cooperate the effect of scraper blade, and then scrape and get remaining citicoline sodium concentrated solution of joining in marriage on the box inside wall, these citicoline sodium concentrated solutions will flow to the bottom of box at last because the action of gravity, realize the recovery to citicoline sodium concentrated solution of joining in marriage, and then avoid the waste of citicoline sodium concentrated solution of joining in marriage.

Furthermore, the bottom of the box body is symmetrically and fixedly connected with a drainage plate; the cross section of the drainage plate is in a right-angled triangle shape; a discharge pipe is fixedly connected to the bottom of the base; the top end of the discharge pipe is opened in the box body; the top of the base is also fixedly connected with a supporting plate; the top of the supporting plate is provided with a funnel in a penetrating way; during the work, earlier with the concentrated solution of joining in marriage of citicoline sodium pour into the funnel, these concentrated solutions of joining in marriage of citicoline sodium will be filtered the active carbon granule by the filter unit, when the concentrated solution of joining in marriage of citicoline sodium flows down from the filter screen, partly will fall into row material pipe, another part will fall into the top of drainage plate, on some splashes the inside wall of box in addition, the concentrated solution of joining in marriage of citicoline sodium that falls on the top of drainage plate and the inside wall of box finally can flow along the drainage plate, make the concentrated solution of joining in marriage of citicoline sodium get into arrange the material pipe in, the effect of drainage plate is exactly that the flow of the concentrated solution of joining in marriage of guide citicoline sodium, it gets into row material pipe in.

Furthermore, an opening of the groove is fixedly connected with elastic cloth; the outer surface of the elastic cloth is fixedly connected with a waterproof membrane; during operation, the effect of elastic cloth is exactly that the opening part that makes the recess is in the closed condition always, and the effect of water proof membrane is exactly that the wet elastic cloth of the dense solution of joining in marriage of citicoline sodium is avoided, just so can avoid the dense solution of joining in marriage of citicoline sodium to get into the inside of recess, and then has avoided the waste to the dense solution of joining in marriage of citicoline sodium to the whole result of use of this device has been improved.

The invention has the following beneficial effects:

1. the medicine for treating disturbance of consciousness and the preparation method thereof reduce the influence of pH value and temperature on the stability and action of the medicine, and can improve the curative effect of treating acute craniocerebral trauma and disturbance of consciousness after brain surgery.

2. According to the medicine for treating disturbance of consciousness and the preparation method thereof, the motor, the U-shaped rod, the first rod, the lantern ring, the filter plate, the through groove, the rectangular groove and the filter screen are matched for use, so that the filter plate swings, the situation that activated carbon particles block the filter plate is avoided, further, the filtration of citicoline sodium concentrated solution is accelerated, the situation that the activated carbon particles fall into the box body is avoided due to the use of the rectangular groove and the filter screen, and therefore the filtration effect of the citicoline sodium concentrated solution is better.

Drawings

The invention will be further explained with reference to the drawings.

FIG. 1 is a flow chart of the present invention;

FIG. 2 is a perspective view of the present invention;

FIG. 3 is a partial cross-sectional view of the present invention;

FIG. 4 is an enlarged view of a portion of FIG. 3 at C;

FIG. 5 is an enlarged view of a portion of FIG. 3 at D;

FIG. 6 is an enlarged view of a portion E of FIG. 3;

FIG. 7 is a perspective view of a filter plate according to the present invention;

in the figure: 1. a base; 2. a box body; 21. a cavity; 3. a filtration unit; 31. a motor; 32. a U-shaped rod; 33. a first rod; 34. a filter plate; 35. a rectangular groove; 36. filtering with a screen; 37. a collar; 38. a through groove; 41. a cam; 42. a first push plate; 43. a second rod; 44. a third rod; 51. an L-shaped plate; 52. a stack airbag; 53. a piston cylinder; 54. a push rod; 55. a second push plate; 56. a guide bar; 57. a squeegee; 58. a groove; 61. a drainage plate; 62. a discharge pipe; 63. a support plate; 64. a funnel; 71. an elastic cloth; 72. a water-resistant membrane.

Detailed Description

In order to make the technical means, the creation characteristics, the achievement purposes and the effects of the invention easy to understand, the invention is further described with the specific embodiments.

Example 1:

s1: adding water for injection into the container A, adding the prescription amount of citicoline sodium, keeping the temperature at 5 ℃, adding the water for injection to prepare a citicoline sodium concentrated solution, adjusting the pH value with 0.1mol/L hydrochloric acid or sodium hydroxide solution, adding activated carbon, keeping the temperature for 10 minutes, and filtering and decarburizing by using a filtering device;

s2: adding water for injection into the container B, heating the container B to 5 ℃, then adding mannitol with the amount of the prescription, stirring the mixture while heating until the mannitol is completely dissolved, then adding the water for injection, keeping the temperature at 5 ℃, adding activated carbon according to 0.3 per mill (w/v) of the total volume of the mannitol solution, keeping the temperature for 10 minutes, and then filtering and decarburizing the mixture by using a filtering device;

s3: mixing the concentrated solution subjected to carbon removal by filtration in S1 and the mannitol solution in S2, adding water for injection, opening a valve of the water for injection of the concentrated solution tank, flushing a pipeline of the concentrated solution tank with the water for injection to a diluted solution tank, merging a washing solution into a filtrate, issuing an intermediate product inspection report form by a laboratory of a quality assurance department after the intermediate product is detected to be qualified, calculating the weight of the added water for injection by a preparation group leader according to the content of the intermediate product, filtering by a 0.1 mu microporous membrane filter, and finally filling.

Example 2:

s1: adding water for injection into the container A, adding the prescription amount of citicoline sodium, keeping the temperature at 8 ℃, adding the water for injection to prepare a citicoline sodium concentrated solution, adjusting the pH value with 0.2mol/L hydrochloric acid or sodium hydroxide solution, adding activated carbon, keeping the temperature for 5 minutes, and filtering and decarburizing by using a filtering device;

s2: adding water for injection into the container B, heating the container B to 8 ℃, then adding mannitol with the amount of the prescription, stirring the mixture while heating until the mannitol is completely dissolved, then adding the water for injection, keeping the temperature at 8 ℃, adding activated carbon according to 0.8 per mill (w/v) of the total volume of the mannitol solution, keeping the temperature for 5 minutes, and then filtering and decarburizing the mixture by using a filtering device;

s3: mixing the concentrated solution subjected to carbon removal by filtration in S1 and the mannitol solution in S2, adding water for injection, opening a valve of the water for injection of the concentrated solution tank, flushing a pipeline of the concentrated solution tank with the water for injection to a diluted solution tank, merging a washing solution into a filtrate, issuing an intermediate product inspection report form by a laboratory of a quality assurance department after the intermediate product is detected to be qualified, calculating the weight of the added water for injection by a preparation group leader according to the content of the intermediate product, filtering by a 0.5 mu microporous membrane filter, and finally filling.

Example 3:

s1: adding water for injection into the container A, adding the prescription amount of citicoline sodium, keeping the temperature at 10 ℃, adding the water for injection to prepare a citicoline sodium concentrated solution, adjusting the pH value with 0.5mol/L hydrochloric acid or sodium hydroxide solution, adding activated carbon, keeping the temperature for 10 minutes, and filtering and decarburizing by using a filtering device;

s2: adding water for injection into the container B, heating the container B to 10 ℃, then adding mannitol with the amount of the prescription, stirring the mixture while heating until the mannitol is completely dissolved, then adding the water for injection, keeping the temperature at 10 ℃, adding activated carbon according to 1.5 per mill (w/v) of the total volume of the mannitol solution, keeping the temperature for 10 minutes, and then filtering and decarburizing the mixture by using a filtering device;

s3: mixing the concentrated solution subjected to carbon removal by filtration in S1 and the mannitol solution in S2, adding water for injection, opening a valve of the water for injection of the concentrated solution tank, flushing a pipeline of the concentrated solution tank with the water for injection to a diluted solution tank, merging a washing solution into a filtrate, issuing an intermediate product inspection report form by a laboratory of a quality assurance department after the intermediate product is detected to be qualified, calculating the weight of the added water for injection by a preparation group leader according to the content of the intermediate product, filtering by a 1.0 mu microporous membrane filter, and finally filling.

It can be seen from examples 1-3 that example 3 is the best example, and the preparation method of the medicament for treating disturbance of consciousness in the invention can effectively reduce the influence of pH value and temperature on the stability and action of the medicament, thereby improving the curative effect of treating acute craniocerebral trauma and disturbance of consciousness after brain surgery.

As shown in fig. 1 to 7, the filter device of the medicine for treating disturbance of consciousness and the preparation method thereof according to the present invention comprises a base 1, a case 2 and a filter unit 3; the box body 2 is fixedly connected to the top of the base 1; the top of the box body 2 is provided with an opening; the filtering unit 3 is arranged inside the box body 2; the filtering unit 3 comprises a motor 31, a U-shaped rod 32, a first rod 33, a filtering plate 34, a rectangular groove 35 and a filtering screen 36; the motors 31 are symmetrically and fixedly connected to the side wall of the box body 2; the U-shaped rod 32 is fixedly connected with an output shaft of the motor 31; the rectangular groove 35 is fixedly connected with the inner side wall of the box body 2; the filter plate 34 is rotatably connected to the inner side wall of the rectangular groove 35; one end of the first rod 33 is connected to the outer wall of the U-shaped rod 32 through a collar 37, and the other end of the first rod is connected to the filter plate 34 in a ball joint mode; the bottom of the rectangular groove 35 is provided with a through groove 38; the filter screen 36 is fixedly connected to the inner side wall of the through groove 38; the during operation, pour into funnel 64 with the concentrated solution of joining in marriage of citicoline sodium, start motor 31 simultaneously, make motor 31 drive U-shaped pole 32 and rotate, and the one end of pole 33 of one end of pole 33 is passed through lantern ring 37 and is connected at the outer wall of U-shaped pole 32, the other end ball connects in filter 34, make motor 31 through pole 33 intermittent type nature extrusion filter 34, because filter 34 rotates and connects in rectangular channel 35, will make filter 34 swing, activated carbon particle jam filter 34 has been avoided, and then accelerate the filtration of the concentrated solution of joining in marriage of citicoline sodium, and the concentrated solution of joining in marriage of citicoline sodium after being filtered by filter 34 will fall into rectangular channel 35 in, then the inside of filtration entering box 2 through filter screen 36, avoid taking place the phenomenon that the activated carbon particle falls into box 2 inside, thereby make the filter effect of the concentrated solution of joining in marriage of citicoline sodium better.

In one embodiment of the present invention, a cavity 21 is provided in a wall of the box body 2; a vibration mechanism is arranged in the cavity 21; the vibration mechanism comprises a cam 41, a first push plate 42, a second rod 43 and a third rod 44; the cam 41 is fixedly connected with an output shaft of the motor 31; the first push plate 42 is connected to the inner wall of the cavity 21 in a sliding manner; one end of the third rod 44 is hinged to the bottom of the cavity 21, and the other end of the third rod is in contact with the filter screen 36; one end of the second rod 43 is ball-jointed with the first push plate 42, and the other end of the second rod is ball-jointed with the third rod 44; when the motor 31 starts to operate, the motor 31 drives the cam 41 on the output shaft to rotate, so that the cam 41 intermittently extrudes the first push plate 42, the first push plate 42 slides downwards along the inner wall of the cavity 21, the second rod 43 is extruded, the second rod 43 is in ball joint with the third rod 44, the third rod 44 is extruded, and the third rod 44 rotates; and when the cam 41 does not extrude the push plate 42, because the lateral wall of the third rod 44 is connected to the bottom of the cavity 21 through the spring, the third rod 44 returns to the initial position, and then the third rod 44 beats the filter screen 36, thereby realizing the function of vibrating the filter screen 36, being convenient for shaking off the residual citicoline sodium concentrated solution on the filter screen 36, realizing the recovery of the citicoline sodium concentrated solution, and further avoiding the waste of the citicoline sodium concentrated solution.

As an embodiment of the present invention, a scraping mechanism is further disposed inside the cavity 21; the scraping mechanism comprises an L-shaped plate 51, a stacked air bag 52, a piston cylinder 53, a push rod 54, a second push plate 55, a guide rod 56 and a scraper 57; the piston cylinder 53 is fixedly connected to the bottom of the cavity 21; the overlapped air bag 52 is fixedly connected to the top of the piston cylinder 53, and the overlapped air bag 52 is communicated with the overlapped air bag 52 of the piston cylinder 53; the top of the L-shaped plate 51 is fixedly connected with the bottom of the first push plate 42, and the bottom of the L-shaped plate is arranged at the top of the stacked air bag 52; a groove 58 is formed in the inner side wall of the box body 2; the guide rod 56 is fixedly connected with the inner wall of the groove 58; the second push plate 55 is sleeved on the guide rod 56 and is in sliding connection with the guide rod 56; one end of the push rod 54 is fixedly connected to a piston rod of the piston cylinder 53, and the other end of the push rod is fixedly connected to the top of the second push plate 55; the scraping plate 57 is fixedly connected to the side wall of the second push plate 55; when the device works, after the motor 31 drives the cam 41 to rotate, the cam 41 intermittently extrudes the first push plate 42, the L-shaped plate 51 at the bottom of the first push plate 42 moves downwards, the overlapped air bag 52 is extruded, the gas inside the overlapped air bag 52 enters the piston cylinder 53 after being extruded, the push rod 54 is pushed to move downwards, the push rod 54 extrudes the second push plate 55, the second push plate 55 moves downwards along the guide rod 56 and then is matched with the scraper 57 to scrape residual citicoline sodium concentrated solution on the inner side wall of the box body 2, and the citicoline sodium concentrated solution finally flows to the bottom of the box body 2 due to the action of gravity, so that the citicoline sodium concentrated solution is recycled, and the waste of the citicoline sodium concentrated solution is avoided.

As an embodiment of the present invention, the bottom of the box body 2 is symmetrically and fixedly connected with a drainage plate 61; the cross section of the drainage plate 61 is in a right-angled triangle shape; a discharge pipe 62 is fixedly connected to the bottom of the base 1; the top end of the discharge pipe 62 is opened in the box body 2; the top of the base 1 is also fixedly connected with a supporting plate 63; a funnel 64 is arranged at the top of the supporting plate 63 in a penetrating manner; during operation, earlier pour into funnel 64 with the concentrated solution of citicoline sodium, these concentrated solutions of citicoline sodium will be filtered the active carbon granule by filter unit 3, when the concentrated solution of citicoline sodium flows down from filter screen 36, partly will fall into row material pipe 62, another part will fall into the top of drainage plate 61, partly spatters on the inside wall of box 2 in addition, fall into the concentrated solution of citicoline sodium on the top of drainage plate 61 and the inside wall of box 2 and finally can flow along drainage plate 61 for the concentrated solution of citicoline sodium gets into to arrange the material pipe 62, the effect of drainage plate 61 is exactly the flow of the concentrated solution of citicoline sodium of guide, it gets into to arrange the material pipe 62 in being convenient for.

As an embodiment of the present invention, an elastic cloth 71 is fixedly connected to an opening of the groove 58; the outer surface of the elastic cloth 71 is fixedly connected with a waterproof membrane 72; during operation, the elastic cloth 71 is used for keeping the opening of the groove 58 in a closed state all the time, and the waterproof membrane 72 is used for preventing the citicoline sodium concentrated solution from wetting the elastic cloth 71, so that the citicoline sodium concentrated solution can be prevented from entering the groove 58, waste of the citicoline sodium concentrated solution is avoided, and the whole using effect of the device is improved.

The working principle is as follows: pouring the citicoline sodium concentrated solution into a funnel 64, starting a motor 31 simultaneously, enabling the motor 31 to drive a U-shaped rod 32 to rotate, enabling one end of a first rod 33 at one end of the first rod 33 to be connected to the outer wall of the U-shaped rod 32 through a lantern ring 37, enabling the motor 31 to intermittently extrude a filter plate 34 through the first rod 33, enabling the filter plate 34 to swing as the filter plate 34 is rotatably connected to a rectangular groove 35, avoiding activated carbon particles from blocking the filter plate 34, further accelerating the filtration of the citicoline sodium concentrated solution, enabling the citicoline sodium concentrated solution filtered by the filter plate 34 to fall into the rectangular groove 35, then entering the inside of a box body 2 through the filtration of a filter screen 36, avoiding the phenomenon that the activated carbon particles fall into the inside of the box body 2, and enabling the filtration effect of the citicoline sodium concentrated solution to be better; when the motor 31 starts to operate, the motor 31 drives the cam 41 on the output shaft thereof to rotate, so that the cam 41 intermittently presses the first push plate 42, the first push plate 42 further slides downwards along the inner wall of the cavity 21, the second rod 43 is pressed, the second rod 43 is in ball joint with the third rod 44, the third rod 44 is pressed, and the third rod 44 rotates; when the cam 41 does not extrude the first push plate 42, the side wall of the third rod 44 is connected to the bottom of the cavity 21 through the spring, so that the third rod 44 returns to the initial position, and the third rod 44 is further used for beating the filter screen 36, thereby realizing the function of vibrating the filter screen 36, being convenient for shaking off the residual citicoline sodium concentrated solution on the filter screen 36, realizing the recovery of the citicoline sodium concentrated solution, and further avoiding the waste of the citicoline sodium concentrated solution; after the motor 31 drives the cam 41 to rotate, the cam 41 intermittently extrudes the first push plate 42, and then the L-shaped plate 51 at the bottom of the first push plate 42 moves downwards, so that the overlapped air bag 52 is extruded, after the overlapped air bag 52 is extruded, the gas in the overlapped air bag 52 enters the piston cylinder 53, and the push rod 54 is pushed to move downwards, so that the push rod 54 extrudes the second push plate 55, and then the second push plate 55 moves downwards along the guide rod 56, and then the residual citicoline sodium concentrated solution on the inner side wall of the box body 2 is scraped under the action of the scraper 57, and finally the citicoline sodium concentrated solution flows to the bottom of the box body 2 under the action of gravity, so that the citicoline sodium concentrated solution is recycled, and further the waste of the citicoline sodium concentrated solution is avoided; the citicoline sodium concentrated solution is poured into the funnel 64, the citicoline sodium concentrated solution is filtered by the filtering unit 3 to remove active carbon particles, when the citicoline sodium concentrated solution flows down from the filter screen 36, one part of the citicoline sodium concentrated solution falls into the discharging pipe 62, the other part of the citicoline sodium concentrated solution falls onto the top of the drainage plate 61, the other part of the citicoline sodium concentrated solution splashes onto the inner side wall of the box body 2, and the citicoline sodium concentrated solution falling onto the top of the drainage plate 61 and the inner side wall of the box body 2 finally flows along the drainage plate 61, so that the citicoline sodium concentrated solution enters the discharging pipe 62, and the drainage plate 61 is used for guiding the citicoline sodium concentrated solution to flow and facilitating the citicoline sodium concentrated solution to enter the discharging pipe; the elastic cloth 71 is used for enabling the opening of the groove 58 to be always in a closed state, and the waterproof membrane 72 is used for preventing the citicoline sodium concentrated solution from wetting the elastic cloth 71, so that the citicoline sodium concentrated solution can be prevented from entering the groove 58, waste of the citicoline sodium concentrated solution is avoided, and the overall using effect of the device is improved.

The front, the back, the left, the right, the upper and the lower are all based on figure 3 in the attached drawings of the specification, according to the standard of the observation angle of a person, the side of the device facing an observer is defined as the front, the left side of the observer is defined as the left, and the like.

In the description of the present invention, it is to be understood that the terms "center", "longitudinal", "lateral", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", etc., indicate orientations or positional relationships based on those shown in the drawings, and are used merely for convenience in describing the present invention and for simplifying the description, but do not indicate or imply that the device or element being referred to must have a particular orientation, be constructed and operated in a particular orientation, and thus, should not be construed as limiting the scope of the present invention.

The foregoing illustrates and describes the principles, general features, and advantages of the present invention. It will be understood by those skilled in the art that the present invention is not limited to the embodiments described above, which are described in the specification and illustrated only to illustrate the principle of the present invention, but that various changes and modifications may be made therein without departing from the spirit and scope of the present invention, which fall within the scope of the invention as claimed. The scope of the invention is defined by the appended claims and equivalents thereof.