阅读说明：本技术 用于放射疗法和诊断成像的制剂和试剂盒 (Formulations and kits for radiation therapy and diagnostic imaging ) 是由 M·J·哈里斯 肖恩·卢姆 于 2019-04-11 设计创作，主要内容包括：公开了用稳定剂诸如L-甲硫氨酸和龙胆酸保护免受辐射分解的通式(II)的放射性药物化合物的水性制剂和试剂盒,其中所述化合物基于与放射性同位素诸如64-铜配位并且与四嗪基团连接的sarcophagine配体,所述四嗪基团用于与具有功能反应性基团诸如反式环辛烯的肿瘤靶向抗体反应,制备所述放射性配体制剂的工艺及其用于放射成像、诊断和治疗癌症的用途。(Aqueous formulations and kits of radiopharmaceutical compounds of general formula (II) protected from radiolysis with stabilizers such as L-methionine and gentisic acid are disclosed, wherein the compounds are based on coordination with a radioisotope such as 64-copper and with a tetrazinyl groupGroup-linked sarcophagine ligands, the tetrazine groups for reaction with tumor-targeting antibodies having functional reactive groups such as trans-cyclooctene, processes for preparing the radioligand formulations and their use for radioimaging, diagnosis and treatment of cancer.)